Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(35 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(450 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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BC-05
CAS:<p>BC-05, an orally active inhibitor targeting CD13 and the proteasome, displays potent inhibition with IC50 values of 0.13 μM against human CD13 and 1.39 μM for</p>Fórmula:C21H29BN2O9Pureza:98%Cor e Forma:SolidPeso molecular:464.27Tyrosinase-IN-7
CAS:<p>Tyrosinase-IN-7 is a small-molecule tyrosinase inhibitor (IC50 1.57 μM) that suppresses melanin activity and cell growth with low cytotoxicity.</p>Fórmula:C15H10O5Pureza:99%Cor e Forma:SolidPeso molecular:270.24Tanomastat
CAS:<p>Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor.</p>Fórmula:C23H19ClO3SPureza:98%Cor e Forma:SolidPeso molecular:410.91HCV-IN-34
CAS:<p>HCV-IN-35, an oral HCV blocker, has an EC50 of 0.010 μM and a CC50 of 7.5 μM, indicating strong antiviral effects.</p>Fórmula:C31H36ClN5Cor e Forma:SolidPeso molecular:514.1Sortin1
CAS:Sortin1, a chemical genetic-hit compound, specifically induces mislocalization of both soluble and membrane-associated vacuolar markers in plants and yeast.Fórmula:C26H19NO6Pureza:98%Cor e Forma:SolidPeso molecular:441.43MDK7677
CAS:<p>MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.</p>Fórmula:C12H10N4O3Cor e Forma:SolidPeso molecular:258.23Furaprofen
CAS:<p>Furaprofen is an HCV inhibitor with anti-inflammatory activity that inhibits carrageenan-induced paw edema in rats.</p>Fórmula:C17H14O3Pureza:98.49% - 99.52%Cor e Forma:SolidPeso molecular:266.29Gemigliptin Tartrate(911637-19-9 free base)
CAS:<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Fórmula:C22H25F8N5O8Pureza:>99.99%Cor e Forma:SolidPeso molecular:639.45GEMSA
CAS:<p>GEMSA is a potent inhibitor of enkephalin convertase ( K i =8.8 nM) with analgesic effect[1].</p>Fórmula:C7H13N3O4SCor e Forma:SolidPeso molecular:235.26Azo-Resveratrol
CAS:<p>Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.</p>Fórmula:C12H10N2O3Cor e Forma:SolidPeso molecular:230.22(3S,4S)-A2-32-01
<p>(3S,4S)-A2-32-01, a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .</p>Fórmula:C19H27NO2Cor e Forma:SolidPeso molecular:301.42AK 275
CAS:<p>AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro.</p>Fórmula:C20H31N3O4Cor e Forma:SolidPeso molecular:377.48AZD-9684
CAS:<p>AZD-9684, a carboxypeptidase U inhibitor, is used potentially for the prevention of thrombosis.</p>Fórmula:C10H14N2O2SCor e Forma:SolidPeso molecular:226.3ITX-4520
CAS:<p>ITX-4520 novel highly potent, orally bioavailable inhibitor of hepatitis C virus (HCV) entry.</p>Fórmula:C24H23F2N3OSCor e Forma:SolidPeso molecular:439.52MMP-1-IN-1
<p>MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM .</p>Fórmula:C14H17ClN2O3Cor e Forma:SolidPeso molecular:296.75L 722151
CAS:<p>L 722151 is an FXIIIa inhibitor.</p>Fórmula:C8H9ClN2O5S3Pureza:98%Cor e Forma:SolidPeso molecular:344.82SAP2-IN-1
CAS:<p>SAP2-IN-1 inhibits secreted aspartate protease 2 (IC50: 0.92 μM), doesn't work in vitro, and helps research infections.</p>Fórmula:C34H29NO7Cor e Forma:SolidPeso molecular:563.6Chymase-IN-1
CAS:<p>Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).</p>Fórmula:C20H15ClNO4PSPureza:99.17%Cor e Forma:SolidPeso molecular:431.83NAAA-IN-2
CAS:<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Fórmula:C11H13N3O2SCor e Forma:SolidPeso molecular:251.3ADAMTS-5-IN-2
CAS:<p>ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 µM, and holds potential for osteoarthritis research.</p>Fórmula:C17H15N3OSCor e Forma:SolidPeso molecular:309.39TAPI-0
CAS:<p>TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.</p>Fórmula:C24H32N4O5Cor e Forma:SolidPeso molecular:456.53Safironil
CAS:<p>Safironil, a novel antifibrotic, competitively inhibits collagen synthesis and modulates fibrosis, impacting type I/III collagen levels.</p>Fórmula:C15H23N3O4Pureza:99.83%Cor e Forma:SolidPeso molecular:309.36Tyrosinase-IN-10
CAS:<p>Tyrosinase-IN-10 serves as a partially competitive inhibitor of tyrosinase, demonstrating an inhibition concentration (IC50) value of 1.6 μM against the enzyme'</p>Fórmula:C16H12O4Cor e Forma:SolidPeso molecular:268.26Calpain-2-IN-1
