GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Jatrorrhizine hydroxide
CAS:<p>Jatrorrhizine hydroxide: alkaloid from Coptis chinensis; neuroprotective, antimicrobial, antiplasmodial, antioxidant; AChE inhibitor, affects 5-HT/NE uptake.</p>Fórmula:C20H21NO5Cor e Forma:SolidPeso molecular:355.38Exendin-3/4 (59-86)
<p>Exendin-3/4 (59-86) is a Exendin-4 peptide derivative.</p>Fórmula:NAPureza:98%Cor e Forma:SolidPeso molecular:3055.49SAR441255
SAR441255 is a potent unimolecular peptide that acts as a GLP-1/GIP/GCG receptor triagonist, demonstrating balanced activation across all three target receptorsCor e Forma:Odour SolidSemaglutide TFA
<p>Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels and reduces cardiovascular risk in diabetic patients</p>Fórmula:C189H290F3N45O61Pureza:99.69%Cor e Forma:SolidPeso molecular:4225.6482d[Cha4]-AVP
CAS:Potent human V1B vasopressin receptor agonist; Ki: V1B=1.2 nM; increases ACTH, corticosterone; low vasopressor effect.Fórmula:C50H71N13O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1094.31HS024 TFA
<p>HS024, a selective MC4 receptor antagonist, exhibits affinity with Ki values of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1 receptors, respectively</p>Fórmula:C60H80F3N19O12S2Cor e Forma:SolidPeso molecular:1380.52APJ receptor agonist 1
CAS:<p>Potent APJ-R agonist 1, biphenyl acid, EC50: 0.093 nM (human), 0.12 nM (rat), targets apelin-13, promising for heart failure study.</p>Fórmula:C31H26ClN3O3Cor e Forma:SolidPeso molecular:524.02MrgprX2 antagonist-5
CAS:<p>MrgprX2 antagonist-5 from patent WO2020223255A1 inhibits MrgprX2, useful for inflammatory skin disorder studies.</p>Fórmula:C19H13ClF2N4O2SCor e Forma:SolidPeso molecular:434.85BIM-23190 hydrochloride
<p>BIM-23190 hydrochloride, somatostatin analog, SSRT2/5 agonist, Ki: 0.34 nM (SSTR2), 11.1 nM (SSTR5). Used in cancer, acromegaly research.</p>Cor e Forma:LiquidGLP-1(28-36)amide TFA
<p>GLP-1(28-36)amide TFA, a nonapeptide cleavage product of GLP-1, shows antioxidant properties with anti-diabetic and cardioprotective effects.</p>Fórmula:C56H86F3N15O11Cor e Forma:SolidPeso molecular:1202.37PACAP-38 (16-38), human, mouse, rat
CAS:<p>PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production</p>Fórmula:C123H215N39O28SPureza:98%Cor e Forma:SolidPeso molecular:2720.33Detomidine carboxylic acid
CAS:<p>Detomidine carboxylic acid, a urine metabolite of detomidine, is a synthetic α2-agonist, animal analgesic, with cardiac, respiratory, and diuretic effects.</p>Fórmula:C12H12N2O2Pureza:98%Cor e Forma:SolidPeso molecular:216.24Vanicoside E
CAS:<p>Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine and L-DOPA with IC 50 s of 45.23 μM and 189.96 μM, respectively [1] [2] .</p>Fórmula:C53H52O22Cor e Forma:SolidPeso molecular:1040.97Pasireotide ditrifluoroacetate
<p>Pasireotide is a stable cyclohexapeptide somatostatin mimic.</p>Fórmula:C62H68F6N10O13Pureza:98%Cor e Forma:SolidPeso molecular:1275.25Scyliorhinin II
CAS:Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.Fórmula:C77H119N21O26S3Pureza:98%Cor e Forma:SolidPeso molecular:1851.0917-trifluoromethylphenyl trinor Prostaglandin F2α
