Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(34 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(449 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ala-Phe-Pro-pNA TFA
<p>Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.</p>Cor e Forma:Odour SolidSofosbuvir impurity M
CAS:<p>Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>Fórmula:C22H30N3O10PPureza:98%Cor e Forma:SolidPeso molecular:527.467BPHA
CAS:<p>BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.</p>Fórmula:C21H20N2O4SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46Obtusifolin-2-O-glucoside
CAS:<p>Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].</p>Fórmula:C22H22O10Cor e Forma:SolidPeso molecular:446.4APC-6860
CAS:<p>APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.</p>Fórmula:C9H7IN2SCor e Forma:SolidPeso molecular:302.13Z-Leu-Tyr-Chloromethylketone
CAS:<p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>Fórmula:C24H29ClN2O5Cor e Forma:SolidPeso molecular:460.95NS5A-IN-4
CAS:<p>NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.</p>Fórmula:C47H48N8O6Cor e Forma:SolidPeso molecular:820.93HIV-1 Rev (34-50)
CAS:<p>HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity.</p>Fórmula:C97H173N51O24Pureza:99.91%Cor e Forma:SolidPeso molecular:2437.74Talabostat
CAS:<p>Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.</p>Fórmula:C9H19BN2O3Cor e Forma:SolidPeso molecular:214.07Nitidanin
<p>Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.</p>Fórmula:C21H24O8Cor e Forma:SolidPeso molecular:404.415Tyrosinase/elastase-IN-1
<p>Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastase</p>Fórmula:C33H52O5Cor e Forma:SolidPeso molecular:528.76Clathrin-IN-1
CAS:<p>Pitstop 2 inhibits clathrin-mediated endocytosis, targeting clathrin's terminal domain, with potential in cancer research.</p>Fórmula:C20H13BrN2O3S2Pureza:99.53%Cor e Forma:SolidPeso molecular:473.36GSK2336805
CAS:<p>GSK-2336805, an HCV NS5A inhibitor, is effective against genotypes 1, 4, 5, and some of 6.</p>Fórmula:C42H52N8O8Cor e Forma:SolidPeso molecular:796.91CL 82198 hydrochloride
CAS:<p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>Fórmula:C17H23ClN2O3Cor e Forma:SolidPeso molecular:338.83Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS:Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFórmula:C26H36ClN7O7SCor e Forma:SolidPeso molecular:626.12VPLSLYSG
CAS:<p>VPLSLYSG, an octapeptide, degraded by MMP-9, MMP-1, MMP-2; potential MMP substrate uses.</p>Fórmula:C39H62N8O12Cor e Forma:SolidPeso molecular:834.96Recombinant Proteinase K
Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.Cor e Forma:SolidZ-Arg-Arg-βNA acetate
CAS:<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Fórmula:C32H43N9O6Cor e Forma:SolidPeso molecular:649.74MMP-3 Inhibitor acetate
<p>MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.</p>Fórmula:C29H50N10O11SPureza:98%Cor e Forma:SolidPeso molecular:746.83Peptide 74
CAS:<p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>Fórmula:C62H107N23O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1558.79Sitagliptin fenilalanil hydrochloride
CAS:<p>Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.</p>Fórmula:C25H25ClF6N6O2Cor e Forma:SolidPeso molecular:590.95PROTAC 20S proteasome subunit β5 degrader 2
<p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>Cor e Forma:Odour SolidAMG-222
CAS:<p>AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.</p>Fórmula:C32H39N9O3Cor e Forma:SolidPeso molecular:597.71PPACK II
CAS:<p>PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .</p>Fórmula:C25H33ClN6O3Cor e Forma:SolidPeso molecular:501.02MMP-3 Inhibitor
