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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5360 produtos de "GPCR/Proteína-G"

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  • Logotipo do CymitQuimica
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    dCNP

    <p>dCNP binds to NPR-B/C receptors (NPR-B/C receptor), initiating the cGMP signaling pathway and regulating vascular function. It exhibits anti-hypoxic effects by downregulating hypoxia-related genes such as HIF1α and HIF2α. Additionally, dCNP inhibits tumor stroma induction, demonstrating antifibrotic properties. It also enhances immune response by upregulating CTL, NK cells, and conventional type 1 dendritic cells in tumors.</p>
    Fórmula:C141H248N38O36S3
    Cor e Forma:Solid
    Peso molecular:3147.91

    Ref: TM-TP3063

  • TDI-10229
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    TDI-10229

    CAS:
    <p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>
    Fórmula:C16H16ClN5
    Pureza:99.85% - 99.89%
    Cor e Forma:Soild
    Peso molecular:313.78

    Ref: TM-T64355

  • Seglitide acetate
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    Seglitide acetate

    CAS:
    <p>Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor.</p>
    Fórmula:C46H60N8O9
    Pureza:98.87%
    Cor e Forma:Solid
    Peso molecular:869.02

    Ref: TM-T28743

  • Cabergoline
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    Cabergoline

    CAS:
    <p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>
    Fórmula:C26H37N5O2
    Pureza:97.69% - 99.86%
    Cor e Forma:White Crystalline Solid
    Peso molecular:451.6

    Ref: TM-T14853

  • PAR-2 (1-6) (human)
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    PAR-2 (1-6) (human)

    CAS:
    <p>PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .</p>
    Fórmula:C28H53N7O8
    Cor e Forma:Solid
    Peso molecular:615.76

    Ref: TM-T76650

  • Logotipo do CymitQuimica
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    Exendin-4 (3-39)

    CAS:
    <p>Exendin-4 (3-39) is a truncated peptide missing first 2 amino acids of Exendin-4, a potent GLP-1r agonist used in diabetes and HPA axis research.</p>
    Fórmula:C176H272N46O58S
    Cor e Forma:Solid
    Peso molecular:3992.44

    Ref: TM-T76290

  • α-Helical CRF(9-41)
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    α-Helical CRF(9-41)

    CAS:
    <p>Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).</p>
    Fórmula:C166H274N46O53S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:3827

    Ref: TM-TP2048

  • Substance P (alligator)
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    Substance P (alligator)

    CAS:
    <p>Substance P from alligator: a neuropeptide with structure Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.</p>
    Fórmula:C63H98N20O13S
    Cor e Forma:Solid
    Peso molecular:1375.64

    Ref: TM-T76449

  • Vedaprofen
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    Vedaprofen

    CAS:
    <p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>
    Fórmula:C19H22O2
    Pureza:99.24% - 99.70%
    Cor e Forma:Solid
    Peso molecular:282.38

    Ref: TM-T36683

  • SHU 9119
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    SHU 9119

    CAS:
    <p>SHU 9119 is a potent antagonist for human MC3R/MC4R and partial agonist for MC5R with IC50 values of 0.23, 0.06, 0.09 nM.</p>
    Fórmula:C54H71N15O9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1074.258

    Ref: TM-T16879

  • SGLT1/2-IN-2
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    SGLT1/2-IN-2

    CAS:
    <p>SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).</p>
    Fórmula:C23H26F2O7
    Cor e Forma:Solid
    Peso molecular:452.451

    Ref: TM-T39966

  • Apraglutide
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    Apraglutide

    CAS:
    <p>Apraglutide (FE 203799 is a synthetic 33-amino acid peptide and long-acting glp-2 analogue.</p>
    Fórmula:C172H263N43O52
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:3765.25

    Ref: TM-TP1172

  • Logotipo do CymitQuimica
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    α-Helical CRF(9-41) TFA

    <p>α-Helical CRF(9-41) TFA acts as a competitive antagonist for the CRF2 receptor, possessing a binding constant (K B) of approximately 100 nM.</p>
    Fórmula:C168H275F3N46O55S2
    Cor e Forma:Solid
    Peso molecular:3940.42

    Ref: TM-T75891

  • HAEGTFTSD acetate(926018-45-3 free base)
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    HAEGTFTSD acetate(926018-45-3 free base)

    <p>HAEGTFTSD acetate is the first N-terminal 1-9 residues of GLP-1 peptide.The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from</p>
    Fórmula:C42H61N11O19
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1024.01

    Ref: TM-TP1452L1

  • PEN (human)
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    PEN (human)

    CAS:
    <p>PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>
    Fórmula:C97H159N27O32
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2215.49

    Ref: TM-TP1949

  • α-MSH TFA
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    α-MSH TFA

    CAS:
    <p>α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the</p>
    Fórmula:C79H110F3N21O21S
    Cor e Forma:Solid
    Peso molecular:1778.93

    Ref: TM-T35406

  • GV-150013X
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    GV-150013X

    CAS:
    <p>GV-150013X ((S)-1-(1-(adamantan-1-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea) is a potent CCKB antiagonist, pKi</p>
    Fórmula:C33H34N4O3
    Pureza:99.94%
    Cor e Forma:Soild
    Peso molecular:534.65

    Ref: TM-T27503L

  • GRK2-IN-1 hydrochloride (2055990-90-2 free base)
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    GRK2-IN-1 hydrochloride (2055990-90-2 free base)

    GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
    Fórmula:C24H26ClFN4O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:488.94

    Ref: TM-T13714L

  • Prostaglandin F2α 1,11-lactone
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    Prostaglandin F2α 1,11-lactone

    CAS:
    <p>Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) is a lipid-soluble prodrug of Prostaglandin F2α and can be used in studies about treating glaucoma.</p>
    Fórmula:C20H32O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:336.47

    Ref: TM-T37326

  • 11-deoxy Prostaglandin E2
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    11-deoxy Prostaglandin E2

    CAS:
    <p>11-deoxy PGE2 is a synthetic PGE2 analog, a potent bronchoconstrictor, 5-30x stronger than PGF2α on human respiratory muscles.</p>
    Fórmula:C20H32O4
    Cor e Forma:Solid
    Peso molecular:336.47

    Ref: TM-T38342