CAS:<p>A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.</p>Fórmula:C24H31F3O5Cor e Forma:SolidPeso molecular:456.50211β-Prostaglandin E2
CAS:<p>11β-PGE2 is the C-11 epimer of PGE2.</p>Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.47LH-RH (7-10)
CAS:LH-RH (7-10), a tetrapeptide, is a key LHRH degradation product found in macrophages and pneumocytes.Fórmula:C19H36N8O4Cor e Forma:SolidPeso molecular:440.54HAEGTFT
CAS:<p>HAEGTFT is the first N-terminal 1-7 residues of GLP-1 peptide.</p>Fórmula:C33H47N9O12Pureza:98%Cor e Forma:SolidPeso molecular:761.78Kisspeptin-10, human
CAS:<p>Kisspeptin-10, human is an effective vasoconstrictor and inhibitor of angiogenesis.</p>Fórmula:C63H83N17O14Pureza:98%Cor e Forma:SolidPeso molecular:1302.462Apraglutide
CAS:Apraglutide (FE 203799 is a synthetic 33-amino acid peptide and long-acting glp-2 analogue.Fórmula:C172H263N43O52Pureza:98%Cor e Forma:SolidPeso molecular:3765.25Kinetensin
CAS:Kinetensin is a neurotensin-like peptide.Fórmula:C56H85N17O11Pureza:98%Cor e Forma:White Lyophilised SolidPeso molecular:1172.38[D-Phe12]-Bombesin
CAS:<p>Bombesin receptor antagonist</p>Fórmula:C74H112N22O18SPureza:98%Cor e Forma:SolidPeso molecular:1629.88Dexbrompheniramine maleate
CAS:<p>Dexbrompheniramine is an antihistamine used for hay fever and urticaria, blocking H1 receptors in the body.</p>Fórmula:C20H23BrN2O4Cor e Forma:SolidPeso molecular:435.318YM 09538
CAS:<p>YM 09538 is a biochemical.</p>Fórmula:C18H25ClN2O5SCor e Forma:SolidPeso molecular:416.92GLP-2(1-33)(human)
CAS:GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.Fórmula:C165H254N44O55SPureza:98%Cor e Forma:SolidPeso molecular:3766.19Pal-Glu(OSu)-OH
CAS:<p>Pal-Glu(OSu)-OH is a Liraglutide side chain, a GLP-1 agonist for type 2 diabetes study.</p>Fórmula:C25H42N2O7Cor e Forma:SolidPeso molecular:482.618Prostaglandin J2
CAS:<p>PGJ2, a PGD2 metabolite, is a DP agonist (Ki: 0.9 nM hDP, 6.6 nM hCRTH2), induces cAMP (EC50: 1.2 nM), oxidative stress, neuronal apoptosis, and neurotoxicity.</p>Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.45CYN 154806
CAS:CYN 154806: potent sst2 antagonist; pIC50: 8.58 (sst2), 5.41 (sst1), 6.07 (sst3), 5.76 (sst4), 6.48 (sst5).Fórmula:C56H68N12O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1197.34NF546
CAS:<p>NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).</p>Fórmula:C47H44N6Na4O17P4Pureza:98%Cor e Forma:SolidPeso molecular:1180.74NPC 567
CAS:<p>NPC 567 is an antagonist of the bradykinin receptor.</p>Fórmula:C60H87N19O13Pureza:98%Cor e Forma:SolidPeso molecular:1282.48[Ala11,D-Leu15]-Orexin B(human)
CAS:<p>OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).</p>Fórmula:C120H206N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2857.28JNJ-40929837 succinate
CAS:<p>JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].</p>Fórmula:C22H24N4O2S·xC4H6O4Cor e Forma:SolidHuman growth hormone-releasing factor TFA
<p>Human growth hormone-releasing factor TFA is a hypothalamic peptide that promotes GH secretion by targeting pituitary GHRHR.</p>Fórmula:C217H359F3N72O68SCor e Forma:SolidPeso molecular:5153.67Substance P (alligator)
