Transportador de Membranas/Canal Iónico
Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.
Subcategorias de "Transportador de Membranas/Canal Iónico"
- ABC(3 produtos)
- ATPase(93 produtos)
- Receptor de adiponectina(5 produtos)
- CFTR(64 produtos)
- Receptor CGRP(51 produtos)
- Canais de Cálcio(493 produtos)
- Canal de cloreto(49 produtos)
- Receptor GABA(336 produtos)
- Transportador de monoamina(23 produtos)
- Transportador de monocarboxilato(17 produtos)
- NKCC(2 produtos)
- NPC1L1(3 produtos)
- Cotransportador Na-K-Cl(8 produtos)
- OAT(27 produtos)
- OCT(7 produtos)
- P-gp(53 produtos)
- Canal de Potássio(276 produtos)
- Bomba de prótons(39 produtos)
- SGLT(30 produtos)
- Canal de Sódio(202 produtos)
- Canal TRP/TRPV(93 produtos)
Exibir 13 mais subcategorias
Foram encontrados 2277 produtos de "Transportador de Membranas/Canal Iónico"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PNU-140975
CAS:<p>PNU-140975 is a bio-active chemical.</p>Fórmula:C3H9N5O2Cor e Forma:SolidPeso molecular:147.138Emamectin B1a
CAS:<p>Emamectin B1a can be used in relevant research in the life sciences. Its product number is T37663 and CAS number is 121124-29-6.</p>Fórmula:C49H75NO13Cor e Forma:SolidPeso molecular:886.133GDC-0334
CAS:<p>GDC-0334 is a TRPA1 antagonist useful in treatment TRPA1-mediated diseases, such as pain or asthma.</p>Fórmula:C24H19F8N5O3SCor e Forma:SolidPeso molecular:609.5Bendroflumethiazide
CAS:<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>Fórmula:C15H14F3N3O4S2Pureza:98% - >99.99%Cor e Forma:Crystals From Dioxane SolidPeso molecular:421.413-Aminopropylphosphonic Acid
CAS:<p>3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding</p>Fórmula:C3H10NO3PPureza:99.84%Cor e Forma:Light Yellow LiquidPeso molecular:139.09Way 125971
CAS:<p>Way 125971 is a bioactive chemcial.</p>Fórmula:C22H28N4O5S2Cor e Forma:SolidPeso molecular:492.61(R)-Funapide
CAS:<p>(R)-Funapide ((R)-TV 45070), the less active R-enantiomer of Funapide, acts as a potent Nav1.7 sodium channel blocker, primarily utilized in pain research [1].</p>Fórmula:C22H14F3NO5Cor e Forma:SolidPeso molecular:429.35SLC6A8 corrector 1
<p>SLC6A8 Corrector 1 is an orally active corrector for mutant SLC6A8 variants, capable of crossing the blood-brain barrier. It is utilized in the study of creatine transporter deficiency (CTD).</p>Fórmula:C21H25N3O2Cor e Forma:SolidPeso molecular:351.44GaTx2
CAS:<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Fórmula:C125H199N39O47S6Pureza:98%Cor e Forma:SolidPeso molecular:3192.54Huwentoxin-IV
CAS:<p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>Fórmula:C174H278N52O51S6Pureza:98%Cor e Forma:SolidPeso molecular:4106.79Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C179H274N50O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4230OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Fórmula:C308H466N90O95S8Pureza:98%Cor e Forma:SolidPeso molecular:7206.1Idactamab
CAS:<p>Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.</p>Pureza:> 95%Cor e Forma:LiquidPeso molecular:146.2 kDaAZD-3161
CAS:<p>AZD-3161 is a sodium channel regulator for pain.</p>Fórmula:C23H21F3N4O4Cor e Forma:SolidPeso molecular:474.43GluN2B-NMDAR antagonist-1
<p>Orally active GluN2B-NMDAR antagonist with neuroprotective properties for ischemic injury research.</p>Fórmula:C26H23BrN2O2Cor e Forma:SolidPeso molecular:475.38TRPV1 activator-1
CAS:<p>TRPV1 Activator-1 (Compound 8), a capsaicin analog featuring a modified neck structure, specifically interacts with the T551 residue [1].</p>Fórmula:C18H27NO2SCor e Forma:SolidPeso molecular:321.48MRS4596
<p>MRS4596: selective P2X4 blocker, IC50 1.38 μM, neuroprotective in stroke research.</p>Fórmula:C21H14N5NaO3SCor e Forma:SolidPeso molecular:439.42(R)-Lanicemine
CAS:<p>(R)-Lanicemine ((R)-AZD6765), an R-enantiomer with less activity, is a low-trapping NMDA blocker with antidepressant effects.</p>Fórmula:C13H14N2Cor e Forma:SolidPeso molecular:198.26AChE/Aβ-IN-2
<p>AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM.</p>Fórmula:C20H25ClN4Cor e Forma:SolidPeso molecular:356.89Digoxigenin Monodigitoxoside
CAS:<p>Digoxigenin monodigitoxoside is a cardiac glycoside metabolite of digoxin and a Na+/K+ ATPase inhibitor.</p>Fórmula:C29H44O8Cor e Forma:SolidPeso molecular:520.663NT 13
