GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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H3R antagonist 5
CAS:<p>H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.</p>Fórmula:C23H32N2O4Cor e Forma:SolidPeso molecular:400.511CI-988
CAS:<p>CCK2 (CCK-B) receptor antagonist</p>Fórmula:C35H42N4O6Pureza:98%Cor e Forma:SolidPeso molecular:614.738-iso Prostaglandin F3α
CAS:<p>8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.</p>Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.47NK1 receptor antagonist 2
CAS:<p>NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.</p>Fórmula:C31H35F7N4O2Cor e Forma:SolidPeso molecular:628.62BI-685509
CAS:<p>BI-685509: potent, oral sGC activator, boosts cGMP, enhances NO pathways, for CKD/DKD research.</p>Fórmula:C34H38N4O5Cor e Forma:SolidPeso molecular:582.69MRGPRX1 agonist 3
<p>Compound 1f, a potent MRGPRX1 agonist, has an EC50 of 0.22 μM, useful for neuropathic pain studies.</p>Fórmula:C14H11FN2OSCor e Forma:SolidPeso molecular:274.31S1PR1 agonist 2
CAS:<p>S1PR1 agonist 2 is potent for autoimmune research (from WO2021175225A1).</p>Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.50YM158 free base
CAS:<p>YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).</p>Fórmula:C32H33ClN6O5S2Pureza:98%Cor e Forma:SolidPeso molecular:681.22SGLT1/2-IN-1
CAS:<p>SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.</p>Fórmula:C25H28O8Cor e Forma:SolidPeso molecular:456.48DSP-1053 benzenesulfonate
CAS:<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62Protease-Activated Receptor-1 antagonist 2
<p>Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.</p>Cor e Forma:SolidUK-432097
CAS:<p>UK 432097 is an adenosine A2A agonist.</p>Fórmula:C40H47N11O6Cor e Forma:SolidPeso molecular:777.87Lisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Fórmula:C20H26N4OCor e Forma:SolidPeso molecular:338.45APJ receptor agonist 3
CAS:<p>APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.</p>Fórmula:C26H29ClN4O5Cor e Forma:SolidPeso molecular:512.98CS-0777
CAS:<p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>Fórmula:C21H31N2O5PCor e Forma:SolidPeso molecular:422.45Sulprostone
CAS:<p>EP3 and EP1 receptor agonist</p>Fórmula:C23H31NO7SPureza:98%Cor e Forma:White To Off-White SolidPeso molecular:465.56NMDAR antagonist 5
CAS:<p>NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.</p>Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.369BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Fórmula:C32H37N3O4SPureza:98%Cor e Forma:SolidPeso molecular:559.72SSTR5 antagonist 2 hydrochloride
<p>SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.</p>Fórmula:C32H36ClFN2O5Cor e Forma:SolidPeso molecular:583.09Abarelix acetate
CAS:<p>Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.</p>Fórmula:C72H95ClN14O14·xC2H4O2Cor e Forma:SolidPeso molecular:1476.14Tofogliflozin
CAS:<p>Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).</p>Fórmula:C22H26O6Pureza:98%Cor e Forma:SolidPeso molecular:386.44LPA2 antagonist 5
CAS:<p>LPA2 antagonist 5 (EX1) functions as an antagonist of LPA2, with an IC50 value of 4.05 nM.</p>Fórmula:C17H17F3N2O5Cor e Forma:SolidPeso molecular:386.323CP-865569
CAS:<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Fórmula:C22H26ClFN2O5SCor e Forma:SolidPeso molecular:484.969LY 292728
CAS:<p>LY 292728 is a highly potent antagonist of leukotriene B4 receptor.</p>Fórmula:C34H29FO9Pureza:98%Cor e Forma:SolidPeso molecular:600.59Vibegron
CAS:<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53MRS2279 diammonium
CAS:<p>MRS2279 diammonium, a P2Y1 antagonist with K i 2.5 nM, IC 50 51.6 nM, blocks ADP-induced platelet aggregation, pK b 8.05.</p>Fórmula:C13H24ClN7O8P2Cor e Forma:SolidPeso molecular:503.77Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95(E/Z)-Ozagrel sodium
CAS:<p>(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.</p>Fórmula:C13H11N2NaO2Cor e Forma:SolidPeso molecular:250.228AAZ-A 154 hydrochloride
CAS:<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Fórmula:C14H21ClN2OCor e Forma:SolidPeso molecular:268.78AAZ-A 154 hydrobromide
CAS:<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Fórmula:C14H21BrN2OCor e Forma:SolidPeso molecular:313.23GLP-1 receptor agonist 15
CAS:<p>GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.</p>Fórmula:C32H31ClFN3O5Cor e Forma:SolidPeso molecular:592.057A3AR antagonist 5
CAS:<p>A3AR antagonist 5 (Compound 16) acts as a selective antagonist for the human adenosine A3 receptor (human adenosine A3 receptor), with an affinity expressed as a pC value of 4.542 μM.</p>Fórmula:C18H16N2O2SCor e Forma:SolidPeso molecular:324.40Cloprostenol
CAS:<p>Cloprostenol is a synthetic prostaglandin and PGF2α analogue used in animals to terminate pregnancy and induce corpus luteum dissolution.</p>Fórmula:C22H29ClO6Pureza:99.81%Cor e Forma:Clear Colorless To Light Yellowish LiquidPeso molecular:424.92(-)-5-HT2C agonist-3
