GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.943 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(196 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(69 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(164 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5337 produtos de "GPCR/Proteína-G"
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5-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Fórmula:C23H29ClN6O2Cor e Forma:SolidPeso molecular:456.97ADORA2A/PDE4D-IN-1
CAS:<p>ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.</p>Fórmula:C14H11N5Cor e Forma:SolidPeso molecular:249.271SSR-241586
CAS:<p>SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.</p>Fórmula:C32H42Cl2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:601.61GLP-1 receptor agonist 11
CAS:<p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>Fórmula:C31H31ClFN3O4Cor e Forma:SolidPeso molecular:564.05Inupadenant HCl
CAS:<p>Inupadenant (EOS-850) is a selective A2a receptor antagonist, targeting immunosuppression in tumors.</p>Fórmula:C25H27ClF2N8O4S2Cor e Forma:SolidPeso molecular:641.11Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95CB2R/5-HT1AR agonist 1
CAS:<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Fórmula:C24H33NO3Cor e Forma:SolidPeso molecular:383.52BW A868C
CAS:BW A868C is a potent, selective PGD2 antagonist and a BW245C analogue, inert to other prostaglandin receptors.Fórmula:C25H37N3O5Cor e Forma:SolidPeso molecular:459.58BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Fórmula:C32H37N3O4SPureza:98%Cor e Forma:SolidPeso molecular:559.72LY210073
CAS:<p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>Fórmula:C30H28O8Pureza:98%Cor e Forma:SolidPeso molecular:516.54Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538(S)-Butaprost free acid
CAS:<p>(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].</p>Fórmula:C23H38O5Cor e Forma:SolidPeso molecular:394.54Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Cor e Forma:SolidPeso molecular:460.42Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Fórmula:C27H29N5OCor e Forma:SolidPeso molecular:439.55PD 135158
CAS:<p>PD 135158 is a CCK2 receptor antagonist.</p>Fórmula:C42H61N5O11Pureza:98%Cor e Forma:SolidPeso molecular:811.96SphK2-IN-1
CAS:<p>SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.</p>Fórmula:C23H22ClF3N8OCor e Forma:SolidPeso molecular:518.92CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Fórmula:C24H29N3O2Cor e Forma:SolidPeso molecular:391.51DMPX
CAS:<p>DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.</p>Fórmula:C10H10N4O2Cor e Forma:SolidPeso molecular:218.212Mrgx2 antagonist-3
CAS:<p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>Fórmula:C15H15F2N3OCor e Forma:SolidPeso molecular:291.30GRK6-IN-5
CAS:<p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C23H21N3O2Cor e Forma:SolidPeso molecular:371.432MRGPRX2 modulator-1
CAS:<p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>Fórmula:C20H19F6N5OCor e Forma:SolidPeso molecular:459.39Nedocromil sodium
CAS:<p>Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.</p>Fórmula:C19H17NNaO7Pureza:98%Cor e Forma:SolidPeso molecular:394.335TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Fórmula:C36H46N4O4SCor e Forma:SolidPeso molecular:630.84GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C15H15N5Cor e Forma:SolidPeso molecular:265.313APJ receptor agonist 3
CAS:<p>APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.</p>Fórmula:C26H29ClN4O5Cor e Forma:SolidPeso molecular:512.98Ici D1542
CAS:<p>Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.</p>Fórmula:C25H30N2O7Pureza:98%Cor e Forma:SolidPeso molecular:470.51Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Fórmula:C27H27ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:561.98SB-423557
CAS:<p>SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM</p>Fórmula:C28H36N2O4Pureza:98%Cor e Forma:SolidPeso molecular:464.60Protease-Activated Receptor-1 antagonist 1
<p>Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.</p>Fórmula:C25H24F2N2O3Cor e Forma:SolidPeso molecular:438.47LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Fórmula:C32H39N3O·HCl·xH2OCor e Forma:SolidA2A receptor antagonist 2
<p>A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).</p>Fórmula:C25H28FN7O3Cor e Forma:SolidPeso molecular:493.53Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392AM8936