CAS:<p>NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.</p>Fórmula:C18H30N4O7Pureza:98%Cor e Forma:SolidPeso molecular:414.45sFTX-3.3
CAS:<p>sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.</p>Fórmula:C12H29N7OCor e Forma:SolidPeso molecular:287.412PDZ1 Domain inhibitor peptide
CAS:<p>Novel cyclic peptide that disrupts interaction between GluR6 and PSD-95</p>Fórmula:C38H61N9O11Pureza:98%Cor e Forma:SolidPeso molecular:819.948-Bromo-ATP
CAS:<p>8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue.</p>Fórmula:C10H15BrN5O13P3Cor e Forma:SolidPeso molecular:586.077Nipecotic acid
CAS:<p>Compound PDK0243, with CAS No. 498-95-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0243 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C6H11NO2Cor e Forma:Off-White To Pale Yellow-Beige PowderPeso molecular:129.16JYL-79
CAS:<p>JYL-79 is an agonist of the vanilloid receptor.</p>Fórmula:C26H36N2O4SCor e Forma:SolidPeso molecular:472.64P-gp inhibitor 13
<p>P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia</p>Fórmula:C32H34O8Cor e Forma:SolidPeso molecular:546.61CHET3
CAS:<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Fórmula:C21H21N5O3SPureza:99.64% - >99.99%Cor e Forma:SoildPeso molecular:423.49Lyso-Globotriaosylceramide (d18:1)
CAS:<p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>Fórmula:C36H67NO17Cor e Forma:SolidPeso molecular:785.922Anticancer agent 108
<p>Anticancer Agent 108 (Compound 3.10) serves as a potent P-gp inhibitor exhibiting considerable antitumor properties while maintaining reduced toxicity to both</p>Fórmula:C18H9NO5S2Cor e Forma:SolidPeso molecular:383.4ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Fórmula:C169H281N57O46S7Pureza:98%Cor e Forma:SolidPeso molecular:4071.86Mesoridazine free base
CAS:<p>Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.</p>Fórmula:C21H26N2OS2Cor e Forma:SolidPeso molecular:386.57Neurotransmitter Receptor Compound Library
<p>A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；</p>Cor e Forma:Odour SolidGpTx-1 TFA
<p>GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.</p>Cor e Forma:Odour SolidD-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Cor e Forma:SoildAQP3-IN-1
CAS:<p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>Fórmula:C11H9AuCl2N2Cor e Forma:SolidPeso molecular:437.08CPI1
<p>CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.</p>Fórmula:C111H131N23O30SCor e Forma:SolidPeso molecular:2299.43Dendrotoxin K
CAS:<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Fórmula:C294H462N84O75S6Cor e Forma:SolidPeso molecular:6559.66Mutabilol
<p>Mutabilol boosts P-gp in NCI-H460/R cells; natural from Plectranthus mutabilis.</p>Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.39Ethacrynic acid D5
CAS:<p>Ethacrynic acid: a diuretic, anti-inflammatory, inhibits calcium channels, GSTs, NF-kB pathway, and modulates leukotriene; has deuterium-labeled form.</p>Fórmula:C13H12Cl2O4Pureza:98%Cor e Forma:SolidPeso molecular:308.17(1S,3R)-3-Aminocyclopentane carboxylic acid
CAS:<p>(1S,3R)-3-Aminocyclopentane carboxylic acid exhibits activity on GABAA receptors.</p>Fórmula:C6H11NO2Cor e Forma:SolidPeso molecular:129.16CP-628006
CAS:<p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>Fórmula:C32H35F3N2O2Cor e Forma:SolidPeso molecular:536.639Atelopidtoxin
CAS:<p>Atelopidtoxin is a biochemical.</p>Fórmula:C16H24N8O12SCor e Forma:SolidPeso molecular:552.47(±)8(9)-EpETE
CAS:<p>(±)8(9)-EpETE ((±)8,9-EEQ) is an epoxide of arachidonic acid biosynthesized by CYP450 epoxygenase.1.2 In rat and rabbit liver microsomes.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45Crocetin meglumine
<p>Crocetin (Transcrocetin) meglumine, sourced from Crocus sativus L. (saffron), functions as a high-affinity antagonist of the NMDA receptor.</p>Fórmula:C34H58N2O14Cor e Forma:SolidPeso molecular:718.83Jingzhaotoxin-XII TFA
<p>Jingzhaotoxin-XII (JzTx-XII) TFA is a specific inhibitor of the Kv4.1 channel, exhibiting an IC50 of 0.363 μM. It interacts with the channel by altering gating behavior.</p>Cor e Forma:Odour SolidBrevetoxin-3
CAS:<p>Brevetoxin-3 activates Na+ channels, binding strongly to site 5, preventing their inactivation.</p>Fórmula:C50H72O14Pureza:98%Cor e Forma:SolidPeso molecular:897.112Nitrazolam
