Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(38 produtos)
- Cisteína Protease(111 produtos)
- DPP-4(27 produtos)
- Glutaminase(46 produtos)
- HIV Protease(507 produtos)
- PAI-1(26 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(55 produtos)
- Proteassoma(86 produtos)
- Protease serina(54 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 977 produtos de "Proteases/Proteassoma"
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Sitagliptin fenilalanil hydrochloride
CAS:Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.Fórmula:C25H25ClF6N6O2Cor e Forma:SolidPeso molecular:590.95AMG-222
CAS:AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.Fórmula:C32H39N9O3Cor e Forma:SolidPeso molecular:597.7115,16-Dihydrotanshindiol C
15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.Fórmula:C18H18O5Cor e Forma:SolidPeso molecular:314.337ADAM8-IN-1
CAS:ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.
Fórmula:C44H44Br4N6O12S2Cor e Forma:SolidPeso molecular:1232.6Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Cor e Forma:Odour SolidZ-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Fórmula:C26H25N3O6Cor e Forma:SolidPeso molecular:475.49Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Fórmula:C111H169N31O35S8Cor e Forma:SolidPeso molecular:2754.24Tyrosinase-IN-36
Tyrosinase-IN-36 is a moderately potent inhibitor of tyrosine, exhibiting an inhibition percentage of 42.75% compared to kojic acid at a concentration of 100 μM and possesses antioxidant activity.Cor e Forma:Odour SolidFotagliptin benzoate
CAS:Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.Fórmula:C24H25FN6O3Cor e Forma:SolidPeso molecular:464.49Ellipyrone B
Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50Fórmula:C25H38O7Cor e Forma:SolidPeso molecular:450.57PSI-353661
CAS:PSI-353661 (GS-558093), inhibits HCV's NS5B polymerase; EC90: 8nM (wild-type), 11nM (S282T); active in human hepatocytes.Fórmula:C24H32FN6O8PCor e Forma:SolidPeso molecular:582.52STK33-IN-1
CAS:STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.Fórmula:C24H27N7O2Cor e Forma:SolidPeso molecular:445.527HCV-IN-7 hydrochloride
CAS:HCV-IN-7 hydrochloride: Oral, potent HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Fórmula:C40H50Cl2N8O6SPureza:98%Cor e Forma:SolidPeso molecular:841.85Ichorcumab
CAS:Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.Cor e Forma:LiquidRivulariapeptolides 1185
Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.Fórmula:C61H87N9O15Cor e Forma:SolidPeso molecular:1186.39Stevia Powder
Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.Cor e Forma:Odour SolidHistatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μMFórmula:C135H196F3N51O35Pureza:98%Cor e Forma:SolidPeso molecular:3150.32CL 82198 hydrochloride
CAS:CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.Fórmula:C17H23ClN2O3Cor e Forma:SolidPeso molecular:338.83HCV-IN-41
CAS:HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.Fórmula:C48H56N6O8Cor e Forma:SolidPeso molecular:844.99Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Cor e Forma:Odour SolidMMP-9/MMP-13 Inhibitor I
CAS:MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.Fórmula:C25H25N3O6SCor e Forma:SolidPeso molecular:495.55HCV-IN-4
CAS:HCV-IN-4: Potent, oral HCV NS5A inhibitor; effective vs GT1a/b, GT2b, GT3a, Y93H, L31V; EC90s: 3 pM-0.02 nM.Fórmula:C52H58FN9O8Pureza:98%Cor e Forma:SolidPeso molecular:956.07TWH106
TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.Cor e Forma:Odour SolidMMP-3 Inhibitor
CAS:MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.Fórmula:C27H46N10O9SPureza:98.87%Cor e Forma:SolidPeso molecular:686.78Ref: TM-T37048
1mg77,00€5mg197,00€1mL*10mM (DMSO)210,00€10mg294,00€25mg497,00€50mg717,00€100mg982,00€500mg1.998,00€Radalbuvir
CAS:Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.Fórmula:C30H41NO6SCor e Forma:SolidPeso molecular:543.71Peptide 74
CAS:Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.Fórmula:C62H107N23O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1558.79CTTHWGFTLC, CYCLIC
CAS:CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.Fórmula:C52H71N13O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1166.33BAY 1217224
CAS:BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.
