Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(34 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(449 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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Z-FG-NHO-BzOME
CAS:<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Fórmula:C27H27N3O7Cor e Forma:SolidPeso molecular:505.52NK3201
CAS:<p>NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.</p>Fórmula:C31H29N5O6Pureza:98%Cor e Forma:SolidPeso molecular:567.59Tyropeptin A-4
CAS:<p>Tyropeptin A-4 is used as a proteasome inhibitor.</p>Fórmula:C31H41N3O6Pureza:98%Cor e Forma:SolidPeso molecular:551.67Ravidasvir HCl
CAS:<p>Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.</p>Fórmula:C42H52Cl2N8O6Cor e Forma:SolidPeso molecular:835.828M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Fórmula:C21H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:375.42BMS-189664 HCl
CAS:<p>BMS-189664 HCl is a selective and orally active thrombin active site inhibitor.</p>Fórmula:C22H35ClN6O4SPureza:98%Cor e Forma:SolidPeso molecular:515.07ABP 25
CAS:<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Fórmula:C55H66ClN5O3Cor e Forma:SolidPeso molecular:880.6SQ 32056
CAS:<p>SQ 32056 is a cathepsin E inhibitor.</p>Fórmula:C37H56N4O5Pureza:98%Cor e Forma:SolidPeso molecular:636.86MDL 101146
CAS:<p>MDL 101146 is an orally active neutrophil elastase inhibitor.</p>Fórmula:C29H37F5N4O6Pureza:98%Cor e Forma:SolidPeso molecular:632.62JTK-853
CAS:<p>JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).</p>Fórmula:C28H23F7N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:704.64NS5A-IN-3
CAS:<p>NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.</p>Fórmula:C44H44N6O8Pureza:98%Cor e Forma:SolidPeso molecular:784.86Ro 32-7315
CAS:<p>Ro 32-7315 is a selective inhibitor of ADAM17.</p>Fórmula:C22H35N3O5SPureza:98%Cor e Forma:SolidPeso molecular:453.6LM-030
CAS:<p>LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).</p>Fórmula:C46H72N8O12Cor e Forma:SolidPeso molecular:929.11MMP-7-IN-2
CAS:<p>MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.</p>Fórmula:C28H40ClF3N6O9SPureza:97.82%Cor e Forma:SolidPeso molecular:729.17ND-378
CAS:<p>ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.</p>Fórmula:C18H19NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:377.48BAY-320
CAS:<p>BAY-320 is a Bub1 inhibitor. With an IC50 of 680 nM for human Bub1 in the presence of 2 mM ATP.</p>Fórmula:C26H26F2N6O2Pureza:98%Cor e Forma:SolidPeso molecular:492.52(1R,4S)-Yimitasvir diphosphate
CAS:<p>Yimitasvir diphosphate, also known as Emitasvir, is an orally-administered inhibitor of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A).</p>Fórmula:C49H64N8O14P2Cor e Forma:SolidPeso molecular:1051.03Flovagatran sodium
CAS:<p>Flovagatran sodium, a thrombin inhibitor, is used potentially for the treatment of thrombosis.</p>Fórmula:C27H36BN3NaO7Pureza:98%Cor e Forma:SolidPeso molecular:548.4HIV-1 protease-IN-11
CAS:<p>HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy</p>Fórmula:C26H37N3O5SPureza:98%Cor e Forma:SolidPeso molecular:503.65BAY-678
CAS:<p>BAY-678: Oral selective human neutrophil elastase inhibitor; IC50: 20 nM; SGC-approved chemical probe.</p>Fórmula:C20H15F3N4O2Pureza:97.89%Cor e Forma:SolidPeso molecular:400.35MMP13-IN-3
CAS:<p>MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.</p>Fórmula:C24H22N4O5Pureza:99.76%Cor e Forma:SolidPeso molecular:446.46MMP-9 Inhibitor I
CAS:<p>MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).</p>Fórmula:C27H33N3O5SCor e Forma:SolidPeso molecular:511.63Apratastat
CAS:<p>Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs)</p>Fórmula:C17H22N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:414.5Berotralstat HCl
CAS:<p>Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.</p>Fórmula:C30H28Cl2F4N6OCor e Forma:SolidPeso molecular:635.4886HIV-1 protease-IN-8
CAS:<p>HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM.</p>Fórmula:C25H35N3O5SPureza:98%Cor e Forma:SolidPeso molecular:489.63O-Benzoylhydroxylamine
CAS:<p>O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].</p>Fórmula:C7H7NO2Cor e Forma:SolidPeso molecular:137.14HIV-1 inhibitor-54
CAS:<p>HIV-1 inhibitor-54: potent anti-HIV (EC50: 32 nM), targets WT HIV-1 IIIB in MT-4 cells for infection research.</p>Fórmula:C27H30N6O4SPureza:98.05% - 99.44%Cor e Forma:SoildPeso molecular:534.63γ-Glu-Tyr
CAS:<p>gamma-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide against dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.</p>Fórmula:C14H18N2O6Pureza:98.92%Cor e Forma:SolidPeso molecular:310.3Nesbuvir
CAS:<p>Nesbuvir: HCV NS5B polymerase inhibitor, IC50 9 nM against HCV 1b replicon in liver cancer cells.</p>Fórmula:C22H23FN2O5SPureza:99.99%Cor e Forma:SolidPeso molecular:446.49Ac-YVAD-AOM
