Imunologia e Inflamação

MC1, an effective NLRP3 inhibitor, exhibits a KD value of 19.3 nM and is devoid of cytotoxicity. This compound enhances cognitive function without causing adverse effects and exhibits no hepatotoxicity. MC1 holds potential for research in Alzheimer's disease.

<p>Compound PS-I (Photosensitizer-4) is an effective photosensitizer that can efficiently kill cancer cells and inhibit tumor growth under light exposure.</p>

TMV-IN-13 (compound 5g) exhibits anti-TMV activity.

<p>Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS), efficiently inactivating nNOS in a time-dependent</p>

<p>ABTIM3-hum11 is a humanized anti-TIM3 blood-brain barrier shuttling monoclonal antibody.</p>

<p>AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.</p>

Pixatimod (also known as PG-545) is a synthetic modified heparan sulfate mimetic and an agonist of Toll-like receptor 9 (TLR9), showcasing potential immunostimulatory, antitumor, and antiviral properties. It effectively inhibits SARS-CoV-2 by disrupting the interaction between the spike protein and ACE2. Moreover, Pixatimod blocks cancer-promoting processes such as cell proliferation, invasion, metastasis, angiogenesis, and epithelial-mesenchymal transition. These activities have demonstrated significant efficacy across various murine cancer models, including approximately 30 xenograft models and 20 syngeneic models. Pixatimod has been tested in combination with several approved anticancer compounds, underscoring its clinical potential, with drugs like gemcitabine, paclitaxel, sorafenib, platinum-based compounds, and an anti-PD-1 antibody.

<p>IKZF-IN-1 (Compound I) is a molecular glue that degrades the karos zinc finger family proteins (IKZF) IKZF 1/2/3/4 and is used as an immune modulator in cancer and viral infection research.</p>

<p>CDD-3290 (Compound 20) is an inhibitor of prostate-specific antigen (PSA) with a Ki value of 216 nM. This compound also exhibits inhibitory effects on α-chymotrypsin and elastase.</p>

<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>

FSL-1 TFA activates TLR2/6, boosts HSV-2 defense, and triggers MMP-9 via TLR2, NF-κB/AP-1 in THP-1 cells.

<p>Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG) 4 κ monoclonal antibody, thereby reducing eosinophil production and survival.</p>

<p>Bixin, from Bixa orellana seeds, has anti-tumor, anti-inflammatory effects and boosts heart health by reducing fibrosis and ROS.</p>

<p>KIN1408 is antivira, is an agonist of the RIG-1-like receptor (RLR) pathway and IRF3 to induce the expression of innate immunity genes , targeting MAVS (.</p>

<p>IX 207-887 inhibits the release of interleukin-1 (IL-1). IX 207-887 is a novel antiarthritic agent.</p>

<p>Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) is an OMPD inhibitor with antiviral activity and has been used in the study of Zika virus (ZIKV) infections.</p>

<p>Gardiquimod diTFA is a TLR7/8 agonist that may block HIV-1 in macrophages and PBMCs, active under 10 μM.</p>

<p>SARM1-IN-2 is a potent SARM1 inhibitor for the study of metabolic and neurological related diseases.</p>

<p>L-NIL HCl selectively inhibits iNOS (IC50 0.4-3.3µM) and is less effective on eNOS/nNOS. It works in vitro/in vivo against L. major infection.</p>

<p>Tat-NR2B9c TFA, a 20-amino acid peptide, inhibits PSD-95 with a 6.7 nM EC50 and has neuroprotective properties.</p>

<p>α-Gracinoic acid, a derivative of Chalcone, exhibits anti-inflammatory activity. This compound inhibits the production of nitric oxide catalyzed by inducible nitric oxide synthase (iNOS) in RAW 264.7 cells treated with lipopolysaccharide (LPS).</p>

<p>Valeroyl Salicylate is a NSAID that extends lifespan, boosts mobility with age, and enhances stress resilience.</p>

MMG-11 is a low-toxicity, selective human TLR2 antagonist, blocking TLR2/1 and TLR2/6 (IC50: 1.7 μM and 5.7 μM respectively).

<p>GKT136901 HCl: Potent, selective NOX1/4 inhibitor, K i of 160/165 nM, combats diabetic complications, stroke, and inflammation.</p>

Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.

<p>Sodium formate has antiviral and antifungal properties, can inhibit carbonic anhydrase, and can also be used as a biochemical buffer.</p>