CAS:<p>Nitrazolam is a benzodiazepine compound that may exhibit central nervous system depressant properties similar to traditional benzodiazepine drugs by acting on the GABA receptors (GABA receptor). These effects include sedation, hypnosis, anxiolytic, and anticonvulsant activities.</p>Fórmula:C17H13N5O2Cor e Forma:SolidPeso molecular:319.32Phrixotoxin 3
CAS:<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Fórmula:C176H269N51O48S6Pureza:98%Cor e Forma:SolidPeso molecular:4059.74Transdermal Peptide Disulfide
CAS:<p>TD 1 peptide, an 11-amino acid, binds ATP1B1's C-terminus, enhancing transdermal drug delivery.</p>Fórmula:C40H64N14O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1061.15Tiludronate disodium hemihydrate
CAS:<p>Tiludronate: an oral bisphosphonate for bone disorder research; inhibits osteoclasts and reduces inflammation.</p>Fórmula:C14H16Cl2Na4O13P4S2Cor e Forma:SolidPeso molecular:743.164'-hydroxy Trazodone
CAS:<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Fórmula:C19H22ClN5O2Cor e Forma:SolidPeso molecular:387.87ω-Agatoxin TK
CAS:<p>Selective blocker of CaV2.1 P/Q-type calcium channels.</p>Fórmula:C215H337N65O70S10Pureza:98%Cor e Forma:SolidPeso molecular:5273.02AVLX-125
CAS:<p>AVLX-125 (UCCB01-125), a potent inhibitor of PSD-95 and PDZ domains, exhibits a dissociation constant (Kd) of 10 nM. It is utilized in researching inflammatory pain [1] [2].</p>Fórmula:C62H104N10O29Cor e Forma:SolidPeso molecular:1453.54TRPV4 antagonist 3
CAS:<p>TRPV4 antagonist 3 is a TRPV4 antagonist (p IC 50 = 8.4).</p>Fórmula:C20H18F4N4O3SCor e Forma:SolidPeso molecular:470.44Phe-Met-Arg-Phe, amide
CAS:<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Fórmula:C29H42N8O4SPureza:98%Cor e Forma:SolidPeso molecular:598.76LTGO-33
CAS:<p>LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.</p>Fórmula:C21H17F4N3O3SPureza:97.6%Cor e Forma:SoildPeso molecular:467.44Tariquidar dimesylate
CAS:<p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>Fórmula:C80H94N8O25S4Pureza:98%Cor e Forma:SolidPeso molecular:1695.9epi-Aszonalenin A
CAS:<p>epi-Aszonalenin A: a psychoactive benzodiazepine from Aspergillus novofumigatus.</p>Fórmula:C25H25N3O3Cor e Forma:SolidPeso molecular:415.48LY-368975 hydrochloride
CAS:<p>LY-368975 hydrochloride is a bioactive chemical.</p>Fórmula:C17H22ClNOSCor e Forma:SolidPeso molecular:323.88NAADP tetrasodium salt
CAS:<p>Ca2+ mobilizing agent</p>Fórmula:C21H27N6O18P3Pureza:98%Cor e Forma:SolidPeso molecular:744.39Imagabalin
CAS:<p>Imagabalin is an active compound used in the study of neurological diseases.</p>Fórmula:C9H19NO2Cor e Forma:SolidPeso molecular:173.25Chlorotoxin(linear)
<p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>Fórmula:C158H256N52O48S11Pureza:98%Cor e Forma:SolidPeso molecular:4004.76TRPV1 activator-2
CAS:<p>TRPV1 activator-2 (Compound 9), a capsaicin head analog, engages in targeted interactions with channel residues at the lipid-water interface [1].</p>Fórmula:C19H29NO3Cor e Forma:SolidPeso molecular:319.44PtdIns-(1,2-dioctanoyl) (sodium salt)
CAS:<p>PtdIns phosphates, a minor membrane lipid fraction, are vital for cell signaling. Synthetic PtdIns-(1,2-dioctanoyl) has C8:0 fatty acids and high solubility.</p>Fórmula:C25H47NaO13PCor e Forma:SolidPeso molecular:609.602P-gp inhibitor 27
<p>P-gp inhibitor 27 (Compound D2) is an inhibitor of P-glycoprotein (P-gp) that reduces the expression of P-gp and MRP1. It increases the accumulation of Rh123 in A2780/T cells and reverses multidrug resistance to Paclitaxel (EC50 of 88 nM) and Cisplatin.</p>Fórmula:C25H25N3O4Cor e Forma:SolidPeso molecular:431.48Withasomniferolide B
CAS:<p>Withasomniferolide B, a withanolide from Withania somnifera root, activates GABAA receptors.</p>Fórmula:C28H36O4Cor e Forma:SolidPeso molecular:436.5817R(18S)-EpETE
CAS:<p>17R(18S)-EpETE: Oxylipin, eicosapentaenoic acid metabolite, activates BKCa channels, has negative chronotropic effects.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.457Conantokin G TFA
<p>Conantokin G TFA, a 17-aa peptide, blocks NMDA receptors with 480 nM IC50 and is neuroprotective.</p>Fórmula:C90H139F3N26O46Cor e Forma:SolidPeso molecular:2378.21Vanzacaftor
CAS:<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Fórmula:C32H39N7O4SPureza:99.14%Cor e Forma:SolidPeso molecular:617.76Idrevloride
