GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Linzagolix choline
CAS:<p>Linzagolix choline is a GnRH antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.</p>Fórmula:C27H28F3N3O8SPureza:99.64%Cor e Forma:SolidPeso molecular:611.59Osanetant
CAS:Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia.Fórmula:C35H41Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:606.62Halometasone
CAS:<p>Halometasone: synthetic corticosteroid for psoriasis and eczema treatment.</p>Fórmula:C22H27ClF2O5Cor e Forma:SolidPeso molecular:444.9GLP-1R/GIPR agonist-1
<p>GLP-1R/GIPR agonist-1 is a dual receptor agonist for GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). It mimics the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while suppressing glucagon release, thus lowering blood sugar. This compound is used in research related to metabolic disorders such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH).</p>Fórmula:C220H342N55O69Peso molecular:4858.49434ACTH (1-17)
CAS:<p>ACTH (1-17), a potent MC1 receptor agonist with a Ki of 0.21 nM, is a variant of corticotropin from the pituitary gland.</p>Fórmula:C95H145N29O23SPureza:98%Cor e Forma:SolidPeso molecular:2093.41Neuropeptide Y (22-36)
CAS:<p>Neuropeptide Y (22-36) is a 15-amino acid fragment of NPY, which is abundant in the mammalian brain and involved in multiple physiological functions.</p>Fórmula:C85H139N29O21Pureza:98%Cor e Forma:SolidPeso molecular:1903.19MCL0129
CAS:<p>MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.</p>Fórmula:C34H47FN4OPureza:98%Cor e Forma:SolidPeso molecular:546.76Neuropeptide Y (13-36), amide, human
CAS:<p>Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.</p>Fórmula:C134H207N41O36SPureza:98%Cor e Forma:SolidPeso molecular:3000.4ALEPH hydrochloride
CAS:<p>ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.</p>Fórmula:C12H20ClNO2SCor e Forma:SolidPeso molecular:277.81Icatibant
CAS:<p>Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).</p>Fórmula:C59H89N19O13SPureza:98%Cor e Forma:White SolidPeso molecular:1304.52VU0453379 hydrochloride
<p>VU0453379 hydrochloride: selective CNS-penetrant GLP-1R PAM, EC50 1.3 μM.</p>Fórmula:C26H35ClN4O2Cor e Forma:SolidPeso molecular:471.03Antidepressant agent 4
<p>Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.</p>Fórmula:C19H38ClN5O2SCor e Forma:SolidPeso molecular:436.06α-Helical CRF(9-41)
CAS:<p>Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).</p>Fórmula:C166H274N46O53S2Pureza:98%Cor e Forma:SolidPeso molecular:3827FSLLRY-NH2
CAS:<p>PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.</p>Fórmula:C39H60N10O8Pureza:98%Cor e Forma:SolidPeso molecular:796.97Hemopressin(rat)
CAS:<p>Peptide inhibitor for ep24.15, neurolysin & ACE with Ki 27.76, 3.43, 1.87 μM. Lowers blood pressure, modulates CB1 receptor, reduces pain & food intake.</p>Fórmula:C53H77N13O12Pureza:98%Cor e Forma:SolidPeso molecular:1088.27SGLT1/2-IN-2
CAS:<p>SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).</p>Fórmula:C23H26F2O7Cor e Forma:SolidPeso molecular:452.451S1P2 antagonist 1
CAS:<p>S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.</p>Fórmula:C23H21ClN4O4Cor e Forma:SolidPeso molecular:452.9Ethylnorepinephrine hydrochloride
CAS:<p>Ethylnorepinephrine hydrochloride is a unique bronchodilator.</p>Fórmula:C10H16ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:233.69TGR5 agonist 7
<p>TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.</p>Fórmula:C37H59N2NaO9SCor e Forma:SolidPeso molecular:730.93Neuromedin N
CAS:<p>Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.</p>Fórmula:C38H63N7O8Pureza:98%Cor e Forma:SolidPeso molecular:745.95PSB 0777 ammonium salt
CAS:<p>adenosine A2A receptor full agonist</p>Fórmula:C18H24N6O7S2Pureza:98%Cor e Forma:SolidPeso molecular:500.55Glucagon-like peptide 1 (1-37), human TFA
<p>Human Glucagon-like peptide 1 (1-37) TFA is a potent GLP-1 receptor agonist derived from proglucagon.</p>Fórmula:C188H276N51F3O61Pureza:98%Cor e Forma:SolidPeso molecular:4283.5Adrogolide HCl
CAS:Adrogolide Hydrochloride is a selective dopamine receptor D1 agonist.Fórmula:C22H26ClNO4SCor e Forma:SolidPeso molecular:435.96NI-203
<p>NI-203 is a monoclonal antibody inhibitor that targets amylin and shows potential for research in type 2 diabetes.</p>Cor e Forma:Odour LiquidMMC(TMZ)-TOC TFA
<p>MMC(TMZ)-TOC TFA exhibits high binding affinity and selectivity for the somatostatin receptor subtype 2 (SSTR2). It targets the delivery of TMZ to SSTR2-positive tumor cells, making MMC(TMZ)-TOC TFA useful for cancer research.</p>Fórmula:C74H99F3N20O21S2Cor e Forma:SolidPeso molecular:1725.82O-Desmethyl Mebeverine alcohol hydrochloride