<p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>Fórmula:C25H33NO3Cor e Forma:SolidPeso molecular:395.53Nipradolol
CAS:<p>Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.</p>Fórmula:C15H22N2O6Cor e Forma:SolidPeso molecular:326.35MRGPRX1 agonist 4
<p>Potent, oral MRGPRX1 agonist 4 modulates receptor positively (EC50: 0.1 μM) and reduces mice's thermal allergy response.</p>Fórmula:C23H17Cl2F3N2O2SCor e Forma:SolidPeso molecular:513.36CVT-5440
CAS:<p>CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.</p>Fórmula:C27H28N6O5Cor e Forma:SolidPeso molecular:516.55CCR1 antagonist 11 hydrochloride
<p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>Cor e Forma:SolidRGS10 modulator-1
CAS:<p>RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.</p>Fórmula:C16H15BrN2O3S2Cor e Forma:SolidPeso molecular:427.336ONO-9780307
CAS:<p>ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).</p>Fórmula:C30H35NO7Cor e Forma:SolidPeso molecular:521.6U92016A hydrochloride
CAS:<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Fórmula:C19H26ClN3Cor e Forma:SolidPeso molecular:331.89AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8SphK1-IN-1
<p>SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.</p>Fórmula:C22H22N6O2Cor e Forma:SolidPeso molecular:402.45Setomagpran
CAS:<p>Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.</p>Fórmula:C22H19Cl2F6N5OCor e Forma:SolidPeso molecular:554.316LX2761
CAS:<p>LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.</p>Fórmula:C32H47N3O6SPureza:98%Cor e Forma:SolidPeso molecular:601.80AM9405
<p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>Fórmula:C24H33BrN2O2Pureza:98%Cor e Forma:SolidPeso molecular:461.44GPBAR1-IN-3
CAS:<p>GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].</p>Fórmula:C21H23NO2Cor e Forma:SolidPeso molecular:321.41(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.406CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Fórmula:C33H48O2Cor e Forma:SolidPeso molecular:476.73S1P1 agonist 4
CAS:<p>S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating</p>Fórmula:C24H31NO3Cor e Forma:SolidPeso molecular:381.51VGD071
CAS:<p>VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.</p>Fórmula:C32H41N3O4S2Cor e Forma:SolidPeso molecular:595.82Nedemelteon
CAS:<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Fórmula:C15H18N2O2Cor e Forma:SolidPeso molecular:258.32IRL 2500
CAS:<p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>Fórmula:C36H35N3O4Pureza:99.36%Cor e Forma:White Crystalline SolidPeso molecular:573.68Nifeviroc
CAS:<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.71Aplaviroc hydrochloride
CAS:<p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>Fórmula:C33H44ClN3O6Cor e Forma:SolidPeso molecular:614.17Sigma-1 receptor antagonist 6
CAS:<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Fórmula:C32H34N6Cor e Forma:SolidPeso molecular:502.65TAK-637
CAS:<p>TAK-637 is a tachykinin 1 (NK1) receptor antagonist.</p>Fórmula:C30H25F6N3O2Pureza:98%Cor e Forma:SolidPeso molecular:573.53SSTR5 antagonist 2 TFA
CAS:<p>Potent, oral SSTR5 antagonist 2 TFA may treat type 2 diabetes.</p>Fórmula:C34H36F4N2O7Pureza:98%Cor e Forma:SolidPeso molecular:660.65KAG-308
CAS:<p>KAG-308: selective EP4 agonist; Ki: 2.57 nM, EC50: 17 nM; suppresses colitis, promotes mucosal healing, inhibits TNF-α.</p>Fórmula:C24H30F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:460.52NK-1 Antagonist 1
CAS:<p>NK-1 Antagonist 1 is a NK-1 receptor antagonist.</p>Fórmula:C25H23F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:539.47hA3AR agonist 1
<p>hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .</p>Fórmula:C10H14N6OSCor e Forma:SolidPeso molecular:266.32Ro-24-4736
CAS:<p>Ro 24-4736 is an effective and selective platelet-activating factor antagonist.</p>Fórmula:C31H20ClN5OSPureza:98%Cor e Forma:SolidPeso molecular:546.04CCR5 antagonist 1
CAS:<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Fórmula:C39H46ClF2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:738.33BI 639667
CAS:<p>BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).</p>Fórmula:C22H18FN5O3SPureza:99.86%Cor e Forma:SolidPeso molecular:451.47MK-3207
CAS:<p>MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.</p>Fórmula:C31H29F2N5O3Cor e Forma:SolidPeso molecular:557.59Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Fórmula:C14H16N2O5Cor e Forma:SolidPeso molecular:292.287Opipramol dihydrochloride