CAS:<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Fórmula:C19H23ClFNO2Cor e Forma:SolidPeso molecular:351.84RTIOXA-43
CAS:<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Fórmula:C37H37N5O5SPureza:99.17%Cor e Forma:SolidPeso molecular:663.79PF-06372222
CAS:<p>PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.</p>Fórmula:C26H28F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:515.53Zafirlukast metabolite M1
CAS:<p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>Fórmula:C25H25N3O4SCor e Forma:SolidPeso molecular:463.549Sulamserod hydrochloride
CAS:<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Fórmula:C19H29Cl2N3O5SCor e Forma:SolidPeso molecular:482.42AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8RBM10-8
CAS:<p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>Fórmula:C17H36NO5PCor e Forma:SolidPeso molecular:365.45Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392H-Glu-Thr-OH
CAS:<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Fórmula:C9H16N2O6Cor e Forma:SolidPeso molecular:248.23UMB24
CAS:<p>UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.</p>Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.37LY 245769
CAS:<p>LY 245769 is an inhibitor of leukotriene E4 (LTE4).</p>Fórmula:C25H33F3N8OSPureza:98%Cor e Forma:SolidPeso molecular:550.64Etoperidone
CAS:<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Fórmula:C19H28ClN5OCor e Forma:SolidPeso molecular:377.91BIIE-0246 HCl
CAS:<p>BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.</p>Fórmula:C49H59Cl2N11O6Cor e Forma:SolidPeso molecular:968.975-HT7R antagonist 3
CAS:<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Fórmula:C30H33FN4O3Cor e Forma:SolidPeso molecular:516.61IMP-1575
CAS:<p>IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.</p>Fórmula:C19H25N3OSPeso molecular:343.49(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Aeruginosin 98-B
CAS:<p>Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.</p>Fórmula:C29H46N6O9SCor e Forma:SolidPeso molecular:654.78MrgprX2 antagonist-6
<p>MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.</p>Fórmula:C24H23F3N6O3Cor e Forma:SolidPeso molecular:500.47Tonapofylline
CAS:<p>Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.</p>Fórmula:C22H32N4O4Pureza:98.57%Cor e Forma:SolidPeso molecular:416.51MrgprX2 antagonist-7
<p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>Fórmula:C24H22ClF3N6O3Cor e Forma:SolidPeso molecular:534.92LK 11
CAS:<p>LK-11, an alkaloid derivative, inhibits the passive uptake of norepinephrine (NA) by synaptic vesicles in the thalamus, similarly to cocaine.</p>Fórmula:C15H26N2O3Cor e Forma:SolidPeso molecular:282.38L-796778 acetate
CAS:<p>L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.</p>Fórmula:C31H44N6O9Cor e Forma:SolidPeso molecular:644.716GLP-1 receptor agonist 11
CAS:<p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>Fórmula:C31H31ClFN3O4Cor e Forma:SolidPeso molecular:564.05Pareptide monohydrochloride
CAS:<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Fórmula:C14H27ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:334.84AA 497 (Free Base)
CAS:<p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>Fórmula:C14H21NO3Pureza:98%Cor e Forma:SolidPeso molecular:251.32Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Fórmula:C27H29N5OCor e Forma:SolidPeso molecular:439.55Nifeviroc
CAS:<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.71CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Fórmula:C33H48O2Cor e Forma:SolidPeso molecular:476.73HU 433
CAS:<p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62Bzo-poxizid
CAS:<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.40SAR-150640
CAS:<p>SAR-150640, a selective β3-adrenergic receptor agonist, prevents an increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis.</p>Fórmula:C25H35ClN2O7SCor e Forma:SolidPeso molecular:543.07RS 61756-007
CAS:<p>RS 61756-007 is a selective thromboxane receptor (TP) agonist.</p>Fórmula:C23H28O5Pureza:98%Cor e Forma:SolidPeso molecular:384.47Sigma-1 receptor antagonist 6
CAS:<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Fórmula:C32H34N6Cor e Forma:SolidPeso molecular:502.65CCR1 antagonist 13
CAS:<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Fórmula:C25H27ClFN3O4Cor e Forma:SolidPeso molecular:487.95GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C15H15N5Cor e Forma:SolidPeso molecular:265.313SR 142948-C3-NHMe
CAS:<p>SR 142948-C3-NHMe is the methylated form of SR 142948.</p>Fórmula:C42H58N6O6Cor e Forma:SolidPeso molecular:742.946Arpromidine
CAS:<p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462Metrazoline
CAS:<p>Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.</p>Fórmula:C14H16N2O4Cor e Forma:SolidPeso molecular:276.288CCG258208