CAS:<p>Idrevloride (WO2016133967) inhibits ENaC, used in skin disorder research.</p>Fórmula:C30H49ClN8O7Cor e Forma:SolidPeso molecular:669.22ML353
<p>ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.</p>Fórmula:C19H15FN2OPureza:99.98% - 99.98%Cor e Forma:SoildPeso molecular:306.33(S)-JNJ-54166060
CAS:<p>(S)-JNJ-54166060, an enantiomer of JNJ-54166060, functions as a potent antagonist of P2X7 [1].</p>Fórmula:C20H15ClF4N4OCor e Forma:SolidPeso molecular:438.81Tenapanor HCl
CAS:<p>Tenapanor (AZD-1722, RDX 5791) inhibits NHE3 for sodium control in the gut and kidneys.</p>Fórmula:C50H68Cl6N8O10S2Cor e Forma:SolidPeso molecular:1217.97BDBM50597431
CAS:<p>BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.</p>Fórmula:C27H43F3O2Pureza:98.64% - 99.28%Cor e Forma:SoildPeso molecular:456.62Homocarnosine TFA
<p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>Fórmula:C12H17F3N4O5Cor e Forma:SolidPeso molecular:354.28Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Fórmula:C106H179N33O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2428.03D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
CAS:<p>Ins(1,3,4,5)-P4, made via Ins(1,4,5)P3 phosphorylation, boosts calcium by opening ER and plasma membrane channels.</p>Fórmula:C6H8Na8O18P4Cor e Forma:SolidPeso molecular:675.93Antidepressant agent 4
<p>Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.</p>Fórmula:C19H38ClN5O2SCor e Forma:SolidPeso molecular:436.06(±)5(6)-DiHETE
CAS:<p>Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47218β-Glycyrrhetyl-3-O-sulfate
CAS:<p>18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2</p>Fórmula:C30H46O7SCor e Forma:SolidPeso molecular:550.75MIDD0301
CAS:<p>MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.</p>Fórmula:C19H13BrFN3O2Pureza:98%Cor e Forma:SolidPeso molecular:414.23Jingzhaotoxin III
CAS:<p>NaV1.5 channels blocker</p>Fórmula:C174H241N47O46S6Pureza:98%Cor e Forma:SolidPeso molecular:3919.47Withaphysalin D
CAS:<p>Withaphysalin D, from water lilies, blocks GluN2B NMDARs and is neuroprotective, crossing the blood-brain barrier.</p>Fórmula:C28H34O6Cor e Forma:SolidPeso molecular:466.57Lifarizine FA
<p>Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.</p>Fórmula:C30H34N4O2Pureza:99.55%Cor e Forma:SolidPeso molecular:482.6224-Hydroxycholesterol
CAS:<p>24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an activator of the LXR and can be used to study cardiogenesis and pancreatic cancer.</p>Fórmula:C27H46O2Pureza:99.8%Cor e Forma:SolidPeso molecular:402.656,7-dimethylisatin
CAS:<p>6,7-Dimethylisatin (6,7-dimethyl-1H-indole-2,3-dione) inhibits hGAT3 with IC50 of 108 μM. 6,7-Dimethylisatin also inhibits hBGT1, hGAT2.</p>Fórmula:C10H9NO2Pureza:98.98%Cor e Forma:SolidPeso molecular:175.18(R)-IDHP
CAS:<p>(R)-IDHP, a salvia derivative, relaxes blood vessels by blocking calcium channels, aiding cardiovascular research.</p>Fórmula:C12H16O5Cor e Forma:SolidPeso molecular:240.25Sinapine hydroxide
CAS:<p>Sinapine hydroxide from crucifer seeds has anti-inflammatory, anti-oxidant, anti-tumor properties, and inhibits AChE, aiding neurodegenerative research.</p>Fórmula:C16H25NO6Cor e Forma:SolidPeso molecular:327.377Volixibat
CAS:<p>Volixibat, a selective inhibitor of the bile acid transporter, may treat non-alcoholic steatohepatitis.</p>Fórmula:C38H51N3O12S2Pureza:98%Cor e Forma:SolidPeso molecular:805.95(±)16-HETE
CAS:<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.473L-Ibotenic acid
CAS:<p>L-Ibotenic acid: a psychoactive found in Amanita mushrooms, mimics glutamate, activates receptors.</p>Fórmula:C5H6N2O4Cor e Forma:SolidPeso molecular:158.11AChE/Aβ-IN-1
<p>AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the</p>Fórmula:C20H25BrN4Cor e Forma:SolidPeso molecular:401.34LU-32-176B
CAS:<p>LU32-176B is a bioactive chemical.</p>Fórmula:C23H24F2N2O2Cor e Forma:SolidPeso molecular:398.45Conantokin-R
CAS:<p>Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM</p>Fórmula:C127H201N35O49S3Cor e Forma:SolidPeso molecular:3098.38Elgodipine
CAS:<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Fórmula:C29H33FN2O6Pureza:98.95% - 99.50%Cor e Forma:SolidPeso molecular:524.58BMS 199264
