GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Dexbrompheniramine
CAS:<p>Dexbrompheniramine: oral H1 antagonist, antihistamine for hay fever and urticaria research.</p>Fórmula:C16H19BrN2Cor e Forma:SolidPeso molecular:319.24N-Nitroso Atenolol
CAS:<p>N-Nitroso Atenolol is a derivative of Atenolol. At concentrations ranging from 0.1 to 1 mM, it induces DNA fragmentation in rat hepatocytes.</p>Fórmula:C14H21N3O4Cor e Forma:SolidPeso molecular:295.33JMV-1645
CAS:<p>JMV-1645 is an effective and selective B(1) bradykinin receptor antagonist.</p>Fórmula:C49H69N13O12SPureza:98%Cor e Forma:SolidPeso molecular:1064.23Azaline
CAS:<p>Azaline is a gonadorelin antagonist.</p>Fórmula:C74H106ClN23O12Pureza:98%Cor e Forma:SolidPeso molecular:1545.26Org 13011
CAS:Org 13011 has CNS activity and induces conditioned taste aversion by mediating 5-HT 1A receptors.Fórmula:C18H25F3N4OPureza:98.02%Cor e Forma:SoildPeso molecular:370.41Clopidogrel-related Compound B hydrochloride
CAS:<p>Clopidogrel Related Compound B is a useful organic compound for research related to life sciences.</p>Fórmula:C16H17Cl2NO2SCor e Forma:SolidPeso molecular:358.28Dexbrompheniramine maleate
CAS:<p>Dexbrompheniramine is an antihistamine used for hay fever and urticaria, blocking H1 receptors in the body.</p>Fórmula:C20H23BrN2O4Cor e Forma:SolidPeso molecular:435.318Antidepressant agent 4
<p>Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.</p>Fórmula:C19H38ClN5O2SCor e Forma:SolidPeso molecular:436.06PSB-22269
<p>PSB-22269 is identified as a GPR17 antagonist with a Ki value of 8.91 nM. It exhibits significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies indicate that the binding site of PSB-22269 includes positively charged arginine residues and a hydrophobic pocket. PSB-22269 promotes myelin regeneration strategies, offering potential for multiple sclerosis research.</p>Fórmula:C26H21NO6Cor e Forma:SolidPeso molecular:443.45Cetirizine Impurity C dihydrochloride
CAS:<p>Cetirizine Impurity C dihydrochloride is a Cetirizine metabolite and long-acting H1-antihistamine.</p>Fórmula:C21H27Cl3N2O3Cor e Forma:SolidPeso molecular:461.81Galanin (1-29)(rat, mouse)
CAS:<p>Non-selective galanin agonist; Ki: GAL1-0.98, GAL2-1.48, GAL3-1.47 nM. Anticonvulsant, stops full seizures in rats.</p>Fórmula:C141H211N43O41Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:3164.499FR252384
CAS:<p>FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM).</p>Fórmula:C18H17N3Pureza:98%Cor e Forma:SolidPeso molecular:275.35Binospirone
CAS:Binospirone (MDL 73005EF) is a 5-HT1A receptor agonist with anxiolytic activity used in the study of movement disorders associated with neurologic dysfunction.Fórmula:C20H26N2O4Pureza:97.57% - 98.96%Cor e Forma:SoildPeso molecular:358.435-HT1AR agonist 2
<p>5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.</p>Fórmula:C31H31N5O3Cor e Forma:SolidPeso molecular:521.61HAEGTFT
CAS:<p>HAEGTFT is the first N-terminal 1-7 residues of GLP-1 peptide.</p>Fórmula:C33H47N9O12Pureza:98%Cor e Forma:SolidPeso molecular:761.78Cenicriviroc Mesylate
CAS:<p>Cenicriviroc Mesylate (TBR-652 Mesylate) is an oral dual CCR2/CCR5 antagonist exhibiting anti-inflammatory and anti-fibrotic effects for liver fibrosis.</p>Fórmula:C42H56N4O7S2Pureza:98.819%Cor e Forma:SolidPeso molecular:793.05Neurokinin A(4-10)
CAS:<p>Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .</p>Fórmula:C34H54N8O10SPureza:98%Cor e Forma:SolidPeso molecular:766.912,6-DMA hydrochloride
