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GPCR/Proteína-G

GPCR/Proteína-G

Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.

Subcategorias de "GPCR/Proteína-G"

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Foram encontrados 5352 produtos de "GPCR/Proteína-G"

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  • R-96544 hydrochloride

    CAS:
    <p>5-HT2 receptor antagonist</p>
    Fórmula:C22H29NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:355.47
  • NK1 receptor antagonist 2

    CAS:
    <p>NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.</p>
    Fórmula:C31H35F7N4O2
    Cor e Forma:Solid
    Peso molecular:628.62
  • KMN-80

    CAS:
    <p>KMN-80 is a potent, selective EP4 agonist with IC50 3 nM, spurring osteoblast differentiation, and showing in vivo bone repair efficacy.</p>
    Fórmula:C21H33NO4
    Cor e Forma:Solid
    Peso molecular:363.49
  • 8-iso Prostaglandin F3α

    CAS:
    <p>8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.</p>
    Fórmula:C20H32O5
    Cor e Forma:Solid
    Peso molecular:352.47
  • Rodatristat ethyl

    CAS:
    <p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels &amp; lowering PAH at low doses.</p>
    Fórmula:C29H31ClF3N5O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:590.04
  • Y1 receptor antagonist 1

    CAS:
    <p>Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor.</p>
    Fórmula:C28H33N5O3
    Pureza:98.17%
    Cor e Forma:Solid
    Peso molecular:487.59
  • EP4 receptor agonist 3

    CAS:
    <p>EP4 receptor agonist 3 is an activator of the EP4 receptor and is useful for research in the DSS-induced colitis mouse model.</p>
    Fórmula:C21H27F2NO4
    Cor e Forma:Solid
    Peso molecular:395.44
  • Aeruginosin 98-B

    CAS:
    <p>Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.</p>
    Fórmula:C29H46N6O9S
    Cor e Forma:Solid
    Peso molecular:654.78
  • BIBO3304 diTFA

    CAS:
    <p>BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].</p>
    Fórmula:C33H37F6N7O7
    Cor e Forma:Solid
    Peso molecular:757.68
  • GLP-1 receptor agonist 16

    CAS:
    <p>GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.</p>
    Fórmula:C33H31ClFN3O4
    Cor e Forma:Solid
    Peso molecular:588.068
  • CB2 receptor antagonist 1

    CAS:
    <p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 &amp; 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>
    Fórmula:C28H47NO3
    Cor e Forma:Solid
    Peso molecular:445.68
  • SphK1-IN-1


    <p>SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.</p>
    Fórmula:C22H22N6O2
    Cor e Forma:Solid
    Peso molecular:402.45
  • MRS2905 trisodium

    CAS:
    <p>MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective P2Y14R agonist with an EC50 of 0.92 nM. It shows no activity on UDP-activated P2Y6 receptors or other P2Y receptors.</p>
    Fórmula:C10H13N2Na3O10P2S
    Cor e Forma:Solid
    Peso molecular:484.199
  • Becondogrel

    CAS:
    <p>Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.</p>
    Fórmula:C16H16ClNO3S
    Cor e Forma:Solid
    Peso molecular:337.821
  • BI-113823

    CAS:
    <p>BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.</p>
    Fórmula:C26H44N4O5S
    Cor e Forma:Solid
    Peso molecular:524.716
  • Danavorexton

    CAS:
    <p>Danavorexton is an orexin receptor agonist.</p>
    Fórmula:C21H32N2O5S
    Cor e Forma:Solid
    Peso molecular:424.55
  • Org-6906

    CAS:
    <p>DCB-3503, a tylophorine analog, may treat cancer and suppress immunity by blocking protein synthesis and modulating HSC70's ATPase activity.</p>
    Fórmula:C13H16ClN
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:221.73
  • H3R antagonist 2


    <p>Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]</p>
    Fórmula:C24H29NO3
    Cor e Forma:Solid
    Peso molecular:379.49
  • SJPYT-310