CAS:<p>Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.</p>Fórmula:C33H42N4O10Pureza:98%Cor e Forma:SolidPeso molecular:654.71Collagen proline hydroxylase inhibitor-1
CAS:<p>Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。</p>Fórmula:C24H21N5O4Pureza:99.62%Cor e Forma:SolidPeso molecular:443.45BMS-212122
CAS:<p>BMS-212122 inhibits MTP, reduces lipids and plaque in animal tests.</p>Fórmula:C43H36F6N4O2Pureza:99.18%Cor e Forma:SolidPeso molecular:754.76MK-0674
CAS:<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Fórmula:C26H27F6N3O2Pureza:97.3% - 99.91%Cor e Forma:SolidPeso molecular:527.5Filibuvir
CAS:<p>Filibuvir (PF-00868554) inhibits HCV polymerase genotypes 1a/1b, EC50s 59 nM.</p>Fórmula:C29H37N5O3Pureza:99.28% - >99.99%Cor e Forma:SolidPeso molecular:503.64Aderamastat
CAS:<p>Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.</p>Fórmula:C21H18N2O4SPureza:99.35%Cor e Forma:SolidPeso molecular:394.44ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Fórmula:C26H36N6O6Pureza:99.04%Cor e Forma:SolidPeso molecular:528.6PDDC inhibitor
CAS:<p>PDDC inhibitor (Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate) is an nSMase2 inhibitor.</p>Fórmula:C27H29N5O4Pureza:96.09% - 99.39%Cor e Forma:SolidPeso molecular:487.55VBY-825
CAS:<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Fórmula:C23H29F4N3O5SPureza:99.91%Cor e Forma:SolidPeso molecular:535.55ABT-072
CAS:<p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>Fórmula:C24H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:469.55DPP-4-IN-15
CAS:<p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>Fórmula:C17H14F3N3O2SCor e Forma:SolidPeso molecular:381.372SD-2590 HCl
CAS:<p>SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.</p>Fórmula:C22H26ClF3N2O7SPureza:98%Cor e Forma:SolidPeso molecular:554.96Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Fórmula:C31H35FN4O3Cor e Forma:SolidPeso molecular:530.633SD-7300
CAS:<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Fórmula:C21H30F3N3O7SCor e Forma:SolidPeso molecular:525.54Anti-infective agent 10
CAS:<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Fórmula:C26H25N3O7SCor e Forma:SolidPeso molecular:523.56BAY-7598
CAS:<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Fórmula:C28H31N3O6Pureza:98%Cor e Forma:SolidPeso molecular:505.56Ciluprevir
CAS:<p>Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.</p>Fórmula:C40H50N6O8SPureza:98%Cor e Forma:SolidPeso molecular:774.93Tilpisertib fosmecarbil
CAS:<p>Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.</p>Fórmula:C35H36ClN8O7PCor e Forma:SolidPeso molecular:747.14Tyrosinase-IN-33
CAS:<p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>Fórmula:C19H17NS2Cor e Forma:SolidPeso molecular:323.48GSK5852
<p>GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.</p>Fórmula:C27H27BF2N2O6SCor e Forma:SolidPeso molecular:556.39GW311616 hydrochloride
CAS:<p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Fórmula:C19H32ClN3O4SPureza:98%Cor e Forma:SolidPeso molecular:433.99TG-2-IN-4
CAS:<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Fórmula:C34H40N6O5Cor e Forma:SolidPeso molecular:612.72Tyrosinase-IN-35
CAS:<p>Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.</p>Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.40AMG-222 tosylate
CAS:<p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>Fórmula:C39H47N9O6SCor e Forma:SolidPeso molecular:769.91RJF02215
CAS:<p>RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.</p>Fórmula:C17H12ClN3OS3Cor e Forma:SolidPeso molecular:405.95Narlaprevir
CAS:<p>Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.</p>Fórmula:C36H61N5O7SPureza:98%Cor e Forma:SolidPeso molecular:707.96TMPRSS6-IN-1 TFA
<p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>Fórmula:C35H41F3N8O6S2Cor e Forma:SolidPeso molecular:790.875(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Fórmula:C26H27F4N3O7Cor e Forma:SolidPeso molecular:569.5GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Cor e Forma:SolidPeso molecular:573.68MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:<p>MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).</p>Fórmula:C20H31ClN4O7Cor e Forma:SolidPeso molecular:474.936(1R,3S)-THCCA-Asn
<p>(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.</p>Fórmula:C24H24N4O6Cor e Forma:SolidPeso molecular:464.47Freselestat
CAS:<p>Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.</p>Fórmula:C23H28N6O4Cor e Forma:SolidPeso molecular:452.51HCV-IN-38
<p>Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.</p>Fórmula:C22H24ClF3N4O4Cor e Forma:SolidPeso molecular:500.9Beclabuvir
CAS:<p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.</p>Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Cor e Forma:SolidPeso molecular:659.84BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Fórmula:C21H37N5O3Cor e Forma:SolidPeso molecular:407.55RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Fórmula:C27H24F6N4O4SCor e Forma:SolidPeso molecular:614.56UK-370106
