Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(35 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(450 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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Apratastat
CAS:<p>Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs)</p>Fórmula:C17H22N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:414.5JW 480
CAS:<p>JW480 is a potent and selective inhibitor of KIAA1363, a serine hydrolase enzyme.</p>Fórmula:C22H23NO2Pureza:99.72%Cor e Forma:SolidPeso molecular:333.42ONO 4817
CAS:ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Fórmula:C22H28N2O6Cor e Forma:SolidPeso molecular:416.47GS-6620
CAS:<p>GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.</p>Fórmula:C29H37N6O9PCor e Forma:SolidPeso molecular:644.61Ro 32-7315
CAS:<p>Ro 32-7315 is a selective inhibitor of ADAM17.</p>Fórmula:C22H35N3O5SPureza:98%Cor e Forma:SolidPeso molecular:453.6AA74-1
CAS:<p>AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].</p>Fórmula:C16H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:308.42Berotralstat HCl
CAS:<p>Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.</p>Fórmula:C30H28Cl2F4N6OCor e Forma:SolidPeso molecular:635.4886Kallikrein-IN-2
CAS:<p>Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>Fórmula:C28H25F3N4O4Cor e Forma:SolidPeso molecular:538.52Thrombin inhibitor 1
CAS:<p>Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).</p>Fórmula:C22H20Cl2F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:497.32Ro 31-9790
CAS:<p>Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).</p>Fórmula:C15H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:315.41Proteasome-IN-4
<p>Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.</p>Fórmula:C44H58N6O5Cor e Forma:SolidPeso molecular:750.97Cathepsin K inhibitor 3
CAS:<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Fórmula:C30H31FN4O4SCor e Forma:SolidPeso molecular:562.65MMP-9 Inhibitor I
CAS:<p>MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).</p>Fórmula:C27H33N3O5SCor e Forma:SolidPeso molecular:511.63Ravidasvir HCl
CAS:<p>Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.</p>Fórmula:C42H52Cl2N8O6Cor e Forma:SolidPeso molecular:835.828Atecegatran metoxil
CAS:<p>Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.</p>Fórmula:C22H23ClF2N4O5Cor e Forma:SolidPeso molecular:496.89Cyclotheonellazole A
CAS:<p>Cyclotheonellazole A inhibits elastase (IC50=0.034nM) & chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.</p>Fórmula:C44H54N9NaO14S2Cor e Forma:SolidPeso molecular:1020.07Inogatran
CAS:<p>Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.</p>Fórmula:C21H38N6O4Pureza:98%Cor e Forma:SolidPeso molecular:438.56LY52
CAS:LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.Fórmula:C22H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:440.45KCC009
CAS:<p>KCC009 is a potent and selective Transglutaminase 2 Inhibitor.</p>Fórmula:C21H22BrN3O5Cor e Forma:SolidPeso molecular:476.32JTK-853
CAS:<p>JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).</p>Fórmula:C28H23F7N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:704.64PTC725
CAS:<p>PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.</p>Fórmula:C23H18F4N6O2SPureza:98%Cor e Forma:SolidPeso molecular:518.49M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Fórmula:C21H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:375.42NS5A-IN-3
CAS:<p>NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.</p>Fórmula:C44H44N6O8Pureza:98%Cor e Forma:SolidPeso molecular:784.86HIV-1 protease-IN-11
CAS:<p>HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy</p>Fórmula:C26H37N3O5SPureza:98%Cor e Forma:SolidPeso molecular:503.65HIV-1 protease-IN-8
CAS:<p>HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM.</p>Fórmula:C25H35N3O5SPureza:98%Cor e Forma:SolidPeso molecular:489.63HIV-1 protease-IN-7