CAS:<p>O-Desmethyl Mebeverine alcohol HCl, a metabolite of Mebeverine, is a strong α1 inhibitor, relaxing the GI tract.</p>Fórmula:C15H26ClNO2Cor e Forma:SolidPeso molecular:287.83ONO-8711
CAS:<p>ONO-8711 is a potent and selective competitive antagonist of EP1 receptor with Kis of 0.6 nM and 1.7 nM for human and mouse EP1, respectively.</p>Fórmula:C22H30ClNO4SCor e Forma:SolidPeso molecular:440Paynantheine
CAS:<p>Paynantheine is an alkaloid with antinociceptive properties, found in Mitragyna speciosa. It also acts as an agonist at 5-HT1AR and 5-HT2BR receptors, inducing lower lip contraction and providing antinociception in rats.</p>Fórmula:C23H28N2O4Cor e Forma:SolidPeso molecular:396.48Vapreotide
CAS:<p>Vapreotide is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).</p>Fórmula:C57H70N12O9S2Pureza:98%Cor e Forma:SolidPeso molecular:1131.38L-803087 TFA
CAS:<p>L-803087 TFA: potent sst4 agonist, Ki=0.7 nM, >280x selective vs other somatostatin receptors; boosts AMPA, heightens seizures.</p>Fórmula:C27H30F5N5O5Cor e Forma:SolidPeso molecular:599.55[Sar9] Substance P
CAS:<p>[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.</p>Fórmula:C64H100N18O13SPureza:98%Cor e Forma:SolidPeso molecular:1361.66PACAP-Related Peptide (PRP), human
<p>PRP, human: 29-amino-acid PACAP precursor segment, synthesized for biological/structural research.</p>Fórmula:C139H229N41O42Pureza:98%Cor e Forma:SolidPeso molecular:3146.57Satavaptan
CAS:<p>Satavaptan is a vasopressin V2 receptor antagonist. Satavaptan improves the control of ascites in cirrhosis.</p>Fórmula:C33H45N3O8SCor e Forma:SolidPeso molecular:643.79Vapreotide diacetate
CAS:<p>Vapreotide diacetate, a synthetic somatostatin analog, blocks NK1R to provide analgesic effects.</p>Fórmula:C61H78N12O13S2Pureza:98%Cor e Forma:SolidPeso molecular:1251.47Desmethyl Mirtazapine (hydrochloride)
CAS:<p>Desmethyl mirtazapine is a metabolite of the antidepressant mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoform CYP3A4.</p>Fórmula:C16H18ClN3Cor e Forma:SolidPeso molecular:287.79Thiothixene
CAS:<p>Thiothixene has a wide range of applications in life science related research.</p>Fórmula:C23H29N3O2S2Cor e Forma:SolidPeso molecular:443.62L-threo Lysosphingomyelin (d18:1)
CAS:<p>L-threo Lysosphingomyelin, a natural S1P receptor agonist, has EC50s: 19.3 nM (hS1P1), 131.8 nM (hS1P3), 313.3 nM (hS1P2).</p>Fórmula:C23H49N2O5PCor e Forma:SolidPeso molecular:464.62Danshenol B
<p>Danshenol B is a natural product that can be used as a reference standard.</p>Fórmula:C22H26O4Cor e Forma:SolidPeso molecular:354.446Synephrine hemitartrate
CAS:<p>Synephrine hemitartrate, an alkaloid from Citrus aurantium, is a sympathomimetic for weight loss, with α and β-adrenergic action.</p>Fórmula:C9H13NO2C4H6O6Cor e Forma:SolidPeso molecular:242.26A6770
CAS:<p>A6770 inhibits S1P lyase, causing [3H]dhS1P build-up in IT-79MTNC3 cells (EC50 <0.01 μM); less effective with vitamin B6 (EC50 <100 μM).</p>Fórmula:C6H8N2O2Cor e Forma:SolidPeso molecular:140.142HAEGT
CAS:<p>HAEGT is the first N-terminal 1-5 residues of GLP-1 peptide.</p>Fórmula:C20H31N7O9Pureza:98%Cor e Forma:SolidPeso molecular:513.5Exendin-3/4 (59-86)
<p>Exendin-3/4 (59-86) is a Exendin-4 peptide derivative.</p>Fórmula:NAPureza:98%Cor e Forma:SolidPeso molecular:3055.49Pentagastrin meglumine
CAS:<p>Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally.</p>Fórmula:C44H66N8O14SCor e Forma:SolidPeso molecular:963.115-HT7R antagonist 1 free base
CAS:<p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>Fórmula:C14H17ClN4Cor e Forma:SolidPeso molecular:276.77Pasireotide
CAS:Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).Fórmula:C58H66N10O9Pureza:98%Cor e Forma:SolidPeso molecular:1047.21Bremelanotide
CAS:<p>Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R.</p>Fórmula:C50H68N14O10Pureza:98%Cor e Forma:White PowderPeso molecular:1025.16Navafenterol
CAS:AZD-8871, a potential COPD and asthma treatment, may work well with ICS.Fórmula:C38H42N6O6S2Cor e Forma:SolidPeso molecular:742.91D5R agonist 1
<p>D5R Agonist 1 (Compound 5j) is a selective, orally active partial agonist of the D5 receptor that can penetrate the blood-brain barrier (EC50: 269.7 nM). It has been demonstrated to enhance cognitive abilities in a scopolamine-induced amnesia model.</p>Cor e Forma:Odour Solid5-HT2A receptor agonist-5
CAS:<p>5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A agonist with a Ki value of 0.017 µM and exhibits antidepressant activity.</p>Fórmula:C23H29N3OCor e Forma:SolidPeso molecular:363.5CCG258208 hydrochloride
<p>GRKs-IN-1 HCl (14as) strongly inhibits GRK2 (IC50=130nM) & GRK5 (IC50=7.1μM), is a paroxetine derivative with 100x cardiac boost.</p>Cor e Forma:Solid
![[Sar9] Substance P](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1862.webp&w=3840&q=75)
