GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PF-03550096
CAS:<p>PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].</p>Fórmula:C19H28N4O4Cor e Forma:SolidPeso molecular:376.45LY3154885
CAS:<p>LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).</p>Fórmula:C23H23Cl2N3O2Cor e Forma:SolidPeso molecular:444.35LK 204-545
CAS:<p>LK 204-545 is a highly selective antagonist of beta1-adrenoceptor.</p>Fórmula:C25H32N4O6Cor e Forma:SolidPeso molecular:484.54Saredutant
CAS:<p>Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits neurokinin A by blocking NK2 receptor, antidepressant and anxiolytic.</p>Fórmula:C31H35Cl2N3O2Pureza:99.12%Cor e Forma:SolidPeso molecular:552.54Y1R probe-1
CAS:<p>Compound 39, or Y1R probe-1, is a fluorescent probe for Neuropeptide Y Y1 Receptor used in cancer research.</p>Fórmula:C64H71F3N10O12Cor e Forma:SolidPeso molecular:1229.3Pecavaptan
CAS:<p>Pecavaptan is a vasopressin receptor antagonist.</p>Fórmula:C22H19Cl2F3N6O3Cor e Forma:SolidPeso molecular:543.33Orvepitant maleate
CAS:<p>Orvepitant maleate, a selective NK-1 receptor antagonist (pKi 10.2), may treat depression and CRC; crosses the blood-brain barrier.</p>Fórmula:C35H39F7N4O6Pureza:98%Cor e Forma:SolidPeso molecular:744.7NGD9002
CAS:<p>NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.</p>Fórmula:C20H31N5OPureza:98%Cor e Forma:SolidPeso molecular:357.49RXFP1 receptor agonist-7
CAS:<p>RXFP1 receptor agonist-7 (Example 2) serves as an RXFP1 receptor agonist, effectively inhibiting cAMP production in HEK293 cells that stably express the human</p>Fórmula:C40H32F5N3O7Cor e Forma:SolidPeso molecular:761.69CP-96021 hydrochloride
CAS:CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM).Fórmula:C29H22ClFN4OSPureza:98%Cor e Forma:SolidPeso molecular:529.03Heptadecanoyl ethanolamide
CAS:<p>Heptadecanoyl ethanolamide, an endogenous cannabinoid, serves as a synthetic analog of PEA, featuring an odd-numbered (17-carbon) fatty acid chain [1].</p>Fórmula:C19H39NO2Cor e Forma:SolidPeso molecular:313.52MRS3558
CAS:<p>MRS3558 is an agonist of A3 adenosine receptors.</p>Fórmula:C20H20Cl2N6O3Cor e Forma:SolidPeso molecular:463.32Orexin receptor antagonist 4
CAS:<p>Orexin antagonist 4: potent, selective for OX2R (IC50=4.27 nM); less for OX1R (IC50=295 nM).</p>Fórmula:C22H24FN5O2Cor e Forma:SolidPeso molecular:409.46AGN 210676
CAS:AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).Fórmula:C23H29NO5SPureza:98%Cor e Forma:SolidPeso molecular:431.55SC 34301
CAS:<p>SC 34301 (Enisoprost), a strong oral PGE1 analog, decreases bacterial translocation and increases burned mice survival.</p>Fórmula:C22H36O5Cor e Forma:SolidPeso molecular:380.52INT-777 R-enantiomer
CAS:<p>INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.</p>Fórmula:C27H46O5Pureza:98%Cor e Forma:SolidPeso molecular:450.65Emicerfont
CAS:<p>Emicerfont is an antagonist of the corticotropin-releasing factor type 1 receptor (IC50: 66 nM).</p>Fórmula:C22H24N6O2Pureza:98%Cor e Forma:SolidPeso molecular:404.46MRS 1754
CAS:<p>MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.</p>Fórmula:C26H26N6O4Pureza:97.57% - 99.3%Cor e Forma:SolidPeso molecular:486.52Xanthine amine congener
CAS:<p>Xanthine amine congener is an Adenosine receptor antagonist.</p>Fórmula:C21H28N6O4Pureza:99.7%Cor e Forma:SolidPeso molecular:428.48Bufuralol
