GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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N-Nitroso Atenolol
CAS:<p>N-Nitroso Atenolol is a derivative of Atenolol. At concentrations ranging from 0.1 to 1 mM, it induces DNA fragmentation in rat hepatocytes.</p>Fórmula:C14H21N3O4Cor e Forma:SolidPeso molecular:295.33Orforglipron hemicalcium hydrate
CAS:<p>Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) represents the hemicalcium hydrate form of the calcium salt of Orforglipron, an orally active agonist targeting the Glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in mitigating type 2 diabetes [1].</p>Fórmula:C48H48F2N10O5Ca·H2OCor e Forma:SolidPeso molecular:921.02PAMP-12 (unmodified)
CAS:<p>PAMP-12 (unmodified), an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM), induces hypotension by inhibiting catecholamine release from</p>Fórmula:C77H118N24O15Cor e Forma:SolidPeso molecular:1619.91Adrenotensin (human)
CAS:<p>Adrenotensin: human 153-185 fragment of Adrenomedullin precursor, a 52-amino acid peptide in CGRP hormone family.</p>Fórmula:C143H224N42O43Cor e Forma:SolidPeso molecular:3219.56Zebrafish Kisspeptin-1
CAS:<p>Zebrafish Kisspeptin-1 is the core sequence of the neuropeptide kisspeptin-1, which plays a crucial role in regulating the release of gonadotropin-releasing hormone (GnRH) and modulating the reproductive system.</p>Fórmula:C58H84N16O15Cor e Forma:SolidPeso molecular:1245.39Biotin-NeurokininA
<p>Biotin-NeurokininA: biotinylated peptide, NK-2 receptor agonist, key in human airway and gut function.</p>Fórmula:C60H94N16O16S2Cor e Forma:SolidPeso molecular:1359.61(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
CAS:<p>Potent VP V1R antagonist, lowers rat MAP: '(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin'.</p>Fórmula:C54H76N14O11Cor e Forma:SolidPeso molecular:1097.27[Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2
CAS:<p>[Arg-15,-20,-21, Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) is a synthetic analogue of PACAP 1-27 that exhibits a relaxant effect [1].</p>Fórmula:C157H253N53O42Cor e Forma:SolidPeso molecular:3555.02GLP-1R agonist 19
CAS:<p>GLP-1R agonist 19 (M3190) is a potent, selective GLP-1 receptor agonist that demonstrates excellent plasma and liver microsomal stability, along with low hERG toxicity [1].</p>Fórmula:C94H136FN21O25Cor e Forma:SolidPeso molecular:1979.21[Nle13]-Motilin
CAS:<p>[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist [1] [2] .</p>Fórmula:C121H190N34O35Cor e Forma:SolidPeso molecular:2681.01ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
CAS:<p>ACTH (3-24) is the fragment 3-24 of ACTH, used in disease research including cancer and immune disorders.</p>Fórmula:C124H196N38O27SCor e Forma:SolidPeso molecular:2683.19TT-OAD2
CAS:<p>TT-OAD2 is a non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with the potential for diabetes treatment.</p>Fórmula:C50H49Cl4N3O6Pureza:98%Cor e Forma:SolidPeso molecular:929.75Mazdutide acetate(2259884-03-0 free base)
Mazdutide acetate is a potent (GLP-1R and GCGR agonist that stimulates insulin secretion from mouse pancreatic islets , which can be used to study obesity.Pureza:98.41%Cor e Forma:Odour SolidSphK1&2-IN-1
CAS:<p>SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.</p>Fórmula:C14H14N2O3SPureza:99.59%Cor e Forma:SolidPeso molecular:290.34TRAP-6 amide
