GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Antibacterial agent 189
Antibacterialagent 189 (compound 3a) is a potent antibacterial agent with high binding affinity to the target proteins OMPA/exo-1,3-β-glucanase. It demonstrates effective antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus flavus. Additionally, Antibacterialagent 189 exhibits strong binding affinity to the target proteins SMO and SUFU/GLI-1.Fórmula:C37H28N4OPeso molecular:544.22631GPR183 antagonist-3
<p>GPR183 antagonist-3 (compound 33) is an orally active GPR183 antagonist with an IC50 value of 8.7 μM. It demonstrates significant in vitro anti-migration and anti-inflammatory activity in monocytes and can alleviate pathological symptoms in experimental colitis induced by dextran sulfate sodium.</p>Fórmula:C21H19BrN4O2SPeso molecular:470.04121BPP-2
<p>BPP-2 is a GHSR ligand containing the element F. By labeling BPP-2 with the isotope 18F, a PET probe targeting GHSR can be produced. The binding affinity (Ki) of 18F-BPP-2 for GHSR is 274 nM.</p>Fórmula:C27H28FN5O2Peso molecular:473.2227L-797,591 hydrochloride
L-797,591 HCl activates SSTR1, boosts p-ERK5 with AG1478, and enhances p38 phosphorylation, reversible by AG1478.Fórmula:C38H50ClN5O2Pureza:98.65% - >99.99%Cor e Forma:SoildPeso molecular:644.30Detomidine carboxylic acid
CAS:<p>Detomidine carboxylic acid, a urine metabolite of detomidine, is a synthetic α2-agonist, animal analgesic, with cardiac, respiratory, and diuretic effects.</p>Fórmula:C12H12N2O2Pureza:98%Cor e Forma:SolidPeso molecular:216.24NPFF2-R ligand 1
<p>NPFF2-R ligand 1 (Compound 16a) is an NPFF2-R ligand with Ki values of 228 nM for NPFF1-R and 27 nM for NPFF2-R, and can be utilized in research on central nervous system-related disorders.</p>Fórmula:C32H41N3OPeso molecular:483.32496MRS2500 tetraammonium
CAS:<p>Highly potent and selective antagonist of the platelet P2Y1 receptor</p>Fórmula:C13H21IN6O8P2Pureza:98%Cor e Forma:SolidPeso molecular:578.19Cyclosomatostatin Acetate
<p>Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell</p>Fórmula:C46H61N7O8Pureza:98.83%Cor e Forma:SolidPeso molecular:840.02Nocistatin(human)
CAS:<p>Blocker of nociceptin-induced allodynia and hyperalgesia</p>Fórmula:C149H238N42O53S3Pureza:98%Cor e Forma:SolidPeso molecular:3561.936α-Prostaglandin I1
CAS:<p>6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions.</p>Fórmula:C20H34O5Cor e Forma:SolidPeso molecular:354.487[Pro34]Neuropeptide Y, porcine
CAS:[Pro34]Neuropeptide Y, porcine functions as a selective agonist for the NPY (Y1) receptor and induces vasoconstriction in the guinea pig's caval vein [1].Fórmula:C190H286N54O56Cor e Forma:SolidPeso molecular:4222.63Dolcanatide
CAS:Dolcanatide: oral GC-C agonist with laxative, pain-relief, and anti-inflammatory properties for IBD research.Fórmula:C65H104N18O26S4Cor e Forma:SolidPeso molecular:1681.89TRAP-6 amide TFA
CAS:<p>TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.</p>Fórmula:C36H58F3N11O10Cor e Forma:SolidPeso molecular:861.922HL2-m5
CAS:HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.Fórmula:C70H101N15O24S3Cor e Forma:SolidPeso molecular:1632.83Neuropeptide Y (13-36), amide, human
CAS:<p>Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.</p>Fórmula:C134H207N41O36SPureza:98%Cor e Forma:SolidPeso molecular:3000.4α-Bulnesene
