GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Apelin-12 acetate
<p>Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor.</p>Fórmula:C66H107N21O16SPureza:98.82%Cor e Forma:SolidPeso molecular:1482.75RGS2-Galpha-q interaction-IN-1
RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. It inhibits the growth of cancer cell lines that express RGS2 and has anti-cell migration properties.Fórmula:C30H30ClN7O3Cor e Forma:SolidPeso molecular:572.06Alverine hydrochloride
CAS:<p>Alverine hydrochloride is a parasympatholytic.</p>Fórmula:C20H28ClNCor e Forma:SolidPeso molecular:317.9R 50595
CAS:<p>R 50595 is a selective non-competitive cisapride antagonist.</p>Fórmula:C30H35Cl2F2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:594.52GLP-1R Antagonist 1
CAS:<p>GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).</p>Fórmula:C16H11ClF6N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:440.73Rubraxanthone
CAS:<p>Rubraxanthone is a PAF inhibitor isolated from Garcinia parvifolia Miq.</p>Fórmula:C24H26O6Cor e Forma:SolidPeso molecular:410.466Lys-(Des-Arg9,Leu8)-Bradykinin
CAS:<p>Lys-(Des-Arg9,Leu8)-Bradykinin is a selective antagonist of the bradykinin B1 receptor [1].</p>Fórmula:C47H75N13O11Pureza:98%Cor e Forma:SolidPeso molecular:998.18A 76154
CAS:<p>A 76154 is an antagonist of leutenizing hormone releasing hormone (LHRH).</p>Fórmula:C70H93FN12O12Cor e Forma:SolidPeso molecular:1313.584LEK 8804
CAS:<p>LEK 8804 is a 5-HT(2) receptor antagonist and 5-HT(1A) receptor agonist.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37PSB-1114 triethylamine
<p>PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50</p>Fórmula:C10H15F2N3O13P3S·xC6H15NPureza:98%Cor e Forma:Solidα-CGRP (mouse, rat) TFA
<p>α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions and</p>Fórmula:C162H262N50O52S2·C2HF3O2Pureza:98%Cor e Forma:Solid17-trifluoromethylphenyl trinor Prostaglandin F2α
CAS:<p>A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.</p>Fórmula:C24H31F3O5Cor e Forma:SolidPeso molecular:456.502BM213 acetate
<p>BM213 acetate is a selective C5aR1 agonist with antitumor activity that induces C5aR1-mediated calcium mobilization and pERK1/2 signaling.</p>Fórmula:C45H74N12O12Pureza:99.88%Cor e Forma:SolidPeso molecular:975.14PACAP-38 (16-38), human, mouse, rat
CAS:<p>PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production</p>Fórmula:C123H215N39O28SPureza:98%Cor e Forma:SolidPeso molecular:2720.33Emoghrelin
CAS:<p>Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].</p>Fórmula:C24H22O13Pureza:98%Cor e Forma:SolidPeso molecular:518.42FFN246
CAS:<p>FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and</p>Fórmula:C15H13FN2OPureza:98%Cor e Forma:SolidPeso molecular:256.27Vanicoside E
CAS:<p>Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine and L-DOPA with IC 50 s of 45.23 μM and 189.96 μM, respectively [1] [2] .</p>Fórmula:C53H52O22Cor e Forma:SolidPeso molecular:1040.9711β-Prostaglandin E2
CAS:<p>11β-PGE2 is the C-11 epimer of PGE2.</p>Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.47Oxmetidine FA
<p>Oxmetidine FA is an orally available specific histamine H2 receptor antagonist with antiulcerogenic properties.</p>Fórmula:C20H23N5O5SPureza:97.34%Cor e Forma:SoildPeso molecular:445.49KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Fórmula:C24H32N2O8Pureza:98.12%Cor e Forma:SolidPeso molecular:476.52MLS1082
CAS:<p>MLS1082 is a D1-like dopamine receptor (D1R) orthosteric modulatothat stimulates G-protein signaling upon dopamine activation for neurodegenerative disorders.</p>Fórmula:C24H23N3O2Pureza:99.53%Cor e Forma:SolidPeso molecular:385.46Prostaglandin K1
CAS:<p>Prostaglandin K1 (compound 46) is a structurally modified prostanoid analog with an EC50 and Ki of 2800 nM for the EP1 receptor.</p>Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.475-HT2A receptor agonist-6
CAS:<p>5-HT2A receptor agonist-6 (compound 47) is a selective agonist of the 5-HT2A receptor with a pEC50 value of 6.58.</p>Fórmula:C18H19N3O3Cor e Forma:SolidPeso molecular:325.364-Hydroxy MPT
CAS:<p>4-Hydroxy MPT (4-OH-MPT) is a serotonin-active compound that acts as an agonist for 5-HT2A and 5-HT2B receptors, with EC50 values of 3.82 nM and 3.4 nM, respectively.</p>Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32exo-Tetrahydrocannabivarin
CAS:<p>exo-Tetrahydrocannabivarin (Compound 12) is an analog of Δ9,11-THC. It weakly binds to cannabinoid receptors (CB) with an IC50 of 1.4 μM. In mice, exo-Tetrahydrocannabivarin exhibits activity related to both motor function and analgesia.</p>Fórmula:C19H26O2Cor e Forma:SolidPeso molecular:286.41Afubiata
CAS:<p>ADB-FUBIATA is a synthetic cannabinoid studied for its metabolic profile, along with AFUBIATA, CH-FUBIATA, and CH-PIATA. This in vitro analysis by Watanabe S, et al., examines these compounds, as published in "Arch Toxicol," 2023 Dec;97(12):3085-3094.</p>Fórmula:C27H29FN2OCor e Forma:SolidPeso molecular:416.53S1R agonist 2
