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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • Nipradolol
    Targetmol
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    Nipradolol

    CAS:
    <p>Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.</p>
    Fórmula:C15H22N2O6
    Cor e Forma:Solid
    Peso molecular:326.35

    Ref: TM-T73083

  • Logotipo do CymitQuimica
    Targetmol
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    CBR Agonist-2

    <p>CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.</p>
    Fórmula:C27H27FN4O
    Cor e Forma:Solid
    Peso molecular:442.53

    Ref: TM-T62584

  • HU 433
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    HU 433

    CAS:
    <p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>
    Fórmula:C27H42O3
    Cor e Forma:Solid
    Peso molecular:414.62

    Ref: TM-T88373

  • Elsovaptan
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    Elsovaptan

    CAS:
    <p>Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.</p>
    Fórmula:C19H20ClN5O2
    Cor e Forma:Solid
    Peso molecular:385.847

    Ref: TM-T206306

  • Thielavin B
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    Thielavin B

    CAS:
    <p>Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.</p>
    Fórmula:C31H34O10
    Cor e Forma:Solid
    Peso molecular:566.6

    Ref: TM-T73066

  • Logotipo do CymitQuimica
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    MrgprX2 antagonist-6

    <p>MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.</p>
    Fórmula:C24H23F3N6O3
    Cor e Forma:Solid
    Peso molecular:500.47

    Ref: TM-T63394

  • AChE/BChE-IN-21
    Targetmol
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    AChE/BChE-IN-21

    CAS:
    <p>AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.</p>
    Fórmula:C38H54N4O4
    Cor e Forma:Solid
    Peso molecular:630.86

    Ref: TM-T200193

  • CCR1 antagonist 13
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    CCR1 antagonist 13

    CAS:
    <p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>
    Fórmula:C25H27ClFN3O4
    Cor e Forma:Solid
    Peso molecular:487.95

    Ref: TM-T207224

  • HU-308
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    HU-308

    CAS:
    <p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>
    Fórmula:C27H42O3
    Cor e Forma:Solid
    Peso molecular:414.62

    Ref: TM-T88361

  • GLP-1 receptor agonist 11
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    GLP-1 receptor agonist 11

    CAS:
    <p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>
    Fórmula:C31H31ClFN3O4
    Cor e Forma:Solid
    Peso molecular:564.05

    Ref: TM-T86503

  • BAY-899
    Targetmol
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    BAY-899

    CAS:
    <p>BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.</p>
    Fórmula:C25H19F2N5O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:459.45

    Ref: TM-T10476

  • Logotipo do CymitQuimica
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    M1069

    <p>M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.</p>
    Fórmula:C25H30N4O8S
    Cor e Forma:Solid
    Peso molecular:546.59

    Ref: TM-T63856

  • Mrgx2 antagonist-3
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    Mrgx2 antagonist-3

    CAS:
    <p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>
    Fórmula:C15H15F2N3O
    Cor e Forma:Solid
    Peso molecular:291.30

    Ref: TM-T207226

  • GRK6-IN-5
    Targetmol
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    GRK6-IN-5

    CAS:
    <p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Fórmula:C23H21N3O2
    Cor e Forma:Solid
    Peso molecular:371.432

    Ref: TM-T205394

  • MRGPRX2 modulator-1
    Targetmol
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    MRGPRX2 modulator-1

    CAS:
    <p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>
    Fórmula:C20H19F6N5O
    Cor e Forma:Solid
    Peso molecular:459.39

    Ref: TM-T86929

  • MRS2279
    Targetmol
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    MRS2279

    CAS:
    <p>Selective, high affinity competitive antagonist of the P2Y1 receptor</p>
    Fórmula:C13H18ClN5O8P2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:469.71

    Ref: TM-T23021

  • AMG-369
    Targetmol
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    AMG-369

    CAS:
    <p>AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.</p>
    Fórmula:C26H22FN3O2S
    Pureza:98.04% - 98.92%
    Cor e Forma:Solid
    Peso molecular:459.54

    Ref: TM-T29971

  • Pareptide monohydrochloride
    Targetmol
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    Pareptide monohydrochloride

    CAS:
    <p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>
    Fórmula:C14H27ClN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:334.84

    Ref: TM-T13707

  • RU 52583
    Targetmol
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    RU 52583

    CAS:
    <p>RU 52583 is an alpha 2-adrenergic receptor antagonist.</p>
    Fórmula:C18H20N2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:264.36

    Ref: TM-T26155

  • GnRH antagonist 2
    Targetmol
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    GnRH antagonist 2

    CAS:
    <p>GnRH antagonist 2 is a GnRH receptor antagonist, useful for studying endocrine diseases.</p>
    Fórmula:C28H27F2N9O5
    Pureza:98.08%
    Cor e Forma:Solid
    Peso molecular:607.57

    Ref: TM-T37003