CAS:<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Fórmula:C35H44N2O5Pureza:98%Cor e Forma:SolidPeso molecular:572.73Isobutylamido thiazolyl resorcinol
CAS:<p>Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.</p>Fórmula:C13H14N2O3SCor e Forma:SolidPeso molecular:278.33LK-732
CAS:<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Fórmula:C25H29N5O3SCor e Forma:SolidPeso molecular:479.59CatD-IN-1
CAS:<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Fórmula:C18H18Cl2N4O5Cor e Forma:SolidPeso molecular:441.265Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Fórmula:C21H39N5O7Cor e Forma:SolidPeso molecular:473.56Plodicitinib
CAS:<p>Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.</p>Fórmula:C19H22FN7O2Cor e Forma:SolidPeso molecular:399.4223-Aminobenzene-1,2-diol
CAS:<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Fórmula:C6H7NO2Cor e Forma:SolidPeso molecular:125.13TGase2-IN-1
CAS:<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46Tyrosinase-IN-39
<p>Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.</p>Fórmula:C23H19N5O4S2Cor e Forma:SolidPeso molecular:493.56PNU-248686A
CAS:<p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>Fórmula:C22H18ClNaO5S2Pureza:98%Cor e Forma:SolidPeso molecular:484.95UK 356618
CAS:<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Fórmula:C34H43N3O4Pureza:98%Cor e Forma:SolidPeso molecular:557.72SAR107375
CAS:<p>SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].</p>Fórmula:C24H30ClN5O5S2Cor e Forma:SolidPeso molecular:568.11Faldaprevir
CAS:<p>Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.</p>Fórmula:C40H49BrN6O9SPureza:99.04% - 99.19%Cor e Forma:SolidPeso molecular:869.82SBI-581
<p>SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.</p>Fórmula:C24H21N3O2Cor e Forma:SolidPeso molecular:383.44Matriptase-IN-2 free base
CAS:<p>Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].</p>Fórmula:C29H33Cl2N5O3SCor e Forma:SolidPeso molecular:602.58Plasma kallikrein-IN-2
<p>Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.</p>Fórmula:C28H24ClF3N8O3Cor e Forma:SolidPeso molecular:612.99Human enteropeptidase-IN-2
<p>Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.</p>Fórmula:C20H19F3N4O7Cor e Forma:SolidPeso molecular:484.38Zetomipzomib
CAS:<p>KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.</p>Fórmula:C30H42N4O8Cor e Forma:SolidPeso molecular:586.68Marizomib
CAS:<p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>Fórmula:C15H20ClNO4Pureza:98.03% - 99.41%Cor e Forma:SolidPeso molecular:313.78Odiparcil
CAS:<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Fórmula:C15H16O6SPureza:98%Cor e Forma:SolidPeso molecular:324.35BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Fórmula:C24H26N4O4Cor e Forma:SolidPeso molecular:434.488CE-2072
CAS:<p>CE-2072 is a synthetic host serine proteases inhibitor.</p>Fórmula:C33H41N5O6Pureza:98%Cor e Forma:SolidPeso molecular:603.71Deleobuvir
CAS:<p>Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.</p>Fórmula:C34H33BrN6O3Cor e Forma:SolidPeso molecular:653.57Enantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Fórmula:C22H29FN3O9PPureza:98%Cor e Forma:SolidPeso molecular:529.45JBJ-08-178-01
CAS:<p>JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.</p>Fórmula:C31H30N8O3Cor e Forma:SolidPeso molecular:562.62Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Fórmula:C15H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:356.37RIPK1-IN-26
CAS:<p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>Fórmula:C15H20FNO2Cor e Forma:SolidPeso molecular:265.32Valopicitabine dihydrochloride
CAS:<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C15H25ClN4O6Cor e Forma:SolidPeso molecular:392.84Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Fórmula:C21H14ClF3N4SCor e Forma:SolidPeso molecular:446.88GW311616
CAS:<p>GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Fórmula:C19H31N3O4SCor e Forma:SolidPeso molecular:397.53MK-8876
CAS:<p>MK-8876 is an Inhibitor of HCV NS5B Site D.</p>Fórmula:C32H24F2N4O5SPureza:98%Cor e Forma:SolidPeso molecular:614.62Cyclophilin inhibitor 1
CAS:<p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>Fórmula:C31H39N5O7Pureza:98%Cor e Forma:SolidPeso molecular:593.67Freselestat quarterhydrate
<p>ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.</p>Fórmula:C23H30N6O5Cor e Forma:SolidPeso molecular:457.03HCV-IN-40
CAS:<p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>Fórmula:C21H26BrFN3O9PCor e Forma:SolidPeso molecular:594.32RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Fórmula:C19H20F2N4O2Cor e Forma:SolidPeso molecular:374.384