CAS:<p>MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.</p>Fórmula:C27H46N10O9SPureza:98.87%Cor e Forma:SolidPeso molecular:686.78HCV-IN-4
CAS:<p>HCV-IN-4: Potent, oral HCV NS5A inhibitor; effective vs GT1a/b, GT2b, GT3a, Y93H, L31V; EC90s: 3 pM-0.02 nM.</p>Fórmula:C52H58FN9O8Pureza:98%Cor e Forma:SolidPeso molecular:956.07Leptosin D
CAS:<p>Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)</p>Fórmula:C25H24N4O3S2Cor e Forma:SolidPeso molecular:492.61HIV-1 protease-IN-14
<p>HIV-1protease-IN-14 (compound 5ae) is an effective inhibitor of HIV-1protease, exhibiting Ki values of 0.28 nM and 56.9 nM against WTHIV-1PR and R41THIV-1PR, respectively. This compound also demonstrates low cytotoxicity.</p>Cor e Forma:Odour SolidIso-VQA-ACC acetate
<p>Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.</p>Cor e Forma:Odour SolidHCV-IN-41
CAS:<p>HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.</p>Fórmula:C48H56N6O8Cor e Forma:SolidPeso molecular:844.99MMP-9/MMP-13 Inhibitor I
CAS:<p>MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.</p>Fórmula:C25H25N3O6SCor e Forma:SolidPeso molecular:495.5515,16-Dihydrotanshindiol C
<p>15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.</p>Fórmula:C18H18O5Cor e Forma:SolidPeso molecular:314.337Grazoprevir potassium salt
CAS:<p>Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.</p>Fórmula:C38H49KN6O9SCor e Forma:SolidPeso molecular:805RXP470
CAS:<p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>Fórmula:C35H35BrClN4O10PCor e Forma:SolidPeso molecular:8186,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Fórmula:C30H42N2O4SCor e Forma:SolidPeso molecular:526.73Ac-PAL-AMC
CAS:<p>Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.</p>Fórmula:C26H34N4O6Cor e Forma:SolidPeso molecular:498.57LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SoildPeso molecular:559.51Tyrosinase-IN-38
<p>Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.</p>Cor e Forma:Odour SolidPROTAC CG167
<p>PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)</p>Fórmula:C65H79N13O11SCor e Forma:SolidPeso molecular:1250.47FFAGLDD TFA
<p>FFAGLDD TFA: MMP9 peptide for controlled DOX delivery to cytoplasm.</p>Fórmula:C39H50F3N7O14Pureza:98%Cor e Forma:SolidPeso molecular:897.855-epi-Arvestonate A
CAS:<p>5-epi-Arvestonate A, a sesquiterpenoid from Seriphidium transiliense, stimulates melanogenesis and suppresses IFN-γ-chemokine in HaCaT cells.</p>Fórmula:C16H26O5Cor e Forma:SolidPeso molecular:298.37VD2173
CAS:<p>VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.</p>Fórmula:C31H45N9O6SCor e Forma:SolidPeso molecular:671.81Bortezomib analog
<p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>Cor e Forma:Odour SolidNIM811
CAS:<p>NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.</p>Fórmula:C62H111N11O12Pureza:98%Cor e Forma:SolidPeso molecular:1202.635SFTI-1
CAS:SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.Fórmula:C67H104N18O18S2Cor e Forma:SolidPeso molecular:1513.78Rivulariapeptolides 1155
<p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>Fórmula:C59H81N9O15Cor e Forma:SolidPeso molecular:1156.33CP-346086 dihydrate
CAS:<p>CP-346086 dihydrate is a strong oral MTP inhibitor with 2.0 nM IC50, reducing cholesterol and triglycerides in vivo.</p>Fórmula:C26H26F3N5O3Cor e Forma:SolidPeso molecular:513.521Cathepsin L-IN-3
CAS:<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Fórmula:C41H49N7O4SCor e Forma:SolidPeso molecular:735.94Pentosan Polysulfate
CAS:<p>Pentosan Polysulfate: anti-HIV, anti-inflammatory, supports cartilage, treats interstitial cystitis.</p>Pureza:98%Cor e Forma:SolidPeso molecular:N/AAnticancer agent 114
<p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>Fórmula:C28H33BF6N2O7Cor e Forma:SolidPeso molecular:634.37
