NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Flaconitine
CAS:<p>Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.</p>Fórmula:C36H49NO12Pureza:98% - 99.84%Cor e Forma:SolidPeso molecular:687.77Vanillic Acid
CAS:<p>Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.</p>Fórmula:C8H8O4Pureza:99.82%Cor e Forma:White Odourless Crystals Or PowderPeso molecular:168.152-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>Fórmula:C11H10N2OSPureza:99.48%Cor e Forma:SolidPeso molecular:218.27BOT-64
CAS:<p>BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole</p>Fórmula:C15H15NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:273.3518α-Glycyrrhetinic acid
CAS:<p>18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.</p>Fórmula:C30H46O4Pureza:98.54% - 99.68%Cor e Forma:SolidPeso molecular:470.68(E/Z)-IT-603
CAS:<p>(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.</p>Fórmula:C11H9BrN2O3SPureza:99.35%Cor e Forma:SolidPeso molecular:329.17Ginsenoside Rk3
CAS:<p>Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.</p>Fórmula:C36H60O8Pureza:99.33% - 99.88%Cor e Forma:SolidPeso molecular:620.86Asperulosidic acid
CAS:<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Fórmula:C18H24O12Pureza:99.47%Cor e Forma:SolidPeso molecular:432.38BX795
CAS:<p>BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.</p>Fórmula:C23H26IN7O2SPureza:98% - 99.57%Cor e Forma:SolidPeso molecular:591.47Galloylpaeoniflorin
CAS:<p>Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress.</p>Fórmula:C30H32O15Pureza:99.82%Cor e Forma:SolidPeso molecular:632.57AS-2444697
CAS:<p>AS-2444697, an IRAK-4 inhibitor (C50=21 nM), offers renal protection via anti-inflammatory effects on human and rat IRAK-4.</p>Fórmula:C19H21ClN6O4Pureza:97.17%Cor e Forma:SolidPeso molecular:432.86AZD3264
CAS:<p>AZD3264 is a new type IKK2 inhibitor.</p>Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.5IRAK4-IN-7
CAS:<p>IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.</p>Fórmula:C21H19N7O3Pureza:99.5%Cor e Forma:SolidPeso molecular:417.42SC-514
CAS:<p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3Cyclo(his-pro)
CAS:<p>Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.</p>Fórmula:C11H14N4O2Pureza:99.87%Cor e Forma:SolidPeso molecular:234.25Astaxanthin
CAS:<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Fórmula:C40H52O4Pureza:95.1% - 99.79%Cor e Forma:Needles From Acetone/Light Petroleum SolidPeso molecular:596.847,4'-Dihydroxyflavone
CAS:<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:SolidPeso molecular:254.24Rucaparib
CAS:<p>Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.</p>Fórmula:C19H18FN3OPureza:98.24% - 99.80%Cor e Forma:SolidPeso molecular:323.36Avicularin
CAS:<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Fórmula:C20H18O11Pureza:97.02% - 99.94%Cor e Forma:White PowderPeso molecular:434.35Berbamine
CAS:<p>Berbamine is a natural product extracted from Phellodendron amurense.</p>Fórmula:C37H40N2O6Pureza:98.92% - 99.67%Cor e Forma:White Crystal PowderPeso molecular:608.72Tizoxanide
CAS:<p>Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.</p>Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Cor e Forma:SolidPeso molecular:265.25Micheliolide
CAS:<p>Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.</p>Fórmula:C15H20O3Pureza:98% - 99.37%Cor e Forma:SolidPeso molecular:248.32Ginsenoside Rb3
CAS:<p>Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.</p>Fórmula:C53H90O22Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:1079.27Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Fórmula:C7H4O6Pureza:99.03%Cor e Forma:SolidPeso molecular:184.1Ac2-26 acetate
<p>Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).</p>Fórmula:C141H210N32O44SPureza:98%Cor e Forma:SolidPeso molecular:3089.43Rhoifolin
