GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(993 produtos)
- Receptor de adenosina(246 produtos)
- Receptor adrenérgico(3.004 produtos)
- Receptor de Bombesina(33 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(153 produtos)
- CaSR(33 produtos)
- Receptor de Canabinóides(212 produtos)
- Receptor de Dopamina(433 produtos)
- Receptor Endotelina(79 produtos)
- Receptor GNRH(77 produtos)
- GPCR19(32 produtos)
- GRK(32 produtos)
- GTPase(22 produtos)
- Receptor Glucagon(182 produtos)
- Hedgehog/Smoothened(47 produtos)
- Receptor de Histamina(381 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(310 produtos)
- PAFR(12 produtos)
- PKA(51 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5745 produtos de "GPCR/Proteína-G"
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MK-3207 Hydrochloride
CAS:MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Fórmula:C31H30ClF2N5O3Pureza:98.19%Cor e Forma:SolidPeso molecular:594.05CB2 receptor antagonist 1
CAS:Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.Fórmula:C28H47NO3Cor e Forma:SolidPeso molecular:445.688-iso Prostaglandin F3α
CAS:8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.47NK1 receptor antagonist 2
CAS:NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.Fórmula:C31H35F7N4O2Cor e Forma:SolidPeso molecular:628.62YM158 free base
CAS:YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).Fórmula:C32H33ClN6O5S2Pureza:98%Cor e Forma:SolidPeso molecular:681.22RBM10-8
CAS:RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.Fórmula:C17H36NO5PCor e Forma:SolidPeso molecular:365.45Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392Nolpitantium besilate
CAS:Nolpitantium besilate is a neurokinin-1 receptor antagonist.Fórmula:C43H50Cl2N2O5SCor e Forma:SolidPeso molecular:777.84Udifitimod
CAS:Udifitimod (BMS-986166) is a potent, selective, and orally active modulator of the S1P1R receptor, showing potential for research in autoimmune diseases.Fórmula:C25H33NO2Cor e Forma:SolidPeso molecular:379.54LY 245769
CAS:LY 245769 is an inhibitor of leukotriene E4 (LTE4).Fórmula:C25H33F3N8OSPureza:98%Cor e Forma:SolidPeso molecular:550.64H3R antagonist 1
CAS:H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Fórmula:C19H23N3O3Cor e Forma:SolidPeso molecular:341.4SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.Fórmula:C32H36ClFN2O5Cor e Forma:SolidPeso molecular:583.09Abarelix acetate
CAS:Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Fórmula:C72H95ClN14O14·xC2H4O2Cor e Forma:SolidPeso molecular:1476.14Vibegron
CAS:Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53MK-8318
CAS:MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).Fórmula:C27H26F4N2O5Pureza:98%Cor e Forma:SolidPeso molecular:534.5FDU-PB-22
CAS:<p>FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.</p>Fórmula:C26H18FNO2Cor e Forma:SolidPeso molecular:395.43GRPR antagonist-1
GRPR antagonist-1 targets GRPR, kills specific cancer cells (e.g., PC3, Pan02, HGC-27), and promotes apoptosis by modulating Bcl-2 and Bax.Fórmula:C29H33F3N4O4Cor e Forma:SolidPeso molecular:558.59CGRP antagonist 7
CAS:CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.Fórmula:C30H32FN5O3Cor e Forma:SolidPeso molecular:529.61UMB24
CAS:UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.37YM-49598 iodide
CAS:YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Fórmula:C36H45Cl2IN2O2Cor e Forma:SolidPeso molecular:735.57Elsovaptan
CAS:Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.Fórmula:C19H20ClN5O2Cor e Forma:SolidPeso molecular:385.847SS-RJW100
SS-RJW100 is an enantiomer of RJW100 targeting LRH-1, SF-1, enhances Tif2 interaction, and disrupts LRH-1 networks with lowered stability.Fórmula:C28H34OCor e Forma:SolidPeso molecular:386.57APJ receptor agonist 8
CAS:<p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>Fórmula:C24H27N7O5SPureza:98.31% - 99.60%Cor e Forma:SolidPeso molecular:525.58MRS4865
CAS:MRS4865 (compound 7a) serves as a chimeric antagonist for the P2Y14 receptor and an agonist for UDP-glucose, offering protection against neuropathic pain.Fórmula:C39H39F3N4O7Cor e Forma:SolidPeso molecular:732.74S1PR1 agonist 2
