NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 390 produtos de "NF-κB"
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Ginsenoside Rg1
CAS:Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Fórmula:C42H72O14Pureza:99% - 99.92%Cor e Forma:White Crystalline PowderPeso molecular:801.01CBL0137 hydrochloride
CAS:CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB.Cost-effective and quality-assured.Fórmula:C21H25ClN2O2Pureza:99.35% - 99.86%Cor e Forma:SolidPeso molecular:372.88Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFórmula:C27H30O15Pureza:96.96% - 98.17%Cor e Forma:SolidPeso molecular:594.5Ref: TM-T5S0089
1mg48,00€5mg92,00€10mg136,00€25mg215,00€50mg323,00€100mg469,00€200mg647,00€1mL*10mM (DMSO)122,00€Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Fórmula:C42H68O13Pureza:98.34% - 99.73%Cor e Forma:White PowderPeso molecular:780.98IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:383.67Ref: TM-T6141
2mg46,00€5mg63,00€10mg87,00€25mg155,00€50mg210,00€100mg294,00€500mg713,00€1mL*10mM (DMSO)65,00€Phellodendrine
CAS:Phellodendrine may treat nephritis by blocking macrophage and T cell activity in glomeruli.Fórmula:C20H24NO4Pureza:98.7% - 99.94%Cor e Forma:SolidPeso molecular:342.41Ref: TM-T6S0781
2mg40,00€5mg56,00€10mg80,00€25mg114,00€50mg167,00€100mg240,00€200mg355,00€1mL*10mM (DMSO)73,00€Muscone
CAS:Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Fórmula:C16H30OPureza:98.97% - ≥98%Cor e Forma:Colourless Liquid LiquidPeso molecular:238.41BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFórmula:C15H15NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:273.35Ref: TM-T8705
1mg50,00€5mg110,00€10mg170,00€25mg323,00€50mg494,00€100mg665,00€200mg893,00€1mL*10mM (DMSO)102,00€Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.
Fórmula:C36H49NO12Pureza:98% - 99.84%Cor e Forma:SolidPeso molecular:687.773'-Sialyllactose
CAS:3'-Sialyllactose (3'-SL), a prebiotic, supports immunity, reduces inflammation and arthritis, and is low-toxicity for research.Fórmula:C23H39NO19Cor e Forma:SolidPeso molecular:633.55EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Fórmula:C18H18ClMnN2O4Pureza:98.39%Cor e Forma:SolidPeso molecular:416.74Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Fórmula:C25H24O6Pureza:98.68% - 99.8%Cor e Forma:SolidPeso molecular:420.45QNZ
CAS:QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.Fórmula:C22H20N4OPureza:99.17% - 99.18%Cor e Forma:White SolidPeso molecular:356.42Ref: TM-T6204
1mg40,00€2mg54,00€5mg88,00€10mg133,00€25mg178,00€50mg313,00€100mg465,00€200mg673,00€1mL*10mM (DMSO)87,00€BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:99.36% - 99.74%Cor e Forma:SolidPeso molecular:255.32Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Fórmula:C21H26O6Pureza:98.77% - 99.41%Cor e Forma:SolidPeso molecular:374.43Ref: TM-T4S1540
1mg44,00€5mg87,00€10mg137,00€25mg236,00€50mg385,00€100mg560,00€1mL*10mM (DMSO)102,00€NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Cor e Forma:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€Laquinimod
CAS:Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral
Fórmula:C19H17ClN2O3Pureza:98.42% - 98.84%Cor e Forma:SolidPeso molecular:356.8Sulindac sodium
CAS:Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.Fórmula:C20H16FNaO3SCor e Forma:SolidPeso molecular:378.39Articaine
CAS:Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-Fórmula:C13H20N2O3SCor e Forma:SolidPeso molecular:284.372,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Fórmula:C8H8O3Pureza:99.75%Cor e Forma:Yellow PowderPeso molecular:152.152-Hydroxychalcone
CAS:2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.Fórmula:C15H12O2Pureza:99.6%Cor e Forma:SolidPeso molecular:224.25Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:99.13% - 99.92%Cor e Forma:SolidPeso molecular:947.15Ref: TM-T2878
1mg37,00€5mg71,00€10mg99,00€25mg170,00€50mg260,00€100mg394,00€200mg570,00€1mL*10mM (DMSO)124,00€Ref: TM-T5S0754
5mg46,00€10mg58,00€25mg92,00€50mg137,00€100mg200,00€200mg295,00€1mL*10mM (DMSO)49,00€Berbamine
CAS:Berbamine is a natural product extracted from Phellodendron amurense.Fórmula:C37H40N2O6Pureza:98.92% - 99.67%Cor e Forma:White Crystal PowderPeso molecular:608.72Dauricine
CAS:1.Fórmula:C38H44N2O6Pureza:99.24% - 99.75%Cor e Forma:White PowderPeso molecular:624.77Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Fórmula:C17H20O5Pureza:98.2% - 99.36%Cor e Forma:SolidPeso molecular:304.34Ref: TM-T3S1707
1mg99,00€2mg138,00€5mg215,00€10mg319,00€25mg530,00€50mg755,00€100mg1.018,00€1mL*10mM (DMSO)234,00€SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3yangonin
CAS:Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.Fórmula:C15H14O4Pureza:98.82% - 99.55%Cor e Forma:Pale Yellow PowderPeso molecular:258.27Ref: TM-T3S0738
1mg70,00€5mg135,00€10mg207,00€25mg349,00€50mg515,00€100mg735,00€1mL*10mM (DMSO)177,00€Iron sucrose
CAS:Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Fórmula:C18H24Fe2O24Pureza:99.97%Cor e Forma:SolidPeso molecular:736.1Neochlorogenic acid
CAS:Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.Fórmula:C16H18O9Pureza:99.12% - 99.54%Cor e Forma:White PowderPeso molecular:354.31Ref: TM-T6S1538
1mg34,00€5mg71,00€10mg90,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€1mL*10mM (DMSO)77,00€Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.