CAS:<p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>Fórmula:C23H31Cl2N3OCor e Forma:SolidPeso molecular:436.418Arpromidine
CAS:<p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462Toladryl
CAS:<p>Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.</p>Fórmula:C18H23NOCor e Forma:SolidPeso molecular:269.38CRHR1 antagonist 1
CAS:<p>CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.</p>Fórmula:C24H34N4OCor e Forma:SolidPeso molecular:394.553AChE/BChE-IN-21
CAS:<p>AChE/BChE-IN-21 is an antagonist of the histamine H3 receptor, a calcium channel blocker, and an acetylcholinesterase inhibitor. It exhibits neuroprotective activities against H2O2 and Aβ1-40, and can restore cognitive functions in AD mice.</p>Fórmula:C38H54N4O4Cor e Forma:SolidPeso molecular:630.86CB1/2 agonist 1
<p>Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.</p>Fórmula:C21H24BrFN2O2Cor e Forma:SolidPeso molecular:435.33PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Fórmula:C25H27FN6O2Pureza:99.9%Cor e Forma:SolidPeso molecular:462.52Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Fórmula:C36H45F4N3O5Pureza:97.35% - 98.23%Cor e Forma:SolidPeso molecular:675.75Vofopitant dihydrochloride
CAS:<p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>Fórmula:C21H25Cl2F3N6OPureza:98.99%Cor e Forma:SolidPeso molecular:505.36Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Fórmula:C21H23F3N6OPureza:97.86%Cor e Forma:SolidPeso molecular:432.44SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Fórmula:C32H33ClN4O3Pureza:97.82% - 98.99%Cor e Forma:SolidPeso molecular:557.08LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Fórmula:C26H23Cl2N3O2Pureza:99.21%Cor e Forma:SolidPeso molecular:480.39AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Fórmula:C32H38F2N2O5S2Pureza:98.1%Cor e Forma:SolidPeso molecular:632.78BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Cor e Forma:SolidPeso molecular:561.63BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Fórmula:C34H51N5O7Pureza:98.81%Cor e Forma:SolidPeso molecular:641.8Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Fórmula:C27H45NO7Pureza:99.86%Cor e Forma:SolidPeso molecular:495.65AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Fórmula:C30H41FN2O6Pureza:98.32% - 99.63%Cor e Forma:SolidPeso molecular:544.65Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Fórmula:C25H27ClF6N2O2Pureza:98.35% - 99.79%Cor e Forma:SolidPeso molecular:536.94HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Fórmula:C12H18ClNO2Cor e Forma:SolidPeso molecular:243.73JMV 2959
CAS:<p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>Fórmula:C30H32N6O2Cor e Forma:SolidPeso molecular:508.61BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Fórmula:C29H32F3N5O5Cor e Forma:SolidPeso molecular:587.59Beraprost sodium
CAS:<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>Fórmula:C24H29NaO5Cor e Forma:SolidPeso molecular:420.481Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Fórmula:C15H21N3O2S3Cor e Forma:White SolidPeso molecular:371.547-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Fórmula:C14H15NO2Cor e Forma:SolidPeso molecular:229.27SB-399885 hydrochloride
CAS:<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Fórmula:C18H22Cl3N3O4SPureza:98%Cor e Forma:SolidPeso molecular:482.81SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Fórmula:C32H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:610.16Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Fórmula:C17H28ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:345.86ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Fórmula:C18H19BrClFN2OCor e Forma:SolidPeso molecular:413.71Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Fórmula:C33H46N8O7Pureza:98%Cor e Forma:SolidPeso molecular:666.77ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Fórmula:C24H21F3N2O5SCor e Forma:SolidPeso molecular:506.49SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Fórmula:C26H24FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:445.49Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Fórmula:C15H18ClN3O2SPureza:98%Cor e Forma:SolidPeso molecular:339.84CYM 9484
CAS:<p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>Fórmula:C27H31N3O3S2Cor e Forma:SolidPeso molecular:509.68(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Fórmula:C19H26ClNOSCor e Forma:SolidPeso molecular:351.93Atenolol
