GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Milenperone
CAS:<p>Milenperone (R 34009) is a novel anti-invasive compound for the control of behavioral disorders in patients with epilepsy and alcoholism.</p>Fórmula:C22H23ClFN3O2Pureza:98.09% - 99.84%Cor e Forma:SolidPeso molecular:415.89Edonentan
CAS:<p>Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.</p>Fórmula:C28H32N4O5SPureza:98.07% - 99.6%Cor e Forma:SolidPeso molecular:536.64NP10679
CAS:<p>NP10679 is a N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit that inhibits histamine H1, hERG channels, and CYPase.</p>Fórmula:C23H26F3N3O3Pureza:99.43%Cor e Forma:SolidPeso molecular:449.47AS-35
CAS:<p>AS-35, an oral selective leukotriene antagonist, counters ileum contractions with IC50: 8 nM (LTC4), 4 nM (LTD4), 3 nM (LTE4); shows antiallergic effects.</p>Fórmula:C21H20N6O4Pureza:96.69%Cor e Forma:SolidPeso molecular:420.42SK609 HCl
CAS:<p>SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties.</p>Fórmula:C10H15Cl2NPureza:99.02%Cor e Forma:SolidPeso molecular:220.14Parogrelil Free Base
CAS:Parogrelil Free Base is a phosphodiesterase inhibitor, improves claudication-limited exercise performance in patients with peripheral arterial disease.Fórmula:C19H18BrClN4O2Pureza:99.16% - 99.17%Cor e Forma:SolidPeso molecular:449.73Thiethylperazine dimaleate
CAS:<p>Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor.</p>Fórmula:C30H37N3O8S2Pureza:99.07%Cor e Forma:SolidPeso molecular:631.76Rocepafant
CAS:<p>Rocepafant (LAU8080), a PAF antagonist, reduces neonatal rat brain damage and inhibits TNF-α toxicity in L929 cells.</p>Fórmula:C26H23ClN6OS2Pureza:97.31% - 98.95%Cor e Forma:SolidPeso molecular:535.08MRS1220
CAS:<p>MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic</p>Fórmula:C21H14ClN5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:403.82Rilapine
CAS:<p>Rilapine (Rilapinum) is an antipsychotic compound that shows high affinity for 5-HT6 receptors and can be used to study neurological disorders.</p>Fórmula:C22H20ClN3Pureza:97.76% - 99.20%Cor e Forma:SolidPeso molecular:361.87Roxindole
CAS:Roxindole: dopamine agonist, serotonin reuptake inhibitor, 5-HT1A agonist, developed for schizophrenia.Fórmula:C23H26N2OPureza:98.03% - 98.93%Cor e Forma:SolidPeso molecular:346.47A2A receptor antagonist 1
CAS:<p>A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.</p>Fórmula:C16H12FN5OPureza:99.52% - 99.93%Cor e Forma:SolidPeso molecular:309.3Remoxipride hydrochloride
CAS:<p>Remoxipride hydrochloride (Roxiam) is a selective antagonist of D2 receptor with IC50s of 1.57 μM, ＞100 μM and 42 μM for D2 receptor, D1 receptor and α1-</p>Fórmula:C16H24BrClN2O3Pureza:99.88%Cor e Forma:SolidPeso molecular:407.735-HT1A modulator 1
CAS:<p>5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).</p>Fórmula:C21H25N3O2SPureza:99.68%Cor e Forma:SolidPeso molecular:383.51TASP0390325
CAS:<p>TASP0390325, a potent and orally active V1B receptor antagonist, has antidepressant and anxiolytic activities in rodents.</p>Fórmula:C25H30Cl2FN5O4Pureza:98.62%Cor e Forma:SolidPeso molecular:554.44U 99194 maleate
CAS:<p>U 99194 maleate (U-99194A maleate) is a D3 antagonist and increases social behaviors of isolation-induced aggressive male mice.</p>Fórmula:C21H31NO6Pureza:99.45%Cor e Forma:SolidPeso molecular:393.47Ricasetron