    CAS:
    <p>SJPYT-310 is a selective PXR antagonist, exhibiting no noticeable cytotoxicity.</p>
    Fórmula:C27H36N4O3
    Cor e Forma:Solid
    Peso molecular:464.6
  • Acyline

    CAS:
    <p>Acyline, a GnRH antagonist, suppresses gonadotropins and testosterone in animals and maintains the effect for 2 weeks in men with one dose.</p>
    Fórmula:C80H102ClN15O14
    Cor e Forma:Solid
    Peso molecular:1533.21
  • Setomagpran

    CAS:
    <p>Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.</p>
    Fórmula:C22H19Cl2F6N5O
    Cor e Forma:Solid
    Peso molecular:554.316
  • Metrazoline

    CAS:
    <p>Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.</p>
    Fórmula:C14H16N2O4
    Cor e Forma:Solid
    Peso molecular:276.288
  • LX2761

    CAS:
    <p>LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.</p>
    Fórmula:C32H47N3O6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:601.80
  • Zaladenant

    CAS:
    <p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>
    Fórmula:C19H15F3N6O
    Cor e Forma:Solid
    Peso molecular:400.357
  • GLP-1 receptor agonist 11

    CAS:
    <p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>
    Fórmula:C31H31ClFN3O4
    Cor e Forma:Solid
    Peso molecular:564.05
  • SSTR5 antagonist 2 TFA

    CAS:
    <p>Potent, oral SSTR5 antagonist 2 TFA may treat type 2 diabetes.</p>
    Fórmula:C34H36F4N2O7
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:660.65
  • D3/5-HT receptor modulator-1

    CAS:
    <p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>
    Fórmula:C24H29N3O2
    Cor e Forma:Solid
    Peso molecular:391.506
  • 25B-NBOH hydrochloride

    CAS:
    <p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>
    Fórmula:C17H21BrClNO3
    Cor e Forma:Solid
    Peso molecular:402.711
  • F 14679

    CAS:
    <p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>
    Fórmula:C21H25ClF2N4O
    Pureza:99.09%
    Cor e Forma:Solid
    Peso molecular:422.9
  • PF-4693627

    CAS:
    <p>PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).</p>
    Fórmula:C26H29Cl2N3O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:502.43
  • LY3154207

    CAS:
    <p>LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.</p>
    Fórmula:C24H29Cl2NO3
    Cor e Forma:Solid
    Peso molecular:450.4
  • LTD4 antagonist 1

    CAS:
    <p>LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).</p>
    Fórmula:C31H32F3N3O5S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:615.66
  • CS-003 Free base

    CAS:
    <p>CS-003: Triple neurokinin receptor antagonist; Ki=2.3 nM (NK1), 0.54 nM (NK2), 0.74 nM (NK3); treats respiratory diseases.</p>
    Fórmula:C34H38Cl2N2O6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:673.65
  • Oral antiplatelet agent 1

    CAS:
    <p>Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro.</p>
    Fórmula:C23H24N4O5S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:468.53
  • Burapitant

    CAS:
    <p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>
    Fórmula:C31H35Cl2F6N3O3
    Pureza:>99.99% - >99.99%
    Cor e Forma:Solid
    Peso molecular:682.52
  • SGLT1/2-IN-8

    CAS:
    <p>SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.</p>
    Fórmula:C22H26O6
    Cor e Forma:Solid
    Peso molecular:386.438
  • CB2R/5-HT1AR agonist 1

    CAS:
    <p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>
    Fórmula:C24H33NO3
    Cor e Forma:Solid
    Peso molecular:383.52
  • Aplaviroc hydrochloride

    CAS:
    <p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>
    Fórmula:C33H44ClN3O6
    Cor e Forma:Solid
    Peso molecular:614.17
  • CRHR1 antagonist 1