CAS:<p>HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].</p>Fórmula:C68H104N10O12SPureza:98%Cor e Forma:SolidPeso molecular:1285.68HIV-1 protease-IN-12
CAS:<p>HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-</p>Fórmula:C25H35N3O5SPureza:98%Cor e Forma:SolidPeso molecular:489.63NS5A-IN-2
CAS:<p>NS5A-IN-2, a potent inhibitor, is highly effective against HCV 1b and shows increased activity for GT 3a with good metabolic stability.</p>Fórmula:C46H45N7O7Pureza:98%Cor e Forma:SolidPeso molecular:807.89HIV-1 protease-IN-9
CAS:<p>HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a</p>Fórmula:C37H41N7O4SPureza:98%Cor e Forma:SolidPeso molecular:679.83TP0556351
CAS:<p>TP0556351: potent MMP2 inhibitor with 0.2 nM IC50, reduces collagen in pulmonary fibrosis mice.</p>Fórmula:C50H70N10O16Pureza:98%Cor e Forma:SolidPeso molecular:1067.15MK-3281
CAS:<p>MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.</p>Fórmula:C29H37N3O3Cor e Forma:SolidPeso molecular:475.62Cipemastat
CAS:<p>Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).</p>Fórmula:C22H36N4O5Pureza:98%Cor e Forma:SolidPeso molecular:436.55Collagen proline hydroxylase inhibitor
CAS:<p>Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.</p>Fórmula:C18H18N4O4Pureza:98%Cor e Forma:SolidPeso molecular:354.36Z-PDLDA-NHOH
CAS:<p>Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].</p>Fórmula:C22H32N4O6Cor e Forma:SolidPeso molecular:448.51GSK-2485852
CAS:<p>GSK-2485852, a NS5B inhibitor, is used potentially for treatment of HCV infection.</p>Fórmula:C27H25BF2N2O6SCor e Forma:SolidPeso molecular:554.37Cathepsin Inhibitor 2
CAS:<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Fórmula:C19H21F6N3OPureza:98%Cor e Forma:SolidPeso molecular:421.38PNU-103017
CAS:<p>PNU-103017 is an inhibitor of HIV protease.</p>Fórmula:C28H28N2O5SPureza:98%Cor e Forma:SolidPeso molecular:504.6XL-784 free base
CAS:<p>XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).</p>Fórmula:C21H22ClF2N3O8SPureza:98%Cor e Forma:SolidPeso molecular:549.93MDL-101146, (R)-
CAS:<p>MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.</p>Fórmula:C29H37F5N4O6Pureza:98%Cor e Forma:SolidPeso molecular:632.62SSR 69071
CAS:<p>SSR69071: selective neutrophil elastase inhibitor, stronger for humans (Ki=0.0168 nM), may treat COPD, asthma, and reduce heart injury.</p>Fórmula:C27H32N4O7SCor e Forma:SolidPeso molecular:556.63MMP-7-IN-2
CAS:<p>MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.</p>Fórmula:C28H40ClF3N6O9SPureza:97.82%Cor e Forma:SolidPeso molecular:729.17Phe-Pro-Ala-pNA
CAS:<p>Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.</p>Fórmula:C23H27N5O5Cor e Forma:SolidPeso molecular:453.49MDL 27324
CAS:<p>MDL 27324 is an inhibitor of human neutrophil elastase.</p>Fórmula:C29H38F3N5O6SPureza:98%Cor e Forma:SolidPeso molecular:641.7I-XW-053
CAS:<p>I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-</p>Fórmula:C22H16N2O2Pureza:99.05%Cor e Forma:SolidPeso molecular:340.37BAY-678
CAS:<p>BAY-678: Oral selective human neutrophil elastase inhibitor; IC50: 20 nM; SGC-approved chemical probe.</p>Fórmula:C20H15F3N4O2Pureza:97.89%Cor e Forma:SolidPeso molecular:400.35Z-FG-NHO-BzOME
CAS:<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Fórmula:C27H27N3O7Cor e Forma:SolidPeso molecular:505.52KB-R7785
CAS:<p>KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.</p>Fórmula:C18H27N3O4Cor e Forma:SolidPeso molecular:349.42MDL 101146
CAS:<p>MDL 101146 is an orally active neutrophil elastase inhibitor.</p>Fórmula:C29H37F5N4O6Pureza:98%Cor e Forma:SolidPeso molecular:632.62Petesicatib
CAS:<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Fórmula:C25H23F6N5O4SPureza:99.76%Cor e Forma:SolidPeso molecular:603.54FK706
CAS:<p>FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.</p>Fórmula:C26H33F3N4NaO7Cor e Forma:SolidPeso molecular:593.556