CAS:<p>Ricasetron (Brl 46470) is a 5-HT3 receptor antagonist with pro-axonal lysing properties and is used in the study of anxiety disorders and anxiety disorders.</p>Fórmula:C19H27N3OPureza:99.52%Cor e Forma:SolidPeso molecular:313.44L 674573
CAS:<p>L 674573 is an inhibitor of leukotriene biosynthesis.</p>Fórmula:C28H27NO3SPureza:99.51%Cor e Forma:SolidPeso molecular:457.58Proxyfan
CAS:<p>Proxyfan is a high-affinity protean antagonist/agonist of H3 receptors from full agonist to full inverse agonist, depending on given tissue or brain region.</p>Fórmula:C13H16N2OPureza:99.68%Cor e Forma:SolidPeso molecular:216.28APJ receptor agonist 5
CAS:<p>Potent oral APJ agonist (EC 50:0.4 nM); improves cardiac function in HF, with good pharmacokinetics and safety.</p>Fórmula:C26H29N3O6Cor e Forma:SolidPeso molecular:479.52LY-368975
CAS:<p>LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.</p>Fórmula:C17H21NOSCor e Forma:SolidPeso molecular:287.42LY-426965
CAS:<p>LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist.</p>Fórmula:C28H38N2O2Cor e Forma:SolidPeso molecular:434.61NVP-SAA164
CAS:<p>NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.</p>Fórmula:C36H45N5O5SPureza:98%Cor e Forma:SolidPeso molecular:659.84γ-Linolenoyl monoethanolamide
CAS:<p>γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].</p>Fórmula:C20H35NO2Cor e Forma:SolidPeso molecular:321.505Gentisein
CAS:<p>Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7</p>Fórmula:C13H8O5Pureza:96.89%Cor e Forma:SolidPeso molecular:244.2PSB-1115 potassium salt
CAS:<p>PSB-1115 potassium salt, a selective A2B Adenosine Receptor antagonist, inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) [1].</p>Fórmula:C14H13KN4O5SCor e Forma:SolidPeso molecular:388.44Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Fórmula:C20H26ClN3O2Pureza:99.6%Cor e Forma:SolidPeso molecular:375.892-Methyl-5-HT
CAS:<p>2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Fórmula:C11H14N2OPureza:97.18%Cor e Forma:SolidPeso molecular:190.24E1R
CAS:<p>E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.</p>Fórmula:C13H16N2O2Cor e Forma:SolidPeso molecular:232.28CCR2 antagonist 4
CAS:<p>CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM</p>Fórmula:C21H21ClF3N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:439.86Hedgehog IN-2
CAS:<p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].</p>Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.46Neladenoson dalanate
CAS:<p>Neladenoson dalanate (BAY-1067197), an oral Adenosine A1 receptor partial agonist, is safe with good pharmacokinetics for chronic heart disease.</p>Fórmula:C35H34ClN7O4S2Cor e Forma:SolidPeso molecular:716.27E-6123
CAS:<p>E-6123 is an antagonist of platelet-activating factor (PAF) receptor.</p>Fórmula:C23H22ClN5OSPureza:98%Cor e Forma:SolidPeso molecular:451.974-Thiouridine 5′-triphosphate tetralithium
CAS:<p>4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4.</p>Fórmula:C9H11Li4N2O14P3SPureza:98%Cor e Forma:SolidPeso molecular:523.94RXFP1 receptor agonist-4