    CAS:
    <p>CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.</p>
    Fórmula:C24H34N4O
    Cor e Forma:Solid
    Peso molecular:394.553
  • Arpromidine

    CAS:
    <p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>
    Fórmula:C21H25FN6
    Cor e Forma:Solid
    Peso molecular:380.462
  • Org 274179-0

    CAS:
    <p>Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI)-mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD).</p>
    Fórmula:C28H27F3N2O2
    Cor e Forma:Solid
    Peso molecular:480.521
  • INCB-9471 dihydrochloride

    CAS:
    <p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration &amp; HIV-1.</p>
    Fórmula:C30H42Cl2F3N5O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:632.59
  • MF-592

    CAS:
    <p>MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.</p>
    Fórmula:C34H33Cl2N3O6S
    Cor e Forma:Solid
    Peso molecular:682.61
  • Opipramol dihydrochloride

    CAS:
    <p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>
    Fórmula:C23H31Cl2N3O
    Cor e Forma:Solid
    Peso molecular:436.418
  • Serotonin maleate

    CAS:
    <p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>
    Fórmula:C14H16N2O5
    Cor e Forma:Solid
    Peso molecular:292.287
  • K-8794

    CAS:
    <p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>
    Fórmula:C36H38N6O6S
    Cor e Forma:Solid
    Peso molecular:682.789
  • SR 142948-C3-NHMe

    CAS:
    <p>SR 142948-C3-NHMe is the methylated form of SR 142948.</p>
    Fórmula:C42H58N6O6
    Cor e Forma:Solid
    Peso molecular:742.946
  • Tofogliflozin

    CAS:
    <p>Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).</p>
    Fórmula:C22H26O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:386.44
  • A1/A3 AR antagonist 1


    <p>Compound 10 is a potent dual A1/A3 AR antagonist, with Ki values of 37.6 nM (hA1), 25.4 nM (hA3), and 1.47 nM (rA1), studied in renal, lung, and Alzheimer's.</p>
    Fórmula:C24H18N2O3S
    Cor e Forma:Solid
    Peso molecular:414.48
  • GAT564


    <p>GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) &amp; 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.</p>
    Fórmula:C20H16N2O2S
    Cor e Forma:Solid
    Peso molecular:348.42
  • 5-HT6R/MAO-B modulator 1


    <p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>
    Fórmula:C33H38N4O3S
    Cor e Forma:Solid
    Peso molecular:570.74
  • MRGPRX2 modulator-1

    CAS:
    <p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>
    Fórmula:C20H19F6N5O
    Cor e Forma:Solid
    Peso molecular:459.39
  • SR2640

    CAS:
    <p>SR2640 is a potent and highly selective LTD4/LTE4 antagonist, specifically inhibiting LTD4-induced contractions in guinea pig ileum and tracheal smooth muscle in a concentration-dependent manner, without affecting histamine-induced contractions. It blocks the binding of 0.4 nM [3H]LTD4 to guinea pig lung membrane receptors with an IC50 of 23 nM. SR2640 also causes a parallel rightward shift in the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, with the degree of shift correlating positively with its dosage. SR2640 is applicable for asthma research.</p>
    Fórmula:C23H18N2O3
    Cor e Forma:Solid
    Peso molecular:370.401
  • EP-3945

    CAS:
    <p>EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist β-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.</p>
    Fórmula:C24H26N4O3
    Cor e Forma:Solid
    Peso molecular:418.488
  • L-657926

    CAS:
    <p>L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.</p>
    Fórmula:C21H19ClFNO2
    Cor e Forma:Solid
    Peso molecular:371.832
  • CBR Agonist-1


    <p>CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.</p>
    Fórmula:C27H27FN4O
    Cor e Forma:Solid
    Peso molecular:442.53
  • GPBAR1-IN-3

    CAS:
    <p>GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].</p>
    Fórmula:C21H23NO2
    Cor e Forma:Solid
    Peso molecular:321.41
  • RGH-122

