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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • AR-C126313
    Targetmol
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    AR-C126313

    CAS:
    <p>AR-C126313 is a thiouracil derivative.</p>
    Fórmula:C28H23N7O3S
    Cor e Forma:Solid
    Peso molecular:537.59

    Ref: TM-T30120

  • Cloprostenol isopropyl ester
    Targetmol
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    Cloprostenol isopropyl ester

    CAS:
    <p>(+)-Chloprostol is a PGF2α agonist, mimics prostaglandin F2α, induces luteal dissolution in mares without side effects or stress.</p>
    Fórmula:C25H35ClO6
    Cor e Forma:Solid
    Peso molecular:466.99

    Ref: TM-T29246

  • Logotipo do CymitQuimica
    Targetmol
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    Y1 receptor antagonist 1 formic

    <p>H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.</p>
    Fórmula:C29H35N5O5
    Cor e Forma:Solid
    Peso molecular:533.62

    Ref: TM-T200259

  • Logotipo do CymitQuimica
    Targetmol
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    Adenosine receptor agonist 1

    <p>Compound 6m, an A3 adenosine receptor (AR) partial agonist, exhibits a K i value of 6.7 nM as an adenosine receptor agonist.</p>
    Fórmula:C12H14ClN5O2Se
    Cor e Forma:Solid
    Peso molecular:374.68

    Ref: TM-T89890

  • FR 113680
    Targetmol
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    FR 113680

    CAS:
    <p>FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.</p>
    Fórmula:C35H39N5O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:625.726

    Ref: TM-T27360

  • Logotipo do CymitQuimica
    Targetmol
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    GLP-1 receptor agonist 13

    <p>Compound (S)-9, a GLP-1 receptor agonist, exhibits an EC50 of 76 nM for the glucagon GLP-1 receptor [1].</p>
    Fórmula:C25H23ClF2N6O
    Cor e Forma:Solid
    Peso molecular:496.94

    Ref: TM-T79348

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    β-CGRP (mouse)

    <p>β-CGRP (mouse), a calcitonin gene-related peptide, induces vasodilation and is applicable in research areas including cardiovascular, pro-inflammatory, migraine, and metabolic studies.</p>
    Fórmula:C165H265N49O55S2
    Cor e Forma:Solid
    Peso molecular:3879.29

    Ref: TM-TP2859

  • GR231118
    Targetmol
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    GR231118

    CAS:
    <p>Potent NPY Y1 antagonist &amp; Y4 agonist; inhibits rat appetite; binds to NPFF receptors (Ki: 43-73 nM).</p>
    Fórmula:C110H170N34O24
    Pureza:98%
    Cor e Forma:Lyophilized Powder
    Peso molecular:2352.77

    Ref: TM-TP2022

  • Logotipo do CymitQuimica
    Targetmol
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    P2Y14R antagonist 3

    <p>P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases.</p>
    Fórmula:C26H25N5O5
    Cor e Forma:Solid
    Peso molecular:487.51

    Ref: TM-T205281

  • Piperulin A
    Targetmol
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    Piperulin A

    CAS:
    <p>Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,</p>
    Fórmula:C23H28O6
    Cor e Forma:Solid
    Peso molecular:400.46

    Ref: TM-T79950

  • Icatibant
    Targetmol
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    Icatibant

    CAS:
    <p>Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).</p>
    Fórmula:C59H89N19O13S
    Pureza:98%
    Cor e Forma:White Solid
    Peso molecular:1304.52

    Ref: TM-T15547

  • KwFwLL-NH2
    Targetmol
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    KwFwLL-NH2

    CAS:
    <p>KwFwLL-NH2 is a hexapeptide that serves as a ligand for the ghrelin receptor (ghrelin receptor). This compound acts as a specific inverse agonist for the ghrelin receptor, exhibiting moderate potency (EC50=45.6 nM).</p>
    Fórmula:C49H66N10O6
    Cor e Forma:Solid
    Peso molecular:891.11

    Ref: TM-TP2863

  • Logotipo do CymitQuimica
    Targetmol
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    NSC380324

    <p>NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.</p>
    Fórmula:C31H24N4O4
    Cor e Forma:Solid
    Peso molecular:516.55

    Ref: TM-T205528

  • Amitraz
    Targetmol
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    Amitraz

    CAS:
    <p>Amitraz (NSC 324552): white monoclinic crystals, mp 86-87°C, water-insoluble, used as acaricide and in canine demodectic mange.</p>
    Fórmula:C19H23N3
    Pureza:99.88%
    Cor e Forma:White/Pale Yellow Crystalline Solid
    Peso molecular:293.41

    Ref: TM-T1632

  • Pexopiprant
    Targetmol
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    Pexopiprant

    CAS:
    <p>Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.</p>
    Fórmula:C21H17Cl2F2NO4
    Cor e Forma:Solid
    Peso molecular:456.27

    Ref: TM-T41073

  • SR142948A
    Targetmol
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    SR142948A

    CAS:
    <p>SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.</p>
    Fórmula:C39H52ClN5O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:722.31

    Ref: TM-T28845

  • Logotipo do CymitQuimica
    Targetmol
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    PACAP (6-38), human, ovine, rat TFA

    <p>PACAP (6-38) is a PACAP receptor blocker with IC50s of 30, 600, 40 nM for type I, VIP1, and VIP2 receptors.</p>
    Fórmula:C184H301N56FO47S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:4138.76

    Ref: TM-TP1438

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    Guanylin TFA (mouse,rat)

    <p>Guanylin (mouse, rat) TFA is a peptide composed of 15 amino acids and acts as an activator of intestinal guanylate cyclase. This compound is utilized in research related to diarrhea.</p>
    Fórmula:C60H90N16O22S4·xC2HF3O2
    Cor e Forma:Solid
    Peso molecular:1515.71 (free base)

    Ref: TM-TP2847

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    5-HT1AR/5-HT6R ligand-1

    <p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>
    Fórmula:C25H29ClN4O2S
    Cor e Forma:Solid
    Peso molecular:485.04

    Ref: TM-T205634

  • 5-HT7R antagonist 1 free base
    Targetmol
    + Info

    5-HT7R antagonist 1 free base

    CAS:
    <p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>
    Fórmula:C14H17ClN4
    Cor e Forma:Solid
    Peso molecular:276.77

    Ref: TM-T39870