Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(35 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(451 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(49 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1039 produtos de "Proteases/Proteassoma"
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Tyrosinase-IN-38
<p>Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.</p>Cor e Forma:Odour SolidTalopeptin
CAS:<p>Talopeptin is a specific thermolysin inhibitor.</p>Fórmula:C23H34N3O10PPureza:98%Cor e Forma:SolidPeso molecular:543.50CL 82198 hydrochloride
CAS:<p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>Fórmula:C17H23ClN2O3Cor e Forma:SolidPeso molecular:338.83TP0597850
CAS:TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].Fórmula:C41H57N9O13SCor e Forma:SolidPeso molecular:916.01PSI-353661
CAS:<p>PSI-353661 (GS-558093), inhibits HCV's NS5B polymerase; EC90: 8nM (wild-type), 11nM (S282T); active in human hepatocytes.</p>Fórmula:C24H32FN6O8PCor e Forma:SolidPeso molecular:582.52Alisporivir
CAS:<p>Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.</p>Fórmula:C63H113N11O12Pureza:99.95%Cor e Forma:SolidPeso molecular:1216.64(-)-Taxifolin
CAS:<p>(-)-Taxifolin, less active enantiomer with anti-tyrosinase, collagenase inhibition (IC50 = 193.3 μM), antifibrotic, antioxidant properties.</p>Fórmula:C15H12O7Cor e Forma:SolidPeso molecular:304.25Sofigatran
CAS:<p>Sofigatran (MCC-977) is an oral anticoagulant targeting thrombin for cardiovascular research.</p>Fórmula:C24H44N4O4SCor e Forma:SolidPeso molecular:484.7APC-6860
CAS:<p>APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.</p>Fórmula:C9H7IN2SCor e Forma:SolidPeso molecular:302.13PS 915
CAS:<p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>Fórmula:C27H36ClN7O6Pureza:98%Cor e Forma:SolidPeso molecular:590.08Ichorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:LiquidKKI-5
CAS:<p>KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.</p>Fórmula:C35H55N11O9Pureza:98%Cor e Forma:SolidPeso molecular:773.88Histargin
CAS:<p>Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.</p>Fórmula:C14H25N7O4Cor e Forma:SolidPeso molecular:355.39Relacatib
CAS:<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Fórmula:C27H32N4O6SCor e Forma:SolidPeso molecular:540.64Recombinant Proteinase K
Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.Cor e Forma:SolidDPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Cor e Forma:Odour SolidADAM8-IN-1
CAS:<p>ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.</p>Fórmula:C44H44Br4N6O12S2Cor e Forma:SolidPeso molecular:1232.6Apovincamine
CAS:<p>Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.</p>Fórmula:C21H24N2O2Pureza:98%Cor e Forma:SolidPeso molecular:336.44LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Fórmula:C26H18Cl2N4O5Peso molecular:536.06543SL44
SL44 is an agonist of human caseinolytic protease P (HsClpP) with an EC50 of 1.30 μM. It inhibits LM3 proliferation with an IC50 of 3.1 μM and induces apoptosis in liver cancer cells by degrading respiratory chain complex subunits. In mouse models, SL44 demonstrates antitumor activity without significant toxicity (LD50=400 mg/kg) and exhibits favorable pharmacokinetic properties in rat models.Fórmula:C22H20ClFN4OPeso molecular:410.13097