CAS:<p>Atenolol (Tenormin) is a selective β1 receptor antagonist.</p>Fórmula:C14H22N2O3Pureza:99.07% - 99.95%Cor e Forma:White Crystalline Powder SolidPeso molecular:266.34Vornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Fórmula:C23H22FN7O2Cor e Forma:SolidPeso molecular:447.4741-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Fórmula:C21H41O7PCor e Forma:SolidPeso molecular:436.52Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Fórmula:C20H30Cl2N4OPureza:98%Cor e Forma:SolidPeso molecular:413.384-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Fórmula:C16H22ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:311.83-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Fórmula:C7H9NOCor e Forma:SolidPeso molecular:123.155Picumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Fórmula:C21H29Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:426.38TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Fórmula:C58H80N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1225.36Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Fórmula:C16H25N3O·xClHPureza:99.25%Cor e Forma:SoildBRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:406.95dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Fórmula:C37H39NO4Cor e Forma:SolidPeso molecular:561.71(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Fórmula:C25H21ClF3N5O2SCor e Forma:SolidPeso molecular:547.98CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Fórmula:C19H20N2O3SPureza:98%Cor e Forma:SolidPeso molecular:356.44TAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Fórmula:C64H83N17O13Pureza:98%Cor e Forma:SolidPeso molecular:1298.45BX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Fórmula:C21H25Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:471.35Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Pureza:98%Cor e Forma:LiquidAmelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Fórmula:C33H34N2O5Pureza:98%Cor e Forma:SolidPeso molecular:538.63(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Fórmula:C6H13Cl2N3Cor e Forma:SolidPeso molecular:198.09Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Fórmula:C22H21FN2OCor e Forma:SolidPeso molecular:348.4214-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Fórmula:C17H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:271.35GRK2 Inhibitor
CAS:<p>GRK2 Inhibitor is an inhibitor of β-Adrenergic Receptor Kinase 1 (β ARK1).</p>Fórmula:C12H9NO6Cor e Forma:SolidPeso molecular:263.2Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Fórmula:C24H25FO5SPureza:98%Cor e Forma:SolidPeso molecular:448.54Ref: TM-T10669
Produto descontinuado2-Methyl-5-HT hydrochloride
CAS:<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Fórmula:C11H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:226.7WIN 55,212-2 Mesylate
CAS:<p>WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. Cannabinoid analogue WIN 55,212-2 Mesylate exhibited a novel anticancer effect against human tumors.</p>Fórmula:C28H30N2O6SPureza:98% - 99.71%Cor e Forma:White To Off-White SolidPeso molecular:522.61TFLLR-NH2 2TFA(197794-83-5(free base))
<p>TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).</p>Fórmula:C35H55F6N9O10Pureza:99.56%Cor e Forma:SolidPeso molecular:875.87Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Fórmula:C23H16O6Pureza:99.99%Cor e Forma:Fine Yellow PowderPeso molecular:388.37AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Fórmula:C24H20N2OPureza:99.37%Cor e Forma:SolidPeso molecular:352.43MEN11467
CAS:<p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Fórmula:C24H33NO3SPureza:98%Cor e Forma:SolidPeso molecular:415.59Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Fórmula:C6H12Br2N4SPureza:98%Cor e Forma:SolidPeso molecular:332.062-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Fórmula:C23H38O4Pureza:95%Cor e Forma:LiquidPeso molecular:378.55Ref: TM-T14011
Produto descontinuadoNeurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Fórmula:C11H12F3NOPureza:98%Cor e Forma:SolidPeso molecular:231.21AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Fórmula:C29H40O3Pureza:99.58%Cor e Forma:SolidPeso molecular:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Fórmula:C25H26F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:445.472-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Fórmula:C8H8N2O3SCor e Forma:LiquidPeso molecular:212.23Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Fórmula:C31H50O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:470.73Ref: TM-T27176
Produto descontinuado