CAS:<p>RXFP1 receptor agonist-4 (Example 268) is an agonist for the RXFP1 receptor, demonstrated to suppress cAMP production in HEK293 cells that stably express the</p>Fórmula:C32H24F7N3O5SCor e Forma:SolidPeso molecular:695.6CCG-63802
CAS:CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.Fórmula:C26H18N4O2SPureza:90%Cor e Forma:SolidPeso molecular:450.51GLP-1R agonist 17
CAS:<p>GLP-1R agonist 17 excels in stimulating GLP-1 receptors, useful for cardiovascular metabolic disease research.</p>Fórmula:C28H26ClFN4O4SCor e Forma:SolidPeso molecular:569.05H4R antagonist 2
CAS:<p>H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoid</p>Fórmula:C13H17N5OPureza:98%Cor e Forma:SolidPeso molecular:259.31Wf-516
CAS:<p>Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant</p>Fórmula:C25H25Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:502.39SC 51322
CAS:<p>SC 51322 is an EP1 prostanoid receptor antagonist.</p>Fórmula:C22H20ClN3O4SPureza:98%Cor e Forma:SolidPeso molecular:457.93AGN-191129
CAS:<p>AGN-191129 (PGF2α-OMe) is a PGF2α analog with C-1 carboxyl replaced by O-methyl; it lowers eye pressure, but its receptors are unclear.</p>Fórmula:C21H38O4Cor e Forma:SolidPeso molecular:354.52RXFP1 receptor agonist-5
CAS:<p>RXFP1 receptor agonist-5 (Example 98) is an agonist that targets the RXFP1 receptor and demonstrates its bioactivity by inhibiting cAMP production in HEK293</p>Fórmula:C30H23F6N3O7Cor e Forma:SolidPeso molecular:651.51Domesticine, (-)-
CAS:<p>Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.</p>Fórmula:C19H19NO4Pureza:98%Cor e Forma:SolidPeso molecular:325.36ABT-670
CAS:<p>ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.</p>Fórmula:C19H23N3O2Pureza:98%Cor e Forma:SolidPeso molecular:325.4CCG-63808
CAS:CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.Fórmula:C25H15FN4O2SPureza:90%Cor e Forma:SolidPeso molecular:454.48Tradipitant
CAS:<p>Tradipitant (VLY-686) is an antagonist of neurokinin-1.</p>Fórmula:C28H16ClF6N5OPureza:99.42%Cor e Forma:SolidPeso molecular:587.9Dibenamine hydrochloride
CAS:<p>Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.</p>Fórmula:C16H19Cl2NPureza:96.43%Cor e Forma:Oily Liquid SolidPeso molecular:296.23TASP0376377
CAS:<p>TASP0376377 is a potent antagonist of CRTH2.</p>Fórmula:C25H16Cl2N2O4Cor e Forma:SolidPeso molecular:479.3115(S)-Fluprostenol
CAS:<p>15(S)-Fluprostenol, an isomer of the FP receptor agonist fluprostenol, serves as a potential active metabolite of 15(S)-fluprostenol isopropyl ester. It can function as an agonist at FP receptors, though with lower potency compared to its 15(R) epimer, fluprostenol.</p>Fórmula:C23H29F3O6Cor e Forma:SolidPeso molecular:458.5SCH 206272
CAS:<p>SCH 206272 is a potent, orally active antagonist of tachykinin NK(1), NK(2), and NK(3) receptor.</p>Fórmula:C33H41Cl4N5O4Cor e Forma:SolidPeso molecular:713.52MNI-444
CAS:<p>MNI-444 is a PET radiotracer for adenosine 2A receptors.</p>Fórmula:C24H26FN9O2Cor e Forma:SolidPeso molecular:491.52PD 168368
CAS:<p>PD 168368 is a mixed neuromodulin B receptor (NMB-R) antagonist and potent FPR1/FPR2/FPR3 agonist that inhibits the gastrin-releasing peptide receptor.</p>Fórmula:C31H34N6O4Pureza:98.44%Cor e Forma:SolidPeso molecular:554.64β3-AR agonist 1
CAS:β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/Fórmula:C22H28N4O4SPureza:98%Cor e Forma:SolidPeso molecular:444.55MIN-117
