GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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AMG-369
CAS:<p>AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.</p>Fórmula:C26H22FN3O2SPureza:98.04% - 98.92%Cor e Forma:SolidPeso molecular:459.54Gemilukast
CAS:<p>Gemilukast (ONO-6950) is a cysteinyl leukotriene 1 and 2 receptor inhibitor that inhibits bronchoconstriction and is used in the treatment of asthma.</p>Fórmula:C36H37F2NO5Pureza:98.27% - 99.5%Cor e Forma:SolidPeso molecular:601.68U92016A hydrochloride
CAS:<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Fórmula:C19H26ClN3Cor e Forma:SolidPeso molecular:331.89ONO-9780307
CAS:<p>ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).</p>Fórmula:C30H35NO7Cor e Forma:SolidPeso molecular:521.6D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Fórmula:C21H25F2NO2Cor e Forma:SolidPeso molecular:361.43Vibegron
CAS:<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53RGS10 modulator-1
CAS:<p>RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.</p>Fórmula:C16H15BrN2O3S2Cor e Forma:SolidPeso molecular:427.336CP-481715
CAS:<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Fórmula:C26H31FN4O4Cor e Forma:SolidPeso molecular:482.55DMPX
CAS:<p>DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.</p>Fórmula:C10H10N4O2Cor e Forma:SolidPeso molecular:218.212Delmadinone acetate
CAS:<p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>Fórmula:C23H27ClO4Cor e Forma:SolidPeso molecular:402.911Aplaviroc hydrochloride
CAS:<p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>Fórmula:C33H44ClN3O6Cor e Forma:SolidPeso molecular:614.17PF-07054894
CAS:<p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>Fórmula:C24H30N6O4Cor e Forma:SolidPeso molecular:466.53TAAR1 agonist 3
CAS:<p>TAAR1 agonist 3 is a potent agonist of Trace Amine-Associated Receptor 1 (TAAR1) with a pEC50 value of 7.6. Additionally, it acts as a full agonist at the α2AR with a pEC50 of 6. TAAR1 agonist 3 is utilized in the research of neuropsychiatric disorders.</p>Fórmula:C10H13NOCor e Forma:SolidPeso molecular:163.22MK-8318
CAS:<p>MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).</p>Fórmula:C27H26F4N2O5Pureza:98%Cor e Forma:SolidPeso molecular:534.5BI-113823
CAS:<p>BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.</p>Fórmula:C26H44N4O5SCor e Forma:SolidPeso molecular:524.716(S)-Bucindolol
CAS:(S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.Fórmula:C22H25N3O2Cor e Forma:SolidPeso molecular:363.45L-657926
CAS:<p>L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.</p>Fórmula:C21H19ClFNO2Cor e Forma:SolidPeso molecular:371.832BRL-37344
CAS:<p>BRL-37344 is a selective β3-adrenergic receptor agonist. It significantly reduces the body weight of obese mice.</p>Fórmula:C19H22ClNO4Cor e Forma:SolidPeso molecular:363.84A1AR antagonist 1
<p>Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).</p>Fórmula:C18H14N4OCor e Forma:SolidPeso molecular:302.33TAAR1 agonist 2
CAS:<p>TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.</p>Fórmula:C9H11NOCor e Forma:SolidPeso molecular:149.19Zaladenant
CAS:<p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>Fórmula:C19H15F3N6OCor e Forma:SolidPeso molecular:400.357Cicaprost
CAS:<p>Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.</p>Fórmula:C22H30O5Cor e Forma:SolidPeso molecular:374.47D3/5-HT receptor modulator-1
CAS:<p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>Fórmula:C24H29N3O2Cor e Forma:SolidPeso molecular:391.506Elsovaptan
CAS:<p>Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.</p>Fórmula:C19H20ClN5O2Cor e Forma:SolidPeso molecular:385.847MED 27
CAS:<p>MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. It effectively inhibits rat platelet aggregation at doses significantly lower than those required for acetylsalicylic acid.</p>Fórmula:C24H25N5O5Cor e Forma:SolidPeso molecular:463.4925B-NBOH hydrochloride
CAS:<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Fórmula:C17H21BrClNO3Cor e Forma:SolidPeso molecular:402.711AM8936
<p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>Fórmula:C25H33NO3Cor e Forma:SolidPeso molecular:395.53SSR-241586
CAS:<p>SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.</p>Fórmula:C32H42Cl2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:601.61UR-AK49
CAS:<p>UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.</p>Fórmula:C16H27N5OCor e Forma:SolidPeso molecular:305.425-HT1A modulator 4
CAS:<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Fórmula:C9H14N4Cor e Forma:SolidPeso molecular:178.234Nedocromil sodium
CAS:<p>Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.</p>Fórmula:C19H17NNaO7Pureza:98%Cor e Forma:SolidPeso molecular:394.335SB 224289
CAS:<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Fórmula:C32H32N4O3Pureza:98%Cor e Forma:SolidPeso molecular:520.62Iralukast (CGP 45715A)
