GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

Exibir 18 mais subcategorias

Foram encontrados 5378 produtos de "GPCR/Proteína-G"

Pureza (%)

100

produtos por página.

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LysoPalloT-NH-amide-C3-ph-m-O-C11
CAS:
- 1778686-61-5
LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist of the GPR174 receptor with an EC50 value of 34 nM.
Fórmula:C₂₇H₄₇N₂O₉P
Cor e Forma:Solid
Peso molecular:574.64
Ref: TM-T203412
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Glucagon-like peptide 1 (1-37), human TFA
Human Glucagon-like peptide 1 (1-37) TFA is a potent GLP-1 receptor agonist derived from proglucagon.
Fórmula:C₁₈₈H₂₇₆N₅₁F₃O₆₁
Pureza:98%
Cor e Forma:Solid
Peso molecular:4283.5
Ref: TM-TP1147
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Agaridoxin
CAS:
- 58298-77-4
Agaridoxin is a mushroom metabolite.
Fórmula:C₁₁H₁₄N₂O₅
Cor e Forma:Solid
Peso molecular:254.242
Ref: TM-T29709
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Neuromedin N
CAS:
- 92169-45-4
Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.
Fórmula:C₃₈H₆₃N₇O₈
Pureza:98%
Cor e Forma:Solid
Peso molecular:745.95
Ref: TM-TP1085
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5(S),6(R)-11-trans DiHETE
CAS:
- 129263-59-8
5(S),6(R)-11-trans DiHETE, a C-11 isomer of 5(S),6(R)-DiHETE, occurs in rat kidneys, formed enzymatically; not a soybean lipoxygenase substrate.
Fórmula:C₂₀H₃₂O₄
Cor e Forma:Solid
Peso molecular:336.47
Ref: TM-T37651
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Olcegepant hydrochloride
CAS:
- 586368-06-1
Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist.
Fórmula:C₃₈H₄₈Br₂ClN₉O₅
Pureza:99.69%
Cor e Forma:Solid
Peso molecular:906.11
Ref: TM-T12293
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GLP-1R agonist 29
GLP-1R agonist 29 (Compound 20) is a GLP-1R agonist that induces hGLP-1R-mediated cAMP stimulation with an EC50 of 0.018 nM. It exhibits favorable pharmacokinetic properties and shows good in vivo exposure, with an AUC0-∞,sc of 77688 ng·h/mL.
Cor e Forma:Odour Solid
Ref: TM-T206400
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Lys-[Des-Arg9]Bradykinin
CAS:
- 71800-36-7
Selective bradykinin B1 agonist with Ki 0.12 nM; inactive at B2 (>30,000 nM). Lowers blood pressure, more potent than Des-Arg9-Bradykinin.
Fórmula:C₅₀H₇₃N₁₃O₁₁
Pureza:98%
Cor e Forma:Solid
Peso molecular:1032.21
Ref: TM-TP1918
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Pentagastrin meglumine
CAS:
- 57448-84-7
Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally.
Fórmula:C₄₄H₆₆N₈O₁₄S
Cor e Forma:Solid
Peso molecular:963.11
Ref: TM-T33916
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(R,R)-Palonosetron Hydrochloride
CAS:
- 135729-75-8
(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron
Fórmula:C₁₉H₂₅ClN₂O
Pureza:98%
Cor e Forma:Solid
Peso molecular:332.87
Ref: TM-T13437
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2-Methyl-N,N-dimethyltryptamine
CAS:
- 1080-95-1
2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.
Fórmula:C₁₃H₁₈N₂
Cor e Forma:Solid
Peso molecular:202.3
Ref: TM-T203691
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YM 09538
CAS:
- 70958-86-0
YM 09538 is a biochemical.
Fórmula:C₁₈H₂₅ClN₂O₅S
Cor e Forma:Solid
Peso molecular:416.92
Ref: TM-T35252
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Leukotriene B5
CAS:
- 80445-66-5
LTB5, an eicosapentaenoic acid metabolite via 5-LO, has varied bioactivities and enhances bullfrog lung strip contraction.
Fórmula:C₂₀H₃₀O₄
Cor e Forma:Solid
Peso molecular:334.456
Ref: TM-T36423
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RF9 acetate
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
Fórmula:C₂₈H₄₂N₆O₅
Pureza:99.77%
Cor e Forma:Solid
Peso molecular:542.67
Ref: TM-T16738L
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15(S)-15-methyl Prostaglandin E2
CAS:
- 35700-27-7
15(S)-15-methyl PGE2: A stable PGE2 analog; strong antiulcer with double PGE2 affinity; excels PGE1 in uterine contraction.
Fórmula:C₂₁H₃₄O₅
Cor e Forma:Solid
Peso molecular:366.49
Ref: TM-T36154
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(S)-V-0219 hydrochloride
(S)-V-0219 hydrochloride, a GLP-1R PAM, triggers calcium in hGLP-1R HEK cells, lowers glucose in mice, and reduces fasting hunger.
Fórmula:C₂₀H₂₆ClF₃N₄O₂
Cor e Forma:Solid
Peso molecular:446.89
Ref: TM-T74265
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Spns2-IN-2
Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.
Fórmula:C₂₂H₃₀ClN₃O₂
Cor e Forma:Solid
Peso molecular:403.95
Ref: TM-T200979
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SGLT1/2-IN-2
CAS:
- 2387812-73-7
SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).
Fórmula:C₂₃H₂₆F₂O₇
Cor e Forma:Solid
Peso molecular:452.451
Ref: TM-T39966
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GLI1-IN-3
GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.
Cor e Forma:Odour Solid
Ref: TM-T206757
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GLP-1R agonist 15
CAS:
- 2763621-11-8
GLP-1R agonist 15 (Compound 101) is a GLP-1 receptor agonist [1] .
Fórmula:C₄₆H₄₇FN₈O₇S
Cor e Forma:Solid
Peso molecular:874.98
Ref: TM-T74609