CAS:<p>Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory.</p>Fórmula:C28H37N3O7Cor e Forma:SolidPeso molecular:527.61BR351
CAS:<p>BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).</p>Fórmula:C20H25FN2O5SPureza:98%Cor e Forma:SolidPeso molecular:424.49Adafosbuvir PM
CAS:<p>Adafosbuvir PM (AL-335 PM) is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.</p>Fórmula:C10H13FN2O6Pureza:97.08%Cor e Forma:SolidPeso molecular:276.22HCV-IN-35
CAS:<p>HCV-IN-35 is a potent inhibitor of HCV and shows potential for infectious disease research.</p>Fórmula:C30H36ClN5Cor e Forma:SolidPeso molecular:502.09Calpain Inhibitor XI
CAS:<p>Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders.</p>Fórmula:C26H40N4O6Cor e Forma:SolidPeso molecular:504.62AM 4299 B
CAS:<p>AM 4299 B is a novel inhibitor of a thiol protease.</p>Fórmula:C16H27N3O7Pureza:98%Cor e Forma:SolidPeso molecular:373.4MDL 27399
CAS:<p>MDL 27399 suppresses human neutrophil cathepsin G.</p>Fórmula:C26H36N4O8Cor e Forma:SolidPeso molecular:532.59α-Glucosidase-IN-5
CAS:<p>α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27BMS-363131
CAS:<p>BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.</p>Fórmula:C28H40N6O5Pureza:97.99%Cor e Forma:SolidPeso molecular:540.65CAA0225
CAS:<p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>Fórmula:C28H29N3O5Cor e Forma:SolidPeso molecular:487.55Immunoproteasome inhibitor 1
CAS:<p>Potent, reversible immunoproteasome inhibitor; Ki: β5c 1.18 μM, β1i 0.27 μM, β5i 1.91 μM; potential in treating cancer.</p>Fórmula:C20H26N2O4Cor e Forma:SolidPeso molecular:358.43JO146
CAS:<p>JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂，其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM，可应用于细菌感染的抑制。</p>Fórmula:C31H44N3O7PCor e Forma:SolidPeso molecular:601.67L-873724
CAS:<p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>Fórmula:C23H26F3N3O3SPureza:98%Cor e Forma:SolidPeso molecular:481.53(R)-ND-336
CAS:<p>(R)-ND-336: potent, selective MMP-9 inhibitor (K i = 19 nM); inhibits MMP-2 (127 nM), MMP-14 (119 nM); studied for diabetic foot ulcers.</p>Fórmula:C16H18ClNO3S2Cor e Forma:SolidPeso molecular:371.89OM-189
CAS:<p>OM-189 is a selective inhibitor of synthetic thrombin.</p>Fórmula:C24H36N6O3SPureza:98%Cor e Forma:SolidPeso molecular:488.65Tyrosinase-IN-1
CAS:<p>Tyrosinase-IN-1: potent inhibitor for skin-whitening & food preservation with uses in cosmetics & medicine.</p>Fórmula:C10H9N3O2S2Cor e Forma:SolidPeso molecular:267.33CA 074
CAS:<p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>Fórmula:C18H29N3O6Pureza:97.80%Cor e Forma:SolidPeso molecular:383.44XMU-MP-2
CAS:<p>XMU-MP-2 is a potent and selective protease inhibitor with anticancer activity that inhibits the growth of oncogenic BRK-driven tumors in a mouse xenograft</p>Fórmula:C32H33F3N8O2Pureza:99.29%Cor e Forma:SolidPeso molecular:618.65MMP-2/9-IN-1
CAS:<p>MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation.</p>Fórmula:C14H16IN7SCor e Forma:SolidPeso molecular:441.29GLS1 Inhibitor-3
CAS:<p>GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.</p>Fórmula:C30H32N10O2SCor e Forma:SolidPeso molecular:596.71HCV-IN-36
CAS:<p>HCV-IN-36: oral HCV inhibitor, EC50 0.016 μM, CC50 8.78 μM, potent antiviral.</p>Fórmula:C30H36ClN5Cor e Forma:SolidPeso molecular:502.092',5-Difluoro-2'-deoxycytidine
CAS:<p>2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.</p>Fórmula:C9H11F2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:263.2BRD-8899
CAS:<p>BRD-8899 is a STK33 inhibitor, with an IC 50 of 11 nM [1].</p>Fórmula:C17H22N4O3SCor e Forma:SolidPeso molecular:362.45Calpain Inhibitor XII
CAS:<p>Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.</p>Fórmula:C26H34N4O5Cor e Forma:SolidPeso molecular:482.57Tyrosinase-IN-5
CAS:<p>Tyrosinase-IN-5 (16c) inhibits tyrosinase with 0.02 μM IC50, reduces melanogenesis, and is low-toxicity.</p>Fórmula:C18H13N3O6Cor e Forma:SolidPeso molecular:367.31Elasnin
CAS:<p>Elasnin is a reversible inhibitor of elastase for human granulocyte and pancreatic enzymes with IC50 values of 1.3 and 30 µg/ml, respectively.</p>Fórmula:C24H40O4Cor e Forma:SolidPeso molecular:392.57Gü1303
CAS:<p>Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).</p>Fórmula:C20H22N4O3Cor e Forma:SolidPeso molecular:366.41