    CAS:
    <p>RGH-122 (compound 43), characterized as an orally active, potent, and selective hV1a receptor antagonist, demonstrates significant affinity with a K i value of 0.3 nM and an IC 50 of 0.9 nM. It exhibits microsomal stability, indicated by a CL int value of 13/28/25 μL/min/mg [1].</p>
    Fórmula:C24H25ClN4O3
    Cor e Forma:Solid
    Peso molecular:452.93
  • DM-4111

    CAS:
    <p>DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.</p>
    Fórmula:C26H25ClN2O4
    Cor e Forma:Solid
    Peso molecular:464.94
  • AChE/BChE-IN-21

    CAS:
    <p>AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.</p>
    Fórmula:C38H54N4O4
    Cor e Forma:Solid
    Peso molecular:630.86
  • CS-0777

    CAS:
    <p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>
    Fórmula:C21H31N2O5P
    Cor e Forma:Solid
    Peso molecular:422.45
  • Monlunabant

    CAS:
    <p>Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].</p>
    Fórmula:C26H22ClF3N6O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:591.00
  • MK-0812

    CAS:
    <p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>
    Fórmula:C24H34F3N3O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:469.54
  • GRK6-IN-5

    CAS:
    <p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Fórmula:C23H21N3O2
    Cor e Forma:Solid
    Peso molecular:371.432
  • ATX inhibitor 27

    CAS:
    <p>ATX inhibitor 27 (Compound 31) is an ATX inhibitor. It demonstrates IC50 values of 13 nM against human autotaxin (hATX) and 23 nM against lysophosphatidylcholine (LPC). By inhibiting the ATX enzyme, ATX inhibitor 27 reduces LPA levels in the body. This compound is applicable in research related to ATX-LPA-associated conditions such as inflammation, neurodegenerative disorders, and cancer.</p>
    Fórmula:C26H26ClN5O3
    Cor e Forma:Solid
    Peso molecular:491.97
  • PSB 36

    CAS:
    <p>A1 adenosine receptor antagonist</p>
    Fórmula:C21H30N4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:386.49
  • Rivenprost

    CAS:
    <p>Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.</p>
    Fórmula:C24H34O6S
    Cor e Forma:Solid
    Peso molecular:450.59
  • Mrgx2 antagonist-3

    CAS:
    <p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>
    Fórmula:C15H15F2N3O
    Cor e Forma:Solid
    Peso molecular:291.30
  • TAK-024

    CAS:
    TAK-024 is an inhibitor of platelet(IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively).
    Fórmula:C27H34N10O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:594.62
  • MrgprX2 antagonist-7


    <p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>
    Fórmula:C24H22ClF3N6O3
    Cor e Forma:Solid
    Peso molecular:534.92
  • Toladryl

    CAS:
    <p>Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.</p>
    Fórmula:C18H23NO
    Cor e Forma:Solid
    Peso molecular:269.38
  • WIN 62577

    CAS:
    <p>WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.</p>
    Fórmula:C29H31N3O
    Cor e Forma:Solid
    Peso molecular:437.576
  • hA3AR agonist 1


    <p>hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .</p>
    Fórmula:C10H14N6OS
    Cor e Forma:Solid
    Peso molecular:266.32
  • 2,3-dinor-11β-Prostaglandin F2α

    CAS:
    <p>2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where</p>
    Fórmula:C18H30O5
    Cor e Forma:Solid
    Peso molecular:326.43
  • LJ-4517


    <p>LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.</p>
    Fórmula:C19H21N5O3S
    Cor e Forma:Solid
    Peso molecular:399.47
  • THRX-194556

    CAS:
    <p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>
    Fórmula:C28H41N5O5S
    Cor e Forma:Solid
    Peso molecular:559.721
  • Nocloprost

    CAS:
    <p>Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.</p>
    Fórmula:C22H37ClO4
    Cor e Forma:Solid
    Peso molecular:400.98
  • Tonapofylline

