Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(36 produtos)
- Cisteína Protease(110 produtos)
- DPP-4(23 produtos)
- Glutaminase(45 produtos)
- HIV Protease(505 produtos)
- PAI-1(26 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(54 produtos)
- Proteassoma(93 produtos)
- Protease serina(55 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1045 produtos de "Proteases/Proteassoma"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Anti-infective agent 10
CAS:Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Fórmula:C26H25N3O7SCor e Forma:SolidPeso molecular:523.56CE-2072
CAS:CE-2072 is a synthetic host serine proteases inhibitor.Fórmula:C33H41N5O6Pureza:98%Cor e Forma:SolidPeso molecular:603.71Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Fórmula:C24H36O10Cor e Forma:SolidPeso molecular:484.54GSK-2878175
CAS:GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Fórmula:C27H23BClFN2O6SPureza:98%Cor e Forma:SolidPeso molecular:568.81RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Fórmula:C39H43N4O6PCor e Forma:SolidPeso molecular:694.76GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Fórmula:C27H27BF2N2O6SCor e Forma:SolidPeso molecular:556.39Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Fórmula:C22H27F8N5O9Cor e Forma:SolidPeso molecular:657.47RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Fórmula:C17H12ClN3OS3Cor e Forma:SolidPeso molecular:405.95Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Fórmula:C23H30N6O5Cor e Forma:SolidPeso molecular:457.03Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.
Fórmula:C21H17ClN6OSCor e Forma:SolidPeso molecular:436.92Odiparcil
CAS:Odiparcil is an orally active beta-d-thioxyloside analog.Fórmula:C15H16O6SPureza:98%Cor e Forma:SolidPeso molecular:324.353-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Fórmula:C6H7NO2Cor e Forma:SolidPeso molecular:125.13Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.40Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Fórmula:C31H35FN4O3Cor e Forma:SolidPeso molecular:530.633Monosodium 2-sulfoterephthalate
CAS:Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
Fórmula:C8H5NaO7SCor e Forma:SolidPeso molecular:268.176GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Cor e Forma:SolidPeso molecular:573.68Kallikrein-IN-1
CAS:Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Fórmula:C28H26FN5O4Cor e Forma:SolidPeso molecular:515.54Matriptase-IN-2 free base
CAS:Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Fórmula:C29H33Cl2N5O3SCor e Forma:SolidPeso molecular:602.58Isobutylamido thiazolyl resorcinol
CAS:Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.Fórmula:C13H14N2O3SCor e Forma:SolidPeso molecular:278.33M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFórmula:C28H45N7O6Pureza:98%Cor e Forma:SolidPeso molecular:575.7Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Cor e Forma:SolidPeso molecular:659.84AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Fórmula:C18H27N3O3Cor e Forma:SolidPeso molecular:333.43Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Fórmula:C30H33F4N5O3Cor e Forma:SolidPeso molecular:587.61JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Fórmula:C23H33NO6Cor e Forma:SolidPeso molecular:419.51RDN2150
CAS:RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Fórmula:C28H29ClN8O4Cor e Forma:SolidPeso molecular:577.03(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Fórmula:C22H30N6OSCor e Forma:SolidPeso molecular:426.578CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Fórmula:C18H18Cl2N4O5Cor e Forma:SolidPeso molecular:441.265Tyrosinase-IN-33
CAS:Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.Fórmula:C19H17NS2Cor e Forma:SolidPeso molecular:323.48Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Fórmula:C28H21F3N6OSCor e Forma:SolidPeso molecular:546.57UK-370106
CAS:UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Fórmula:C35H44N2O5Pureza:98%Cor e Forma:SolidPeso molecular:572.73JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Fórmula:C37H33ClFN3O4Pureza:98.48% - 99.68%Cor e Forma:SolidPeso molecular:638.13Ref: TM-T27696
1mg296,00€5mg718,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€1mL*10mM (DMSO)1.108,00€MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Fórmula:C17H24F3N3O4Pureza:99.27%Cor e Forma:SolidPeso molecular:391.39IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Fórmula:C25H35N6O9PSPureza:97.15%Cor e Forma:SolidPeso molecular:626.62Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Fórmula:C38H55N5O9SPureza:97.41%Cor e Forma:SolidPeso molecular:757.94PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Cor e Forma:SolidPeso molecular:237.25Sebetralstat
CAS:Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Fórmula:C26H26FN5O4Pureza:99.85%Cor e Forma:SolidPeso molecular:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Fórmula:C37H48N6O5S2Pureza:≥98%Cor e Forma:SolidPeso molecular:720.9442ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Fórmula:C24H32KN3O8SCor e Forma:SolidPeso molecular:561.69IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Fórmula:C24H29Cl2F3N8O3Cor e Forma:SolidPeso molecular:605.44ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Cor e Forma:White PowderPeso molecular:401.56MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Fórmula:C24H19FN6O4SCor e Forma:SolidPeso molecular:506.513-Deazaadenosine
CAS:3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Fórmula:C11H14N4O4Pureza:98%Cor e Forma:SolidPeso molecular:266.25Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Fórmula:C8H7NOPureza:99.34%Cor e Forma:Off-White Crystalline PowderPeso molecular:133.15Butabindide oxalate
CAS:CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFórmula:C19H27N3O6Pureza:98%Cor e Forma:SolidPeso molecular:393.43Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Fórmula:C21H26BF2N3O7Pureza:98%Cor e Forma:SolidPeso molecular:481.25