CAS:<p>Substance P from alligator: a neuropeptide with structure Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.</p>Fórmula:C63H98N20O13SCor e Forma:SolidPeso molecular:1375.64Kisspeptin 234
CAS:<p>Kisspeptin receptor antagonist; blocks kisspeptin-10 effects on IP (IC50 = 7 nM) and GnRH release.</p>Fórmula:C63H78N18O13Pureza:98%Cor e Forma:SolidPeso molecular:1295.42Proglumide hemicalcium
CAS:Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities.Fórmula:C18H28CaN2O4Pureza:98%Cor e Forma:SolidPeso molecular:376.51PROTAC(H-PGDS)-8
CAS:<p>PROTAC(H-PGDS)-8 is a PROTAC degrader targeting Hematopoietic prostaglandin D synthase (H-PGDS), exhibiting an IC50 of 0.14 μM [1].</p>Fórmula:C41H40N8O7Cor e Forma:SolidPeso molecular:756.81HAEGTFTSDVS
CAS:HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.Fórmula:C48H71N13O20Pureza:98%Cor e Forma:SolidPeso molecular:1150.18β2AR/M-receptor agonist-1
CAS:<p>β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and</p>Fórmula:C43H56BrN3O7Cor e Forma:SolidPeso molecular:806.82Lobeline sulfate
CAS:<p>Lobeline sulfate, an alkaloid like nicotine, aids in smoking cessation, insomnia, and respiratory issues. Less potent on nicotinic receptors.</p>Fórmula:C22H29NO6SPureza:98%Cor e Forma:White PowderPeso molecular:435.549-deoxy-9-methylene Prostaglandin E2
CAS:<p>9-deoxy-9-methylene PGE2: stable PGE2 analog with similar effects, less side effects, equal potency in rats, gerbils, primates.</p>Fórmula:C21H34O4Cor e Forma:SolidPeso molecular:350.499[Des-Arg9]-Bradykinin
CAS:<p>[Des-Arg9]-Bradykinin ([Des-Arg9]-Bradykinin(2TFA))(2TFA) is an agonist of Bradykinin (B1) receptor.</p>Fórmula:C44H61N11O10Pureza:98%Cor e Forma:SolidPeso molecular:904.02QWF
CAS:<p>Tripeptide SP antagonist (IC50: 90 μM); blocks SP-MRGPR X2 binding and mast cell degranulation; reduces 48/80-induced scratching in mice.</p>Fórmula:C38H43N5O8Pureza:98%Cor e Forma:SolidPeso molecular:697.78SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Fórmula:C19H18F2N4OPureza:99.81%Cor e Forma:SolidPeso molecular:356.37(+)-Cloprostenol sodium
CAS:<p>Cloprostenol sodium is a water-soluble PGF2α analog and FP receptor agonist, promoting luteolysis in rats and hamsters.</p>Fórmula:C22H28ClNaO6Cor e Forma:SolidPeso molecular:446.9(R)-(+)-Atenolol
CAS:<p>(R)-(+)-Atenolol ((R)-Atenolol) is a cardioselective beta-1 adrenergic blocker, which properties are similar to propranolol, but without a negative inotropic effect.</p>Fórmula:C14H22N2O3Pureza:98.72%Cor e Forma:SolidPeso molecular:266.34Zoliprofen
CAS:<p>Zoliprofen: potent, oral NSAID with anti-inflammatory, antipyretic, analgesic effects. Exceeds ibuprofen's efficacy in rats and rabbits.</p>Fórmula:C12H11NO3SPureza:99.62%Cor e Forma:SolidPeso molecular:249.29PF-232798
CAS:<p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>Fórmula:C29H40FN5O2Cor e Forma:SolidPeso molecular:509.66(-)-Eseroline fumarate
CAS:<p>(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.</p>Fórmula:C17H22N2O5Cor e Forma:SolidPeso molecular:334.37
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