CAS:<p>S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.</p>Fórmula:C21H27NOPureza:98.85%Cor e Forma:SolidPeso molecular:309.45LTD4 antagonist 2
CAS:<p>LTD4 antagonist 2 (compound 6) functions as a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM for the cysteinyl leukotriene 1 receptor (CysLT1R). Additionally, it acts as an agonist for the G protein-coupled bile acid receptor 1 (GPBAR1), making it applicable for research into colitis, metabolic syndrome, and other GPBAR1- and CysLT1R-related diseases.</p>Fórmula:C17H13NO3Cor e Forma:SolidPeso molecular:279.29Methicillin sodium hydrate
CAS:<p>Methicillin sodium hydrate, a narrow-spectrum antibiotic, combats methicillin-resistant Staphylococcus strains and treats various infections.</p>Fórmula:C17H21N2NaO7SCor e Forma:SolidPeso molecular:420.41DOTA-EB-TATE
DOTA-EB-TATE is formed by combining the SST peptide derivative DOTA-octreotate with an Evans blue analog (EB). This peptide drug conjugate (PDC) enhances the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. Additionally, DOTA-EB-TATE serves in the synthesis/research of radiopharmaceutical conjugates (RDC).Fórmula:C105H133N21O30S5Peso molecular:2329.63Endothelin-3, human, mouse, rabbit, rat
CAS:<p>Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.</p>Fórmula:C121H168N26O33S4Pureza:98%Cor e Forma:SolidPeso molecular:2643.04Stressin I TFA
<p>Stressin I (Cyclo(31-34)[DPhe12, Nle21, 38, Glu31, Lys34]Ac-hCRF(4-41)) TFA, with a K i of 1.7 nM, is a potent and selective agonist of the CRF1 receptor.</p>Pureza:98%Cor e Forma:Odour SolidKisspeptin 13
CAS:<p>Kisspeptin 13 activates GPR54 & GnRH receptors, boosts memory, and aids in Alzheimer's research.</p>Fórmula:C78H107N21O18Cor e Forma:SolidPeso molecular:1626.81Methionyl-Lysyl-Bradykinin
CAS:Methionyl-Lysyl-Bradykinin (Met-Lys-Bradykinin), a Bradykinin analogue, is a kinin [1] [2] .Fórmula:C61H94N18O13SCor e Forma:SolidPeso molecular:1319.58YFLLRNP
CAS:<p>YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.</p>Fórmula:C45H67N11O10Cor e Forma:SolidPeso molecular:922.08Parstatin(human) TFA
<p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>Fórmula:C193H331F3N64O55S3Cor e Forma:SolidPeso molecular:4581.28SFNGGP-NH2
CAS:SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.Fórmula:C25H36N8O8Cor e Forma:SolidPeso molecular:576.6Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Fórmula:C130H219N45O40S2Cor e Forma:SolidPeso molecular:3116.54Levocarnitine propionate hydrochloride
CAS:<p>Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.</p>Fórmula:C10H20ClNO4Pureza:90% - 99.77%Cor e Forma:SolidPeso molecular:253.72Cyclosomatostatin Acetate
<p>Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell</p>Fórmula:C46H61N7O8Pureza:98.83%Cor e Forma:SolidPeso molecular:840.02ORG 2766
CAS:<p>ORG 2766 is an ACTH 4-9 (H-Met(O)-Glu-His-Phe-D-Lys-Phe-OH) analog and neurotrophic peptide.</p>Fórmula:C40H55N9O11SCor e Forma:SolidPeso molecular:869.99Secretoneurin, rat
CAS:<p>Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).</p>Fórmula:C159H252N40O58Pureza:98%Cor e Forma:SolidPeso molecular:3651.95A3AR agonist 2
<p>Compound 19, a selective A3 Adenosine Receptor (A3AR) agonist (K i : 22.1 nM), effectively stimulates β-arrestin2 recruitment with an EC 50 value of 4.36 nM.</p>Fórmula:C34H34N6O6Pureza:98%Cor e Forma:SolidPeso molecular:622.67Somatostatin 1-28 acetate
<p>Somatostatin 1-28 acetate circulates in human plasma.</p>Pureza:99.22%Cor e Forma:SoildUlaritide
CAS:<p>Ularitide is a 32-amino acid peptide from ANP prohormone, resistant to dog kidney cortex peptidase.</p>Fórmula:C145H234N52O44S3Pureza:98%Cor e Forma:SolidPeso molecular:3505.97Guanylin (mouse, rat)
CAS:<p>Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1].</p>Fórmula:C60H90N16O22S4Pureza:98%Cor e Forma:SolidPeso molecular:1515.71NF546 hydrate
<p>NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived</p>Fórmula:C47H44N6Na4O17P4·5H2OPureza:98%Cor e Forma:SolidPeso molecular:1424.011,8-Cineole
CAS:<p>Eucalyptol, a natural monoterpenoid and cyclic ether found in eucalyptus species, effectively controls excessive airway mucus secretion and asthma by inhibiting pro-inflammatory cytokines. It serves as an efficacious treatment for non-purulent sinusitis, reducing inflammation and pain when applied topically, and demonstrating leukemic cell-killing capabilities in vitro.</p>Fórmula:C10H18OPureza:97.44% - 97.44%Cor e Forma:SolidPeso molecular:154.25(+)-ORM-10921
CAS:<p>(+)-ORM-10921 is a conformation of ORM-10921 and can be used in chemical synthesis studies.</p>Fórmula:C18H23NO2Pureza:99.85%Cor e Forma:SoildPeso molecular:285.38TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Fórmula:C16H16ClN5Pureza:99.85% - 99.89%Cor e Forma:SoildPeso molecular:313.78