CAS:<p>BMS 199264 hydrochlorid a inhibitor of mitochondrial F1F0 ATP hydrolase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia.</p>Fórmula:C26H31ClN4O4SPureza:99.83%Cor e Forma:SoildPeso molecular:531.07S-WJM992
<p>S-WJM992 (compound 10ahb) serves as an antiparasitic agent, effectively inhibiting ATPase activity in high [Na+] environments. It also significantly counteracts parasites resistant to PfATP4 inhibitors. Additionally, S-WJM992 acts as a potential transmission blocker by impeding gamete development and halting the transmission of parasites to mosquitoes during blood feeding.</p>Fórmula:C22H18ClFN6O3Cor e Forma:SolidPeso molecular:468.87KCC2 potentiators-1
CAS:<p>Compound 2, known as KCC2 potentiators-1, acts as an enhancer of the potassium chloride cotransporter-2 (KCC2). It holds potential for applications in studies related to neurological disorders.</p>Fórmula:C15H17N3OSCor e Forma:SolidPeso molecular:287.38Carbonic anhydrase inhibitor 32
<p>Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.</p>Fórmula:C17H16N6O3SCor e Forma:SolidPeso molecular:384.41α-Casozepine
CAS:<p>α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.</p>Fórmula:C60H94N14O16Cor e Forma:SolidPeso molecular:1267.47Ruzinurad
CAS:<p>Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.</p>Fórmula:C14H12BrNO2SCor e Forma:SolidPeso molecular:338.22AR-C141990 hydrochloride
CAS:<p>AR-C141990 HCl inhibits MCT-1 (pKi 7.6) and MCT-2 (pKi 6.6), and has immunosuppressive effects.</p>Fórmula:C26H29ClN4O4SCor e Forma:SolidPeso molecular:529.05Venturicidin A
CAS:<p>Venturicidin A is a macrolide antibiotic.</p>Fórmula:C41H67NO11Pureza:98%Cor e Forma:SolidPeso molecular:749.97P-gp/BCRP-IN-2
<p>P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP</p>Fórmula:C32H35N3O6Cor e Forma:SolidPeso molecular:557.64Chlorpropylate
CAS:<p>Chlorpropylate is an insecticide.</p>Fórmula:C17H16Cl2O3Pureza:98%Cor e Forma:SolidPeso molecular:339.21URAT1 inhibitor 11
CAS:<p>URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.</p>Fórmula:C20H16F4N2O2Cor e Forma:SolidPeso molecular:392.35Camegliptin
CAS:<p>Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C20H28FN3O3Cor e Forma:SolidPeso molecular:377.45FD 12-9
CAS:<p>FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.</p>Fórmula:C51H47N3O11Pureza:98%Cor e Forma:SolidPeso molecular:877.93Aglafoline
CAS:<p>Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating</p>Fórmula:C28H28O8Cor e Forma:SolidPeso molecular:492.52TRPA1 Antagonist 3
CAS:<p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>Fórmula:C11H8ClN3Cor e Forma:SolidPeso molecular:217.66Cyclocreatine
CAS:<p>Cyclocreatine, a creatine analogue and substrate for creatine kinase, inhibits creatine metabolism and prostate cancer cell proliferation.</p>Fórmula:C5H9N3O2Pureza:99.864%Cor e Forma:SolidPeso molecular:143.144-Hydroxytolbutamide
CAS:<p>4-Hydroxytolbutamide is a drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 a sulfonylurea hypoglycemic agent.</p>Fórmula:C12H18N2O4SPureza:98%Cor e Forma:White To Off-WhitePeso molecular:286.35Bafilomycin B1
CAS:<p>Bafilomycin B1, a Streptomyces-derived macrolide, inhibits E. coli ATPase and fights Gram-positive bacteria and fungi.</p>Fórmula:C44H65NO13Pureza:98%Cor e Forma:White PowderPeso molecular:815.998Antimalarial agent 41
<p>Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase β (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 μM, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 μM. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.</p>Fórmula:C19H18F3N5Peso molecular:373.15143UK-59811 hydrochloride
CAS:<p>UK-59811 hydrochloride, Br-dihydropyridine derivative, blocks Ca V Ab channels in bacteria, IC50: 194 nM.</p>Fórmula:C22H30BrClN2O5Cor e Forma:SolidPeso molecular:517.85Conantokin-T
CAS:<p>Non-competitive NMDA receptor antagonist</p>Fórmula:C110H175N31O45SPureza:98%Cor e Forma:SolidPeso molecular:2683.81Homocarnosine
CAS:<p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>Fórmula:C10H16N4O3Cor e Forma:SolidPeso molecular:240.26APETx2 TFA
<p>APETx2 TFA from sea anemone is a selective ASIC3 inhibitor with a 63 nM IC50, reversing acid and inflammatory pain.</p>Fórmula:C198H281F3N54O62S6Cor e Forma:SolidPeso molecular:4675.02CALP3
