Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(148 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(60 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(444 produtos)
- NOD(17 produtos)
- NOS(63 produtos)
- Nrf2(79 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3045 produtos de "Imunologia e Inflamação"
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NLRP3-IN-58
CAS:<p>NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.</p>Fórmula:C22H18ClN3O3SCor e Forma:SolidPeso molecular:439.92STING agonist-42
CAS:<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Fórmula:C17H8F2LiN5O3Cor e Forma:SolidPeso molecular:375.22NLRP3-IN-70
CAS:<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Fórmula:C23H23NO5Cor e Forma:SolidPeso molecular:393.432MG-T-19
CAS:<p>MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.</p>Fórmula:C18H8Br2ClF3N4O2SPureza:99.14%Cor e Forma:SolidPeso molecular:596.6STING-IN-15
CAS:<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Fórmula:C20H14F2N4O3Cor e Forma:SolidPeso molecular:396.35NLRP3-IN-80
CAS:<p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>Fórmula:C24H22F2N4O3Cor e Forma:SolidPeso molecular:452.45NP3-146 sodium
CAS:<p>NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.</p>Fórmula:C20H26ClN2NaO5SCor e Forma:SolidPeso molecular:464.94AS2690168 hydrochloride
CAS:<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H15Cl2F3N4OCor e Forma:SolidPeso molecular:419.228mPGES1-IN-9
CAS:<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Fórmula:C25H18N4OSCor e Forma:SolidPeso molecular:422.502FK-565
CAS:<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Fórmula:C22H38N4O9Cor e Forma:SolidPeso molecular:502.559AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H13F3N4OCor e Forma:SolidPeso molecular:346.306(Rel)-Factor B-IN-5
CAS:<p>(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.</p>Fórmula:C27H32N2O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:448.55CD73-IN-19
CAS:<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Fórmula:C18H17N3O3SCor e Forma:SolidPeso molecular:355.411LHC-165
CAS:<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Fórmula:C29H32F2N3O7PPureza:98%Cor e Forma:SolidPeso molecular:603.55G108
CAS:<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Fórmula:C16H14Cl2N4O2Pureza:99.13% - 99.75%Cor e Forma:SolidPeso molecular:365.21SP4206
CAS:<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Fórmula:C30H37Cl2N7O6Pureza:98%Cor e Forma:SolidPeso molecular:662.56oxLig-1
CAS:<p>OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).</p>Fórmula:C36H58O5Cor e Forma:SolidPeso molecular:570.84Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Cor e Forma:SolidPeso molecular:476.39OP-5244 sodium
<p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>Fórmula:C19H28ClN5NaO9PCor e Forma:SolidPeso molecular:559.87RGT-068A
CAS:<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Fórmula:C17H16ClN9O2Cor e Forma:SolidPeso molecular:413.82COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Fórmula:C25H23N5O4S2Cor e Forma:SolidPeso molecular:521.61C5aR-IN-3
CAS:<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Fórmula:C36H40FN5O3Cor e Forma:SolidPeso molecular:609.73Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Cor e Forma:SolidPeso molecular:614.11AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Fórmula:C25H23Br2N5O4Cor e Forma:SolidPeso molecular:617.289TLR7/8 antagonist 1
<p>Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.</p>Fórmula:C24H27N5O2Cor e Forma:SolidPeso molecular:417.5SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Fórmula:C13H17F2N3O2Cor e Forma:SolidPeso molecular:285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Fórmula:C19H14ClN5S2Cor e Forma:SolidPeso molecular:411.93STING agonist-20
CAS:<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Fórmula:C36H39N11O8Cor e Forma:SolidPeso molecular:753.76Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Fórmula:C18H14O8Cor e Forma:SolidPeso molecular:358.3NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Cor e Forma:SolidPeso molecular:454.97SMW139
CAS:<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Fórmula:C19H21ClF3NO2Cor e Forma:SolidPeso molecular:387.824COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Fórmula:C15H10ClIN2OCor e Forma:SolidPeso molecular:396.61CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307Gardiquimod hydrochloride
CAS:<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Fórmula:C17H24ClN5OCor e Forma:SolidPeso molecular:349.858IACS-8779 disodium
CAS:<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Fórmula:C21H23N9Na2O10P2S2Cor e Forma:SolidPeso molecular:733.52COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Cor e Forma:SolidPeso molecular:494.56IL-17 modulator 1 disodium
CAS:<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Fórmula:C28H37N6NaO6PCor e Forma:SolidPeso molecular:607.604TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Fórmula:C20H16ClN7O3SCor e Forma:SolidPeso molecular:469.9MSA-2 dimer
CAS:<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Fórmula:C29H28O8S2Cor e Forma:SolidPeso molecular:568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Fórmula:C18H15N5O2SCor e Forma:SolidPeso molecular:365.41IKZF2-degrader 1
CAS:<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Fórmula:C27H30FN7O3Cor e Forma:SolidPeso molecular:519.57Balsalazide disodium
CAS:<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Fórmula:C17H13N3Na2O6Cor e Forma:SolidPeso molecular:401.281C-di-IMP
CAS:<p>Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.</p>Fórmula:C20H22N8O14P2Cor e Forma:SolidPeso molecular:660.386-Alkyne-F-araNAD
CAS:<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Fórmula:C24H28FN7O13P2Cor e Forma:SolidPeso molecular:703.464MMG-11 quarterhydrate
<p>MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.</p>Fórmula:C15H16O8Cor e Forma:SolidPeso molecular:310.78Polvitolimod
CAS:<p>Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.</p>Fórmula:C13H14FN5O4Cor e Forma:SolidPeso molecular:323.28NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Fórmula:C14H20N2O3Cor e Forma:SolidPeso molecular:264.32IRAK4 ligand-13
CAS:<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Fórmula:C23H26N10Cor e Forma:SolidPeso molecular:442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Fórmula:C36H62O5Pureza:98%Cor e Forma:SolidPeso molecular:574.87Fexlamose
CAS:<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Fórmula:C12H22O9S2Cor e Forma:SolidPeso molecular:374.428