CAS:MIN-117, a SSRI/5-HT receptor antagonist, is potentially used for the treatment of depression.Fórmula:C25H26Cl3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:538.85Ginkgolic acid 2-phosphate
CAS:<p>Ginkgolic acid 2-phosphate, a potent sphingosine 1-phosphate (S1P) agonist, induces ERK phosphorylation and interacts with S1P1 [1].</p>Fórmula:C22H37O6PCor e Forma:SolidPeso molecular:428.5KP496
CAS:<p>KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor.</p>Fórmula:C31H34ClN3O7S3Pureza:98%Cor e Forma:SolidPeso molecular:692.27MK-0493
CAS:<p>MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake.</p>Fórmula:C30H38ClF2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:546.09Mocravimod hydrochloride
CAS:<p>Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).</p>Fórmula:C24H27Cl2NO3SPureza:90%Cor e Forma:SolidPeso molecular:480.4515(R)-Prostaglandin D2
CAS:<p>15(R)-Prostaglandin D2 functions as a DP(2) receptor (Prostaglandin Receptor) agonist with potential roles in prostatic hormone signaling and exhibits anti-inflammatory properties. It enhances actin polymerization in human eosinophils and elevates cAMP levels in platelets [1].</p>Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.471Kisspeptin 234 TFA
CAS:<p>Kisspeptin 234 TFA is a 10-amino acid peptide analog of Kisspeptin 10 [1] that functions as an antagonist to the kisspeptin receptor (KISS1, GPR54).</p>Fórmula:C63H78N18O13·xC2HF3O2Cor e Forma:SolidPeso molecular:1409.43Bunazosin Hydrochloride
CAS:<p>Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug.</p>Fórmula:C19H28ClN5O3Pureza:99.12%Cor e Forma:SolidPeso molecular:409.91GYKI-46903 HCl
CAS:<p>GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.</p>Fórmula:C17H21ClFNO2Cor e Forma:SolidPeso molecular:325.81PSB-1114 tetrasodium
CAS:<p>PSB-1114 tetrasodium, a stable P2Y2 agonist (EC50: 134 nM), is >50x more selective over P2Y4 and P2Y6.</p>Fórmula:C10H15F2N2Na4O13P3SPureza:98%Cor e Forma:SolidPeso molecular:626.17NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
CAS:<p>Compound 39, an APJ receptor agonist, has a K i of 0.6 nM, activates Gαi1 (EC50 0.8 nM), recruits β-arrestin2 (EC50 31 nM), and affects heart function.</p>Fórmula:C49H73N13O11Cor e Forma:SolidPeso molecular:1020.18PZ-1190
CAS:<p>PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].</p>Fórmula:C27H30N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:506.68AGN 192836
CAS:<p>AGN 192836 is a potent and selective α2 adrenergic agonist (EC50s: 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor).</p>Fórmula:C12H13N3O2Cor e Forma:SolidPeso molecular:231.25Firazorexton hydrate
CAS:<p>Firazorexton hydrate (TAK-994) is a brain-penetrant and orally active agonist of the orexin type 2 receptor (OX2R) with a potent EC50 of 19 nM.</p>Fórmula:C22H25F3N2O4SH2OCor e Forma:SolidPeso molecular:497.53AC-099 hydrochloride
CAS:<p>AC-099 hydrochloride is a full agonist of neuropeptide FF2 receptor NPFF2R and a partial agonist of neuropeptide FF1 receptor NPFF1R.</p>Fórmula:C9H9Cl2F3N4Pureza:99.86%Cor e Forma:SolidPeso molecular:301.1NAD 299 hydrochloride
CAS:Selective, high affinity 5-HT1A receptor antagonistFórmula:C18H24ClFN2O2Pureza:98%Cor e Forma:SolidPeso molecular:354.85Fazamorexant
