Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(38 produtos)
- Cisteína Protease(111 produtos)
- DPP-4(27 produtos)
- Glutaminase(46 produtos)
- HIV Protease(507 produtos)
- PAI-1(26 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(55 produtos)
- Proteassoma(86 produtos)
- Protease serina(54 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 980 produtos de "Proteases/Proteassoma"
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Matriptase-IN-2 free base
CAS:Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Fórmula:C29H33Cl2N5O3SCor e Forma:SolidPeso molecular:602.58GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Cor e Forma:SolidPeso molecular:573.68Valopicitabine
CAS:Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFórmula:C15H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:356.37Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Fórmula:C31H35FN4O3Cor e Forma:SolidPeso molecular:530.633PNU-248686A
CAS:PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Fórmula:C22H18ClNaO5S2Pureza:98%Cor e Forma:SolidPeso molecular:484.95CE-2072
CAS:CE-2072 is a synthetic host serine proteases inhibitor.Fórmula:C33H41N5O6Pureza:98%Cor e Forma:SolidPeso molecular:603.71Enantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Fórmula:C22H29FN3O9PPureza:98%Cor e Forma:SolidPeso molecular:529.45JBJ-08-178-01
CAS:JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Fórmula:C31H30N8O3Cor e Forma:SolidPeso molecular:562.62RIPK1-IN-26
CAS:RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.Fórmula:C15H20FNO2Cor e Forma:SolidPeso molecular:265.32MK-8876
CAS:MK-8876 is an Inhibitor of HCV NS5B Site D.Fórmula:C32H24F2N4O5SPureza:98%Cor e Forma:SolidPeso molecular:614.62Feniralstat
CAS:Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Fórmula:C26H25F2N5O4Pureza:99.52%Cor e Forma:SolidPeso molecular:509.51NAPAP
CAS:NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Fórmula:C27H31N5O4SCor e Forma:SolidPeso molecular:521.63MMP-13-IN-1
CAS:MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Fórmula:C19H16F3N3O3Cor e Forma:SolidPeso molecular:391.34PLGLAG
CAS:PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.Fórmula:C24H42N6O7Cor e Forma:SolidPeso molecular:526.63Pyridoxatin
CAS:Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.Fórmula:C15H21NO3Cor e Forma:SolidPeso molecular:263.33Faldaprevir sodium
CAS:Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.Fórmula:C40H48BrN6NaO9SCor e Forma:SolidPeso molecular:891.81Faldaprevir
CAS:Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Fórmula:C40H49BrN6O9SPureza:99.04% - 99.19%Cor e Forma:SolidPeso molecular:869.82RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Fórmula:C39H43N4O6PCor e Forma:SolidPeso molecular:694.76Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Fórmula:C22H27F8N5O9Cor e Forma:SolidPeso molecular:657.47Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Fórmula:C36H45N5O5SPureza:99.87% - 99.93%Cor e Forma:SolidPeso molecular:659.84Odiparcil
CAS:Odiparcil is an orally active beta-d-thioxyloside analog.Fórmula:C15H16O6SPureza:98%Cor e Forma:SolidPeso molecular:324.35Monosodium 2-sulfoterephthalate
CAS:Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
Fórmula:C8H5NaO7SCor e Forma:SolidPeso molecular:268.176AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Fórmula:C18H27N3O3Cor e Forma:SolidPeso molecular:333.43Tyrosinase-IN-37
CAS:Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.Fórmula:C12H12N6SCor e Forma:SolidPeso molecular:272.33ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Fórmula:C24H25N3O5Cor e Forma:SolidPeso molecular:435.47JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Fórmula:C23H33NO6Cor e Forma:SolidPeso molecular:419.51RDN2150
CAS:RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Fórmula:C28H29ClN8O4Cor e Forma:SolidPeso molecular:577.03Napsagatran hydrate
CAS:Napsagatran hydrate is a novel and specific inhibitor of thrombin.Fórmula:C26H36N6O7SPureza:98%Cor e Forma:SolidPeso molecular:576.66TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Fórmula:C19H14BrClN4O2SCor e Forma:SolidPeso molecular:477.762GW311616
CAS:GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Fórmula:C19H31N3O4SCor e Forma:SolidPeso molecular:397.53Deleobuvir
CAS:Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.Fórmula:C34H33BrN6O3Cor e Forma:SolidPeso molecular:653.57Zetomipzomib
CAS:KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Fórmula:C30H42N4O8Cor e Forma:SolidPeso molecular:586.68SD-7300
CAS:SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.Fórmula:C21H30F3N3O7SCor e Forma:SolidPeso molecular:525.54Dup-714
CAS:Dup-714 is a thrombin inhibitor.Fórmula:C21H33BN6O5Pureza:98%Cor e Forma:SolidPeso molecular:460.33Plodicitinib
CAS:Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Fórmula:C19H22FN7O2Cor e Forma:SolidPeso molecular:399.422Antiplatelet agent 3
CAS:Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Fórmula:C38H32N2O5Cor e Forma:SolidPeso molecular:596.671Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Fórmula:C15H25ClN4O6Cor e Forma:SolidPeso molecular:392.84BI-1942
CAS:BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.Fórmula:C24H26N4O4Cor e Forma:SolidPeso molecular:434.488BMT-052