Fórmula:C24H27ClFN3O5Cor e Forma:SolidPeso molecular:491.94FiVe1
CAS:FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.Fórmula:C18H16Cl2N4Pureza:99.67%Cor e Forma:SolidPeso molecular:359.25Ref: TM-T9657
1mL*10mM (DMSO)A consultar1mg86,00€5mg182,00€10mg274,00€25mg495,00€50mg745,00€100mg1.108,00€MeOSuc-AAPA-CMK
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].Fórmula:C20H31ClN4O8Cor e Forma:SolidPeso molecular:490.94TR-107
CAS:TR-107 (Anticancer agent 230) is a mitochondrial protease ClpP activator that inhibits tumor growth in the MDA-MB-231 xenograft model.Fórmula:C22H19ClN4OCor e Forma:SoildPeso molecular:390.87Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Fórmula:C24H35N3O5Peso molecular:445.25767Talopeptin
CAS:Talopeptin is a specific thermolysin inhibitor.Fórmula:C23H34N3O10PPureza:98%Cor e Forma:SolidPeso molecular:543.50Chymotrypsinogen
CAS:Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .Cor e Forma:SolidFFAGLDD
"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."Fórmula:C37H49N7O12Pureza:98%Cor e Forma:SolidPeso molecular:783.82VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Fórmula:C18H32N4O5SCor e Forma:SolidPeso molecular:416.535Suc-AAP-Abu-pNA
CAS:Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,Fórmula:C25H34N6O9Cor e Forma:SolidPeso molecular:562.57Ac-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Fórmula:C19H20N4O5Cor e Forma:SolidPeso molecular:384.39Z-Arg-Arg-βNA acetate
CAS:Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Fórmula:C32H43N9O6Cor e Forma:SolidPeso molecular:649.74Ala-Phe-Pro-pNA TFA
Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.Cor e Forma:Odour SolidRivulariapeptolides 988
Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).Fórmula:C50H68N8O13Cor e Forma:SolidPeso molecular:989.12Sadopeptins B
Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].Fórmula:C48H69N9O13SCor e Forma:SolidPeso molecular:1012.18Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFórmula:C47H64N14O10Cor e Forma:SolidPeso molecular:985.1Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Fórmula:C25H33N5O6Cor e Forma:SolidPeso molecular:499.56HIV-1 inhibitor-6
CAS:HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicingFórmula:C14H10N4O4SPureza:99.33%Cor e Forma:SolidPeso molecular:330.32Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Fórmula:C144H231F3N36O46SCor e Forma:SolidPeso molecular:3291.65Lonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Fórmula:C73H112F3N15O21Cor e Forma:SolidPeso molecular:1592.75Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Fórmula:C24H29ClN2O5Cor e Forma:SolidPeso molecular:460.95BMS-767778
CAS:BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.Fórmula:C19H20Cl2N4O2Cor e Forma:SolidPeso molecular:407.29Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SCor e Forma:SolidPeso molecular:909.06NIM811
CAS:NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.Fórmula:C62H111N11O12Pureza:98%Cor e Forma:SolidPeso molecular:1202.635Histatin 5
CAS:Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Fórmula:C133H195N51O33Pureza:98%Cor e Forma:SolidPeso molecular:3036.29AR-H067637
CAS:AR-H067637 is a fast-acting, reversible thrombin inhibitor with K(i) 2-4 nM; it also reduces clot-bound thrombin and platelet activation/aggregation.Fórmula:C21H21ClF2N4O4Cor e Forma:SolidPeso molecular:466.87ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrialCor e Forma:Odour SolidDansyl-Glu-Gly-Arg-Chloromethylketone
CAS:Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFórmula:C26H36ClN7O7SCor e Forma:SolidPeso molecular:626.12Sulodexide
CAS:Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.Cor e Forma:SolidN-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Fórmula:C33H36N6O6Pureza:98%Cor e Forma:White To Off-White PowderPeso molecular:612.68Tilpisertib fosmecarbil TFA
CAS:Tilpisertib fosmecarbil TFA, the TFA salt form of Tilpisertib, acts as an inhibitor of serine/threonine kinases. This compound also exhibits anti-inflammatory activity.Fórmula:C37H37ClF3N8O9PCor e Forma:SolidPeso molecular:861.16PSI-7409
CAS:PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
Fórmula:C10H16FN2O14P3Pureza:98%Cor e Forma:SolidPeso molecular:500.16Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
CAS:Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic probe for MMP-1 and MMP-9 detection, releasing fluorescent Nma upon cleavage (Ex/Em: 340/440 nm).Fórmula:C49H68N14O12SCor e Forma:SolidPeso molecular:1077.22VD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Fórmula:C31H45N9O6SCor e Forma:SolidPeso molecular:671.81AL-611
CAS:AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).
Fórmula:C25H33F2N6O8PCor e Forma:SolidPeso molecular:614.544MK-6169
CAS:MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Fórmula:C54H62FN9O8SPureza:98%Cor e Forma:SolidPeso molecular:1016.2Sofosbuvir impurity J
CAS:Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.Fórmula:C22H30FN4O8PPureza:98%Cor e Forma:SolidPeso molecular:528.47DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Cor e Forma:Odour SolidCRA-2059 TFA
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Cor e Forma:SolidDPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Fórmula:C33H27N7O3Cor e Forma:SolidPeso molecular:569.613Elastatinal
CAS:Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.Fórmula:C21H36N8O7Cor e Forma:Yellowish SolidPeso molecular:512.56PF 00356231
CAS:PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).