CAS:<p>Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.</p>Fórmula:C38H37F3O8SCor e Forma:SolidPeso molecular:710.76AAZ-A 154 mesylate
CAS:<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Fórmula:C15H24N2O4SCor e Forma:SolidPeso molecular:328.43Lp(a)-IN-8
CAS:<p>LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).</p>Fórmula:C21H40Cl2N4O5Cor e Forma:SolidPeso molecular:499.472LY3154207
CAS:<p>LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.</p>Fórmula:C24H29Cl2NO3Cor e Forma:SolidPeso molecular:450.4BMS-741672
CAS:<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.56Sulprostone
CAS:<p>EP3 and EP1 receptor agonist</p>Fórmula:C23H31NO7SPureza:98%Cor e Forma:White To Off-White SolidPeso molecular:465.56Lisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Fórmula:C20H26N4OCor e Forma:SolidPeso molecular:338.45Tofogliflozin
CAS:<p>Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).</p>Fórmula:C22H26O6Pureza:98%Cor e Forma:SolidPeso molecular:386.44BD-1047
CAS:<p>BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.</p>Fórmula:C13H20Cl2N2Cor e Forma:SolidPeso molecular:275.217LY210073
CAS:<p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>Fórmula:C30H28O8Pureza:98%Cor e Forma:SolidPeso molecular:516.54AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32Tiprenolol hydrochloride
CAS:<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Fórmula:C13H22ClNO2SCor e Forma:SolidPeso molecular:291.845-HT7R antagonist 3
CAS:<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Fórmula:C30H33FN4O3Cor e Forma:SolidPeso molecular:516.61Sigma-2 Radioligand 2
CAS:<p>Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).</p>Fórmula:C23H28FN3O3Cor e Forma:SolidPeso molecular:413.49F 14679
CAS:<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Fórmula:C21H25ClF2N4OPureza:99.09%Cor e Forma:SolidPeso molecular:422.9CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Fórmula:C28H47NO3Cor e Forma:SolidPeso molecular:445.68RBM10-8
CAS:<p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>Fórmula:C17H36NO5PCor e Forma:SolidPeso molecular:365.45Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392Butopamine hydrochloride
CAS:<p>Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.</p>Fórmula:C18H24ClNO3Cor e Forma:SolidPeso molecular:337.84Nifeviroc
CAS:<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.71L-796778 acetate
CAS:<p>L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.</p>Fórmula:C31H44N6O9Cor e Forma:SolidPeso molecular:644.716CP-199330
CAS:<p>CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.</p>Fórmula:C28H24ClF3N2O6SCor e Forma:SolidPeso molecular:609.01AChE/BChE-IN-21
CAS:<p>AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.</p>Fórmula:C38H54N4O4Cor e Forma:SolidPeso molecular:630.86Merigolix
CAS:<p>Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .</p>Fórmula:C36H35F7N4O6Cor e Forma:SolidPeso molecular:752.68CBR Agonist-2
<p>CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.</p>Fórmula:C27H27FN4OCor e Forma:SolidPeso molecular:442.53MRS4865
CAS:<p>MRS4865 (compound 7a) serves as a chimeric antagonist for the P2Y14 receptor and an agonist for UDP-glucose, offering protection against neuropathic pain.</p>Fórmula:C39H39F3N4O7Cor e Forma:SolidPeso molecular:732.74KF26777
CAS:<p>KF26777 is a potent and selective antagonist of adenosine A3 receptor.</p>Fórmula:C16H16BrN5OPureza:98%Cor e Forma:SolidPeso molecular:374.23GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C15H15N5Cor e Forma:SolidPeso molecular:265.313(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Beloxepin
CAS:<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Fórmula:C19H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:295.38Metrazoline
CAS:<p>Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.</p>Fórmula:C14H16N2O4Cor e Forma:SolidPeso molecular:276.288Ersentilide
CAS:<p>Ersentilide, a benzamide derivative, functions as both a β1-adrenergic receptor antagonist and an Ikr blocker. It has demonstrated efficacy in animal models of cardiac arrhythmias.</p>Fórmula:C21H26N4O5SCor e Forma:SolidPeso molecular:446.52Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Fórmula:C27H29N5OCor e Forma:SolidPeso molecular:439.55(S)-Butaprost free acid
CAS:<p>(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].</p>Fórmula:C23H38O5Cor e Forma:SolidPeso molecular:394.54RS 61756-007
CAS:<p>RS 61756-007 is a selective thromboxane receptor (TP) agonist.</p>Fórmula:C23H28O5Pureza:98%Cor e Forma:SolidPeso molecular:384.47IMP-1575
CAS:<p>IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.</p>Fórmula:C19H25N3OSPeso molecular:343.49SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Fórmula:C19H31ClN2O2SCor e Forma:SolidPeso molecular:386.98A2A receptor antagonist 2
<p>A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).</p>Fórmula:C25H28FN7O3Cor e Forma:SolidPeso molecular:493.53SGLT1/2-IN-1
