Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(35 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(450 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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ABT-770
CAS:<p>ABT-770: an orally potent and selective MMP inhibitor, shown to reduce tumor growth in animal models.</p>Fórmula:C22H22F3N3O6Cor e Forma:SolidPeso molecular:481.42ASPER-29
CAS:<p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>Fórmula:C31H29BrN2O5SCor e Forma:SolidPeso molecular:621.54CAY10704
CAS:<p>CAY10704: Potent HCV inhibitor, EC50=17 nM, low cytotoxicity, good in mice, liver-targeted, not hepatotoxic, weak against dengue.</p>Fórmula:C18H20Cl2N2Cor e Forma:SolidPeso molecular:335.27DPP-4-IN-1
CAS:<p>DPP-4-IN-1 inhibits DPP-4 with 49 nM IC50, ideal for diabetes study, akin to Alogliptin.</p>Fórmula:C19H19ClN6Cor e Forma:SolidPeso molecular:366.85AA10 TG2 inhibitor
CAS:<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65Antiviral agent 30
CAS:<p>Antiviral Agent 30 (Example 118) is an active compound against HCV and RSV with an inhibitory concentration (IC 50) of greater than 25μM [1].</p>Fórmula:C21H32N2O3SCor e Forma:SolidPeso molecular:392.56BAY8040
CAS:<p>BAY8040 is a potent selective human neutrophilic elastase inhibitor with excellent potency and selectivity with promising pharmacokinetic characteristics.</p>Fórmula:C21H16F3N5O2Cor e Forma:SolidPeso molecular:427.38PK44 phosphate
CAS:<p>PK44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 15.8 nM).</p>Fórmula:C17H19F5N7O5PCor e Forma:SolidPeso molecular:527.349BrBzGCp2
CAS:<p>BrBzGCp2 (p BrBzGSH(Cp)2) is a GLO1 inhibitor with antitumor activities, relieving anxiety, and is useful in researching neurological disorders.</p>Fórmula:C27H38BrN3O6SPureza:98.68% - 98.68%Cor e Forma:SolidPeso molecular:612.58ACH-806
CAS:<p>ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.</p>Fórmula:C19H20F3N3O2SPureza:98%Cor e Forma:SolidPeso molecular:411.44VEL-0230
CAS:<p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>Fórmula:C14H24NNaO5Cor e Forma:SolidPeso molecular:309.33AZD5248
CAS:<p>AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).</p>Fórmula:C22H22N4O2Cor e Forma:SolidPeso molecular:374.44A-933548
CAS:<p>A-933548: potent calpain inhibitor, selective vs. cathepsins, stable, effective in cell assays.</p>Fórmula:C25H21N5O3Pureza:98%Cor e Forma:SolidPeso molecular:439.47Alicapistat
CAS:<p>Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).</p>Fórmula:C25H27N3O4Pureza:98%Cor e Forma:SolidPeso molecular:433.5SP-Chymostatin B
CAS:<p>SP-Chymostatin B inhibits proteases like chymotrypsin and papain; less effective on human elastase; works at 100-200 μg/ml.</p>Fórmula:C30H41N7O6Pureza:98%Cor e Forma:SolidPeso molecular:595.69DPP-IV-IN-1
CAS:<p>DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).</p>Fórmula:C11H18FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:243.28Tyrosinase-IN-6
CAS:<p>Tyrosinase-IN-6 (4B) is a potent tyrosinase inhibitor (IC50=3.80 μM) with good antioxidant activity.</p>Fórmula:C24H31N3O2Cor e Forma:SolidPeso molecular:393.52Anticancer agent 82
CAS:<p>Anticancer agent 82, a FiVe1 derivative, selectively targets VIM in cancer cells to disrupt mitosis, with improved oral bioavailability.</p>Fórmula:C19H18Cl2N4OCor e Forma:SolidPeso molecular:389.28MK-2048
CAS:<p>MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.</p>Fórmula:C21H21ClFN5O4Pureza:98%Cor e Forma:SolidPeso molecular:461.87Tyrosinase-IN-3
CAS:<p>Tyrosinase-IN-3 inhibits melanin production; potential for skin whitening and food preservation.</p>Fórmula:C21H23NO5Cor e Forma:SolidPeso molecular:369.41Gü2602
CAS:<p>Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature</p>Fórmula:C16H22N4O3Cor e Forma:SolidPeso molecular:318.37VA4 TG2 inhibitor
CAS:<p>VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.</p>Fórmula:C33H41N5O6SCor e Forma:SolidPeso molecular:635.77Gosogliptin
CAS:<p>Gosogliptin is a potent, orally active, highly selective, reversible and competitive inhibitor of DPP-4, increasing the level of intestinal GLP-1 and GIP.</p>Fórmula:C17H24F2N6OPureza:99.74%Cor e Forma:SolidPeso molecular:366.41HCV-IN-33
CAS:<p>HCV-IN-33 (Compound (S)-3i) is an inhibitor of HCV entry.</p>Fórmula:C31H36ClN5Cor e Forma:SolidPeso molecular:514.1JNJ-10329670
CAS:<p>JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.</p>Fórmula:C30H34ClF3N6O3SCor e Forma:SolidPeso molecular:651.14(Rac)-Tanomastat