CAS:<p>Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.</p>Fórmula:C27H30O14Pureza:98.11% - 98.58%Cor e Forma:SolidPeso molecular:578.52Isoquercetin
CAS:<p>1.</p>Fórmula:C21H20O12Pureza:98.08% - 99.76%Cor e Forma:SolidPeso molecular:464.38Muscone
CAS:<p>Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.</p>Fórmula:C16H30OPureza:98.97% - ≥98%Cor e Forma:Colourless Liquid LiquidPeso molecular:238.41Eclitasertib
CAS:<p>Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).</p>Fórmula:C19H18N6O3Pureza:99.85%Cor e Forma:SolidPeso molecular:378.38Sodium Aescinate
CAS:<p>Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.</p>Fórmula:C54H83NaO23Pureza:95.17%Cor e Forma:SolidPeso molecular:1123.21Ginsenoside Rd
CAS:<p>Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.</p>Fórmula:C48H82O18Pureza:99.13% - 99.92%Cor e Forma:SolidPeso molecular:947.15WITHAFERIN A
CAS:<p>WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/</p>Fórmula:C28H38O6Pureza:97.41% - 99.99%Cor e Forma:SolidPeso molecular:470.6Dehydroevodiamine
CAS:<p>Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant</p>Fórmula:C19H15N3OPureza:99.54%Cor e Forma:SolidPeso molecular:301.34Diethylmaleate
CAS:<p>Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.</p>Fórmula:C8H12O4Pureza:98%Cor e Forma:Colourless LiquidPeso molecular:172.18Sinomenine
CAS:<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Fórmula:C19H23NO4Pureza:99.02% - 99.73%Cor e Forma:White PowderPeso molecular:329.392-Hydroxychalcone
CAS:<p>2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.</p>Fórmula:C15H12O2Pureza:99.6%Cor e Forma:SolidPeso molecular:224.252,5-Dihydroxyacetophenone
CAS:<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Fórmula:C8H8O3Pureza:99.75%Cor e Forma:Yellow PowderPeso molecular:152.15Dauricine
CAS:<p>1.</p>Fórmula:C38H44N2O6Pureza:99.24% - 99.75%Cor e Forma:White PowderPeso molecular:624.77Dendrophenol
CAS:<p>Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.</p>Fórmula:C17H20O5Pureza:98.2% - 99.36%Cor e Forma:SolidPeso molecular:304.34GSK8612
CAS:<p>GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .</p>Fórmula:C17H17BrF3N7O2SPureza:99.46% - 99.8%Cor e Forma:SolidPeso molecular:520.33IRAK inhibitor 6
CAS:<p>IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).</p>Fórmula:C20H20N4O3SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46Phellodendrine
CAS:<p>Phellodendrine may treat nephritis by blocking macrophage and T cell activity in glomeruli.</p>Fórmula:C20H24NO4Pureza:98.7% - 99.94%Cor e Forma:SolidPeso molecular:342.41yangonin
CAS:<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Fórmula:C15H14O4Pureza:98.82% - 99.55%Cor e Forma:Pale Yellow PowderPeso molecular:258.27Iron sucrose
CAS:<p>Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.</p>Fórmula:C18H24Fe2O24Pureza:99.97%Cor e Forma:SolidPeso molecular:736.1Isovitexin
CAS:<p>1.</p>Fórmula:C21H20O10Pureza:99.79% - 99.97%Cor e Forma:SolidPeso molecular:432.38Neochlorogenic acid
CAS:<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Fórmula:C16H18O9Pureza:99.12% - 99.54%Cor e Forma:White PowderPeso molecular:354.31Denosumab
CAS:<p>Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand</p>Fórmula:C6404H9912N1724O2004S50Pureza:95.9% (SDS-PAGE); 98.4% (SEC-HPLC) - 99.90%Cor e Forma:LiquidPeso molecular:144.71 kDaTriacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Fórmula:C20H18O6Pureza:99.81%Cor e Forma:Off White PowderPeso molecular:354.35IMD-0354
CAS:<p>IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.</p>Fórmula:C15H8ClF6NO2Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:383.67Necrostatin-34
CAS:<p>Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a</p>Fórmula:C18H16N4O2S2Pureza:98.66% - 98.8%Cor e Forma:SolidPeso molecular:384.48