    CAS:
    <p>Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.</p>
    Fórmula:C22H32N4O4
    Pureza:98.57%
    Cor e Forma:Solid
    Peso molecular:416.51
  • SB-423557

    CAS:
    <p>SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM</p>
    Fórmula:C28H36N2O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:464.60
  • MK-3207 Hydrochloride

    CAS:
    <p>MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.</p>
    Fórmula:C31H30ClF2N5O3
    Pureza:98.19%
    Cor e Forma:Solid
    Peso molecular:594.05
  • SSR 146977

    CAS:
    <p>NK3 receptor antagonist</p>
    Fórmula:C35H42Cl2N4O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:621.64
  • PD 140376

    CAS:
    <p>PD 140376: Selective CCK-B/gastrin receptor antagonist radioligand for guinea pig stomach &amp; brain.</p>
    Fórmula:C33H40N4O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:572.69
  • H3R antagonist 1

    CAS:
    <p>H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).</p>
    Fórmula:C19H23N3O3
    Cor e Forma:Solid
    Peso molecular:341.4
  • (Rac)-Nebivolol

    CAS:
    <p>(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.</p>
    Fórmula:C22H25F2NO4
    Cor e Forma:Solid
    Peso molecular:405.43
  • AM9405


    <p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>
    Fórmula:C24H33BrN2O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:461.44
  • CHF-6366

    CAS:
    <p>CHF-6366: M3 antagonist &amp; β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>
    Fórmula:C42H48N6O8
    Cor e Forma:Solid
    Peso molecular:764.87
  • Sigma-1 receptor antagonist 6

    CAS:
    <p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>
    Fórmula:C32H34N6
    Cor e Forma:Solid
    Peso molecular:502.65
  • DA-302168S

    CAS:
    <p>DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.</p>
    Fórmula:C33H24ClF2N3O5
    Cor e Forma:Solid
    Peso molecular:616.011
  • SB-423562

    CAS:
    <p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>
    Fórmula:C26H32N2O4
    Pureza:99.22%
    Cor e Forma:Solid
    Peso molecular:436.54
  • LSN3318839

    CAS:
    <p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>
    Fórmula:C26H23Cl2N3O2
    Pureza:99.21%
    Cor e Forma:Solid
    Peso molecular:480.39
  • BMS-986141

    CAS:
    <p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>
    Fórmula:C27H23N5O5S2
    Pureza:98.43% - 99.26%
    Cor e Forma:Solid
    Peso molecular:561.63
  • AZD5462

    CAS:
    <p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>
    Fórmula:C30H41FN2O6
    Pureza:98.32% - 99.63%
    Cor e Forma:Solid
    Peso molecular:544.65
  • PF-07258669

    CAS:
    <p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>
    Fórmula:C25H27FN6O2
    Pureza:99.9%
    Cor e Forma:Solid
    Peso molecular:462.52
  • SB-224289 hydrochloride

    CAS:
    <p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>
    Fórmula:C32H33ClN4O3
    Pureza:97.82% - 98.99%
    Cor e Forma:Solid
    Peso molecular:557.08
  • Dersimelagon

    CAS:
    <p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>
    Fórmula:C36H45F4N3O5
    Pureza:97.35% - 98.23%
    Cor e Forma:Solid
    Peso molecular:675.75
  • Treprostinil diethanolamine

    CAS:
    <p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>
    Fórmula:C27H45NO7
    Pureza:99.86%
    Cor e Forma:Solid
    Peso molecular:495.65
  • BQ-788

    CAS:
    <p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>
    Fórmula:C34H51N5O7
    Pureza:98.81%
    Cor e Forma:Solid
    Peso molecular:641.8
  • AZD-5672

    CAS:
    <p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>
    Fórmula:C32H38F2N2O5S2
    Pureza:98.1%
    Cor e Forma:Solid
    Peso molecular:632.78
  • Vofopitant