CAS:α-Bulnesene, a novel PAF (platelet-activating factor) receptor antagonist, exhibits an IC50 of 17.62 μM. It can be isolated from patchouli. α-Bulnesene inhibits both PAF and arachidonic acid-induced aggregation of rabbit platelets.Fórmula:C15H24Cor e Forma:SolidPeso molecular:204.35FLLRN
CAS:<p>FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.</p>Fórmula:C31H51N9O7Cor e Forma:SolidPeso molecular:661.79Neuropeptide AF (cattle)
CAS:Neuropeptide AF (cattle) is an RFamide that acts on MrgprA4 (~60 nM), MrgprC11 (~300 nM), NPFF1 (~25-325 nM), NPFF2 (~1-5 nM), and modulates pain.Fórmula:C89H130N24O24Cor e Forma:SolidPeso molecular:1920.13Kisspeptin 13
CAS:<p>Kisspeptin 13 activates GPR54 & GnRH receptors, boosts memory, and aids in Alzheimer's research.</p>Fórmula:C78H107N21O18Cor e Forma:SolidPeso molecular:1626.81Cortistatin 14, human, rat
CAS:<p>Cortistatin 14: a neuropeptide similar to somatostatin; induces sleep, depresses neuronal activity; found in cortex, hippocampus.</p>Fórmula:C81H113N19O19S2Pureza:98%Cor e Forma:SolidPeso molecular:1721.01Parstatin(human) TFA
<p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>Fórmula:C193H331F3N64O55S3Cor e Forma:SolidPeso molecular:4581.28Levocarnitine propionate hydrochloride
CAS:<p>Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.</p>Fórmula:C10H20ClNO4Pureza:90% - 99.77%Cor e Forma:SolidPeso molecular:253.72Wy 43657
CAS:<p>Wy 43657 is a gonadorelin antagonist.</p>Fórmula:C71H86N14O13Pureza:98%Cor e Forma:SolidPeso molecular:1343.554Nesiritide
CAS:<p>Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.</p>Fórmula:C143H244N50O42S4Pureza:98%Cor e Forma:SolidPeso molecular:3464.0426Rfa, Hypothalamic Peptide, human
CAS:<p>26RFa, a human neuropeptide, stimulates appetite and possibly regulates feeding and the gonadotropic axis, with ≈80% identity across human, rat, and frog.</p>Fórmula:C127H195N37O37Pureza:98%Cor e Forma:SolidPeso molecular:2832.13Tezusomant
CAS:Tezusomant is an antagonist of the growth hormone receptor (growth hormone receptor). It is being investigated for potential use in conditions like acromegaly, which are caused by excessive secretion of growth hormone.Fórmula:C120H171N23O32SCor e Forma:SolidPeso molecular:2479.84σ1R-IN-1
σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.Fórmula:C15H22N2Cor e Forma:SolidPeso molecular:230.35GLP-1(7-36), amide acetate
CAS:<p>GLP-1(7-36), amide acetate is a derivative of GLP-1 peptide , activate the GLP-1 receptor, promote insulin secretion,Type 2 diabetes mellitus and obesity.</p>Fórmula:C151H230N40O47Pureza:99.89%Cor e Forma:SolidPeso molecular:3357.68Thioperamide maleate
CAS:<p>Thioperamide maleate (MR-12842 maleate) is an effective and selective antagonist of H3 receptor (Ki = 4.3 nM) for inhibition of [3H]histamine synthesis (Ki = 31</p>Fórmula:C19H28N4O4SPureza:98.48%Cor e Forma:SolidPeso molecular:408.52[Ala17]-MCH acetate
<p>[Ala17]-MCH acetate is a selective ligand for MCHR1 with a Ki of 0.16 nM and Kd of 0.37 nM(Eu3+ chelate-labeled).</p>Fórmula:C99H159N29O28S4Pureza:98.92%Cor e Forma:SolidPeso molecular:2331.761,2,3-Trilinoelaidoyl-rac-glycerol
CAS:<p>1,2,3-Trilinoelaidoyl-glycerol is a TAG with linoelaidic acid; reduces rat serum thromboxane B2, PGF2, and PGE.</p>Fórmula:C57H98O6Cor e Forma:SolidPeso molecular:879.405α-Helical CRF(9-41)
