Proteases/Proteassoma

Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Proteases/Proteassoma"

Exibir 3 mais subcategorias

Foram encontrados 1094 produtos de "Proteases/Proteassoma"

Pureza (%)

100

produtos por página.

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Sadopeptins B
Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
Fórmula:C₄₈H₆₉N₉O₁₃S
Cor e Forma:Solid
Peso molecular:1012.18
Ref: TM-T75624
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Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:
- 82188-67-8
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
Fórmula:C₄₇H₆₄N₁₄O₁₀
Cor e Forma:Solid
Peso molecular:985.1
Ref: TM-T76347
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Histatin 5
CAS:
- 115966-68-2
Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.
Fórmula:C₁₃₃H₁₉₅N₅₁O₃₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:3036.29
Ref: TM-TP1741
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Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).
Fórmula:C₂₅H₃₃N₅O₆
Cor e Forma:Solid
Peso molecular:499.56
Ref: TM-T75647
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ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrial
Cor e Forma:Odour Solid
Ref: TM-T80737
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HCVP-IN-1
CAS:
- 877225-09-7
HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
Fórmula:C₃₀H₃₄FN₅O₃
Cor e Forma:Solid
Peso molecular:531.632
Ref: TM-T41002
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Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.
Fórmula:C₁₄₄H₂₃₁F₃N₃₆O₄₆S
Cor e Forma:Solid
Peso molecular:3291.65
Ref: TM-T75794
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VD2173
CAS:
- 2574389-19-6
VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.
Fórmula:C₃₁H₄₅N₉O₆S
Cor e Forma:Solid
Peso molecular:671.81
Ref: TM-T74390
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PSI-7409
CAS:
- 1015073-42-3
PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
Fórmula:C₁₀H₁₆FN₂O₁₄P₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:500.16
Ref: TM-T12572
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Dutogliptin
CAS:
- 852329-66-9
Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
Fórmula:C₁₀H₂₀BN₃O₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:241.10
Ref: TM-T11128
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Tyrosinase-IN-32
Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.
Fórmula:C₁₅H₁₉NO₃
Cor e Forma:Solid
Peso molecular:261.32
Ref: TM-TN8160
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Acetyl-Calpastatin(184-210)(human)
CAS:
- 123714-50-1
Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.
Fórmula:C₁₄₂H₂₃₀N₃₆O₄₄S
Pureza:98%
Cor e Forma:Solid
Peso molecular:3177.65
Ref: TM-TP2056
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AP-C2
CAS:
- 682793-07-3
AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.
Fórmula:C₁₈H₁₆N₄S
Pureza:99.87%
Cor e Forma:Soild
Peso molecular:320.41
Ref: TM-T77570
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Histatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM
Fórmula:C₁₃₅H₁₉₆F₃N₅₁O₃₅
Pureza:98%
Cor e Forma:Solid
Peso molecular:3150.32
Ref: TM-TP1446
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GSK2818713
CAS:
- 1422484-32-9
GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.
Fórmula:C₄₆H₅₆N₈O₈
Cor e Forma:Solid
Peso molecular:849.002
Ref: TM-T38858
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C-telopeptide
CAS:
- 162929-64-8
C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.
Fórmula:C₃₄H₅₆N₁₄O₁₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:868.9
Ref: TM-TP1779
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NVP-DPP728 dihydrochloride
CAS:
- 207556-62-5
NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.
Fórmula:C₁₅H₂₀Cl₂N₆O
Cor e Forma:Solid
Peso molecular:371.27
Ref: TM-T39481
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Monodes(N-carboxymethyl)valine Daclatasvir
CAS:
- 1007884-60-7
Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.
Fórmula:C₃₃H₃₉N₇O₃
Cor e Forma:Solid
Peso molecular:581.71
Ref: TM-T37915
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Pseudostellarin G
CAS:
- 156525-71-2
Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.
Fórmula:C₄₂H₅₆N₈O₉
Cor e Forma:Solid
Peso molecular:816.94
Ref: TM-TP2861
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NIM811
CAS:
- 143205-42-9
NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
Fórmula:C₆₂H₁₁₁N₁₁O₁₂
Pureza:98%
Cor e Forma:Solid
Peso molecular:1202.635
Ref: TM-T12226