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Proteases/Proteassoma

Proteases/Proteassoma

Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Proteases/Proteassoma"

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Foram encontrados 1092 produtos de "Proteases/Proteassoma"

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  • GPLGLAGGWGERDGS
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    GPLGLAGGWGERDGS

    CAS:
    GPLGLAGGWGERDGS is a polypeptide with MMP enzyme responsiveness and tumor-targeting properties, suitable for research on enzyme-guided nanoparticle assembly within tumors.
    Fórmula:C61H93N19O21
    Cor e Forma:Solid
    Peso molecular:1428.51

    Ref: TM-TP3038

  • Logotipo do CymitQuimica
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    Ellipyrone A

    Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).
    Fórmula:C25H34O8
    Cor e Forma:Solid
    Peso molecular:462.53

    Ref: TM-T75492

  • Leptosin D
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    Leptosin D

    CAS:
    Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)
    Fórmula:C25H24N4O3S2
    Cor e Forma:Solid
    Peso molecular:492.61

    Ref: TM-T75472

  • AP-C2
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    AP-C2

    CAS:
    AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.
    Fórmula:C18H16N4S
    Pureza:99.99%
    Cor e Forma:Soild
    Peso molecular:320.41

    Ref: TM-T77570

  • Ac-DEMEEC-OH
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    Ac-DEMEEC-OH

    CAS:
    Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.
    Fórmula:C29H44N6O16S2
    Cor e Forma:Solid
    Peso molecular:796.82

    Ref: TM-TP2848

  • Logotipo do CymitQuimica
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    Sadopeptins A

    Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
    Fórmula:C49H71N9O13S
    Cor e Forma:Solid
    Peso molecular:1026.21

    Ref: TM-T75623

  • C-telopeptide
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    C-telopeptide

    CAS:
    C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.
    Fórmula:C34H56N14O13
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:868.9

    Ref: TM-TP1779

  • Peptide 74
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    Peptide 74

    CAS:
    Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.
    Fórmula:C62H107N23O20S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1558.79

    Ref: TM-TP2335

  • Aristololactam IIIa
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    Aristololactam IIIa

    CAS:
    Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.
    Fórmula:C16H9NO4
    Cor e Forma:Solid
    Peso molecular:279.25

    Ref: TM-T75619

  • Enzyme-IN-1
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    Enzyme-IN-1

    CAS:
    Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。
    Fórmula:C36H50N4O7
    Cor e Forma:Solid
    Peso molecular:650.8

    Ref: TM-T74878

  • Phepropeptin B
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    Phepropeptin B

    CAS:
    Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.
    Fórmula:C40H56N6O6
    Cor e Forma:Solid
    Peso molecular:716.91

    Ref: TM-T203201

  • 6,6′-Dihydroxythiobinupharidine
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    6,6′-Dihydroxythiobinupharidine

    CAS:
    6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
    Fórmula:C30H42N2O4S
    Cor e Forma:Solid
    Peso molecular:526.73

    Ref: TM-T79978

  • Paritaprevir dihydrate
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    Paritaprevir dihydrate

    CAS:
    Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.
    Fórmula:C40H47N7O9S
    Cor e Forma:Solid
    Peso molecular:801.91

    Ref: TM-T73898

  • Logotipo do CymitQuimica
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    Rivulariapeptolides 988

    Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).
    Fórmula:C50H68N8O13
    Cor e Forma:Solid
    Peso molecular:989.12

    Ref: TM-T75651

  • CTTHWGFTLC, CYCLIC
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    CTTHWGFTLC, CYCLIC

    CAS:
    CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.
    Fórmula:C52H71N13O14S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1166.33

    Ref: TM-TP1501

  • Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
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    Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

    CAS:
    Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic probe for MMP-1 and MMP-9 detection, releasing fluorescent Nma upon cleavage (Ex/Em: 340/440 nm).
    Fórmula:C49H68N14O12S
    Cor e Forma:Solid
    Peso molecular:1077.22

    Ref: TM-T36360

  • Grazoprevir potassium salt
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    Grazoprevir potassium salt

    CAS:
    <p>Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.</p>
    Fórmula:C38H49KN6O9S
    Cor e Forma:Solid
    Peso molecular:805

    Ref: TM-T19948

  • Logotipo do CymitQuimica
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    DPP8/9-IN-1

    <p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T206718

  • 15,16-Dihydrotanshindiol C
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    15,16-Dihydrotanshindiol C

    15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.
    Fórmula:C18H18O5
    Cor e Forma:Solid
    Peso molecular:314.337

    Ref: TM-T123985

  • Pirmitegravir
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    Pirmitegravir

    CAS:
    <p>Pirmitegravir (STP0404) is a potent ALLINI, blocks LEDGF/p75 site, shows antiviral action against HIV.</p>
    Fórmula:C27H31ClN4O3
    Pureza:99.79% - 99.79%
    Cor e Forma:Solid
    Peso molecular:495.01

    Ref: TM-T39755