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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • Rivenprost
    Targetmol
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    Rivenprost

    CAS:
    <p>Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.</p>
    Fórmula:C24H34O6S
    Cor e Forma:Solid
    Peso molecular:450.59

    Ref: TM-T36080

  • BI-44370
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    BI-44370

    CAS:
    <p>BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.</p>
    Fórmula:C35H47N5O6
    Cor e Forma:Solid
    Peso molecular:633.78

    Ref: TM-T26796

  • IRL 2500
    Targetmol
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    IRL 2500

    CAS:
    <p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>
    Fórmula:C36H35N3O4
    Pureza:99.36%
    Cor e Forma:White Crystalline Solid
    Peso molecular:573.68

    Ref: TM-T15596

  • Logotipo do CymitQuimica
    Targetmol
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    SB 258741 hydrochloride

    <p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>
    Fórmula:C19H31ClN2O2S
    Cor e Forma:Solid
    Peso molecular:386.98

    Ref: TM-T61724

  • Butaprost
    Targetmol
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    Butaprost

    CAS:
    <p>Butaprost: EP2 receptor agonist, EC50=33 nM, Ki=2.4 μM (murine), reduces fibrosis via TGF-β/Smad2.</p>
    Fórmula:C24H40O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:408.57

    Ref: TM-T26925

  • LY210073
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    LY210073

    CAS:
    <p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>
    Fórmula:C30H28O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:516.54

    Ref: TM-T15801

  • Lisuride
    Targetmol
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    Lisuride

    CAS:
    <p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>
    Fórmula:C20H26N4O
    Cor e Forma:Solid
    Peso molecular:338.45

    Ref: TM-T61065

  • MRS2179 tetrasodium hydrate
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    MRS2179 tetrasodium hydrate

    <p>MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.</p>
    Fórmula:C11H15N5Na4O10P2
    Cor e Forma:Solid
    Peso molecular:576.21

    Ref: TM-T64078

  • 2,3-dinor-11β-Prostaglandin F2α
    Targetmol
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    2,3-dinor-11β-Prostaglandin F2α

    CAS:
    <p>2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where</p>
    Fórmula:C18H30O5
    Cor e Forma:Solid
    Peso molecular:326.43

    Ref: TM-T37275

  • Logotipo do CymitQuimica
    Targetmol
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    PAR4 antagonist 3

    CAS:
    <p>PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.</p>
    Fórmula:C22H16FN3O5S
    Peso molecular:453.44

    Ref: TM-T209701

  • S1P1 agonist 4
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    S1P1 agonist 4

    CAS:
    <p>S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating</p>
    Fórmula:C24H31NO3
    Cor e Forma:Solid
    Peso molecular:381.51

    Ref: TM-T61639

  • Sulprostone
    Targetmol
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    Sulprostone

    CAS:
    <p>EP3 and EP1 receptor agonist</p>
    Fórmula:C23H31NO7S
    Pureza:98%
    Cor e Forma:White To Off-White Solid
    Peso molecular:465.56

    Ref: TM-T23404

  • MK-3207 Hydrochloride
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    MK-3207 Hydrochloride

    CAS:
    <p>MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.</p>
    Fórmula:C31H30ClF2N5O3
    Pureza:98.19%
    Cor e Forma:Solid
    Peso molecular:594.05

    Ref: TM-T6590

  • Netupitant metabolite Monohydroxy Netupitant
    Targetmol
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    Netupitant metabolite Monohydroxy Netupitant

    CAS:
    <p>Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.</p>
    Fórmula:C30H32F6N4O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:594.59

    Ref: TM-T12211

  • Logotipo do CymitQuimica
    Targetmol
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    hA3AR agonist 1

    <p>hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .</p>
    Fórmula:C10H14N6OS
    Cor e Forma:Solid
    Peso molecular:266.32

    Ref: TM-T60444

  • MRS2279
    Targetmol
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    MRS2279

    CAS:
    <p>Selective, high affinity competitive antagonist of the P2Y1 receptor</p>
    Fórmula:C13H18ClN5O8P2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:469.71

    Ref: TM-T23021

  • P2Y14R antagonist 4
    Targetmol
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    P2Y14R antagonist 4

    CAS:
    <p>Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.</p>
    Fórmula:C27H27F3N2O4S
    Cor e Forma:Solid
    Peso molecular:532.574

    Ref: TM-T206785

  • Vibegron
    Targetmol
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    Vibegron

    CAS:
    <p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>
    Fórmula:C26H28N4O3
    Cor e Forma:Solid
    Peso molecular:444.53

    Ref: TM-T35052

  • Logotipo do CymitQuimica
    Targetmol
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    (R)-MrgprX2 antagonist-3

    CAS:
    <p>(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.</p>
    Fórmula:C16H20FN3O2S
    Peso molecular:337.41

    Ref: TM-T208997

  • PF-9404C
    Targetmol
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    PF-9404C

    CAS:
    <p>PF-9404C: S-S diastereoisomer, beta-blocker with vasodilation, boosts cyclic GMP in rat aorta cells from 3 to 53 pmol/mg protein.</p>
    Fórmula:C16H25N3O9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:403.38

    Ref: TM-T28391