CAS:<p>Cell-permeable CaM agonist, binds EF-hand, activates phosphodiesterase without Ca2+, inhibits Ca2+ toxicity, IC50=33μM.</p>Fórmula:C44H68N10O9Pureza:98%Cor e Forma:SolidPeso molecular:881.08(S)-PF-03716556
CAS:<p>(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.</p>Fórmula:C22H26N4O3Pureza:99.8% - 99.91%Cor e Forma:SoildPeso molecular:394.47ω-Conotoxin MVIIC
CAS:<p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>Fórmula:C106H178N40O32S7Pureza:98%Cor e Forma:White Lyophilised SolidPeso molecular:2749ω-Conotoxin MVIIC TFA
<p>ω-Conotoxin MVIIC TFA is a peptide and neurotoxin blocks P-type and q-type voltage-sensitive neuronal Ca ++ channels (VGCCs) radiolabel immunoprecipitation.</p>Fórmula:C106H178N40O32S7·C2HF3O2Cor e Forma:SolidPeso molecular:2863.27Isotachysterol 3
CAS:<p>Isotachysterol 3 boosts calcium transport in gut and bone mobilization in kidneyless rats.</p>Fórmula:C27H44OCor e Forma:SolidPeso molecular:384.64Guangxitoxin 1E
CAS:<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Fórmula:C178H248N44O45S7Pureza:98%Cor e Forma:SolidPeso molecular:3948.61AP14145 hydrochloride
CAS:<p>AP14145 hydrochloride inhibits KCa2.2 and KCa2.3 channels with 1.1 μM IC50, affecting AERP and antiarrhythmic in AF models.</p>Fórmula:C18H18ClF3N4OCor e Forma:SolidPeso molecular:398.816-FAM-AEEAC-SHK TFA
<p>6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.</p>Fórmula:C196H295N55O57S7·xCHF3O2Cor e Forma:SolidPeso molecular:4558.23 (free acid)17(S)-HETE
CAS:<p>Arachidonic acid and its CYP450 metabolite, 17(S)-HETE, regulate kidney electrolytes; 17(S)-HETE reduces proximal tubule ATPase activity by 70% at 2 μM.</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.473Detajmium bitartrate
CAS:<p>Detajmium bitartrate is used as an antiarrhythmic drug.</p>Fórmula:C31H47N3O9Cor e Forma:SolidPeso molecular:605.72Huwentoxin I
CAS:<p>Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.</p>Fórmula:C161H246N48O44S6Pureza:98%Cor e Forma:SolidPeso molecular:3750.36Trans (2,3)-Dihydrotetrabenazine
CAS:<p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>Fórmula:C19H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:319.44TP-050
CAS:<p>TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.</p>Fórmula:C16H15ClF2N6OCor e Forma:SolidPeso molecular:380.78(R)-AMPA
CAS:<p>inactive enantiomer of AMPA</p>Fórmula:C7H10N2O4Pureza:98%Cor e Forma:SolidPeso molecular:186.17BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Fórmula:C174H261N51O52S6Pureza:98%Cor e Forma:SolidPeso molecular:4091.65NSC799462
<p>NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.</p>Fórmula:C30H32F2N6O3SCor e Forma:SolidPeso molecular:594.68NF110
CAS:<p>P2X3 antagonist</p>Fórmula:C41H32N6NaO17S4Pureza:98%Cor e Forma:SolidPeso molecular:1031.97N-hydroxy Riluzole
CAS:<p>N-hydroxy Riluzole, a metabolite of riluzole, is mainly produced by CYP1A2 in human liver.</p>Fórmula:C8H5F3N2O2SCor e Forma:SolidPeso molecular:250.20Cavα2δ-IN-1
CAS:<p>Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki</p>Fórmula:C18H27N5OCor e Forma:SolidPeso molecular:329.448Sulcardine 2HCl
CAS:<p>Sulcardine 2HCl is a multi-ion channel blocker that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation.</p>Fórmula:C24H35Cl2N3O4SPureza:99.33% - 99.76%Cor e Forma:SoildPeso molecular:532.523EVT-401
<p>EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].</p>Fórmula:C22H20F4N2O3Cor e Forma:SolidPeso molecular:436.4ω-Conotoxin GVIA
CAS:<p>Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.</p>Fórmula:C120H182N38O43S6Pureza:98%Cor e Forma:SolidPeso molecular:3037A-317567
CAS:A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].Fórmula:C27H31N3Pureza:98%Cor e Forma:SolidPeso molecular:397.56Cevadine
<p>Cevadine is a natural product that can be used as a reference standard.</p>Fórmula:C32H49NO9Cor e Forma:SolidPeso molecular:591.742GsMTx4
CAS:<p>GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8).</p>Fórmula:C185H273N49O45S6Pureza:98%Cor e Forma:SolidPeso molecular:4095.84Resolvin D2
CAS:<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Fórmula:C22H32O5Pureza:98%Cor e Forma:SolidPeso molecular:376.49Caloxin 2A1 acetate
<p>Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide.</p>Fórmula:C66H95N19O24Pureza:98.2%Cor e Forma:SolidPeso molecular:1538.5712,14-Dichlorodehydroabietic acid