CAS:<p>GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Fórmula:C24H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:452.48Pexacerfont
CAS:<p>Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).</p>Fórmula:C18H24N6OPureza:99.77%Cor e Forma:SolidPeso molecular:340.42APJ receptor agonist 8
CAS:<p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>Fórmula:C24H27N7O5SPureza:98.31% - 99.60%Cor e Forma:SolidPeso molecular:525.58CP-199330
CAS:<p>CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.</p>Fórmula:C28H24ClF3N2O6SCor e Forma:SolidPeso molecular:609.01Tixanox sodium
CAS:<p>Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.</p>Fórmula:C15H9NaO5SCor e Forma:SolidPeso molecular:324.28RU 52583
CAS:<p>RU 52583 is an alpha 2-adrenergic receptor antagonist.</p>Fórmula:C18H20N2Pureza:98%Cor e Forma:SolidPeso molecular:264.36BAY 38-7271
CAS:<p>BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).</p>Fórmula:C20H21F3O5SPureza:98%Cor e Forma:SolidPeso molecular:430.44(R)-MrgprX2 antagonist-3
CAS:<p>(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.</p>Fórmula:C16H20FN3O2SPeso molecular:337.41DA-302168S
CAS:<p>DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.</p>Fórmula:C33H24ClF2N3O5Cor e Forma:SolidPeso molecular:616.011LJ-4517
<p>LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.</p>Fórmula:C19H21N5O3SCor e Forma:SolidPeso molecular:399.47AB-FUBINACA 3-fluorobenzyl isomer
CAS:<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Fórmula:C20H21FN4O2Cor e Forma:SolidPeso molecular:368.41MF-592
CAS:<p>MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.</p>Fórmula:C34H33Cl2N3O6SCor e Forma:SolidPeso molecular:682.61(±)-Penbutolol
CAS:<p>(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.</p>Fórmula:C18H29NO2Cor e Forma:SolidPeso molecular:291.43O-1269
CAS:<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Fórmula:C22H22Cl3N3OCor e Forma:SolidPeso molecular:450.79GLP-1 receptor agonist 16
CAS:<p>GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.</p>Fórmula:C33H31ClFN3O4Cor e Forma:SolidPeso molecular:588.068DHICA
CAS:<p>DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.</p>Fórmula:C9H7NO4Cor e Forma:SolidPeso molecular:193.16Mafoprazine
CAS:<p>Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.</p>Fórmula:C22H28FN3O3Cor e Forma:SolidPeso molecular:401.47BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Fórmula:C34H51N5O7Pureza:98.81%Cor e Forma:SolidPeso molecular:641.8AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Fórmula:C30H41FN2O6Pureza:98.32% - 99.63%Cor e Forma:SolidPeso molecular:544.65SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Fórmula:C32H33ClN4O3Pureza:97.82% - 98.99%Cor e Forma:SolidPeso molecular:557.08Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Fórmula:C21H23F3N6OPureza:97.86%Cor e Forma:SolidPeso molecular:432.44SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54Vofopitant dihydrochloride
CAS:<p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>Fórmula:C21H25Cl2F3N6OPureza:98.99%Cor e Forma:SolidPeso molecular:505.36Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Fórmula:C36H45F4N3O5Pureza:97.35% - 98.23%Cor e Forma:SolidPeso molecular:675.75AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Fórmula:C32H38F2N2O5S2Pureza:98.1%Cor e Forma:SolidPeso molecular:632.78Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Fórmula:C27H45NO7Pureza:99.86%Cor e Forma:SolidPeso molecular:495.65PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Fórmula:C25H27FN6O2Pureza:99.9%Cor e Forma:SolidPeso molecular:462.52LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Fórmula:C26H23Cl2N3O2Pureza:99.21%Cor e Forma:SolidPeso molecular:480.39BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Cor e Forma:SolidPeso molecular:561.63Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Fórmula:C25H27ClF6N2O2Pureza:98.35% - 99.79%Cor e Forma:SolidPeso molecular:536.94Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Fórmula:C33H46N8O7Pureza:98%Cor e Forma:SolidPeso molecular:666.77SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Fórmula:C26H24FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:445.49ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Fórmula:C24H21F3N2O5SCor e Forma:SolidPeso molecular:506.49JMV 2959
CAS:<p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>Fórmula:C30H32N6O2Cor e Forma:SolidPeso molecular:508.61SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Fórmula:C32H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:610.16Beraprost sodium
CAS:<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>Fórmula:C24H29NaO5Cor e Forma:SolidPeso molecular:420.481HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Fórmula:C12H18ClNO2Cor e Forma:SolidPeso molecular:243.73BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Fórmula:C29H32F3N5O5Cor e Forma:SolidPeso molecular:587.59ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Fórmula:C18H19BrClFN2OCor e Forma:SolidPeso molecular:413.71CYM 9484