Fórmula:C20H18O6Pureza:99.81%Cor e Forma:Off White PowderPeso molecular:354.35Micheliolide
CAS:Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.Fórmula:C15H20O3Pureza:98% - 99.37%Cor e Forma:SolidPeso molecular:248.32Ref: TM-T5688
1mg44,00€5mg113,00€10mg177,00€25mg299,00€50mg447,00€100mg623,00€500mg1.305,00€1mL*10mM (DMSO)124,00€Licochalcone D
CAS:Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Fórmula:C21H22O5Pureza:99.03% - 99.9%Cor e Forma:SolidPeso molecular:354.4Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Cor e Forma:SolidPeso molecular:383.82Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Fórmula:C27H30O14Pureza:98.11% - 98.58%Cor e Forma:SolidPeso molecular:578.52Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Fórmula:C54H92O23Pureza:99.12% - 99.76%Cor e Forma:SolidPeso molecular:1109.29Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27% - 99.53%Cor e Forma:Prisms From Methanol + Ether SolidPeso molecular:550.64Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Fórmula:C24H30O14Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:542.49Ref: TM-T4S2326
1mg96,00€5mg264,00€10mg415,00€25mg677,00€50mg935,00€100mg1.254,00€500mg2.527,00€1mL*10mM (DMSO)315,00€Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Fórmula:C19H25BN4O4Pureza:97.79% - >99.99%Cor e Forma:Yellow SolidPeso molecular:384.24Ref: TM-T2399
5mg50,00€10mg60,00€25mg75,00€50mg92,00€100mg137,00€200mg213,00€500mg353,00€1mL*10mM (DMSO)50,00€Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Fórmula:C30H32O13Pureza:98.52% - 99.96%Cor e Forma:SolidPeso molecular:600.57Ref: TM-T4S1658
1mg120,00€5mg281,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€1mL*10mM (DMSO)358,00€Pyrrolidinedithiocarbamate ammonium
CAS:Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxideFórmula:C5H12N2S2Pureza:98% - >99.99%Cor e Forma:Off-White To Pale Yellow CrystalsPeso molecular:164.29Sodium Aescinate
CAS:Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Fórmula:C54H83NaO23Pureza:95.17%Cor e Forma:SolidPeso molecular:1123.21Specnuezhenide
CAS:Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling.Cost-effective and quality-assured.Fórmula:C31H42O17Pureza:98% - 99.93%Cor e Forma:SolidPeso molecular:686.66Ref: TM-T3803
2mg34,00€5mg50,00€10mg80,00€25mg152,00€50mg219,00€100mg319,00€200mg474,00€1mL*10mM (DMSO)77,00€γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Cor e Forma:SolidPeso molecular:410.63Ref: TM-T19768
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg224,00€50mg333,00€100mg489,00€200mg705,00€1mL*10mM (DMSO)92,00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Fórmula:C36H60O8Pureza:99.88%Cor e Forma:SolidPeso molecular:620.86Ref: TM-T6S1495
1mg80,00€5mg169,00€10mg241,00€25mg404,00€50mg597,00€100mg850,00€1mL*10mM (DMSO)268,00€MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8Ref: TM-TQ0306
1mg50,00€2mg66,00€5mg90,00€10mg152,00€25mg313,00€50mg537,00€100mg735,00€1mL*10mM (DMSO)110,00€PTP1B-IN-1
CAS:PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)Fórmula:C8H8N2O3SPureza:99.27%Cor e Forma:SolidPeso molecular:212.23MD2-TLR4-IN-1
CAS:MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.Fórmula:C22H14Cl2N4OPureza:97.74%Cor e Forma:SolidPeso molecular:421.28Ref: TM-T7672
1mg58,00€5mg128,00€10mg200,00€25mg344,00€50mg482,00€100mg637,00€200mg858,00€1mL*10mM (DMSO)141,00€Rubiadin-1-methyl ether
CAS:Rubiadin-1-methyl ether: a natural inhibitor of bone resorption, blocking NF-κB p65 phosphorylation and IκBα degradation.
Fórmula:C16H12O4Pureza:98.32%Cor e Forma:SolidPeso molecular:268.26Rhynchophylline
CAS:Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.Fórmula:C22H28N2O4Pureza:99.44% - 99.98%Cor e Forma:Red Brown Or White Fine PowderPeso molecular:384.47