CAS:<p>12,14-Dichlorodehydroabietic acid activates BK channels, blocks GABA A receptors, and increases calcium and neurotransmitter release.</p>Fórmula:C20H26Cl2O2Cor e Forma:SolidPeso molecular:369.33Halazone
CAS:<p>Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.</p>Fórmula:C7H5Cl2NO4SPureza:98.64%Cor e Forma:Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Peso molecular:270.09CW2158
<p>CW2158 (Compound 13) is a modulator of exportin1 (XPO1). It disrupts chromatin binding and inhibits the activation of NFAT transcription factors and T cells.</p>Fórmula:C14H8F4N4O2Peso molecular:340.05834Eltanexor
CAS:<p>Eltanexor, an oral XPO1 inhibitor, induces apoptosis in leukemia cells; EC50=60.9 nM.</p>Fórmula:C17H10F6N6OPureza:99.6% - ≥98%Cor e Forma:SolidPeso molecular:428.29AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Fórmula:C158H262N50O48S6Pureza:98%Cor e Forma:SolidPeso molecular:3822.47Verruculogen
CAS:<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>Fórmula:C27H33N3O7Pureza:98%Cor e Forma:White PowderPeso molecular:511.57Furosemide sodium
CAS:<p>Furosemide sodium: potent NKCC inhibitor, loop diuretic, treats heart failure, hypertension, edema, selective GABAA antagonist.</p>Fórmula:C12H10ClN2NaO5SPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:352.73GS-9191 PM
<p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>Fórmula:C11H16N6OPureza:99.79%Cor e Forma:SoildPeso molecular:248.28SLC26A3-IN-2
CAS:<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Fórmula:C19H13ClN2O2SPureza:99.86%Cor e Forma:SolidPeso molecular:368.84SNX-482
CAS:<p>Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.</p>Fórmula:C192H274N52O60S7Pureza:98%Cor e Forma:SolidPeso molecular:4495.01TRPA1-IN-2
CAS:<p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>Fórmula:C24H25F3N4OPureza:98.05%Cor e Forma:SoildPeso molecular:442.48NSC156529
CAS:<p>NSC156529 suppresses AKT1, reduces cancer cell growth in vitro, and inhibits prostate tumors in vivo.</p>Fórmula:C28H21ClS2Pureza:98%Cor e Forma:SolidPeso molecular:457.05Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2027.34(Rac)-Tezacaftor
CAS:<p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>Fórmula:C26H27F3N2O6Cor e Forma:SolidPeso molecular:520.5c-Met-IN-23
<p>c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.</p>Fórmula:C16H13N7OPeso molecular:319.118163-Aminopropylphosphinic acid
CAS:<p>3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA).</p>Fórmula:C3H10NO2PCor e Forma:SolidPeso molecular:123.092Analgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Fórmula:C22H25ClN2O2Cor e Forma:SolidPeso molecular:384.9ProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Fórmula:C168H250N46O41S8Pureza:98%Cor e Forma:SolidPeso molecular:3826.59Astressin 2B
CAS:<p>CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.</p>Fórmula:C183H307N49O53Pureza:98%Cor e Forma:SolidPeso molecular:4041.69Dihydroisopimaric acid
CAS:<p>Dihydroisopimaric acid opens BKαβ1 channels - large Ca²⁺-activated K⁺ conductors, verified by whole-cell voltage clamp.</p>Fórmula:C20H32O2Cor e Forma:SolidPeso molecular:304.47Vedroprevir
CAS:<p>Vedroprevir (GS9451), a selective HCV NS3 protease inhibitor, targets genotype 1 HCV.</p>Fórmula:C45H60ClN7O9SCor e Forma:SolidPeso molecular:910.53NF864
CAS:<p>NF864, a suramin analog, is a P2X1 receptor inhibitor.</p>Fórmula:C57H28N6Na12O41S12Pureza:98%Cor e Forma:SolidPeso molecular:2113.5rac-trans-4-hydroxy Glyburide
CAS:<p>rac-trans-4-hydroxy Glyburide, a metabolite of glyburide, inhibits binding at SUR1/Kir6.2 sites with IC50 values of 0.95 and 100 nM.</p>Fórmula:C23H28ClN3O6SCor e Forma:SolidPeso molecular:510.0AQP4 (201-220)
CAS:<p>AQP4 (201-220) is the encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal lesions, and lesions at the gray matter/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>Fórmula:C97H143N27O27SCor e Forma:SolidPeso molecular:2151.4N-Arachidonoyl Taurine
CAS:<p>N-Arachidonoyl taurine, an amino acid, activates TRPV1/TRPV4, is metabolized by lipoxygenase, and affects insulin secretion and calcium flux.</p>Fórmula:C22H37NO4SCor e Forma:SolidPeso molecular:411.6P2X4 antagonist-3
<p>P2X4 antagonist-3 (Compound 14c) is a P2X4 inhibitor with an IC50 value of 1.2 μM. It holds potential for research into neuroinflammation, chronic pain, and cancer progression.</p>Fórmula:C19H20FN3O4Cor e Forma:SolidPeso molecular:373.38JAMI1001A
