Proteases/Proteassoma

Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Proteases/Proteassoma"

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Foram encontrados 1044 produtos de "Proteases/Proteassoma"

Pureza (%)

100

produtos por página.

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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:
- 82188-67-8
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
Fórmula:C₄₇H₆₄N₁₄O₁₀
Cor e Forma:Solid
Peso molecular:985.1
Ref: TM-T76347
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6,6′-Dihydroxythiobinupharidine
CAS:
- 30343-70-5
6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
Fórmula:C₃₀H₄₂N₂O₄S
Cor e Forma:Solid
Peso molecular:526.73
Ref: TM-T79978
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Grazoprevir potassium salt
CAS:
- 1206524-86-8
Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.
Fórmula:C₃₈H₄₉KN₆O₉S
Cor e Forma:Solid
Peso molecular:805
Ref: TM-T19948
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Ac-PAL-AMC
CAS:
- 1431362-79-6
Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
Fórmula:C₂₆H₃₄N₄O₆
Cor e Forma:Solid
Peso molecular:498.57
Ref: TM-T37421
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Phaeosphaone D
CAS:
- 2640137-78-4
Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).
Fórmula:C₂₀H₂₇N₃O₃S₂
Cor e Forma:Solid
Peso molecular:421.58
Ref: TM-T75470
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Ac-VDQQD-pNA
CAS:
- 189684-52-4
Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).
Fórmula:C₃₁H₄₃N₉O₁₄
Cor e Forma:Solid
Peso molecular:765.73
Ref: TM-TP2849
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Sadopeptins B
Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
Fórmula:C₄₈H₆₉N₉O₁₃S
Cor e Forma:Solid
Peso molecular:1012.18
Ref: TM-T75624
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15,16-Dihydrotanshindiol C
15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.
Fórmula:C₁₈H₁₈O₅
Cor e Forma:Solid
Peso molecular:314.337
Ref: TM-T123985
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Talabostat
CAS:
- 149682-77-9
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
Fórmula:C₉H₁₉BN₂O₃
Cor e Forma:Solid
Peso molecular:214.07
Ref: TM-T37861
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ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrial
Cor e Forma:Odour Solid
Ref: TM-T80737
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Tyrosinase-IN-34
Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.
Fórmula:C₁₉H₁₄BrClN₄O
Cor e Forma:Solid
Peso molecular:429.7
Ref: TM-T89968
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Histatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM
Fórmula:C₁₃₅H₁₉₆F₃N₅₁O₃₅
Pureza:98%
Cor e Forma:Solid
Peso molecular:3150.32
Ref: TM-TP1446
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NVP-DPP728 dihydrochloride
CAS:
- 207556-62-5
NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.
Fórmula:C₁₅H₂₀Cl₂N₆O
Cor e Forma:Solid
Peso molecular:371.27
Ref: TM-T39481
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Stevia Powder
Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.
Cor e Forma:Odour Solid
Ref: TM-TN8189
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HIV-1 TAT (48-60) Acetate
Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.
Fórmula:C₇₂H₁₃₅N₃₅O₁₈
Pureza:99.93%
Cor e Forma:Soild
Peso molecular:1779.07
Ref: TM-T75964L
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Ecallantide TFA
Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of
Cor e Forma:Odour Solid
Ref: TM-T82510
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Pseudostellarin G
CAS:
- 156525-71-2
Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.
Fórmula:C₄₂H₅₆N₈O₉
Cor e Forma:Solid
Peso molecular:816.94
Ref: TM-TP2861
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STK33-IN-1
CAS:
- 1404437-49-5
STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.
Fórmula:C₂₄H₂₇N₇O₂
Cor e Forma:Solid
Peso molecular:445.527
Ref: TM-T38835
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Plasma kallikrein-IN-1
CAS:
- 2691030-28-9
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
Fórmula:C₂₃H₂₅F₂N₇O
Cor e Forma:Solid
Peso molecular:453.498
Ref: TM-T40312
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Histatin 5
CAS:
- 115966-68-2
Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.
Fórmula:C₁₃₃H₁₉₅N₅₁O₃₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:3036.29
Ref: TM-TP1741