Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(35 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(450 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Cor e Forma:Odour SolidBortezomib analog
<p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>Cor e Forma:Odour SolidPROTAC CG167
<p>PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)</p>Fórmula:C65H79N13O11SCor e Forma:SolidPeso molecular:1250.47Rivulariapeptolides 1185
<p>Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.</p>Fórmula:C61H87N9O15Cor e Forma:SolidPeso molecular:1186.39Anticancer agent 114
<p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>Fórmula:C28H33BF6N2O7Cor e Forma:SolidPeso molecular:634.37HIV-1 Rev (34-50)
CAS:<p>HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity.</p>Fórmula:C97H173N51O24Pureza:99.91%Cor e Forma:SolidPeso molecular:2437.74FiVe1
CAS:<p>FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.</p>Fórmula:C18H16Cl2N4Pureza:99.67%Cor e Forma:SolidPeso molecular:359.25Sulodexide
CAS:<p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>Cor e Forma:SolidCerpegin
CAS:<p>Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.</p>Fórmula:C10H11NO3Cor e Forma:SolidPeso molecular:193.2DPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Fórmula:C33H27N7O3Cor e Forma:SolidPeso molecular:569.613Rivulariapeptolides 988
<p>Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).</p>Fórmula:C50H68N8O13Cor e Forma:SolidPeso molecular:989.12MMP-2 Inhibitor-4
<p>MMP-2Inhibitor-4 (Compound 5g) is an MMP-2 inhibitor with an IC50 of 152.62 nM. It effectively reduces MMP-2 levels in K562 cell lines by stably binding to the active site of MMP-2 and exhibits strong anti-angiogenic effects in ACHN cell lines. MMP-2Inhibitor-4 shows potential for research in chronic myelogenous leukemia (CML).</p>Fórmula:C19H23N3O5SCor e Forma:SolidPeso molecular:405.468Sadopeptins A
<p>Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>Fórmula:C49H71N9O13SCor e Forma:SolidPeso molecular:1026.21Iso-VQA-ACC acetate
<p>Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.</p>Cor e Forma:Odour Solid6,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Fórmula:C30H42N2O4SCor e Forma:SolidPeso molecular:526.73Sofosbuvir impurity M
CAS:<p>Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>Fórmula:C22H30N3O10PPureza:98%Cor e Forma:SolidPeso molecular:527.467Paritaprevir dihydrate
CAS:<p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>Fórmula:C40H47N7O9SCor e Forma:SolidPeso molecular:801.91Dutogliptin tartrate
CAS:Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.Fórmula:C14H26BN3O9Pureza:98%Cor e Forma:SolidPeso molecular:391.18FFAGLDD
<p>"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."</p>Fórmula:C37H49N7O12Pureza:98%Cor e Forma:SolidPeso molecular:783.82PROTAC 20S proteasome subunit β5 degrader 2
<p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>Cor e Forma:Odour Solid