CAS:<p>Bufuralol (Ro 3-4787) is a 尾-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.</p>Fórmula:C16H23NO2Pureza:98.26%Cor e Forma:SolidPeso molecular:261.36L 640035
CAS:L 640035 inhibits human platelet aggregation which is induced by arachidonic acid, collagen, and the prostaglandin-endoperoxide analog of U44069.Fórmula:C15H12O3SPureza:98%Cor e Forma:SolidPeso molecular:272.32GYKI-46903 HCl
CAS:<p>GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.</p>Fórmula:C17H21ClFNO2Cor e Forma:SolidPeso molecular:325.81BMS-194449
CAS:<p>BMS-194449 is a full beta 3 agonist.</p>Fórmula:C24H24F4N2O6SCor e Forma:SolidPeso molecular:544.52GSK-1004723
CAS:<p>GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis.</p>Fórmula:C39H49ClN4O2Cor e Forma:SolidPeso molecular:641.28Abaperidone
CAS:<p>Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.</p>Fórmula:C25H25FN2O5Pureza:98.22%Cor e Forma:SolidPeso molecular:452.47GSK726701A
CAS:<p>GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).</p>Fórmula:C24H22FNO5Pureza:98%Cor e Forma:SolidPeso molecular:423.43L-749329
CAS:<p>L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.</p>Fórmula:C28H29NO8SPureza:98%Cor e Forma:SolidPeso molecular:539.6NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
CAS:<p>Compound 39, an APJ receptor agonist, has a K i of 0.6 nM, activates Gαi1 (EC50 0.8 nM), recruits β-arrestin2 (EC50 31 nM), and affects heart function.</p>Fórmula:C49H73N13O11Cor e Forma:SolidPeso molecular:1020.18Lazuvapagon
CAS:<p>Lazuvapagon is a vasopressin V2 receptor agonist that can be used to study enuresis.</p>Fórmula:C27H32N4O3Cor e Forma:SolidPeso molecular:460.57Fosnetupitant chloride monohydrochloride
CAS:<p>Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1</p>Fórmula:C31H37Cl2F6N4O5PPureza:98%Cor e Forma:SolidPeso molecular:761.52Phentolamine Analogue 1
CAS:<p>Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic.</p>Fórmula:C17H19N3OPureza:99.96%Cor e Forma:SolidPeso molecular:281.35SUCNR1-IN-1
CAS:<p>SUCNR1-IN-1 (Compound 20) serves as a potent SUCNR1 inhibitor, exhibiting an IC50 of 88 nM against hSUCNR1.</p>Fórmula:C26H22ClF3N2O4Cor e Forma:SolidPeso molecular:518.91Prostaglandin F2α serinol amide
CAS:<p>Prostaglandin F2α serinol amide, a serinolamide G protein-coupled receptor, elevates calcium levels in human non-small cell lung cancer cells. Additionally, Prostaglandin F2α functions as a luteinizing hormone in sheep and potentially serves as a nociceptive mediator in the spinal cord [1] [2] [3].</p>Fórmula:C23H41NO6Cor e Forma:SolidPeso molecular:427.582MK 0893
CAS:MK 0893 is a potent and selective Glucagon Receptor (GR) antagonist competitive, reversible cAMP activity, which attenuates blood glucose elevation.Fórmula:C32H27Cl2N3O4Pureza:98.79%Cor e Forma:SolidPeso molecular:588.48NTNCB hydrochloride
CAS:<p>NTNCB hydrochloride is an antagonist of neuropeptide Y (NPY) Y5 receptor.</p>Fórmula:C25H34ClN3O4SPureza:98.38%Cor e Forma:SolidPeso molecular:508.075-HT2A receptor agonist-3
CAS:<p>5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.</p>Fórmula:C21H26BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:420.34BMS-764459
CAS:<p>BMS-764459 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).</p>Fórmula:C19H21F2N5O3Cor e Forma:SolidPeso molecular:405.4Domesticine, (-)-