CAS:<p>2,6-DMA hydrochloride is a phenethylamine and acts as an agonist of the serotonin 5-HT2 receptor, with a pA2 value of 5.09.</p>Fórmula:C11H18ClNO2Cor e Forma:SolidPeso molecular:231.72Nadolol
CAS:<p>Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.</p>Fórmula:C17H27NO4Pureza:99.87% - 99.92%Cor e Forma:White To Off-White Crystalline Powder SolidPeso molecular:309.40SphK1&2-IN-1
CAS:<p>SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.</p>Fórmula:C14H14N2O3SPureza:99.59%Cor e Forma:SolidPeso molecular:290.34Benzquinamide
CAS:<p>Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer</p>Fórmula:C22H32N2O5Pureza:94.86%Cor e Forma:SolidPeso molecular:404.5Tirzepatide
CAS:<p>Tirzepatide (LY-3298176) is a dual glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptor agonist.</p>Fórmula:C225H348N48O68Pureza:99.52% - 99.99%Cor e Forma:SolidPeso molecular:4813.45[Ala11,D-Leu15]-Orexin B acetate
<p>[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).</p>Fórmula:C122H210N44O37SPureza:98.18%Cor e Forma:SolidPeso molecular:2917.31Urocortin II, mouse
CAS:<p>Mouse Urocortin II: Selective CRF2 agonist, Ki 0.66 nM for CRFR2, >100 nM for CRFR1, affects central neural circuits.</p>Fórmula:C187H320N56O50Cor e Forma:SolidPeso molecular:4152.96PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Fórmula:C28H41N7O9·xC2HF3O2Cor e Forma:SolidDolcanatide
CAS:Dolcanatide: oral GC-C agonist with laxative, pain-relief, and anti-inflammatory properties for IBD research.Fórmula:C65H104N18O26S4Cor e Forma:SolidPeso molecular:1681.89Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Fórmula:C130H219N45O40S2Cor e Forma:SolidPeso molecular:3116.54Azaline B
CAS:<p>Azaline B is an antagonist of the gonadotropin-releasing hormone (GnRH), with an IC50 of 1.37 nM. It is utilized in research related to pathologies associated with sex hormones, ovulation induction, and male contraception.</p>Fórmula:C80H102ClN23O12Cor e Forma:SolidPeso molecular:1613.27Cyclosomatostatin Acetate
<p>Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell</p>Fórmula:C46H61N7O8Pureza:98.83%Cor e Forma:SolidPeso molecular:840.02CB2R/FAAH modulator-2
CAS:<p>CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH.</p>Fórmula:C24H33NO2Pureza:99.15%Cor e Forma:SoildPeso molecular:367.52Antipsychotic agent-2
<p>Compound 11: potent antipsychotic, binds 5-HT1A/2A/2C, D2, H1 receptors; K is 56.6-1140 nM, BBB permeable.</p>Fórmula:C22H26FN5OCor e Forma:SolidPeso molecular:395.47L-797,591 hydrochloride
L-797,591 HCl activates SSTR1, boosts p-ERK5 with AG1478, and enhances p38 phosphorylation, reversible by AG1478.Fórmula:C38H50ClN5O2Pureza:98.65% - >99.99%Cor e Forma:SoildPeso molecular:644.30N,N′-Diferuloylputrescine
CAS:<p>N,N′-Diferuloylputrescine acts as a pigment inhibitor, showing a 57% reduction in pigmentation.</p>Fórmula:C24H28N2O6Pureza:98%Cor e Forma:SolidPeso molecular:440.49Methylhexanamine hydrochloride
CAS:<p>Methylhexanamine hydrochloride is a fatty amine and vasoconstrictor that functions as a nasal decongestant when inhaled through the nasal mucosa.</p>Fórmula:C7H18ClNCor e Forma:SolidPeso molecular:151.68SB 216641
CAS:<p>SB 216641 is a 5-HT (1B/1D) antagonist with anxiolytic activity for the study of anxiety disorders and depression.</p>Fórmula:C28H30N4O4Pureza:98.09%Cor e Forma:SolidPeso molecular:486.56Adatanserin hydrochloride
