Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(34 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(449 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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FFAGLDD
<p>"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."</p>Fórmula:C37H49N7O12Pureza:98%Cor e Forma:SolidPeso molecular:783.82Sadopeptins B
<p>Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>Fórmula:C48H69N9O13SCor e Forma:SolidPeso molecular:1012.18Peptide 74
CAS:<p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>Fórmula:C62H107N23O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1558.79FFAGLDD TFA
<p>FFAGLDD TFA: MMP9 peptide for controlled DOX delivery to cytoplasm.</p>Fórmula:C39H50F3N7O14Pureza:98%Cor e Forma:SolidPeso molecular:897.85Monodes(N-carboxymethyl)valine Daclatasvir
CAS:<p>Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.</p>Fórmula:C33H39N7O3Cor e Forma:SolidPeso molecular:581.71Neutrophil elastase inhibitor 4
<p>Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM.</p>Fórmula:C20H21N3O5Cor e Forma:SolidPeso molecular:383.4BAY 1217224
CAS:<p>BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.</p>Fórmula:C24H27ClFN3O5Cor e Forma:SolidPeso molecular:491.94Calpain Inhibitor-1
CAS:<p>Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.</p>Fórmula:C19H17FN6O5SCor e Forma:SolidPeso molecular:460.44TAPI1 acetate
<p>TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .</p>Fórmula:C28H41N5O7Pureza:98.82% - 99.94%Cor e Forma:SolidPeso molecular:559.65EP 171
CAS:<p>EP 171 is a potent agonist of TP-receptors.</p>Fórmula:C23H29FO5Cor e Forma:SolidPeso molecular:404.47Histatin 5
CAS:<p>Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.</p>Fórmula:C133H195N51O33Pureza:98%Cor e Forma:SolidPeso molecular:3036.29Aristololactam IIIa
CAS:<p>Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.</p>Fórmula:C16H9NO4Cor e Forma:SolidPeso molecular:279.25Imitrodast
CAS:<p>Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and</p>Fórmula:C13H12N2O2SPureza:98.39%Cor e Forma:SolidPeso molecular:260.31AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Fórmula:C18H16N4SPureza:99.87%Cor e Forma:SoildPeso molecular:320.41NS5A-IN-4
CAS:<p>NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.</p>Fórmula:C47H48N8O6Cor e Forma:SolidPeso molecular:820.93Sucunamostat
CAS:<p>Sucunamostat is an L-aspartic acid enteropeptidase inhibitor.</p>Fórmula:C22H22N4O8Cor e Forma:SolidPeso molecular:470.438Plasma kallikrein-IN-1
CAS:<p>Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.</p>Fórmula:C23H25F2N7OCor e Forma:SolidPeso molecular:453.498Sofosbuvir impurity J
CAS:<p>Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>Fórmula:C22H30FN4O8PPureza:98%Cor e Forma:SolidPeso molecular:528.47Acetyl-Calpastatin(184-210)(human)
CAS:<p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.</p>Fórmula:C142H230N36O44SPureza:98%Cor e Forma:SolidPeso molecular:3177.65Berotralstat
CAS:<p>Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.</p>Fórmula:C30H26F4N6OCor e Forma:SolidPeso molecular:562.56PF 00356231
CAS:<p>PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).</p>Fórmula:C25H20N2O3SPureza:99.35%Cor e Forma:SolidPeso molecular:428.5Phaeosphaone D
CAS:<p>Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).</p>Fórmula:C20H27N3O3S2Cor e Forma:SolidPeso molecular:421.58Sofosbuvir impurity A
CAS:<p>Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.</p>Fórmula:C22H29FN3O9PPureza:98%Cor e Forma:SolidPeso molecular:529.45HIV-1 inhibitor-6
CAS:<p>HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing</p>Fórmula:C14H10N4O4SPureza:99.33%Cor e Forma:SolidPeso molecular:330.32Nostosin G
<p>Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).</p>Fórmula:C25H33N5O6Cor e Forma:SolidPeso molecular:499.56BPHA
CAS:<p>BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.</p>Fórmula:C21H20N2O4SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46CRA-2059 hydrochloride
<p>CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>Cor e Forma:SolidEnzyme-IN-1
CAS:<p>Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。</p>Fórmula:C36H50N4O7Cor e Forma:SolidPeso molecular:650.8Sadopeptins A
<p>Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>Fórmula:C49H71N9O13SCor e Forma:SolidPeso molecular:1026.21JC-10
CAS:<p>JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.</p>Fórmula:C25H29Cl2IN4Pureza:95%Cor e Forma:SolidPeso molecular:583.34Ellipyrone A
<p>Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).</p>Fórmula:C25H34O8Cor e Forma:SolidPeso molecular:462.53Leptosin D
CAS:<p>Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)</p>Fórmula:C25H24N4O3S2Cor e Forma:SolidPeso molecular:492.61Cys-TAT(47-57) acetate(583836-55-9 Free base)
<p>Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.</p>Fórmula:C69H128N34O16SPureza:95.1100%Cor e Forma:SolidPeso molecular:1722.04CRA-2059 TFA
<p>CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>Cor e Forma:SolidCL 82198 hydrochloride
CAS:<p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>Fórmula:C17H23ClN2O3Cor e Forma:SolidPeso molecular:338.83Nitidanin
<p>Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.</p>Fórmula:C21H24O8Cor e Forma:SolidPeso molecular:404.415RJS308
<p>RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)</p>Fórmula:C63H75N13O11SCor e Forma:SolidPeso molecular:1222.42N-CBZ-Phe-Arg-AMC TFA
<p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>Fórmula:C35H37F3N6O8Pureza:99.88%Cor e Forma:SolidPeso molecular:726.7RXP470
CAS:<p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>Fórmula:C35H35BrClN4O10PCor e Forma:SolidPeso molecular:818L 659286
CAS:<p>L 659286 is one kind of cephalosporin derivative.</p>Fórmula:C17H21N5O7S2Cor e Forma:SolidPeso molecular:471.51α 1(I) Collagen (614-639), human
CAS:<p>This is a peptide inhibitor of collagen fibrillar matrix assembly.</p>Fórmula:C134H189N37O39Pureza:98%Cor e Forma:SolidPeso molecular:2942.16Linagliptin Methyldimer
CAS:<p>Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.</p>Fórmula:C50H56N16O4Pureza:97.23%Cor e Forma:SolidPeso molecular:945.08Alisporivir
CAS:<p>Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.</p>Fórmula:C63H113N11O12Pureza:99.95%Cor e Forma:SolidPeso molecular:1216.64Ecallantide TFA
<p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>Cor e Forma:Odour SolidObtusifolin-2-O-glucoside
CAS:<p>Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].</p>Fórmula:C22H22O10Cor e Forma:SolidPeso molecular:446.4DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Cor e Forma:Odour SolidRecombinant Proteinase K
<p>Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.</p>Cor e Forma:SolidRivulariapeptolides 1155
<p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>Fórmula:C59H81N9O15Cor e Forma:SolidPeso molecular:1156.33Ac-DEMEEC-OH
CAS:<p>Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.</p>Fórmula:C29H44N6O16S2Cor e Forma:SolidPeso molecular:796.82Relacatib
CAS:<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Fórmula:C27H32N4O6SCor e Forma:SolidPeso molecular:540.64