    CAS:
    <p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>
    Fórmula:C21H23F3N6O
    Pureza:97.86%
    Cor e Forma:Solid
    Peso molecular:432.44
  • Vofopitant dihydrochloride

    CAS:
    <p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>
    Fórmula:C21H25Cl2F3N6O
    Pureza:98.99%
    Cor e Forma:Solid
    Peso molecular:505.36
  • Rolapitant hydrochloride

    CAS:
    <p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>
    Fórmula:C25H27ClF6N2O2
    Pureza:98.35% - 99.79%
    Cor e Forma:Solid
    Peso molecular:536.94
  • ML-290

    CAS:
    <p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>
    Fórmula:C24H21F3N2O5S
    Cor e Forma:Solid
    Peso molecular:506.49

    Ref: TM-T16101

    1mg
    Descontinuado
    Produto descontinuado
  • HOKU-81

    CAS:
    <p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>
    Fórmula:C12H18ClNO2
    Cor e Forma:Solid
    Peso molecular:243.73

    Ref: TM-T15498

    1mg
    Descontinuado
    Produto descontinuado
  • CYM 9484

    CAS:
    <p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>
    Fórmula:C27H31N3O3S2
    Cor e Forma:Solid
    Peso molecular:509.68

    Ref: TM-T10921

    1mg
    Descontinuado
    2mg
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    Produto descontinuado
  • Beraprost sodium

    CAS:
    <p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>
    Fórmula:C24H29NaO5
    Cor e Forma:Solid
    Peso molecular:420.481

    Ref: TM-T13859

    1mg
    Descontinuado
    Produto descontinuado
  • Metipranolol hydrochloride

    CAS:
    <p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>
    Fórmula:C17H28ClNO4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:345.86

    Ref: TM-T16066

    1mg
    Descontinuado
    2mg
    Descontinuado
    Produto descontinuado
  • Arotinolol

    CAS:
    <p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>
    Fórmula:C15H21N3O2S3
    Cor e Forma:White Solid
    Peso molecular:371.54

    Ref: TM-T10371

    1mg
    Descontinuado
    Produto descontinuado
  • Protease-Activated Receptor-4

    CAS:
    <p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>
    Fórmula:C33H46N8O7
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:666.77

    Ref: TM-T7380

    1mg
    Descontinuado
    Produto descontinuado
  • 7-Desmethyl-agomelatine

    CAS:
    <p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>
    Fórmula:C14H15NO2
    Cor e Forma:Solid
    Peso molecular:229.27

    Ref: TM-T10193

    1mg
    Descontinuado
    Produto descontinuado
  • ML-00253764 hydrochloride

    CAS:
    <p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>
    Fórmula:C18H19BrClFN2O
    Cor e Forma:Solid
    Peso molecular:413.71

    Ref: TM-T12072

    1mg
    Descontinuado
    Produto descontinuado
  • JMV 2959

    CAS:
    <p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>
    Fórmula:C30H32N6O2
    Cor e Forma:Solid
    Peso molecular:508.61

    Ref: TM-T11719L

    1mg
    Descontinuado
    2mg
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  • Pumosetrag Hydrochloride

    CAS:
    <p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>
    Fórmula:C15H18ClN3O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:339.84

    Ref: TM-T16683

    1mg
    Descontinuado
    Produto descontinuado
  • SB-399885 hydrochloride

    CAS:
    <p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>
    Fórmula:C18H22Cl3N3O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:482.81

    Ref: TM-T12843

    1mg
    Descontinuado
    Produto descontinuado
  • SHA 68

    CAS:
    <p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>
    Fórmula:C26H24FN3O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:445.49

    Ref: TM-T12895

    1mg
    Descontinuado
    Produto descontinuado
  • SR 146131

    CAS:
    <p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>
    Fórmula:C32H36ClN3O5S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:610.16