CAS:S1PR1 agonist 2 is potent for autoimmune research (from WO2021175225A1).Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.50BI-685509
CAS:BI-685509: potent, oral sGC activator, boosts cGMP, enhances NO pathways, for CKD/DKD research.Fórmula:C34H38N4O5Cor e Forma:SolidPeso molecular:582.69Osanetant HCl
CAS:Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonistFórmula:C35H42Cl3N3O2Cor e Forma:SolidPeso molecular:643.09GLP-1 receptor agonist 16
CAS:GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.Fórmula:C33H31ClFN3O4Cor e Forma:SolidPeso molecular:588.068RF9 hydrochloride
<p>RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).</p>Fórmula:C26H39ClN6O3Cor e Forma:SolidPeso molecular:519.08CB1/2 agonist 1
Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.Fórmula:C21H24BrFN2O2Cor e Forma:SolidPeso molecular:435.33NK-1 Antagonist 1
CAS:NK-1 Antagonist 1 is a NK-1 receptor antagonist.Fórmula:C25H23F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:539.47U92016A hydrochloride
CAS:U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.Fórmula:C19H26ClN3Cor e Forma:SolidPeso molecular:331.89ONO-9780307
CAS:ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).Fórmula:C30H35NO7Cor e Forma:SolidPeso molecular:521.6COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Fórmula:C20H27NO6SPureza:99.29% - 99.32%Cor e Forma:SoildPeso molecular:409.5A1AR antagonist 1
Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).Fórmula:C18H14N4OCor e Forma:SolidPeso molecular:302.33WIN 62577
CAS:WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Fórmula:C29H31N3OCor e Forma:SolidPeso molecular:437.576Iralukast (CGP 45715A)
CAS:Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.Fórmula:C38H37F3O8SCor e Forma:SolidPeso molecular:710.76MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54Toladryl
CAS:<p>Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.</p>Fórmula:C18H23NOCor e Forma:SolidPeso molecular:269.38BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Fórmula:C22H18FN5O3SPureza:99.86%Cor e Forma:SolidPeso molecular:451.47CCR5 antagonist 1
CAS:CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Fórmula:C39H46ClF2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:738.33RS 61756-007
CAS:RS 61756-007 is a selective thromboxane receptor (TP) agonist.Fórmula:C23H28O5Pureza:98%Cor e Forma:SolidPeso molecular:384.47Leukotriene B4 dimethyl amide
CAS:LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).Fórmula:C22H37NO3Cor e Forma:SolidPeso molecular:363.53PF-4693627
CAS:PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).Fórmula:C26H29Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:502.43Aeruginosin 98-B
CAS:Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.Fórmula:C29H46N6O9SCor e Forma:SolidPeso molecular:654.78MRS4833
CAS:MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.Fórmula:C30H24F3NO3Cor e Forma:SolidPeso molecular:503.51LRH-1 modulator-1
CAS:LRH-1 modulator-1: potent agonist, boosts IL-10, reduces IL-1b/TNFa, anti-inflammatory in gut.Fórmula:C28H36N2O2SCor e Forma:SolidPeso molecular:464.66Ophiobolin C
CAS:inhibitor of human CCR5 binding to HIV-1 gp120Fórmula:C25H38O3Pureza:98%Cor e Forma:SolidPeso molecular:386.57Fosrolapitant
CAS:Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.Fórmula:C27H29F6N2O8PCor e Forma:SolidPeso molecular:654.49BMS-986104
CAS:BMS-986104 is an effective selective modulator of the S1P1 receptor. It demonstrates efficacy in the mouse EAE model, comparable to that of FTY720. Furthermore, BMS-986104 shows promising remyelination properties in three-dimensional brain cell cultures subjected to lysophosphatidylcholine (LPC)-induced demyelination.Fórmula:C22H35NOCor e Forma:SolidPeso molecular:329.52SAR-150640
CAS:SAR-150640, a selective β3-adrenergic receptor agonist, prevents an increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis.Fórmula:C25H35ClN2O7SCor e Forma:SolidPeso molecular:543.07AL 8810
CAS:AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Fórmula:C24H31FO4Cor e Forma:SolidPeso molecular:402.5Protease-Activated Receptor-1 antagonist 2
Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.Cor e Forma:Solid(±)-Penbutolol