CAS:BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).Fórmula:C30H17D9F4N6O5Pureza:98%Cor e Forma:SolidPeso molecular:635.61SSR-182289A (Free)
CAS:SSR-182289A (Free) is a thrombin inhibitor.Fórmula:C30H33F2N5O4SPureza:98%Cor e Forma:SolidPeso molecular:597.68AMG-222 tosylate
CAS:AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.Fórmula:C39H47N9O6SCor e Forma:SolidPeso molecular:769.91Tyrosinase-IN-33
CAS:Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.Fórmula:C19H17NS2Cor e Forma:SolidPeso molecular:323.48Belactin A
CAS:Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.Fórmula:C17H21ClN2O4Cor e Forma:SolidPeso molecular:352.81GW311616 hydrochloride
CAS:GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Fórmula:C19H32ClN3O4SPureza:98%Cor e Forma:SolidPeso molecular:433.99HCV NS5B polymerase-IN-2
CAS:HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.Fórmula:C26H24N2O4Cor e Forma:SolidPeso molecular:428.48Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Cor e Forma:SolidPeso molecular:401.46GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Fórmula:C26H25FN4OSCor e Forma:SolidPeso molecular:460.57Idraparinux Na
CAS:Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa InhibitorFórmula:C38H55Na9O49S7Cor e Forma:SolidPeso molecular:1727.14Duazomycin sodium
CAS:Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Fórmula:C8H10N3NaO4Cor e Forma:SolidPeso molecular:235.17HCV-IN-7
CAS:HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Fórmula:C40H48N8O6SPureza:98%Cor e Forma:SolidPeso molecular:768.92HsClpP activator-1
CAS:HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.Fórmula:C23H20F5N3O2Cor e Forma:SolidPeso molecular:465.42Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.Fórmula:C21H17ClN6OSCor e Forma:SolidPeso molecular:436.92ABT-072
CAS:ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Fórmula:C24H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:469.55Cyclophilin inhibitor 1
CAS:Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Fórmula:C31H39N5O7Pureza:98%Cor e Forma:SolidPeso molecular:593.67SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Fórmula:C24H21N3O2Cor e Forma:SolidPeso molecular:383.44Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.40DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Fórmula:C17H14F3N3O2SCor e Forma:SolidPeso molecular:381.372Anti-infective agent 10
CAS:Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Fórmula:C26H25N3O7SCor e Forma:SolidPeso molecular:523.56RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Fórmula:C17H12ClN3OS3Cor e Forma:SolidPeso molecular:405.95Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Fórmula:C23H30N6O5Cor e Forma:SolidPeso molecular:457.03RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Fórmula:C27H24F6N4O4SCor e Forma:SolidPeso molecular:614.56Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Fórmula:C35H36ClN8O7PCor e Forma:SolidPeso molecular:747.14RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Fórmula:C19H20F2N4O2Cor e Forma:SolidPeso molecular:374.384(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.Fórmula:C24H24N4O6Cor e Forma:SolidPeso molecular:464.47GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Fórmula:C27H27BF2N2O6SCor e Forma:SolidPeso molecular:556.39HCV-IN-40
CAS:HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.Fórmula:C21H26BrFN3O9PCor e Forma:SolidPeso molecular:594.32JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Fórmula:C37H33ClFN3O4Pureza:98.48% - 99.68%Cor e Forma:SolidPeso molecular:638.13Ref: TM-T27696
1mg296,00€5mg718,00€10mg982,00€1mL*10mM (DMSO)1.108,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Fórmula:C25H35N6O9PSPureza:97.15%Cor e Forma:SolidPeso molecular:626.62Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Fórmula:C38H55N5O9SPureza:97.41%Cor e Forma:SolidPeso molecular:757.94MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Fórmula:C17H24F3N3O4Pureza:99.27%Cor e Forma:SolidPeso molecular:391.39PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Cor e Forma:SolidPeso molecular:237.25Sebetralstat
CAS:Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Fórmula:C26H26FN5O4Pureza:99.85%Cor e Forma:SolidPeso molecular:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Fórmula:C37H48N6O5S2Pureza:≥98%Cor e Forma:SolidPeso molecular:720.9442IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Fórmula:C24H29Cl2F3N8O3Cor e Forma:SolidPeso molecular:605.44ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Cor e Forma:White PowderPeso molecular:401.56MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Fórmula:C24H19FN6O4SCor e Forma:SolidPeso molecular:506.51ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Fórmula:C24H32KN3O8SCor e Forma:SolidPeso molecular:561.69Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Fórmula:C8H7NOPureza:99.34%Cor e Forma:Off-White Crystalline PowderPeso molecular:133.15Butabindide oxalate
CAS:CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFórmula:C19H27N3O6Pureza:98%Cor e Forma:SolidPeso molecular:393.43Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Fórmula:C21H26BF2N3O7Pureza:98%Cor e Forma:SolidPeso molecular:481.25