CAS:<p>Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).</p>Fórmula:C166H274N46O53S2Pureza:98%Cor e Forma:SolidPeso molecular:3827(R)-Preclamol hydrochloride
CAS:<p>(R)-Preclamol HCl is a dopamine agonist stimulating both auto and postsynaptic receptors.</p>Fórmula:C14H22ClNOCor e Forma:SolidPeso molecular:255.78Ceruletide Ammonium Salt
<p>Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and</p>Fórmula:C58H77N14O21S2Pureza:98.47% - 98.54%Cor e Forma:SoildPeso molecular:1370.44[Nle13]-Motilin
CAS:<p>[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist [1] [2] .</p>Fórmula:C121H190N34O35Cor e Forma:SolidPeso molecular:2681.01Cortistatin-14 acetate
<p>Cortistatin-14 acetate, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5).</p>Fórmula:C83H118N20O20S2Pureza:98.24% - 99.63%Cor e Forma:SoildPeso molecular:1780.08ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
CAS:<p>ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.</p>Fórmula:C22H18N4O3Pureza:99.86%Cor e Forma:SolidPeso molecular:386.4Setmelanotide Acetate(920014-72-8 free base)
CAS:<p>Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM</p>Fórmula:C51H72N18O11S2Pureza:99.71%Cor e Forma:SolidPeso molecular:1177.354-Oxo-5-phenylpentanoic aci
CAS:<p>4-Oxo-5-phenylpentanoic aci is a useful organic compound for research related to life sciences. The catalog number is T125056 and the CAS number is 3183-15-1.</p>Fórmula:C11H12O3Cor e Forma:SolidPeso molecular:192.214a-Helical Corticotropin Releasing Factor (9-41)
CAS:<p>α-Helical CRF (9-41) is a CRF antagonist that lowers in vivo plasma GH levels.</p>Fórmula:C166H273N45O54S2Cor e Forma:SolidPeso molecular:3827.34cAC 253 acetate
<p>cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.</p>Fórmula:C128H206N42O42S2Pureza:98.16% - 99.99%Cor e Forma:SoildPeso molecular:3069.39Relaxin H3 (human)
CAS:<p>Relaxin H3 (human) is a relaxin peptide that exhibits antifibrotic effects through activation of RXFP1 [1].</p>Cor e Forma:Solid[Sar4] Substance P (4-11)
<p>'[Sar4] Substance P (4-11) is a C-terminus fragment and agonist of Substance P.'</p>Fórmula:C44H65N11O10SCor e Forma:SolidPeso molecular:940.12(D-Phe7)-α-MSH
CAS:<p>(D-Phe7)-α-MSH is an α-MSH analogue [1] .</p>Fórmula:C77H109N21O19SCor e Forma:SolidPeso molecular:1664.88GnRH Associated Peptide (1-24), human
CAS:<p>GnRH Associated Peptide (GAP) (1-24), human, is the 1-24 fragment of hGAP linked to LH-RH via a 3 amino acid site.</p>Fórmula:C117H190N32O43Cor e Forma:SolidPeso molecular:2732.95Jmv 179
CAS:<p>Jmv 179 is an antagonist of the cholecystokinin receptor.</p>Fórmula:C51H67N7O15SCor e Forma:SolidPeso molecular:1050.19MAO-B-IN-3
<p>MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki</p>Fórmula:C24H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.47Pasireotide
CAS:Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).Fórmula:C58H66N10O9Pureza:98%Cor e Forma:SolidPeso molecular:1047.21MGV354
<p>MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].</p>Fórmula:C35H37N5O3Pureza:98%Cor e Forma:SolidPeso molecular:575.7CYM5442 hydrochloride
CAS:<p>CYM 5442 HCl: potent, selective S1P1 agonist (EC50 = 1.35 nM), induces MAPK activation & lymphopenia, brain-penetrant.</p>Fórmula:C23H28ClN3O4Cor e Forma:SolidPeso molecular:445.94
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