CAS:<p>SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.</p>Fórmula:C25H28O8Cor e Forma:SolidPeso molecular:456.48YM-31636 free base
CAS:<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Fórmula:C14H11N3SCor e Forma:SolidPeso molecular:253.32Taranabant
CAS:<p>Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.</p>Fórmula:C27H25ClF3N3O2Pureza:99.06% - 99.06%Cor e Forma:SolidPeso molecular:515.96SR 142948-C3-NHMe
CAS:<p>SR 142948-C3-NHMe is the methylated form of SR 142948.</p>Fórmula:C42H58N6O6Cor e Forma:SolidPeso molecular:742.946CP-608039
CAS:<p>CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.</p>Fórmula:C23H25ClN8O5Cor e Forma:SolidPeso molecular:528.95Remlifanserin
CAS:<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Fórmula:C24H29F2N3O2Cor e Forma:SolidPeso molecular:429.50Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538Neflumozide
CAS:<p>Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.</p>Fórmula:C22H23FN4O2Cor e Forma:SolidPeso molecular:394.44Protease-Activated Receptor-1 antagonist 1
<p>Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.</p>Fórmula:C25H24F2N2O3Cor e Forma:SolidPeso molecular:438.47YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749WIN 62577
CAS:<p>WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.</p>Fórmula:C29H31N3OCor e Forma:SolidPeso molecular:437.576HU-308
CAS:<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62MrgprX2 antagonist-6
<p>MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.</p>Fórmula:C24H23F3N6O3Cor e Forma:SolidPeso molecular:500.47CRHR1 antagonist 1
CAS:<p>CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.</p>Fórmula:C24H34N4OCor e Forma:SolidPeso molecular:394.553K-8794
CAS:<p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>Fórmula:C36H38N6O6SCor e Forma:SolidPeso molecular:682.789HU 433
CAS:<p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62Tonapofylline
CAS:<p>Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.</p>Fórmula:C22H32N4O4Pureza:98.57%Cor e Forma:SolidPeso molecular:416.51EP-3945
CAS:<p>EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.</p>Fórmula:C24H26N4O3Cor e Forma:SolidPeso molecular:418.488RGH-122
CAS:<p>RGH-122 (compound 43), characterized as an orally active, potent, and selective hV1a receptor antagonist, demonstrates significant affinity with a K i value of 0.3 nM and an IC 50 of 0.9 nM. It exhibits microsomal stability, indicated by a CL int value of 13/28/25 μL/min/mg [1].</p>Fórmula:C24H25ClN4O3Cor e Forma:SolidPeso molecular:452.93BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Fórmula:C34H51N5O7Pureza:98.81%Cor e Forma:SolidPeso molecular:641.8BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Cor e Forma:SolidPeso molecular:561.63PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Fórmula:C25H27FN6O2Pureza:99.9%Cor e Forma:SolidPeso molecular:462.52AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Fórmula:C30H41FN2O6Pureza:98.32% - 99.63%Cor e Forma:SolidPeso molecular:544.65Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Fórmula:C27H45NO7Pureza:99.86%Cor e Forma:SolidPeso molecular:495.65SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Fórmula:C21H23F3N6OPureza:97.86%Cor e Forma:SolidPeso molecular:432.44Vofopitant dihydrochloride
CAS:<p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>Fórmula:C21H25Cl2F3N6OPureza:98.99%Cor e Forma:SolidPeso molecular:505.36LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Fórmula:C26H23Cl2N3O2Pureza:99.21%Cor e Forma:SolidPeso molecular:480.39Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Fórmula:C36H45F4N3O5Pureza:97.35% - 98.23%Cor e Forma:SolidPeso molecular:675.75AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Fórmula:C32H38F2N2O5S2Pureza:98.1%Cor e Forma:SolidPeso molecular:632.78SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Fórmula:C32H33ClN4O3Pureza:97.82% - 98.99%Cor e Forma:SolidPeso molecular:557.08Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Fórmula:C25H27ClF6N2O2Pureza:98.35% - 99.79%Cor e Forma:SolidPeso molecular:536.94SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Fórmula:C26H24FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:445.497-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Fórmula:C14H15NO2Cor e Forma:SolidPeso molecular:229.27Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Fórmula:C33H46N8O7Pureza:98%Cor e Forma:SolidPeso molecular:666.77Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Fórmula:C15H18ClN3O2SPureza:98%Cor e Forma:SolidPeso molecular:339.84ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Fórmula:C24H21F3N2O5SCor e Forma:SolidPeso molecular:506.49HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Fórmula:C12H18ClNO2Cor e Forma:SolidPeso molecular:243.73SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Fórmula:C32H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:610.16Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Fórmula:C17H28ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:345.86SB-399885 hydrochloride