CAS:<p>Fazamorexant (YZJ-1139) is a powerful orexin receptor antagonist effective for insomnia research.</p>Fórmula:C25H25FN4O2Cor e Forma:SolidPeso molecular:432.49PF-04634817
CAS:<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Fórmula:C25H36F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.58Cipralisant maleate
CAS:<p>Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.</p>Fórmula:C18H24N2O4Cor e Forma:SolidPeso molecular:332.399-keto Fluprostenol isopropyl ester
CAS:<p>9-Keto Fluprostenol Isopropyl Ester, an ester derivative of the FP receptor agonist fluprostenol, undergoes oxidation at carbon 9. This compound serves as a potential prodrug for 9-keto fluprostenol, which may function as an agonist at EP receptors. Additionally, it is considered a possible metabolite of fluprostenol isopropyl ester (travoprost), drawing parallels to the metabolism of latanoprost by 15-hydroxyprostaglandin dehydrogenase observed in monkey cornea. Furthermore, certain F-series prostaglandins, such as 6-keto prostaglandin F1α (PGF1α), undergo conversion to their E-series counterparts in isolated human platelets, highlighting a metabolic pathway of relevance.</p>Fórmula:C26H33F3O6Cor e Forma:SolidPeso molecular:498.5KUC-7322
CAS:<p>Ritobegron is used as a selective β3-adrenoceptor agonist and the prodrug of the active compound, KUC-7322.</p>Fórmula:C21H27NO5Cor e Forma:SolidPeso molecular:373.44(R)-Monlunabant
CAS:<p>(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].</p>Fórmula:C26H22ClF3N6O3SPureza:98%Cor e Forma:SolidPeso molecular:591(±)-Fabesetron hydrochloride
CAS:<p>FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.</p>Fórmula:C18H20ClN3OPureza:98%Cor e Forma:SolidPeso molecular:329.82PSB 0788
CAS:<p>adenosine A2B receptor antagonist</p>Fórmula:C25H27ClN6O4SPureza:98%Cor e Forma:SolidPeso molecular:543.04TC-SP 14
CAS:<p>TC-SP 14 (compound 14) is a potent, orally available S1P1 agonist with EC50 of 0.042 μM; minimal S1P3 binding (EC50 3.47 μM); reduces blood lymphocytes.</p>Fórmula:C25H20F2N2O2SCor e Forma:SolidPeso molecular:450.52,3-dinor Prostaglandin E1
CAS:<p>Prostaglandin E1 (PGE1), though not predominantly found in nature, plays a significant role in clinical treatments, addressing conditions such as peripheral occlusive vascular disease, erectile dysfunction, and neonatal cardiology issues. The metabolism of PGE1 primarily begins with the oxidation at C-15, producing 13,14-dihydro-15-keto PGE1 as its major metabolite. Alternatively, inhibiting this pathway or overwhelming it with too much PGE1 could potentially enhance the production of 2,3-dinor metabolites, like 2,3-dinor PGE1, though their biological activities remain unreported. Cayman Chemical stands out as a prominent provider of prostaglandins and their metabolites, uniquely manufacturing 2,3-dinor PGE1.</p>Fórmula:C18H30O5Cor e Forma:SolidPeso molecular:326.4β3-AR agonist 2
CAS:β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM).Fórmula:C27H38N4O7SPureza:98%Cor e Forma:SolidPeso molecular:562.68Alclofenac
CAS:<p>Alclofenac (W-7320) aids chronic rheumatism by affecting acute phase proteins and L-tryptophan binding.</p>Fórmula:C11H11ClO3Pureza:99.89%Cor e Forma:SolidPeso molecular:226.6616-phenoxy tetranor Prostaglandin E2