CAS:<p>(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.</p>Fórmula:C18H29NO2Cor e Forma:SolidPeso molecular:291.43Methacycline
CAS:<p>Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.</p>Fórmula:C22H22N2O8Cor e Forma:SolidPeso molecular:442.42DSP-1053 benzenesulfonate
CAS:DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62L-654284
CAS:L-654284 is an α2-adrenergic receptor antagonist characterized by its notable selectivity. It competes with 3H-clonidine and 3H-rauwolscine for binding in vitro, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 effectively blocks the pre-ejaculatory effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. The compound demonstrates significant selectivity for α2 over α1 adrenergic receptors, with a Ki value of 110 nM against 3H-prazosin binding. In vivo, L-654284 significantly increases the turnover of norepinephrine in the rat cerebral cortex, indicating its activity in blocking α2-adrenergic receptors within the central nervous system.Fórmula:C18H24N2O4SCor e Forma:SolidPeso molecular:364.46Butopamine hydrochloride
CAS:Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.Fórmula:C18H24ClNO3Cor e Forma:SolidPeso molecular:337.84AB-FUBINACA 3-fluorobenzyl isomer
CAS:<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Fórmula:C20H21FN4O2Cor e Forma:SolidPeso molecular:368.41O-1269
CAS:<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Fórmula:C22H22Cl3N3OCor e Forma:SolidPeso molecular:450.79L-97-1
CAS:L-97-1 is an antagonist of the adenosine A1 receptor.Fórmula:C29H38N6O3Pureza:98%Cor e Forma:SolidPeso molecular:518.65BAY-3153
CAS:BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .Fórmula:C25H29Cl2N3O4Cor e Forma:SolidPeso molecular:506.42CS-0777
CAS:<p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>Fórmula:C21H31N2O5PCor e Forma:SolidPeso molecular:422.45PF-07054894
CAS:PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.Fórmula:C24H30N6O4Cor e Forma:SolidPeso molecular:466.53D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Fórmula:C21H23ClF2N2O2Cor e Forma:SolidPeso molecular:408.87AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8ZK118182 isopropyl ester
CAS:ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).Fórmula:C23H37ClO5Pureza:98%Cor e Forma:SolidPeso molecular:428.99Substituted piperidines-1
CAS:Substituted piperidines-1 can promote the release of growth hormone in humans and animals.Fórmula:C29H39N7O2Pureza:98%Cor e Forma:SolidPeso molecular:517.67AA 497 (Free Base)
CAS:AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.Fórmula:C14H21NO3Pureza:98%Cor e Forma:SolidPeso molecular:251.32ASN-1377642
CAS:<p>ASN-1377642 is an NK1 receptor antagonist with a Ki value of 251 nM. It demonstrates antitumor activity in breast cancer cells with high expression of NK1R-Tr.</p>Fórmula:C21H16ClN5OSCor e Forma:SolidPeso molecular:421.90Neladenoson
CAS:Neladenoson is an effective and selective agonist of the Adenosine A1 Receptor (A1R). EGFR-IN-162 shows potential for research in heart failure.Fórmula:C29H24ClN5O2S2Cor e Forma:SolidPeso molecular:574.12Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Fórmula:C24H28F3N3O2Cor e Forma:SolidPeso molecular:447.49D1R antagonist 1
CAS:<p>Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].</p>Fórmula:C22H26BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:448.35HU-308
CAS:<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62N-methyl Leukotriene C4
CAS:N-methyl LTC4 is a stable synthetic analog of LTC4 and a selective CysLT2 agonist, useful in studying leukotriene pharmacology.Fórmula:C31H49N3O9SCor e Forma:SolidPeso molecular:639.8Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Fórmula:C14H16N2O5Cor e Forma:SolidPeso molecular:292.287Sitamaquine hydrochloride
CAS:Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Fórmula:C21H35Cl2N3OCor e Forma:SolidPeso molecular:416.43Arpromidine
CAS:<p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462Thielavin B