    Ref: TM-T16935

    1mg
    Descontinuado
    Produto descontinuado
  • (Rac)-Rotigotine hydrochloride

    CAS:
    <p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>
    Fórmula:C19H26ClNOS
    Cor e Forma:Solid
    Peso molecular:351.93

    Ref: TM-T12676

    1ml*10 (DMSO)
    Descontinuado
    Produto descontinuado
  • BIBP3226 TFA

    CAS:
    <p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>
    Fórmula:C29H32F3N5O5
    Cor e Forma:Solid
    Peso molecular:587.59

    Ref: TM-T10540

    1mg
    Descontinuado
    Produto descontinuado
  • (Rac)-Zevaquenabant

    CAS:
    <p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>
    Fórmula:C25H21ClF3N5O2S
    Cor e Forma:Solid
    Peso molecular:547.98

    Ref: TM-T39074

    Produto descontinuado
  • 1-Oleoyl Lysophosphatidic Acid

    CAS:
    <p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>
    Fórmula:C21H41O7P
    Cor e Forma:Solid
    Peso molecular:436.52

    Ref: TM-T36907

    22.91mM*1
    Descontinuado
    22.91mM*100
    Descontinuado
    22.91mM*2.5
    Descontinuado
    22.91mM*500
    Descontinuado
    Produto descontinuado
  • Anti-GLP1R Antibody


    <p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>
    Cor e Forma:Odour Liquid

    Ref: TM-T9901A-804

    1mg
    Descontinuado
    5mg
    Descontinuado
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  • Goserelin acetate(65807-02-5 Free base)


    <p>Goserelin acetate (ICI-118630 acetate) is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>
    Pureza:99.77%
    Cor e Forma:Odour Solid

    Ref: TM-T36918L

    1mg
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  • BRL 15572

    CAS:
    <p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>
    Fórmula:C25H27ClN2O
    Cor e Forma:Solid
    Peso molecular:406.95

    Ref: TM-T64501

    Produto descontinuado
  • 3-Hydroxybenzylamine

    CAS:
    <p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>
    Fórmula:C7H9NO
    Cor e Forma:Solid
    Peso molecular:123.155

    Ref: TM-T124305

    Produto descontinuado
  • 4-Hydroxypropranolol hydrochloride

    CAS:
    <p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>
    Fórmula:C16H22ClNO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:311.8

    Ref: TM-T10150

    100mg
    Descontinuado
    500mg
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  • dapitant

    CAS:
    <p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>
    Fórmula:C37H39NO4
    Cor e Forma:Solid
    Peso molecular:561.71

    Ref: TM-T68049

    Produto descontinuado
  • Patecibart

    CAS:
    <p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>
    Pureza:98%
    Cor e Forma:Liquid

    Ref: TM-T81538

    1mg
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  • CRTh2 antagonist 3

    CAS:
    <p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>
    Fórmula:C19H20N2O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:356.44

    Ref: TM-T10890

    100mg
    Descontinuado
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  • (R)-(-)-α-Methylhistamine dihydrochloride

    CAS:
    <p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>
    Fórmula:C6H13Cl2N3
    Cor e Forma:Solid
    Peso molecular:198.09

    Ref: TM-T24698

    Produto descontinuado
  • Picumeterol

    CAS:
    <p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>
    Fórmula:C21H29Cl2N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:426.38

    Ref: TM-T68129

    Produto descontinuado
  • Amelubant

    CAS:
    <p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>
    Fórmula:C33H34N2O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:538.63

    Ref: TM-T14210

    100mg
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  • TAK-448

    CAS:
    <p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>
    Fórmula:C58H80N16O14
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1225.36

    Ref: TM-TP1094

    1mg
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  • Vornorexant

    CAS:
    <p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>
    Fórmula:C23H22FN7O2
    Cor e Forma:Solid
    Peso molecular:447.474

