Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(49 produtos)
- Cisteína Protease(119 produtos)
- DPP-4(26 produtos)
- Glutaminase(46 produtos)
- HIV Protease(486 produtos)
- PAI-1(29 produtos)
- Inibidores de Protease(49 produtos)
- Receptor activado por protease(57 produtos)
- Proteassoma(91 produtos)
- Protease serina(66 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 922 produtos para "Proteases/Proteassoma".
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PPACK Dihydrochloride
CAS:PPACK Dihydrochloride is a selective thrombin inhibitor used in anticoagulation and serine protease studies.Fórmula:C21H33Cl3N6O3Pureza:98%Cor e Forma:White SolidPeso molecular:523.88Calpain Inhibitor-1
CAS:Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.Fórmula:C19H17FN6O5SCor e Forma:SolidPeso molecular:460.44D-DOPA
CAS:D-DOPA, an L-DOPA enantiomer, alters rat dopamine neurons and can modulate Parkinson's symptoms.Fórmula:C9H11NO4Cor e Forma:SolidPeso molecular:197.19APC-6860
CAS:APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.Fórmula:C9H7IN2SCor e Forma:SolidPeso molecular:302.13CDD-3290
CDD-3290 serves as a functional therapeutic tool specifically designed to enable the precise detection and inhibition of the proteolytic activity of PSA which plays a pivotal role in the progression of prostate cancer during strictly monitored laboratory observation periods and molecular investigations to evaluate the pharmacological potential of targeted kallikrein inhibition in specialized preclinical research environments.Fórmula:C17H14N6O2Pureza:99.13%Cor e Forma:White SolidPeso molecular:334.33EP 171
CAS:EP 171 is a potent agonist of TP-receptors.Fórmula:C23H29FO5Cor e Forma:SolidPeso molecular:404.47PF 00356231
CAS:PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).Fórmula:C25H20N2O3SPureza:99.35%Cor e Forma:SolidPeso molecular:428.5Fotagliptin benzoate
CAS:Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.Fórmula:C24H25FN6O3Cor e Forma:SolidPeso molecular:464.49N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Fórmula:C35H37F3N6O8Pureza:99.88%Cor e Forma:White SolidPeso molecular:726.7BPHA
CAS:BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.Fórmula:C21H20N2O4SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46Ref: TM-T36712
1mg167,00€5mg442,00€1mL*10mM (DMSO)442,00€10mg620,00€25mg954,00€50mg1.305,00€100mg1.738,00€200mg2.322,00€LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SolidPeso molecular:559.51Ref: TM-T39214L
1mg299,00€2mg447,00€5mg563,00€1mL*10mM (DMSO)830,00€10mg897,00€25mg1.324,00€50mg1.791,00€100mg2.412,00€Alisporivir
CAS:Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.Fórmula:C63H113N11O12Pureza:99.95%Cor e Forma:White SolidPeso molecular:1216.64PS 915
CAS:PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.Fórmula:C27H36ClN7O6Pureza:98%Cor e Forma:SolidPeso molecular:590.08MMP-9/MMP-13 Inhibitor I
CAS:MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.Fórmula:C25H25N3O6SCor e Forma:SolidPeso molecular:495.55Barbituric acid
CAS:Barbituric acid is a pyrimidine derivative and the basic skeleton of barbiturate drugs, barbiturate drugs and other heterocyclic compounds.Fórmula:C4H4N2O3Pureza:99.83%Peso molecular:128.09Tyrosinase-IN-38
Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.Cor e Forma:Odour SolidAR-H067637
CAS:AR-H067637 is a fast-acting, reversible thrombin inhibitor with K(i) 2-4 nM; it also reduces clot-bound thrombin and platelet activation/aggregation.Fórmula:C21H21ClF2N4O4Cor e Forma:SolidPeso molecular:466.87Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Cor e Forma:Odour SolidAc-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFórmula:C47H64N14O10Cor e Forma:SolidPeso molecular:985.1KKI-5
CAS:KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.Fórmula:C35H55N11O9Pureza:98%Cor e Forma:SolidPeso molecular:773.88HEP-1
CAS:HEP-1 (Human ezrin peptide (324-337)) is an orally active peptide exhibiting anti-HIV properties and has been shown to augment antibody titers followingFórmula:C74H132N26O27Cor e Forma:SolidPeso molecular:1818BAY 1217224
CAS:BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.Fórmula:C24H27ClFN3O5Cor e Forma:SolidPeso molecular:491.94Histatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μMFórmula:C135H196F3N51O35Pureza:98%Cor e Forma:SolidPeso molecular:3150.32Histargin