CAS:<p>Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.</p>Fórmula:C19H19NO4Pureza:98%Cor e Forma:SolidPeso molecular:325.36Ubrogepant
CAS:Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Fórmula:C29H26F3N5O3Pureza:99.452% - 99.78%Cor e Forma:SolidPeso molecular:549.54RXFP1 receptor agonist-2
CAS:<p>RXFP1 Receptor Agonist-2 (Example 124), an EC50 value of 1 nM [1].</p>Fórmula:C33H32F7N3O5Cor e Forma:SolidPeso molecular:683.61Nemonapride
CAS:Nemonapride is a dopamine D2-like receptor antagonist.Fórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9(1S)-CCR2 antagonist 1
CAS:<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47GLP-1R agonist 3
CAS:<p>GLP-1R agonist 3 is a GLP-1R agonist, an imidazole derivative.GLP-1R agonist 3 can be used to study diabetes and obesity.</p>Fórmula:C31H28FN5O4Pureza:97.19%Cor e Forma:SolidPeso molecular:553.58OMDM-5
CAS:<p>OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).</p>Fórmula:C26H44N2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:432.64Encaleret
CAS:<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Fórmula:C29H33ClFNO4Cor e Forma:SolidPeso molecular:514.03Z1078601926
CAS:<p>Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].</p>Fórmula:C14H19FN2OCor e Forma:SolidPeso molecular:250.315-HT2C agonist-3
CAS:<p>5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced</p>Fórmula:C19H23ClFNO2Pureza:98%Cor e Forma:SolidPeso molecular:351.84A-349821
CAS:<p>A-349821 is an H3 receptor agonist radioligand.</p>Fórmula:C28H35F3N2O5Cor e Forma:SolidPeso molecular:536.594-Thiouridine 5′-triphosphate tetralithium
CAS:<p>4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4.</p>Fórmula:C9H11Li4N2O14P3SPureza:98%Cor e Forma:SolidPeso molecular:523.94GLP-1R agonist 10
CAS:<p>GLP-1R agonist 10 is a GLP-1 agonist (EC50: 0.051 nM).</p>Fórmula:C29H29ClFN5O4Cor e Forma:SolidPeso molecular:566.02(S)-Bexicaserin
CAS:<p>(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].</p>Fórmula:C15H19F2N3OPureza:98%Cor e Forma:SolidPeso molecular:295.33Cipralisant maleate
CAS:<p>Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.</p>Fórmula:C18H24N2O4Cor e Forma:SolidPeso molecular:332.39Setipafant
CAS:<p>Setipafant is an antagonist of the platelet-activating factor.</p>Fórmula:C26H23ClN6O2SPureza:98%Cor e Forma:SolidPeso molecular:519.02Ro-24-0238
CAS:<p>Ro-24-0238 blocks PAF, curbing thromboxane creation and inflammation caused by PAF release.</p>Fórmula:C27H36N2O2Pureza:98%Cor e Forma:SolidPeso molecular:420.59Nolomirole HCl
CAS:<p>Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study</p>Fórmula:C19H28ClNO4Pureza:99.03% - >99.99%Cor e Forma:SolidPeso molecular:369.88Firazorexton hydrate
CAS:<p>Firazorexton hydrate (TAK-994) is a brain-penetrant and orally active agonist of the orexin type 2 receptor (OX2R) with a potent EC50 of 19 nM.</p>Fórmula:C22H25F3N2O4SH2OCor e Forma:SolidPeso molecular:497.53GT-2331
CAS:<p>GT-2331 is a histamine H3 receptor antagonist.</p>Fórmula:C14H20N2Cor e Forma:SolidPeso molecular:216.325-HT2 agonist-1 free base
CAS:<p>Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,</p>Fórmula:C19H22N2O2Pureza:98%Cor e Forma:SolidPeso molecular:310.39Cipralisant
CAS:<p>Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.</p>Fórmula:C14H20N2Pureza:98%Cor e Forma:SolidPeso molecular:216.32Omidenepag isopropyl