CAS:<p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>Fórmula:C27H31N3O3S2Cor e Forma:SolidPeso molecular:509.68Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Fórmula:C17H28ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:345.86Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Fórmula:C15H18ClN3O2SPureza:98%Cor e Forma:SolidPeso molecular:339.84(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Fórmula:C19H26ClNOSCor e Forma:SolidPeso molecular:351.93Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Fórmula:C15H21N3O2S3Cor e Forma:White SolidPeso molecular:371.54SB-399885 hydrochloride
CAS:<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Fórmula:C18H22Cl3N3O4SPureza:98%Cor e Forma:SolidPeso molecular:482.817-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Fórmula:C14H15NO2Cor e Forma:SolidPeso molecular:229.27Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Cor e Forma:Odour LiquidPicumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Fórmula:C21H29Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:426.38TAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Fórmula:C64H83N17O13Pureza:98%Cor e Forma:SolidPeso molecular:1298.451-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Fórmula:C21H41O7PCor e Forma:SolidPeso molecular:436.52Ref: TM-T36907
Produto descontinuadoPatecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Pureza:98%Cor e Forma:LiquidBX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Fórmula:C21H25Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:471.35BRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:406.95Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Fórmula:C16H25N3O·xClHPureza:99.25%Cor e Forma:Soilddapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Fórmula:C37H39NO4Cor e Forma:SolidPeso molecular:561.71(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Fórmula:C25H21ClF3N5O2SCor e Forma:SolidPeso molecular:547.984-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Fórmula:C16H22ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:311.8Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Fórmula:C22H21FN2OCor e Forma:SolidPeso molecular:348.4213-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Fórmula:C7H9NOCor e Forma:SolidPeso molecular:123.1554-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Fórmula:C17H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:271.35Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Fórmula:C20H30Cl2N4OPureza:98%Cor e Forma:SolidPeso molecular:413.38Vornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Fórmula:C23H22FN7O2Cor e Forma:SolidPeso molecular:447.474CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Fórmula:C19H20N2O3SPureza:98%Cor e Forma:SolidPeso molecular:356.44(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Fórmula:C6H13Cl2N3Cor e Forma:SolidPeso molecular:198.09TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Fórmula:C58H80N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1225.36Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Fórmula:C33H34N2O5Pureza:98%Cor e Forma:SolidPeso molecular:538.63Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Fórmula:C24H25FO5SPureza:98%Cor e Forma:SolidPeso molecular:448.54Ref: TM-T10669
Produto descontinuadoPamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Fórmula:C23H16O6Pureza:99.99%Cor e Forma:Fine Yellow PowderPeso molecular:388.372-Methyl-5-HT hydrochloride
CAS:<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Fórmula:C11H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:226.7AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Fórmula:C24H20N2OPureza:99.37%Cor e Forma:SolidPeso molecular:352.43Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Fórmula:C6H12Br2N4SPureza:98%Cor e Forma:SolidPeso molecular:332.06Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Fórmula:C11H12F3NOPureza:98%Cor e Forma:SolidPeso molecular:231.21GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Fórmula:C24H33NO3SPureza:98%Cor e Forma:SolidPeso molecular:415.59MEN11467
CAS:<p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.752-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Fórmula:C23H38O4Pureza:95%Cor e Forma:LiquidPeso molecular:378.55S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Fórmula:C25H26F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:445.47AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Fórmula:C29H40O3Pureza:99.58%Cor e Forma:SolidPeso molecular:436.63Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Fórmula:C31H50O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:470.73Ref: TM-T27176
Produto descontinuado2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Fórmula:C8H8N2O3SCor e Forma:LiquidPeso molecular:212.23