CAS:TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.Fórmula:C34H57N11O8Cor e Forma:SolidPeso molecular:747.899Methionyl-Lysyl-Bradykinin
CAS:Methionyl-Lysyl-Bradykinin (Met-Lys-Bradykinin), a Bradykinin analogue, is a kinin [1] [2] .Fórmula:C61H94N18O13SCor e Forma:SolidPeso molecular:1319.58FLLRN
CAS:<p>FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.</p>Fórmula:C31H51N9O7Cor e Forma:SolidPeso molecular:661.79Neuropeptide AF (cattle)
CAS:Neuropeptide AF (cattle) is an RFamide that acts on MrgprA4 (~60 nM), MrgprC11 (~300 nM), NPFF1 (~25-325 nM), NPFF2 (~1-5 nM), and modulates pain.Fórmula:C89H130N24O24Cor e Forma:SolidPeso molecular:1920.13Dolcanatide
CAS:Dolcanatide: oral GC-C agonist with laxative, pain-relief, and anti-inflammatory properties for IBD research.Fórmula:C65H104N18O26S4Cor e Forma:SolidPeso molecular:1681.89Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Fórmula:C130H219N45O40S2Cor e Forma:SolidPeso molecular:3116.54Levocarnitine propionate hydrochloride
CAS:<p>Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.</p>Fórmula:C10H20ClNO4Pureza:90% - 99.77%Cor e Forma:SolidPeso molecular:253.72Zicronapine fumarate
CAS:<p>Zicronapine fumarate, an antipsychotic, targets D1/D2 & 5-HT2A receptors; may treat neuropsychiatric conditions.</p>Fórmula:C26H31ClN2O4Cor e Forma:SolidPeso molecular:470.99L-797,591 hydrochloride
L-797,591 HCl activates SSTR1, boosts p-ERK5 with AG1478, and enhances p38 phosphorylation, reversible by AG1478.Fórmula:C38H50ClN5O2Pureza:98.65% - >99.99%Cor e Forma:SoildPeso molecular:644.30Ghrelin receptor full agonist-2
CAS:<p>Ghrelin receptor full agonist-2 is a highly potent Ghrelin receptor full agonist.</p>Fórmula:C26H28ClN5O5SCor e Forma:SolidPeso molecular:558.05GLP-1R/GIPR agonist-1
<p>GLP-1R/GIPR agonist-1 is a dual receptor agonist for GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). It mimics the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while suppressing glucagon release, thus lowering blood sugar. This compound is used in research related to metabolic disorders such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH).</p>Fórmula:C220H342N55O69Peso molecular:4858.49434Palmitoyl tetrapeptide-20 TFA
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide and acts as an agonist of α-MSH. It protects follicular melanocytes by boosting catalase expression and activating melanogenesis.Fórmula:C38H70N6O8·xC2HF3O2Endolide F
Endolide F (Compound 2) is a proline-containing lactone that serves as a moderate antagonist of the arginine vasopressin V1A receptor.Fórmula:C25H32N4O6Peso molecular:484.23218GLP-1R agonist 20
<p>GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.</p>Fórmula:C31H30Cl2F2N4O5Peso molecular:646.15613palm11-PrRP31
<p>Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.</p>Fórmula:C181H289N55O46SPeso molecular:4001.16865SPN009
SPN009 (Sequence 3) is a GLP-1 receptor (GLP-1 Receptor) agonist, with an EC50 of 2.84 nM, and improves type 2 diabetes in DB/DB mouse models.Fórmula:C191H299N45O59Peso molecular:4167.17798A 77636 hydrochloride
CAS:<p>A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM).</p>Fórmula:C20H28ClNO3Pureza:99.57%Cor e Forma:SolidPeso molecular:365.89palm-PrRP31