CAS:<p>Omidenepag isopropyl (DE-117) is a prostaglandin EP2 receptor agonist used in the study of glaucoma and hypertension.</p>Fórmula:C26H28N6O4SPureza:99.86%Cor e Forma:SolidPeso molecular:520.6GSK2263167
CAS:<p>GSK2263167 is an agonist of S1P1 receptor.</p>Fórmula:C25H26N4O4Cor e Forma:SolidPeso molecular:446.5TASP0376377
CAS:<p>TASP0376377 is a potent antagonist of CRTH2.</p>Fórmula:C25H16Cl2N2O4Cor e Forma:SolidPeso molecular:479.31Hh-Ag1.5
CAS:<p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>Fórmula:C28H26ClF2N3OSPureza:99.8%Cor e Forma:SolidPeso molecular:526.04Uridine 5'-diphosphate
CAS:<p>Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].</p>Fórmula:C9H14N2O12P2Pureza:98%Cor e Forma:SolidPeso molecular:404.16NBI 35965 methanesulfonate
CAS:NBI 35965 hydrochloride is a CRF1 antagonist.Fórmula:C22H26Cl2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:497.44T 98475
CAS:<p>gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist,orally active</p>Fórmula:C37H37F2N3O4SPureza:98%Cor e Forma:SolidPeso molecular:657.77NAS181
CAS:<p>rat 5-HT1B receptor antagonist</p>Fórmula:C21H34N2O10S2Pureza:98%Cor e Forma:SolidPeso molecular:538.63Fiboflapon sodium
CAS:Fiboflapon sodium, an oral 5-LOX-activating protein inhibitor, binds FLAP at 2.9 nM, inhibits LTB4 at 76 nM.Fórmula:C38H43N3NaO4SCor e Forma:SolidPeso molecular:660.83NVP-SAA164
CAS:<p>NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent.</p>Fórmula:C36H45N5O5SPureza:98%Cor e Forma:SolidPeso molecular:659.84GW-597901
CAS:<p>GW-597901, an β2 adrenergic receptor agonist, is used potentially for the treatment of asthma and chronic obstructive.</p>Fórmula:C25H38N2O6SCor e Forma:SolidPeso molecular:494.64Isopropyl dodec-11-enylfluorophosphonate
CAS:<p>Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits</p>Fórmula:C15H30FO2PPureza:98%Cor e Forma:SolidPeso molecular:292.37LX-1031
CAS:<p>LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.</p>Fórmula:C28H25F3N4O4Pureza:97.123% - 98.97%Cor e Forma:SolidPeso molecular:538.52ACT 335827
CAS:<p>ACT-335827: oral, brain-penetrant OXR1 selective antagonist; IC50: 6 nM (OXR1), 417 nM (OXR2); for neurological research.</p>Fórmula:C31H38N2O5Cor e Forma:SolidPeso molecular:518.642-Linoleoyl Glycerol
CAS:<p>2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.</p>Fórmula:C21H38O4Cor e Forma:SolidPeso molecular:354.531AH13205
CAS:<p>AH13205 is an agonist of EP2 prostanoid receptor.</p>Fórmula:C24H36O4Pureza:98%Cor e Forma:SolidPeso molecular:388.54LY-426965
CAS:<p>LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist.</p>Fórmula:C28H38N2O2Cor e Forma:SolidPeso molecular:434.61LY-368975
CAS:<p>LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.</p>Fórmula:C17H21NOSCor e Forma:SolidPeso molecular:287.42JNJ-19567470
CAS:<p>JNJ-19567470 is a selective, non-peptide CRF receptor 1 antagonist.</p>Fórmula:C22H27BrN4OCor e Forma:SolidPeso molecular:443.38Crisdesalazine
CAS:<p>Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1).</p>Fórmula:C16H14F3NO3Pureza:98.96%Cor e Forma:SolidPeso molecular:325.28DORA 42
CAS:<p>DORA 42 is a dual antagonist of the orexin receptor OX1R and OX2R.</p>Fórmula:C22H24N8OSPureza:98%Cor e Forma:SolidPeso molecular:448.54ATP-γ-S tetrasodium