    Ref: TM-T39004

    Produto descontinuado
  • Propiram fumarate HCl

    CAS:
    <p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>
    Fórmula:C16H25N3O·xClH
    Pureza:99.25%
    Cor e Forma:Soild

    Ref: TM-T28453L

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  • Sarizotan

    CAS:
    <p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>
    Fórmula:C22H21FN2O
    Cor e Forma:Solid
    Peso molecular:348.421

    Ref: TM-T40439

    Produto descontinuado
  • 4-Hydroxyatomoxetine

    CAS:
    <p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>
    Fórmula:C17H21NO2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:271.35

    Ref: TM-T10145

    100mg
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  • TAK-683

    CAS:
    <p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>
    Fórmula:C64H83N17O13
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1298.45

    Ref: TM-TP2156L

    100mg
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    500mg
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  • Desmethyl cariprazine

    CAS:
    <p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>
    Fórmula:C20H30Cl2N4O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:413.38

    Ref: TM-T15100

    100mg
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  • BX471 hydrochloride

    CAS:
    <p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>
    Fórmula:C21H25Cl2FN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:471.35

    Ref: TM-T14845

    Produto descontinuado
  • Canagliflozin-d4

    CAS:
    <p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>
    Fórmula:C24H25FO5S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:448.54

    Ref: TM-T10669

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  • Pamoic acid

    CAS:
    <p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>
    Fórmula:C23H16O6
    Pureza:99.99%
    Cor e Forma:Fine Yellow Powder
    Peso molecular:388.37

    Ref: TM-T8353

    1ml*10 (DMSO)
    Descontinuado
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  • 2-Methyl-5-HT hydrochloride

    CAS:
    <p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>
    Fórmula:C11H15ClN2O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:226.7

    Ref: TM-T10075L2

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  • AM-2232

    CAS:
    <p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>
    Fórmula:C24H20N2O
    Pureza:99.37%
    Cor e Forma:Solid
    Peso molecular:352.43

    Ref: TM-T21450

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    1ml*10 (DMSO)
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    1mL*10mM (DMSO)_old
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  • MEN11467

    CAS:
    <p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>
    Fórmula:C38H40N4O3
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:600.75

    Ref: TM-T12000

    1mg
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  • 2-Arachidonoylglycerol

    CAS:
    <p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>
    Fórmula:C23H38O4
    Pureza:95%
    Cor e Forma:Liquid
    Peso molecular:378.55

    Ref: TM-T14011

    5mg
    Descontinuado
    26.4mM*100
    Descontinuado
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  • GR 218,231

    CAS:
    <p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>
    Fórmula:C24H33NO3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:415.59

    Ref: TM-T27431

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  • Imetit dihydrobromide

    CAS:
    <p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>
    Fórmula:C6H12Br2N4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:332.06

    Ref: TM-T15565

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  • Neurokinin antagonist 1

    CAS:
    <p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>
    Fórmula:C38H40N4O3
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:600.75

    Ref: TM-T10056

    1mg
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  • Flumexadol

    CAS:
    <p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>
    Fórmula:C11H12F3NO
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:231.21

    Ref: TM-T11302

    50mg
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  • S1P1 agonist 6

    CAS:
    <p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>
    Fórmula:C25H26F3NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:445.47

    Ref: TM-T79816

    5mg
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  • AEF0117

    CAS:
    <p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>
    Fórmula:C29H40O3
    Pureza:99.58%
    Cor e Forma:Solid
    Peso molecular:436.63

    Ref: TM-T79909

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  • Dimethandrolone Undecanoate

    CAS:
    <p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>
    Fórmula:C31H50O3
    Pureza:99.65% - >99.99%
    Cor e Forma:Solid
    Peso molecular:470.73

    Ref: TM-T27176

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  • 2-MNG

    CAS:
    <p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>
    Fórmula:C8H8N2O3S
    Cor e Forma:Liquid
    Peso molecular:212.23

    Ref: TM-T89029

    1mg
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