CAS:<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Fórmula:C18H22Cl3N3O4SPureza:98%Cor e Forma:SolidPeso molecular:482.81Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Fórmula:C15H21N3O2S3Cor e Forma:White SolidPeso molecular:371.54BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Fórmula:C29H32F3N5O5Cor e Forma:SolidPeso molecular:587.59Beraprost sodium
CAS:<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>Fórmula:C24H29NaO5Cor e Forma:SolidPeso molecular:420.481ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Fórmula:C18H19BrClFN2OCor e Forma:SolidPeso molecular:413.71JMV 2959
CAS:<p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>Fórmula:C30H32N6O2Cor e Forma:SolidPeso molecular:508.61CYM 9484
CAS:<p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>Fórmula:C27H31N3O3S2Cor e Forma:SolidPeso molecular:509.68(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Fórmula:C19H26ClNOSCor e Forma:SolidPeso molecular:351.93Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Fórmula:C16H25N3O·xClHPureza:99.25%Cor e Forma:SoildAnti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Cor e Forma:Odour LiquidTAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Fórmula:C64H83N17O13Pureza:98%Cor e Forma:SolidPeso molecular:1298.45Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Fórmula:C33H34N2O5Pureza:98%Cor e Forma:SolidPeso molecular:538.631-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Fórmula:C21H41O7PCor e Forma:SolidPeso molecular:436.52Ref: TM-T36907
Produto descontinuadodapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Fórmula:C37H39NO4Cor e Forma:SolidPeso molecular:561.71TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Fórmula:C58H80N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1225.364-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Fórmula:C17H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:271.35Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Fórmula:C22H21FN2OCor e Forma:SolidPeso molecular:348.421(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Fórmula:C25H21ClF3N5O2SCor e Forma:SolidPeso molecular:547.98CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Fórmula:C19H20N2O3SPureza:98%Cor e Forma:SolidPeso molecular:356.44Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Fórmula:C20H30Cl2N4OPureza:98%Cor e Forma:SolidPeso molecular:413.384-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Fórmula:C16H22ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:311.8Vornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Fórmula:C23H22FN7O2Cor e Forma:SolidPeso molecular:447.474(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Fórmula:C6H13Cl2N3Cor e Forma:SolidPeso molecular:198.09BX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Fórmula:C21H25Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:471.35BRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:406.953-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Fórmula:C7H9NOCor e Forma:SolidPeso molecular:123.155Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Pureza:98%Cor e Forma:LiquidPicumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Fórmula:C21H29Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:426.38Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Fórmula:C24H25FO5SPureza:98%Cor e Forma:SolidPeso molecular:448.54Ref: TM-T10669
Produto descontinuadoAM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Fórmula:C24H20N2OPureza:99.37%Cor e Forma:SolidPeso molecular:352.432-Methyl-5-HT hydrochloride
CAS:<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Fórmula:C11H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:226.7Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Fórmula:C23H16O6Pureza:99.99%Cor e Forma:Fine Yellow PowderPeso molecular:388.372-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Fórmula:C23H38O4Pureza:95%Cor e Forma:LiquidPeso molecular:378.55Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Fórmula:C11H12F3NOPureza:98%Cor e Forma:SolidPeso molecular:231.21GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Fórmula:C24H33NO3SPureza:98%Cor e Forma:SolidPeso molecular:415.59Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Fórmula:C6H12Br2N4SPureza:98%Cor e Forma:SolidPeso molecular:332.06MEN11467
CAS:<p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Fórmula:C25H26F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:445.47AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Fórmula:C29H40O3Pureza:99.58%Cor e Forma:SolidPeso molecular:436.63Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Fórmula:C31H50O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:470.73Ref: TM-T27176
Produto descontinuado2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Fórmula:C8H8N2O3SCor e Forma:LiquidPeso molecular:212.23
