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Transportador de Membranas/Canal Iónico

Transportador de Membranas/Canal Iónico

Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.

Subcategorias de "Transportador de Membranas/Canal Iónico"

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Foram encontrados 2430 produtos de "Transportador de Membranas/Canal Iónico"

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  • ICA-105665
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    ICA-105665

    CAS:
    ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.
    Fórmula:C19H15F2N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:355.34

    Ref: TM-T11606

  • GNE-616
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    GNE-616

    CAS:
    <p>GNE-616: a potent, stable, oral Nav1.7 inhibitor; Ki: 0.79 nM, Kd: 0.38 nM; for chronic pain.</p>
    Fórmula:C24H23F4N5O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:537.53

    Ref: TM-T11439

  • (RS)-AMPA hydrobromide
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    (RS)-AMPA hydrobromide

    CAS:
    AMPAR agonist
    Fórmula:C7H11BrN2O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:267.08

    Ref: TM-T23267

  • KV1.3-IN-2
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    KV1.3-IN-2

    CAS:
    <p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>
    Fórmula:C16H23ClN2O4
    Cor e Forma:Solid
    Peso molecular:342.818

    Ref: TM-T205655

  • Opakalim
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    Opakalim

    CAS:
    <p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>
    Fórmula:C18H22F2N4O
    Cor e Forma:Solid
    Peso molecular:348.39

    Ref: TM-T206117

  • Logotipo do CymitQuimica
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    WS-898

    <p>WS-898 boosts paclitaxel efficacy in resistant cells by inhibiting ABCB1; IC50: SW620/Ad300 - 5.0 nM, KB-C2 - 3.67 nM, HEK293/ABCB1 - 3.68 nM.</p>
    Fórmula:C33H25N7OS
    Cor e Forma:Solid
    Peso molecular:567.66

    Ref: TM-T64016

  • Blixeprodil
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    Blixeprodil

    CAS:
    <p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>
    Fórmula:C13H16FNO
    Cor e Forma:Solid
    Peso molecular:221.271

    Ref: TM-T206599

  • Logotipo do CymitQuimica
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    IAA65

    CAS:
    <p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>
    Fórmula:C16H13F6NO2
    Cor e Forma:Solid
    Peso molecular:365.27

    Ref: TM-T61393

  • Logotipo do CymitQuimica
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    VU0463271 quarterhydrate

    VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].
    Fórmula:C19H20N4O2S2
    Cor e Forma:Solid
    Peso molecular:387

    Ref: TM-T61725

  • V-ATPase-IN-1
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    V-ATPase-IN-1

    CAS:
    <p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>
    Fórmula:C21H20ClNO2
    Cor e Forma:Solid
    Peso molecular:353.84

    Ref: TM-T200467

  • (S)-Albuterol
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    (S)-Albuterol

    CAS:
    <p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>
    Fórmula:C13H21NO3
    Cor e Forma:Solid
    Peso molecular:239.311

    Ref: TM-T206288

  • ATPase-IN-6
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    ATPase-IN-6

    CAS:
    ATPase-IN-6 is an inhibitor of H+/K+-ATPase (ATPase) and a derivative of imidazopyridine. It exhibits significant antiviral activity against various viruses, such as HIV-1 and SARS-CoV-2. ATPase-IN-6 is applicable in antiviral infection research.
    Fórmula:C29H25N3O4S
    Cor e Forma:Solid
    Peso molecular:511.59

    Ref: TM-T211132

  • AqF026
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    AqF026

    CAS:
    AqF026 is an AQP1 agonist that enhances AQP1-mediated water transport. It is utilized in research related to peritoneal dialysis and diseases associated with local water metabolism defects, such as subretinal edema and cerebral edema.
    Fórmula:C20H19ClN2O5S
    Cor e Forma:Solid
    Peso molecular:434.89

    Ref: TM-T210886

  • PF-06462894
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    PF-06462894

    CAS:
    PF-06462894: morpholinopyrimidone, mGlu5 antagonist (Ki=6nM), no immune activation in mouse model.
    Fórmula:C18H23N3O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:329.39

    Ref: TM-T28372

  • 2-PPA
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    2-PPA

    CAS:
    2-PPA serves as a selective TMEM175 inhibitor (IC 50 =32 μM), primarily influencing lysosomal activity. Through acute inhibition of TMEM175, 2-PPA enhances lysosomal macromolecular catabolism, which in turn boosts macrophage activity and other digestive processes. This compound holds significance in Parkinson's disease research.
    Fórmula:C11H10N2
    Cor e Forma:Solid
    Peso molecular:170.21

    Ref: TM-T89916

  • Thiomuscimol hydrobromide
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    Thiomuscimol hydrobromide

    CAS:
    Thiomuscimol hydrobromide is an agonist of GABAA receptor.
    Fórmula:C4H6N2OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:130.17

    Ref: TM-T28965

  • URAT1-IN-14
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    URAT1-IN-14

    CAS:
    URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.
    Fórmula:C19H19NO3S
    Cor e Forma:Solid
    Peso molecular:341.42

    Ref: TM-T212313

  • Kv3 modulator 5
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    Kv3 modulator 5

    CAS:
    Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].
    Fórmula:C20H20N4O4
    Cor e Forma:Solid
    Peso molecular:380.4

    Ref: TM-T86792

  • SW016789
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    SW016789

    CAS:
    SW016789 is a potent high-secretion inducer targeting VDAC1, which directly stimulates insulin secretion and calcium ion influx in β cells. It transiently induces endoplasmic reticulum stress (ER stress) without causing β cell death. The response it triggers is reversible and non-apoptotic, making SW016789 useful for studying β cell dysfunction in type 2 diabetes (T2DM).
    Fórmula:C20H19N3OS
    Cor e Forma:Solid
    Peso molecular:349.45

    Ref: TM-T210734

  • Caramboxin
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    Caramboxin

    CAS:
    Caramboxin, a neurotoxin, can induce acute kidney injury.
    Fórmula:C11H13NO6
    Cor e Forma:Solid
    Peso molecular:255.22

    Ref: TM-T201088