Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(36 produtos)
- Cisteína Protease(110 produtos)
- DPP-4(23 produtos)
- Glutaminase(44 produtos)
- HIV Protease(495 produtos)
- PAI-1(26 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(54 produtos)
- Proteassoma(88 produtos)
- Protease serina(51 produtos)
- p97(15 produtos)
Exibir 3 mais subcategorias
Foram encontrados 993 produtos de "Proteases/Proteassoma"
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Mergetpa
CAS:Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].Fórmula:C7H15N3O2S2Pureza:98%Cor e Forma:SolidPeso molecular:237.34Neurodegenerative Disorder-Targeting Compound 1
CAS:Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].Fórmula:C28H28N4O4Pureza:98%Cor e Forma:SolidPeso molecular:484.55LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Fórmula:C35H52N4O7Pureza:98%Cor e Forma:SolidPeso molecular:640.81MMP-145
CAS:MMP-145 is used as a protease inhibitor.Fórmula:C20H20N2O7SPureza:98%Cor e Forma:SolidPeso molecular:432.45BMS-189664
CAS:BMS-189664 is an inhibitor of thrombin.Fórmula:C22H34N6O4SPureza:98%Cor e Forma:SolidPeso molecular:478.61MMP-3 Inhibitor VIII
CAS:Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.Fórmula:C20H26N2O5SCor e Forma:SolidPeso molecular:406.5GSK-625433
CAS:GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.Fórmula:C26H32N4O5SCor e Forma:SolidPeso molecular:512.62AA74-1
CAS:AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].Fórmula:C16H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:308.42Z-LVG
CAS:Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFórmula:C21H31N3O6Cor e Forma:SolidPeso molecular:421.49Berotralstat HCl
CAS:Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.Fórmula:C30H28Cl2F4N6OCor e Forma:SolidPeso molecular:635.4886Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Fórmula:C20H30BN5O7Pureza:98%Cor e Forma:SolidPeso molecular:463.29SQ 32056
CAS:SQ 32056 is a cathepsin E inhibitor.Fórmula:C37H56N4O5Pureza:98%Cor e Forma:SolidPeso molecular:636.86Dim16
CAS:Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interactionFórmula:C29H38IN5Cor e Forma:SolidPeso molecular:583.55M867
CAS:M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Fórmula:C27H43N7O6Pureza:98%Cor e Forma:SolidPeso molecular:561.67HCV-IN-43
CAS:HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].Fórmula:C26H26FN3O5SCor e Forma:SolidPeso molecular:511.57Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Fórmula:C32H48N4O7Pureza:98%Cor e Forma:SolidPeso molecular:600.75Kallikrein-IN-2
CAS:Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.Fórmula:C28H25F3N4O4Cor e Forma:SolidPeso molecular:538.52Proteasome-IN-4
Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.Fórmula:C44H58N6O5Cor e Forma:SolidPeso molecular:750.97HCV-IN-44
CAS:HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1].Fórmula:C24H26FN3O5SCor e Forma:SolidPeso molecular:487.54MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Fórmula:C24H22N4O5Pureza:99.76%Cor e Forma:SolidPeso molecular:446.46Ref: TM-T16124
1mg93,00€5mg205,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€1mL*10mM (DMSO)227,00€