CAS:<p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>Fórmula:C16H17F3N4O3SCor e Forma:SolidPeso molecular:402.39PDDHV
CAS:<p>PDDHV: a capsaicin-like vanilloid selective for rat TRPV1; induces Ca2+ uptake in neurons, EC50 of 70 nM.</p>Fórmula:C49H72O11Cor e Forma:SolidPeso molecular:837.09AHN-683
CAS:<p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>Fórmula:C42H32FN3O7Pureza:98%Cor e Forma:SolidPeso molecular:709.72Hyp9
CAS:<p>Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].</p>Fórmula:C18H26O5Cor e Forma:SolidPeso molecular:322.40Atagabalin
CAS:<p>Atagabalin (PD 0200390), a gabamimetic for insomnia treatment and related to gabapentin, was halted due to poor trial outcomes.</p>Fórmula:C10H19NO2Cor e Forma:SolidPeso molecular:185.26Cyclic ADP-ribose ammonium
<p>cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.</p>Cor e Forma:LiquidChlorotoxin
CAS:<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Fórmula:C158H249N53O47S11Pureza:98%Cor e Forma:SolidPeso molecular:3995.71NSC265473
CAS:<p>NSC265473 is an ABCG2 substrate.</p>Fórmula:C21H35N3O4SCor e Forma:SolidPeso molecular:425.58Foslevcromakalim
CAS:<p>Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].</p>Fórmula:C16H19N2O6PCor e Forma:SolidPeso molecular:366.31Antidepressant agent 3
<p>Agent 3: orally active, antidepressant, anxiolytic, boosts performance and cognition.</p>Fórmula:C17H30ClN5O2SCor e Forma:SolidPeso molecular:403.97Mambalgin 1
CAS:<p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>Fórmula:C272H429N85O84S10Pureza:98%Cor e Forma:SolidPeso molecular:6554.51ProTx-I
CAS:<p>Selective blocker for CaV3.1 (IC50 = 0.2 μM), CaV3.2 (31.8 μM), also inhibits NaV1.8 and blocks KV2.1 channels.</p>Fórmula:C171H245N53O47S6Pureza:98%Cor e Forma:SolidPeso molecular:3987.51N-Oleoyl Glutamine
CAS:<p>N-Oleoyl Glutamine (Oleoyl-L-glutamine) antagonizes TRPV1 of the transient receptor potential (TRP) calcium channel.</p>Fórmula:C23H42N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:410.595-Hydroxy-2′,3,4′,7-tetramethoxyflavone
CAS:<p>5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.</p>Fórmula:C19H18O7Pureza:98%Cor e Forma:SoildPeso molecular:358.34(±)17-HETE
CAS:<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.473RuBi-GABA
CAS:<p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>Fórmula:C42H39F6N5O2P2RuPureza:98%Cor e Forma:SolidPeso molecular:922.8Kurtoxin
<p>Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor, exhibiting a dissociation constant (Kd) of 15 nM for the Cav3.1 (α1G T-type)</p>Fórmula:C324H478N94O90S8Pureza:98%Cor e Forma:SolidPeso molecular:7386.36GSK2332255B
CAS:<p>GSK2332255B: potent TRPC3/6 antagonist; IC50 5 nM (TRPC3), 4 nM (TRPC6); over 100-fold selectivity vs other Ca2+ channels.</p>Fórmula:C18H19ClFN3O3SCor e Forma:SolidPeso molecular:411.88HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Fórmula:C337H503N103O97S6Peso molecular:7736.59176L-Palmitoylcarnitine TFA
<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia & inhibits KATP channels via Kir6.2 interaction.</p>Fórmula:C25H46F3NO6Cor e Forma:SolidPeso molecular:513.63Ziconotide
CAS:<p>Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.</p>Fórmula:C102H172N36O32S7Pureza:98%Cor e Forma:White PowderPeso molecular:2639.13SC 4453
CAS:<p>SC 4453 is a digoxin analog and a cardiac glycoside derivative.</p>Fórmula:C41H64N2O12Cor e Forma:SolidPeso molecular:776.965APETx2
CAS:<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Fórmula:C196H280N54O61S6Pureza:98%Cor e Forma:SolidPeso molecular:4561.06Nav1.7-IN-8
CAS:<p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>Fórmula:C21H12ClF2N5O4S2Cor e Forma:SolidPeso molecular:535.93Levamlodipine besylate Hemipentahydrate
CAS:<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Fórmula:C20H25ClN2O5·C6H6O3SH2OCor e Forma:SolidPeso molecular:1224.18ATP Synthesis-IN-2
<p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>Cor e Forma:Odour SolidEbio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Fórmula:C19H23F2N3O2Cor e Forma:SolidPeso molecular:363.4Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Fórmula:C22H24N4O2Cor e Forma:SolidPeso molecular:376.45
