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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • YM-49598 iodide
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    YM-49598 iodide

    CAS:
    <p>YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.</p>
    Fórmula:C36H45Cl2IN2O2
    Cor e Forma:Solid
    Peso molecular:735.57

    Ref: TM-T201470

  • Leukotriene B4 dimethyl amide
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    Leukotriene B4 dimethyl amide

    CAS:
    <p>LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).</p>
    Fórmula:C22H37NO3
    Cor e Forma:Solid
    Peso molecular:363.53

    Ref: TM-T37618

  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    <p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>
    Fórmula:C21H23Cl3N4
    Cor e Forma:Solid
    Peso molecular:437.79

    Ref: TM-T86978

  • BAY-899
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    BAY-899

    CAS:
    <p>BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.</p>
    Fórmula:C25H19F2N5O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:459.45

    Ref: TM-T10476

  • Sulprostone
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    Sulprostone

    CAS:
    <p>EP3 and EP1 receptor agonist</p>
    Fórmula:C23H31NO7S
    Pureza:98%
    Cor e Forma:White To Off-White Solid
    Peso molecular:465.56

    Ref: TM-T23404

  • MK-8318
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    MK-8318

    CAS:
    <p>MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).</p>
    Fórmula:C27H26F4N2O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:534.5

    Ref: TM-T16097

  • PF-9404C
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    PF-9404C

    CAS:
    <p>PF-9404C: S-S diastereoisomer, beta-blocker with vasodilation, boosts cyclic GMP in rat aorta cells from 3 to 53 pmol/mg protein.</p>
    Fórmula:C16H25N3O9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:403.38

    Ref: TM-T28391

  • Cicaprost
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    Cicaprost

    CAS:
    <p>Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.</p>
    Fórmula:C22H30O5
    Cor e Forma:Solid
    Peso molecular:374.47

    Ref: TM-T61526

  • SSTR5 antagonist 6
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    SSTR5 antagonist 6

    CAS:
    <p>SSTR5 antagonist 6, an orally active antagonist specific to the somatostatin receptor subtype 5 (SSTR5), exhibits an IC50 value of 24 nM. This compound is utilized in researching type 2 diabetes [1].</p>
    Fórmula:C22H28ClN3O4
    Cor e Forma:Solid
    Peso molecular:433.93

    Ref: TM-T87442

  • AZD-5672
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    AZD-5672

    CAS:
    <p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>
    Fórmula:C32H38F2N2O5S2
    Pureza:98.1%
    Cor e Forma:Solid
    Peso molecular:632.78

    Ref: TM-T30260

  • BMS-986141
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    BMS-986141

    CAS:
    <p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>
    Fórmula:C27H23N5O5S2
    Pureza:98.43% - 99.26%
    Cor e Forma:Solid
    Peso molecular:561.63

    Ref: TM-T63966

  • LSN3318839
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    LSN3318839

    CAS:
    <p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>
    Fórmula:C26H23Cl2N3O2
    Pureza:99.21%
    Cor e Forma:Solid
    Peso molecular:480.39

    Ref: TM-T63166

  • AZD5462
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    AZD5462

    CAS:
    <p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>
    Fórmula:C30H41FN2O6
    Pureza:98.32% - 99.63%
    Cor e Forma:Solid
    Peso molecular:544.65

    Ref: TM-T63838

  • Treprostinil diethanolamine
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    Treprostinil diethanolamine

    CAS:
    <p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>
    Fórmula:C27H45NO7
    Pureza:99.86%
    Cor e Forma:Solid
    Peso molecular:495.65

    Ref: TM-T63349

  • PF-07258669
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    PF-07258669

    CAS:
    <p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>
    Fórmula:C25H27FN6O2
    Pureza:99.9%
    Cor e Forma:Solid
    Peso molecular:462.52

    Ref: TM-T69526

  • Vofopitant dihydrochloride
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    Vofopitant dihydrochloride

    CAS:
    <p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>
    Fórmula:C21H25Cl2F3N6O
    Pureza:98.99%
    Cor e Forma:Solid
    Peso molecular:505.36

    Ref: TM-T13329L

  • BQ-788
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    BQ-788

    CAS:
    <p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>
    Fórmula:C34H51N5O7
    Pureza:98.81%
    Cor e Forma:Solid
    Peso molecular:641.8

    Ref: TM-T10595

  • Vofopitant
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    Vofopitant

    CAS:
    <p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>
    Fórmula:C21H23F3N6O
    Pureza:97.86%
    Cor e Forma:Solid
    Peso molecular:432.44

    Ref: TM-T13329

  • Dersimelagon
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    Dersimelagon

    CAS:
    <p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>
    Fórmula:C36H45F4N3O5
    Pureza:97.35% - 98.23%
    Cor e Forma:Solid
    Peso molecular:675.75

    Ref: TM-T25310

  • SB-423562
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    SB-423562

    CAS:
    <p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>
    Fórmula:C26H32N2O4
    Pureza:99.22%
    Cor e Forma:Solid
    Peso molecular:436.54

    Ref: TM-T12846