CAS:<p>Tanomastat (BAY 12-9566) is an oral biphenyl MMP inhibitor; blocks MMP-2, -3, -9, -13, with anti-invasive and anti-metastatic properties.</p>Fórmula:C23H19ClO3SCor e Forma:SolidPeso molecular:410.91GSK2793660 HCl
CAS:<p>GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.</p>Fórmula:C22H32ClN3O3Cor e Forma:SolidPeso molecular:421.96Cysteine Protease inhibitor
CAS:<p>Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease</p>Fórmula:C18H14N4OPureza:98%Cor e Forma:SolidPeso molecular:302.33Cysteine Protease inhibitor hydrochloride
CAS:<p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>Fórmula:C18H15ClN4OPureza:98%Cor e Forma:SolidPeso molecular:338.79Kallikrein 5-IN-2
CAS:<p>Kallikrein 5-IN-2 inhibits KLK5 (pIC50=7.1); may normalize skin shedding, lessen inflammation & itching.</p>Fórmula:C23H22N6OCor e Forma:SolidPeso molecular:398.46BI-L 45XX
CAS:<p>BI-L 45XX, an anti-inflammatory benzimidazole derivative, has inhibitory effects on neutrophil function.</p>Fórmula:C10H9F3N2O2SCor e Forma:SolidPeso molecular:278.25Tec-IN-21
CAS:<p>Tec-IN-21 is an inhibitor of Tec kinase, it also blocks unconventional secretion of fibroblast growth factor 2 (FGF2).</p>Fórmula:C16H15ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:362.83Sheng Gelieting
CAS:<p>CGT-8012 inhibits DP-IV enzyme, aiding type II diabetes research, with an IC50 of 87 nM.</p>Fórmula:C17H16F6N4OCor e Forma:SolidPeso molecular:406.33CP-471474
CAS:<p>MMP inhibitor with IC50: MMP-2 (0.7 nM), MMP-13 (0.9 nM), MMP-9 (13 nM), MMP-3 (16 nM), MMP-1 (1170 nM); reduces heart dilation post-infarct.</p>Fórmula:C16H17FN2O5SPureza:98%Cor e Forma:SolidPeso molecular:368.38Tyrphostin 47
CAS:<p>Tyrphostin 47 inhibits the protein-tyrosine kinase activity of EGF-R.</p>Fórmula:C10H8N2O2SCor e Forma:SolidPeso molecular:220.25Elastase-IN-1
CAS:<p>Elastase-IN-1 (Compound Q11) is a non-toxic elastase inhibitor with an IC 50 of 0.897 μM [1].</p>Fórmula:C17H12N4O3Cor e Forma:SolidPeso molecular:320.3SJA6017
CAS:<p>SJA6017: inhibits calpain-1/2, cathepsins B/L; prevents apoptosis, protects spinal cord, boosts function. IC50s: 7.5-78 nM.</p>Fórmula:C17H25FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:372.45Plasma kallikrein-IN-3
CAS:<p>Plasma kallikrein-IN-3 is a potent inhibitor (IC50: 0.15 μM) used in hereditary angioedema and diabetic eye disease research.</p>Fórmula:C20H23N5O2Cor e Forma:SolidPeso molecular:365.43HIV-1 integrase inhibitor 8
CAS:<p>HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1].</p>Fórmula:C21H24O2Pureza:98.91%Cor e Forma:SolidPeso molecular:308.41Tyrosinase-IN-2
CAS:<p>Tyrosinase-IN-2, a potent tyrosinase inhibitor, may help in skin lightening and food preservation research.</p>Fórmula:C8H8N4O2SPureza:99.78%Cor e Forma:SolidPeso molecular:224.24BILB-1941
CAS:<p>BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.</p>Fórmula:C34H34N4O4Pureza:99.51% - 99.65%Cor e Forma:SolidPeso molecular:562.66CP-544439
CAS:<p>CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.</p>Fórmula:C18H19FN2O6SPureza:95.02% - 98.66%Cor e Forma:SolidPeso molecular:410.42BMS-929075
CAS:<p>BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic</p>Fórmula:C31H24F2N4O3Pureza:98.44% - 99.94%Cor e Forma:SolidPeso molecular:538.54Emivirine
CAS:<p>Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.</p>Fórmula:C17H22N2O3Pureza:99.8%Cor e Forma:SolidPeso molecular:302.37AGPS-IN-2i
CAS:AGPS-IN-2i inhibits alkylglycerol phosphate synthase, affecting ether lipid metabolism and reducing cancer cell migration and proliferation.Fórmula:C18H17F2N3O2Pureza:98.92%Cor e Forma:SolidPeso molecular:345.34TS-021
CAS:<p>TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes.</p>Fórmula:C17H24FN3O5SPureza:>99.99% - >99.99%Cor e Forma:SolidPeso molecular:401.45GSK-364735
CAS:<p>GSK-364735 is an HIV-1 IN inhibitor.</p>Fórmula:C19H18FN3O4Pureza:97.73%Cor e Forma:SolidPeso molecular:371.362'-C-Methyladenosine
CAS:<p>2'-C-Methyladenosine from C. renalis inhibits HCV, NS5B RNA synthesis (IC50: 0.3, 1.9µM), and LRV1 in L. guyanensis, L. braziliensis.</p>Fórmula:C11H15N5O4Pureza:99.85%Cor e Forma:SolidPeso molecular:281.27Isatoribine
CAS:<p>Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.</p>Fórmula:C10H12N4O6SPureza:98.99% - 99.75%Cor e Forma:SolidPeso molecular:316.29JNJ-10311795
CAS:<p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>Fórmula:C40H35N2O6PPureza:97.43%Cor e Forma:SolidPeso molecular:670.69