CAS:<p>16-phenoxy tetranor PGE2, the free acid form of sulprostone, results from the hydrolysis of the methylsulfonamide bond. It is identified as a minor metabolite in human plasma following the parenteral administration of sulprostone.</p>Fórmula:C22H28O6Cor e Forma:SolidPeso molecular:388.46(±)-N-Methylcoclaurine
CAS:<p>N-Methylcoclaurine (±) acts as a selective antagonist at the α2-adrenoceptor [1].</p>Fórmula:C18H21NO3Pureza:98%Cor e Forma:SolidPeso molecular:299.36S1p receptor agonist 2
CAS:<p>S1P5-selective agonist; less so for S1P1/S1P3; useful for CNS disorders.</p>Fórmula:C24H23ClN2O4Cor e Forma:SolidPeso molecular:438.9L 662025
CAS:<p>L 662025 is a PAF receptor antagonist.</p>Fórmula:C23H27N3O6Pureza:98%Cor e Forma:SolidPeso molecular:441.48(2S,3S)-E1R
CAS:<p>(2R,3R)-E1R is a sigma-1 receptor modulator for cognitive/memory disorder treatment.</p>Fórmula:C13H16N2O2Pureza:98%Cor e Forma:SolidPeso molecular:232.28MK3577
CAS:<p>MK3577 is a glucagon receptor antagonist.</p>Fórmula:C30H30ClFN2O3Cor e Forma:SolidPeso molecular:521.02ZINC49534341
CAS:<p>ZINC49534341 is a potent MRGPRX2 antagonist, exhibiting a K_i (inhibition constant) of 32 nM [1].</p>Fórmula:C12H9N3OS2Cor e Forma:SolidPeso molecular:275.35A1/A3 AR antagonist 3
CAS:<p>A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful in</p>Fórmula:C22H19N5O3Pureza:98%Cor e Forma:SolidPeso molecular:401.42Dothiepin
CAS:<p>Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing</p>Fórmula:C19H21NSPureza:98%Cor e Forma:SolidPeso molecular:295.44FTY720 (S)-Phosphate
CAS:<p>FTY720 (S)-Phosphate is an active FTY720 derivative modulating S1P receptors, preventing lymphocyte egress, enhancing barrier integrity, aiding immune research.</p>Fórmula:C19H34NO5PPureza:99.37%Cor e Forma:SolidPeso molecular:387.45Nolomirole HCl
CAS:<p>Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study</p>Fórmula:C19H28ClNO4Pureza:99.03% - >99.99%Cor e Forma:SolidPeso molecular:369.88SLIGRL-NH2 TFA
CAS:<p>SLIGRL-NH2 TFA, also known as Protease-Activated Receptor-2 Activating Peptide TFA, is a Protease-Activated Receptor-2 (PAR-2) agonist [1].</p>Fórmula:C31H57F3N10O9Cor e Forma:SolidPeso molecular:770.845-HT3 antagonist 1
CAS:5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48Pentiapine
CAS:<p>Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.</p>Fórmula:C15H17N5SPureza:99.35%Cor e Forma:SolidPeso molecular:299.39L 659837
CAS:<p>L 659837 is an antagonist of ANC-2, lactam, and tackykinin.</p>Fórmula:C40H52N8O7SCor e Forma:SolidPeso molecular:788.96PD 160170
CAS:<p>neuropeptide Y1 receptor antagonist</p>Fórmula:C18H17N3O4SPureza:98%Cor e Forma:SolidPeso molecular:371.41AJ-76 hydrochloride
CAS:<p>AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.</p>Fórmula:C15H24ClNOCor e Forma:SolidPeso molecular:269.81Encaleret
CAS:<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Fórmula:C29H33ClFNO4Cor e Forma:SolidPeso molecular:514.0311(Z),14(Z)-Eicosadienoic acid
CAS:<p>11(Z),14(Z)-Eicosadienoic acid is an unsaturated fatty acid and metabolite that inhibits the binding of [3H]LTB4 to neutrophil modules (Ki=3 μm).</p>Fórmula:C20H36O2Pureza:99.94%Cor e Forma:SolidPeso molecular:308.5
