Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(34 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(449 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSCor e Forma:SolidPeso molecular:436.92BI 224436
CAS:<p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>Fórmula:C27H26N2O4Cor e Forma:SolidPeso molecular:442.51SMCypI C31
<p>SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).</p>Fórmula:C27H30N4O2SCor e Forma:SolidPeso molecular:474.62TCL1
CAS:<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Fórmula:C19H14BrClN4O2SCor e Forma:SolidPeso molecular:477.762HCV NS5B polymerase-IN-2
CAS:<p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>Fórmula:C26H24N2O4Cor e Forma:SolidPeso molecular:428.48Cathepsin K inhibitor 2
CAS:<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Fórmula:C30H33F4N5O3Cor e Forma:SolidPeso molecular:587.61M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Fórmula:C28H45N7O6Pureza:98%Cor e Forma:SolidPeso molecular:575.7Dup-714
CAS:<p>Dup-714 is a thrombin inhibitor.</p>Fórmula:C21H33BN6O5Pureza:98%Cor e Forma:SolidPeso molecular:460.33Feniralstat
CAS:<p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>Fórmula:C26H25F2N5O4Pureza:99.52%Cor e Forma:SolidPeso molecular:509.51Napsagatran hydrate
CAS:<p>Napsagatran hydrate is a novel and specific inhibitor of thrombin.</p>Fórmula:C26H36N6O7SPureza:98%Cor e Forma:SolidPeso molecular:576.66ZINC09518833
CAS:<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Fórmula:C24H25N3O5Cor e Forma:SolidPeso molecular:435.47Tyrosinase-IN-37
CAS:<p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>Fórmula:C12H12N6SCor e Forma:SolidPeso molecular:272.33Tyrosinase-IN-29
CAS:<p>Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.</p>Fórmula:C10H9NO2Cor e Forma:SolidPeso molecular:175.18(2S,4R)-Teneligliptin
CAS:<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Fórmula:C22H30N6OSCor e Forma:SolidPeso molecular:426.578HCV-IN-7
CAS:<p>HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>Fórmula:C40H48N8O6SPureza:98%Cor e Forma:SolidPeso molecular:768.92Idraparinux Na
CAS:<p>Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor</p>Fórmula:C38H55Na9O49S7Cor e Forma:SolidPeso molecular:1727.14Tyrosinase-IN-20
CAS:<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Fórmula:C17H18N2O2SCor e Forma:SolidPeso molecular:314.4Monosodium 2-sulfoterephthalate
CAS:<p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>Fórmula:C8H5NaO7SCor e Forma:SolidPeso molecular:268.176BMT-052
CAS:<p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>Fórmula:C30H17D9F4N6O5Pureza:98%Cor e Forma:SolidPeso molecular:635.61SSR-182289A (Free)
CAS:<p>SSR-182289A (Free) is a thrombin inhibitor.</p>Fórmula:C30H33F2N5O4SPureza:98%Cor e Forma:SolidPeso molecular:597.68