CAS:Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.Fórmula:C31H34O10Cor e Forma:SolidPeso molecular:566.6PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Fórmula:C25H27FN6O2Pureza:99.9%Cor e Forma:SolidPeso molecular:462.52BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Cor e Forma:SolidPeso molecular:561.63BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Fórmula:C34H51N5O7Pureza:98.81%Cor e Forma:SolidPeso molecular:641.8Vofopitant
CAS:Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).Fórmula:C21H23F3N6OPureza:97.86%Cor e Forma:SolidPeso molecular:432.44LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Fórmula:C26H23Cl2N3O2Pureza:99.21%Cor e Forma:SolidPeso molecular:480.39AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Fórmula:C32H38F2N2O5S2Pureza:98.1%Cor e Forma:SolidPeso molecular:632.78SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Fórmula:C32H33ClN4O3Pureza:97.82% - 98.99%Cor e Forma:SolidPeso molecular:557.08Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Fórmula:C36H45F4N3O5Pureza:97.35% - 98.23%Cor e Forma:SolidPeso molecular:675.75Vofopitant dihydrochloride
CAS:Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.Fórmula:C21H25Cl2F3N6OPureza:98.99%Cor e Forma:SolidPeso molecular:505.36SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Fórmula:C30H41FN2O6Pureza:98.32% - 99.63%Cor e Forma:SolidPeso molecular:544.65Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Fórmula:C27H45NO7Pureza:99.86%Cor e Forma:SolidPeso molecular:495.65Rolapitant hydrochloride
CAS:Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.Fórmula:C25H27ClF6N2O2Pureza:98.35% - 99.79%Cor e Forma:SolidPeso molecular:536.947-Desmethyl-agomelatine
CAS:7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.Fórmula:C14H15NO2Cor e Forma:SolidPeso molecular:229.27JMV 2959
CAS:JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).Fórmula:C30H32N6O2Cor e Forma:SolidPeso molecular:508.61ML-00253764 hydrochloride
CAS:ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).Fórmula:C18H19BrClFN2OCor e Forma:SolidPeso molecular:413.71SR 146131
CAS:SR 146131 is a potent and selective agonist of the nonpeptide receptor.Fórmula:C32H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:610.16SB-399885 hydrochloride
CAS:SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.Fórmula:C18H22Cl3N3O4SPureza:98%Cor e Forma:SolidPeso molecular:482.81CYM 9484
CAS:CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.Fórmula:C27H31N3O3S2Cor e Forma:SolidPeso molecular:509.68BIBP3226 TFA
CAS:BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).Fórmula:C29H32F3N5O5Cor e Forma:SolidPeso molecular:587.59Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Fórmula:C33H46N8O7Pureza:98%Cor e Forma:SolidPeso molecular:666.77Arotinolol
CAS:Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Fórmula:C15H21N3O2S3Cor e Forma:White SolidPeso molecular:371.54ML-290
CAS:ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.Fórmula:C24H21F3N2O5SCor e Forma:SolidPeso molecular:506.49SHA 68
CAS:SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.Fórmula:C26H24FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:445.49HOKU-81
CAS:HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.Fórmula:C12H18ClNO2Cor e Forma:SolidPeso molecular:243.73Pumosetrag Hydrochloride
CAS:Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.Fórmula:C15H18ClN3O2SPureza:98%Cor e Forma:SolidPeso molecular:339.84Beraprost sodium
CAS:Beraprost sodium is a stable and orally active prodrug of PGI2.Fórmula:C24H29NaO5Cor e Forma:SolidPeso molecular:420.481Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Fórmula:C33H34N2O5Pureza:98%Cor e Forma:SolidPeso molecular:538.63dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Fórmula:C37H39NO4Cor e Forma:SolidPeso molecular:561.71(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Fórmula:C6H13Cl2N3Cor e Forma:SolidPeso molecular:198.094-Hydroxyatomoxetine
CAS:4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.Fórmula:C17H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:271.35Vornorexant
CAS:Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.Fórmula:C23H22FN7O2Cor e Forma:SolidPeso molecular:447.474Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Fórmula:C20H30Cl2N4OPureza:98%Cor e Forma:SolidPeso molecular:413.38Goserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Pureza:99.77%Cor e Forma:Odour SolidBRL 15572
