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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5378 produtos de "GPCR/Proteína-G"

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  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    <p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>
    Fórmula:C21H23Cl3N4
    Cor e Forma:Solid
    Peso molecular:437.79

    Ref: TM-T86978

  • SSTR5 antagonist 6
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    SSTR5 antagonist 6

    CAS:
    <p>SSTR5 antagonist 6, an orally active antagonist specific to the somatostatin receptor subtype 5 (SSTR5), exhibits an IC50 value of 24 nM. This compound is utilized in researching type 2 diabetes [1].</p>
    Fórmula:C22H28ClN3O4
    Cor e Forma:Solid
    Peso molecular:433.93

    Ref: TM-T87442

  • GLP-1 receptor agonist 11
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    GLP-1 receptor agonist 11

    CAS:
    <p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>
    Fórmula:C31H31ClFN3O4
    Cor e Forma:Solid
    Peso molecular:564.05

    Ref: TM-T86503

  • CB2R/5-HT1AR agonist 1
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    CB2R/5-HT1AR agonist 1

    CAS:
    <p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>
    Fórmula:C24H33NO3
    Cor e Forma:Solid
    Peso molecular:383.52

    Ref: TM-T86012

  • Tebideutorexant
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    Tebideutorexant

    CAS:
    <p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>
    Fórmula:C23H16D2F4N4O2
    Pureza:98.89%
    Cor e Forma:Solid
    Peso molecular:460.42

    Ref: TM-T70332

  • Mrgx2 antagonist-3
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    Mrgx2 antagonist-3

    CAS:
    <p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>
    Fórmula:C15H15F2N3O
    Cor e Forma:Solid
    Peso molecular:291.30

    Ref: TM-T207226

  • GRK6-IN-5
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    GRK6-IN-5

    CAS:
    <p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Fórmula:C23H21N3O2
    Cor e Forma:Solid
    Peso molecular:371.432

    Ref: TM-T205394

  • MRGPRX2 modulator-1
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    MRGPRX2 modulator-1

    CAS:
    <p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>
    Fórmula:C20H19F6N5O
    Cor e Forma:Solid
    Peso molecular:459.39

    Ref: TM-T86929

  • Pareptide monohydrochloride
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    Pareptide monohydrochloride

    CAS:
    <p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>
    Fórmula:C14H27ClN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:334.84

    Ref: TM-T13707

  • Enprostil
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    Enprostil

    CAS:
    <p>Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.</p>
    Fórmula:C23H28O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:400.46

    Ref: TM-T25375

  • Disulergine
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    Disulergine

    CAS:
    <p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>
    Fórmula:C17H24N4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:348.46

    Ref: TM-T24003

  • Iralukast (CGP 45715A)
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    Iralukast (CGP 45715A)

    CAS:
    <p>Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.</p>
    Fórmula:C38H37F3O8S
    Cor e Forma:Solid
    Peso molecular:710.76

    Ref: TM-T37016

  • CS-003 Free base
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    CS-003 Free base

    CAS:
    <p>CS-003: Triple neurokinin receptor antagonist; Ki=2.3 nM (NK1), 0.54 nM (NK2), 0.74 nM (NK3); treats respiratory diseases.</p>
    Fórmula:C34H38Cl2N2O6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:673.65

    Ref: TM-T10892

  • Burapitant
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    Burapitant

    CAS:
    <p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>
    Fórmula:C31H35Cl2F6N3O3
    Pureza:>99.99% - >99.99%
    Cor e Forma:Solid
    Peso molecular:682.52

    Ref: TM-T69140

  • Taprostene
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    Taprostene

    CAS:
    <p>Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.</p>
    Fórmula:C24H30O5
    Cor e Forma:Solid
    Peso molecular:398.49

    Ref: TM-T41251

  • APJ receptor agonist 8
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    APJ receptor agonist 8

    CAS:
    <p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>
    Fórmula:C24H27N7O5S
    Pureza:98.31% - 99.60%
    Cor e Forma:Solid
    Peso molecular:525.58

    Ref: TM-T85710

  • Logotipo do CymitQuimica
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    AM8936

    <p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>
    Fórmula:C25H33NO3
    Cor e Forma:Solid
    Peso molecular:395.53

    Ref: TM-T61849

  • AA 497 (Free Base)
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    AA 497 (Free Base)

    CAS:
    <p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>
    Fórmula:C14H21NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:251.32

    Ref: TM-T26359

  • Logotipo do CymitQuimica
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    CCR1 antagonist 11 hydrochloride

    <p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>
    Cor e Forma:Solid

    Ref: TM-T64242

  • Ro-24-4736
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    Ro-24-4736

    CAS:
    <p>Ro 24-4736 is an effective and selective platelet-activating factor antagonist.</p>
    Fórmula:C31H20ClN5OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:546.04

    Ref: TM-T16768