Fórmula:C25H20N2O3SPureza:99.35%Cor e Forma:SolidPeso molecular:428.5L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Cor e Forma:White Crystalline PowderPeso molecular:180.23HCVP-IN-1
CAS:HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.Fórmula:C30H34FN5O3Cor e Forma:SolidPeso molecular:531.632SFTI-1
CAS:SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.Fórmula:C67H104N18O18S2Cor e Forma:SolidPeso molecular:1513.78VPLSLYSG
CAS:VPLSLYSG, an octapeptide, degraded by MMP-9, MMP-1, MMP-2; potential MMP substrate uses.Fórmula:C39H62N8O12Cor e Forma:SolidPeso molecular:834.96Zetomipzomib maleate
CAS:Zetomipzomib maleate (KZR-616) selectively targets LMP7/2 in immunoproteasomes, potential for autoimmune research.Fórmula:C34H46N4O12Cor e Forma:SolidPeso molecular:702.758Histatin 5 TFA
Histatin 5 TFA effectively inhibits host matrix metalloproteinases (MMP-2) and (MMP-9), demonstrating inhibition concentrations (IC 50s) of 0.57 μM and 0.25 μMFórmula:C135H196N51F3O35Cor e Forma:SolidPeso molecular:3150.31Neutrophil elastase inhibitor 4
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM.Fórmula:C20H21N3O5Cor e Forma:SolidPeso molecular:383.4Talabostat
CAS:Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.Fórmula:C9H19BN2O3Cor e Forma:SolidPeso molecular:214.07BPHA
CAS:BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.Fórmula:C21H20N2O4SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46Ref: TM-T36712
1mg167,00€5mg442,00€1mL*10mM (DMSO)442,00€10mg620,00€25mg954,00€50mg1.305,00€100mg1.738,00€200mg2.322,00€L 659286
CAS:L 659286 is one kind of cephalosporin derivative.Fórmula:C17H21N5O7S2Cor e Forma:SolidPeso molecular:471.51TMC647055 Choline salt
TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).Fórmula:C37H53N5O8SPureza:98%Cor e Forma:SolidPeso molecular:727.91Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFórmula:C24H35N5O4·xC2HF3O2Cor e Forma:SolidPhaeosphaone D
CAS:Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).Fórmula:C20H27N3O3S2Cor e Forma:SolidPeso molecular:421.58Ellipyrone A
Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).Fórmula:C25H34O8Cor e Forma:SolidPeso molecular:462.53LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.
Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SoildPeso molecular:559.51RJS308
RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)Fórmula:C63H75N13O11SCor e Forma:SolidPeso molecular:1222.42Carboxypeptidase C
CAS:Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.Cor e Forma:SolidGSK2818713
CAS:GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.Fórmula:C46H56N8O8Cor e Forma:SolidPeso molecular:849.002Leptosin D
CAS:Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)Fórmula:C25H24N4O3S2Cor e Forma:SolidPeso molecular:492.61Sadopeptins A
Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].Fórmula:C49H71N9O13SCor e Forma:SolidPeso molecular:1026.21Aristololactam IIIa
CAS:Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.Fórmula:C16H9NO4Cor e Forma:SolidPeso molecular:279.25Enzyme-IN-1
CAS:Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。Fórmula:C36H50N4O7Cor e Forma:SolidPeso molecular:650.8Monodes(N-carboxymethyl)valine Daclatasvir
CAS:Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.Fórmula:C33H39N7O3Cor e Forma:SolidPeso molecular:581.71Calpain Inhibitor-1
CAS:Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.Fórmula:C19H17FN6O5SCor e Forma:SolidPeso molecular:460.44Tyrosinase-IN-38
Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.Cor e Forma:Odour Solidmidesteine
CAS:Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.Fórmula:C12H13NO3S3Pureza:99.87% - 99.98%Cor e Forma:SolidPeso molecular:315.43Anticancer agent 114
Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.Fórmula:C28H33BF6N2O7Cor e Forma:SolidPeso molecular:634.37Berotralstat
CAS:Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.Fórmula:C30H26F4N6OCor e Forma:SolidPeso molecular:562.56EP 171
CAS:EP 171 is a potent agonist of TP-receptors.Fórmula:C23H29FO5Cor e Forma:SolidPeso molecular:404.47PROTAC CG167
PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)Fórmula:C65H79N13O11SCor e Forma:SolidPeso molecular:1250.47N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Fórmula:C35H37F3N6O8Pureza:99.88%Cor e Forma:SolidPeso molecular:726.7
![Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT76347.webp&w=3840&q=75)