CAS:BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:406.95(Rac)-Zevaquenabant
CAS:(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.Fórmula:C25H21ClF3N5O2SCor e Forma:SolidPeso molecular:547.98Sarizotan
CAS:Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.Fórmula:C22H21FN2OCor e Forma:SolidPeso molecular:348.421Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Fórmula:C16H25N3O·xClHPureza:99.25%Cor e Forma:SoildCRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Fórmula:C19H20N2O3SPureza:98%Cor e Forma:SolidPeso molecular:356.44Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Cor e Forma:Odour LiquidBX471 hydrochloride
CAS:BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.Fórmula:C21H25Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:471.351-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
CAS:1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65156 and the CAS number is 24155-42-8.Fórmula:C11H10Cl2N2OCor e Forma:SolidPeso molecular:257.11SKF 89748
CAS:SKF 89748 is an agonists of alpha 1-adrenoceptor.Fórmula:C12H17NOSPureza:98%Cor e Forma:SolidPeso molecular:223.334-Hydroxypropranolol hydrochloride
CAS:4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).Fórmula:C16H22ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:311.8TAK-683
CAS:TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.Fórmula:C64H83N17O13Pureza:98%Cor e Forma:SolidPeso molecular:1298.45Picumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Fórmula:C21H29Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:426.383-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Fórmula:C7H9NOCor e Forma:SolidPeso molecular:123.1551-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Fórmula:C21H41O7PCor e Forma:SolidPeso molecular:436.52Ref: TM-T36907
Produto descontinuado6-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Fórmula:C10H9Cl2NOCor e Forma:SolidPeso molecular:230.09GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Cor e Forma:Odour LiquidTAK-448
CAS:TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.Fórmula:C58H80N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1225.36Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Pureza:98%Cor e Forma:LiquidCanagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Fórmula:C24H25FO5SPureza:98%Cor e Forma:SolidPeso molecular:448.54Ref: TM-T10669
Produto descontinuado2-Methyl-5-HT hydrochloride
CAS:2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Fórmula:C11H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:226.7Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Fórmula:C23H16O6Pureza:99.99%Cor e Forma:Fine Yellow PowderPeso molecular:388.37AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Fórmula:C24H20N2OPureza:99.37%Cor e Forma:SolidPeso molecular:352.43MEN11467
CAS:MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75Flumexadol
CAS:Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.Fórmula:C11H12F3NOPureza:98%Cor e Forma:SolidPeso molecular:231.21GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Fórmula:C24H33NO3SPureza:98%Cor e Forma:SolidPeso molecular:415.59Imetit dihydrobromide
CAS:Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Fórmula:C6H12Br2N4SPureza:98%Cor e Forma:SolidPeso molecular:332.06SB251023
CAS:SB251023 is an agonist of β3-adrenoceptor.Fórmula:C28H34NO6PCor e Forma:SolidPeso molecular:511.55Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Fórmula:C38H40N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:600.75S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Fórmula:C25H26F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:445.47AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Fórmula:C29H40O3Pureza:99.58%Cor e Forma:SolidPeso molecular:436.632-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Fórmula:C8H8N2O3SCor e Forma:LiquidPeso molecular:212.23Dimethandrolone Undecanoate
CAS:Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.Fórmula:C31H50O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:470.73Ref: TM-T27176
Produto descontinuado