palm-PrRP31 is a potent dual agonist for GPR10 (EC50=72 pM) and NPFF-R2. It activates downstream signaling pathways by binding to GPR10 and NPFF-R2 receptors, leading to reduced appetite and increased energy expenditure. palm-PrRP31 can be utilized to investigate its mechanism of action in the nervous system, thereby elucidating the complex biological processes involved in the regulation of appetite and energy expenditure.Fórmula:C176H282N56O43SPeso molecular:3900.1322Cafelkibart
<p>Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Cor e Forma:Odour LiquidNPS ALX Compound 4a hydrochloride(1:1)
<p>NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.</p>Fórmula:C25H26ClN3O2SPureza:99.84%Cor e Forma:SoildPeso molecular:468.01M617
CAS:<p>Galanin GAL1 agonist, Ki: GAL1 0.23 nM, GAL2 5.71 nM; boosts rat appetite, lessens inflammation pain.</p>Fórmula:C112H161N29O28Pureza:98%Cor e Forma:SolidPeso molecular:2361.68Adatanserin hydrochloride
CAS:Adatanserin hydrochloride (WY50324 hydrochloride) is a 5-HT(1A)/5-HT(2) receptor ligand that is neuroprotective and may be used in the study of depression.Fórmula:C21H32ClN5OPureza:99.64%Cor e Forma:SolidPeso molecular:405.96Nα-Methylhistamine FA
<p>Nα-Methylhistamine FA is a histamine H3 receptor agonist</p>Fórmula:C7H13N3O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:171.2Nadolol
CAS:<p>Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.</p>Fórmula:C17H27NO4Pureza:99.87% - 99.92%Cor e Forma:White To Off-White Crystalline Powder SolidPeso molecular:309.40Roxatidine
CAS:<p>Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.</p>Fórmula:C17H26N2O3Cor e Forma:SolidPeso molecular:306.4Azaline
CAS:<p>Azaline is a gonadorelin antagonist.</p>Fórmula:C74H106ClN23O12Pureza:98%Cor e Forma:SolidPeso molecular:1545.26RWJ 676070
CAS:<p>RWJ 676070 is an antagonist of vasopressin V1A/V2 receptor.</p>Fórmula:C30H26ClFN2O5Cor e Forma:SolidPeso molecular:548.99Pancreatic Polypeptide, rat
CAS:<p>Rat Pancreatic Polypeptide: 36-amino acid peptide, NPYR4 agonist, secreted by islet PP cells.</p>Fórmula:C195H298N58O57SPureza:98%Cor e Forma:SolidPeso molecular:4398.87A-286501
CAS:<p>A-286501: Oral adenosine kinase inhibitor, IC50=0.47 nM, reduces pain via non-opioid, non-NSAID ADO receptors.</p>Fórmula:C11H14BrN5O2Pureza:98%Cor e Forma:SolidPeso molecular:328.17Bremelanotide
CAS:<p>Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R.</p>Fórmula:C50H68N14O10Pureza:98%Cor e Forma:White PowderPeso molecular:1025.16Jmv 176
CAS:<p>Jmv 176 is a CCK agonist when first given and becomes a cholecystokinin antagonist after 3-4 hours.</p>Fórmula:C53H70N8O15SPureza:98%Cor e Forma:SolidPeso molecular:1091.24Calcitonin (8-32), salmon
CAS:Calcitonin (8-32), salmon: selective amylin receptor antagonist, regulates calcium/phosphorus, thyroid origin, 32-aa peptide.Fórmula:C119H198N36O37Pureza:98%Cor e Forma:SolidPeso molecular:2725.06Anthramycin
CAS:<p>Anthramycin: a PBD family antibiotic with antitumor effects and CNS cholecystokinin antagonist properties in mice.</p>Fórmula:C16H17N3O4Cor e Forma:SolidPeso molecular:315.32Fluphenazine free base
CAS:<p>Flufenazine: antipsychotic for schizophrenia, blocks dopamine D2 receptors, reduces hallucinations and delusions.</p>Fórmula:C22H26F3N3OSCor e Forma:SolidPeso molecular:437.52NXT-10796
<p>NXT-10796 is an orally active, intestinally restricted agonist of the EP4 receptor [1].</p>Fórmula:C23H31N3O6Pureza:98%Cor e Forma:SolidPeso molecular:445.51YM 09538
CAS:<p>YM 09538 is a biochemical.</p>Fórmula:C18H25ClN2O5SCor e Forma:SolidPeso molecular:416.92
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