CAS:Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.Fórmula:C14H25N7O4Cor e Forma:SolidPeso molecular:355.39Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Cor e Forma:Odour SolidDihydrofuran-3(2H)-one
CAS:Dihydrofuran-3(2H)-one, with CAS No. 22929-52-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Dihydrofuran-3(2H)-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C4H6O2Pureza:99.92%Peso molecular:86.09Adamtsostatin 4
CAS:Adamtsostatin 4, an anti-angiogenic peptide, is utilized in research related to angiogenesis inhibition [1].Fórmula:C80H121N27O27S2Peso molecular:1957.11Neutrophil elastase inhibitor 4
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM.Fórmula:C20H21N3O5Cor e Forma:SolidPeso molecular:383.4PROTAC CG167
PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)Fórmula:C65H79N13O11SCor e Forma:SolidPeso molecular:1250.47C3TD879
CAS:C3TD879 is an active molecule that can be used in life science related research. The CAS number of C3TD879 is 2850259-33-3.Fórmula:C22H28N4OPeso molecular:364.48Plasma kallikrein-IN-1
CAS:Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.Fórmula:C23H25F2N7OCor e Forma:SolidPeso molecular:453.498VD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Fórmula:C31H45N9O6SCor e Forma:SolidPeso molecular:671.81Z-APF-CMK
CAS:Z-APF-CMK is a selective inhibitor of the calcium (Ca2+)-regulated nuclear scaffold protease (CRNSP), as reported in reference [1].Fórmula:C26H30ClN3O5Cor e Forma:SolidPeso molecular:499.99Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFórmula:C24H35N5O4·xC2HF3O2Cor e Forma:SolidParitaprevir dihydrate
CAS:Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.Fórmula:C40H47N7O9SCor e Forma:SolidPeso molecular:801.91CTTHWGFTLC, CYCLIC
CAS:CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.Fórmula:C52H71N13O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1166.33Rivulariapeptolides 988
Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).Fórmula:C50H68N8O13Cor e Forma:SolidPeso molecular:989.12Ac-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Fórmula:C19H20N4O5Cor e Forma:SolidPeso molecular:384.39Talabostat
CAS:Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.Fórmula:C9H19BN2O3Cor e Forma:SolidPeso molecular:214.07FFAGLDD
"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."Fórmula:C37H49N7O12Pureza:98%Cor e Forma:SolidPeso molecular:783.82DPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Fórmula:C33H27N7O3Cor e Forma:SolidPeso molecular:569.613Tyrosinase-IN-43
Tyrosinase-IN-43 (Compound 12j) is a competitive tyrosinase inhibitor with an IC50 value of 10.49 μM for tyrosinase. It exhibits significant antioxidant activity and can be used in the study and treatment of pigmentation-related conditions such as melasma, freckles, age spots, and post-inflammatory hyperpigmentation.TMC647055 Choline salt
TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).Fórmula:C37H53N5O8SPureza:98%Cor e Forma:SolidPeso molecular:727.91α 1(I) Collagen (614-639), human
CAS:This is a peptide inhibitor of collagen fibrillar matrix assembly.Fórmula:C134H189N37O39Pureza:98%Cor e Forma:SolidPeso molecular:2942.16Ac-DEMEEC-OH
CAS:Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.Fórmula:C29H44N6O16S2Cor e Forma:SolidPeso molecular:796.82Collagen Type II Fragment
CAS:Collagen Type II Fragment is a peptide with anti-inflammatory properties that effectively inhibits collagen-induced arthritis (CIA) in mice. It is useful for research focused on inflammation and immunity [1].Fórmula:C106H174N32O37Cor e Forma:SolidPeso molecular:2488.71RXP470
CAS:RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).Fórmula:C35H35BrClN4O10PCor e Forma:SolidPeso molecular:818Anticancer agent 114
Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.Fórmula:C28H33BF6N2O7Cor e Forma:SolidPeso molecular:634.37Sofigatran
CAS:Sofigatran (MCC-977) is an oral anticoagulant targeting thrombin for cardiovascular research.Fórmula:C24H44N4O4SCor e Forma:SolidPeso molecular:484.7C-telopeptide
CAS:C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.Fórmula:C34H56N14O13Pureza:98%Cor e Forma:SolidPeso molecular:868.9
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