CAS:Adatanserin hydrochloride (WY50324 hydrochloride) is a 5-HT(1A)/5-HT(2) receptor ligand that is neuroprotective and may be used in the study of depression.Fórmula:C21H32ClN5OPureza:99.64%Cor e Forma:SolidPeso molecular:405.96GLP-1R Agonist DMB
CAS:<p>GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor).</p>Fórmula:C13H15Cl2N3O2SPureza:99.52%Cor e Forma:SolidPeso molecular:348.25GPR183 antagonist-3
<p>GPR183 antagonist-3 (compound 33) is an orally active GPR183 antagonist with an IC50 value of 8.7 μM. It demonstrates significant in vitro anti-migration and anti-inflammatory activity in monocytes and can alleviate pathological symptoms in experimental colitis induced by dextran sulfate sodium.</p>Fórmula:C21H19BrN4O2SPeso molecular:470.04121Kisspeptin 234
CAS:<p>Kisspeptin receptor antagonist; blocks kisspeptin-10 effects on IP (IC50 = 7 nM) and GnRH release.</p>Fórmula:C63H78N18O13Pureza:98%Cor e Forma:SolidPeso molecular:1295.42NPFF2-R ligand 1
<p>NPFF2-R ligand 1 (Compound 16a) is an NPFF2-R ligand with Ki values of 228 nM for NPFF1-R and 27 nM for NPFF2-R, and can be utilized in research on central nervous system-related disorders.</p>Fórmula:C32H41N3OPeso molecular:483.32496Myristoylated ARF6 (2-13)
<p>Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.</p>Fórmula:C74H128N16O18Peso molecular:1528.95925CI-988 hemihydrate
<p>CI-988 hemihydrate (PD134308) is a potent and selective orally active CCK2R (cholecystokinin 2 receptor) antagonist, with an IC50 of 1.7 nM for mouse cortical CCK2. It is over 1600 times more selective for CCK2 than for CCK1 receptors. CI-988 hemihydrate exhibits anxiolytic and antitumor properties.</p>Fórmula:C35H42N4O6H2OPeso molecular:632.3218-Chloro caffeine
CAS:<p>8-Chloro caffeine binds to adenosine receptors with a Ki of 30 µM. It enhances UV-induced chromosomal aberrations in the Cl-I type Chinese hamster embryo lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine.</p>Fórmula:C8H9ClN4O2Cor e Forma:SolidPeso molecular:228.64Somatostatin-28 (1-14)
CAS:<p>Somatostatin-28 (1-14) is a truncated neuropeptide from prosomatostatin cleavage.</p>Fórmula:C61H105N23O21SPureza:98%Cor e Forma:SolidPeso molecular:1528.71Hemokinin 1 (mouse)
CAS:<p>Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.</p>Fórmula:C61H100N22O15SPureza:98%Cor e Forma:White PowderPeso molecular:1413.65Etelcalcetide
CAS:<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Fórmula:C38H73N21O10S2Pureza:98%Cor e Forma:SolidPeso molecular:1048.26Nebentan
CAS:<p>Nebentan (YM598) is an oral, selective ETA antagonist; Ki: 0.697 nM (ETA), 569 nM (ETB); may slow cor pulmonale, myocardial infarction.</p>Fórmula:C24H21N5O5SCor e Forma:SolidPeso molecular:491.52Neuropeptide S(Mouse)
CAS:<p>Endogenous NPSR agonist, EC50 = 3 nM. Boosts Ca2+ levels, activity, wakefulness, reduces anxiety in mice.</p>Fórmula:C93H156N34O27Pureza:98%Cor e Forma:SolidPeso molecular:2182.4716-phenoxy tetranor Prostaglandin F2α methyl ester
CAS:<p>Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.</p>Fórmula:C23H32O6Cor e Forma:SolidPeso molecular:404.503BMS-604992 dihydrochloride
CAS:<p>BMS-604992 dihydrochloride is a selective GHSR agonist with high affinity (Ki=2.3 nM) and potent activity (EC50=0.4 nM), stimulating rodent appetite.</p>Fórmula:C24H33Cl2N7O5Cor e Forma:SolidPeso molecular:570.47
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