CAS:<p>Collagen, Type I, from bovine achilles tendon is a type I collagen extracted from bovine achilles tendon.</p>Fórmula:C10H12N5Na4O12P3SCor e Forma:SolidPeso molecular:611.17CP-293019
CAS:CP-293019 is a potent, selective antagonist of dopamine D4 receptor.Fórmula:C19H22F2N4OPureza:98%Cor e Forma:SolidPeso molecular:360.4RBC10
CAS:<p>RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-</p>Fórmula:C24H25ClN2O2Pureza:99.71%Cor e Forma:SolidPeso molecular:408.92SC-50605
CAS:<p>SC-50605 is a second-generation LTB4 receptor antagonist.</p>Fórmula:C30H35NO6SCor e Forma:SolidPeso molecular:537.67URB447
CAS:<p>URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].</p>Fórmula:C25H21ClN2OCor e Forma:SolidPeso molecular:400.9Tianagliflozin
CAS:<p>Tianagliflozin, a sodium/glucose cotransporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C21H25ClO5Pureza:98%Cor e Forma:SolidPeso molecular:392.87Gentisein
CAS:<p>Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7</p>Fórmula:C13H8O5Pureza:96.89%Cor e Forma:SolidPeso molecular:244.2TC-SP 14
CAS:<p>TC-SP 14 (compound 14) is a potent, orally available S1P1 agonist with EC50 of 0.042 μM; minimal S1P3 binding (EC50 3.47 μM); reduces blood lymphocytes.</p>Fórmula:C25H20F2N2O2SCor e Forma:SolidPeso molecular:450.5JNJ-37822681 dihydrochloride
CAS:<p>JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。</p>Fórmula:C17H19Cl2F5N4Pureza:99.78%Cor e Forma:SolidPeso molecular:445.26Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Fórmula:C20H26ClN3O2Pureza:99.6%Cor e Forma:SolidPeso molecular:375.89BVFP
CAS:<p>BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN,blocking PGRN-SORT1 binding and having potential for FTLD-TDP.</p>Fórmula:C13H8BrF3N2OPureza:98.74%Cor e Forma:SolidPeso molecular:345.12L 743310
CAS:<p>L 743310 is an antagonist of the neurokinin-1 receptor.</p>Fórmula:C30H33BrF6N4O2Pureza:98%Cor e Forma:SolidPeso molecular:675.5GSK1842799
CAS:GSK1842799 is a selective S1P1 receptor agonist with good oral bioavailability.Fórmula:C24H30F9N3O6SCor e Forma:SolidPeso molecular:659.56GW405833 hydrochloride
CAS:<p>GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].</p>Fórmula:C23H25Cl3N2O3Cor e Forma:SolidPeso molecular:483.82GR 125487 sulfamate
CAS:<p>GR 125487 sulfamate is a 5-HT4 receptor antagonist.</p>Fórmula:C19H29FN4O8S2Pureza:98%Cor e Forma:SolidPeso molecular:524.58Ebrotidine
CAS:<p>Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.</p>Fórmula:C14H17BrN6O2S3Pureza:97.519%Cor e Forma:SolidPeso molecular:477.42TM-N1324
CAS:<p>TM-N1324 is a GPR39 agonist; 280 nM potency without Zn2+, 9 nM with; similar effects on murine GPR39 (EC50s: 180 nM/5 nM).</p>Fórmula:C18H13ClFN7OPureza:99.88%Cor e Forma:SolidPeso molecular:397.79PSNCBAM-1
CAS:<p>PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.</p>Fórmula:C22H21ClN4OPureza:99.86%Cor e Forma:SolidPeso molecular:392.88Epinephrine HCl
CAS:<p>Epinephrine HCl is a hormone and neurotransmitter secreted by the adrenal medulla, agonist of α-adrenergic and β-adrenergic receptor.</p>Fórmula:C9H14ClNO3Pureza:99.48%Cor e Forma:SolidPeso molecular:219.672-Chloro-ATP
CAS:2-Chloro-ATP is a soluble inhibitor of guanylate cyclase (guanylate cyclase) that can increase intracellular calcium ion concentrations at low concentrations through a mechanism independent of inositol phosphate production.Fórmula:C10H15ClN5O13P3Cor e Forma:SolidPeso molecular:541.63
