GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.948 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(409 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5373 produtos de "GPCR/Proteína-G"
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Vapiprost hydrochloride
CAS:<p>Vapiprost hydrochloride is a biochemicla.</p>Fórmula:C30H40ClNO4Cor e Forma:SolidPeso molecular:514.1Benzomalvin A
CAS:<p>Benzomalvin A is a filamentous fungal secondary metabolite.</p>Fórmula:C24H19N3O2Cor e Forma:SolidPeso molecular:381.43HDAC6-IN-49
<p>HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.</p>Cor e Forma:Odour Solid2-Methyl-N,N-dimethyltryptamine
CAS:<p>2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.</p>Fórmula:C13H18N2Cor e Forma:SolidPeso molecular:202.3Bim 21009
CAS:Bim 21009 is an inhibitor of gonadorelin.Fórmula:C74H92ClN17O13Pureza:98%Cor e Forma:SolidPeso molecular:1463.08RF9 acetate
<p>RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.</p>Fórmula:C28H42N6O5Pureza:99.77%Cor e Forma:SolidPeso molecular:542.67GLP-1R agonist 27
<p>GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. It enhances the accumulation of cyclic adenosine monophosphate (cAMP), reduces blood glucose levels, and decreases food intake. GLP-1R agonist 27 shows potential for research in obesity and type 2 diabetes mellitus (T2DM).</p>Fórmula:C32H33N5O4SeCor e Forma:SolidPeso molecular:630.6MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.Fórmula:C21H21FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:416.47Spns2-IN-2
<p>Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.</p>Fórmula:C22H30ClN3O2Cor e Forma:SolidPeso molecular:403.95γ1-MSH
CAS:<p>Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4.</p>Fórmula:C72H97N21O14SPureza:98%Cor e Forma:SolidPeso molecular:1512.76Adenosine receptor antagonist 1
CAS:<p>A2aR-selective antagonist with IC50 of 0.29 nM; 14x more selective over A2bR.</p>Fórmula:C22H15ClFN7OCor e Forma:SolidPeso molecular:447.86pCPA methyl ester hydrochloride
CAS:<p>pCPA methyl ester HCl inhibits tryptophan hydroxylase, 5-HT synthesis, crosses blood-brain barrier, lowers central 5-HT.</p>Fórmula:C10H13Cl2NO2Pureza:99.73% - 99.88%Cor e Forma:SolidPeso molecular:250.12GM-60186
GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.Fórmula:C30H33FN2O4Cor e Forma:SolidPeso molecular:504.59PD 142893
CAS:<p>PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.</p>Fórmula:C50H65N7O10Pureza:98%Cor e Forma:SolidPeso molecular:924.09Bradykinin (1-7)
CAS:<p>Bradykinin (1-7), an amino-truncated peptide derived from Bradykinin, is a metabolite formed through enzymatic cleavage by endopeptidase.</p>Fórmula:C35H52N10O9Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:756.85Neuropeptide W-30 (rat)
CAS:<p>Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].</p>Fórmula:C165H249N49O38SCor e Forma:SolidPeso molecular:3559.11ARC 239 dihydrochloride
CAS:<p>ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).</p>Fórmula:C24H31Cl2N3O3Pureza:99.72%Cor e Forma:SolidPeso molecular:480.43Fenoldopam
CAS:<p>Fenoldopam is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM).</p>Fórmula:C16H16ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:305.76Conessine hydrobromide
CAS:<p>Conessine hydrobromide is a naturally occurring steroid alkaloid and has been used in traditional herbal medicine as a treatment for amoebic dysentery.</p>Fórmula:C24H41BrN2Cor e Forma:SolidPeso molecular:437.51Substance P(1-7)
CAS:<p>Substance P(1-7) is a bioactive metabolite of tachykinin SP with anti-inflammatory and analgesic properties.</p>Fórmula:C41H65N13O10Pureza:98%Cor e Forma:SolidPeso molecular:900.04Luseogliflozin
CAS:<p>Luseogliflozin inhibits SGLT2 for glucose uptake with 1.10 nM potency.</p>Fórmula:C23H30O6SCor e Forma:SolidPeso molecular:434.55Serazapine
CAS:<p>Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders.</p>Fórmula:C22H23N3O2Pureza:98.71% - 99.57%Cor e Forma:SolidPeso molecular:361.44Benzoquinamide hydrochloride
CAS:<p>Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic</p>Fórmula:C22H33ClN2O5Pureza:97.13% - 99.56%Cor e Forma:SolidPeso molecular:440.96Dexchlorpheniramine free base
CAS:<p>Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.</p>Fórmula:C16H19ClN2Pureza:98%Cor e Forma:Oily Liquid SolidPeso molecular:274.79CCK Octapeptide, non-sulfated acetate
<p>CCK Octapeptide, non-sulfated acetate is a synthetic desulfated peptide of cholecystokinin.</p>Fórmula:C51H66N10O15S2Pureza:98.9700%Cor e Forma:SolidPeso molecular:1123.26Alosetron
CAS:<p>Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.</p>Fórmula:C17H18N4OPureza:98%Cor e Forma:Crystalline PowderPeso molecular:294.36[Des-His1,Glu9]-Glucagon amide
CAS:<p>Glucagon blocker with pA2 of 7.2; no agonist effect. Boosts insulin; prevents glucagon-driven hyperglycemia in rabbits and diabetic rats.</p>Fórmula:C148H221N41O47SPureza:98%Cor e Forma:SolidPeso molecular:3358.68Bradykinin (1-6)
CAS:<p>Bradykinin (1-6) is a stable, CPY-cleaved metabolite that triggers pain, induces muscle contractions, and activates NO synthetase.</p>Fórmula:C30H45N9O8Pureza:98%Cor e Forma:SolidPeso molecular:659.73Femoxetine
CAS:<p>Femoxetine: antidepressant, enhances morphine, inhibits MAO-A/B, boosts mice's exercise capacity.</p>Fórmula:C20H25NO2Pureza:99.1% - 99.35%Cor e Forma:SolidPeso molecular:311.42Met-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Cor e Forma:Odour SolidLanepitant
CAS:<p>Lanepitant (LY303870) is a non-peptide neurokinin-1 (NK-1) antagonist with analgesic activity for the prevention of migraine.</p>Fórmula:C33H45N5O3Pureza:97.71%Cor e Forma:SolidPeso molecular:559.744-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS:<p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>Fórmula:C27H28ClFN2OSPureza:99.02%Cor e Forma:SoildPeso molecular:483.04Protease-Activated Receptor-1 antagonist 2
CAS:<p>Orally active PAR-1 antagonist with 7 nM IC50; potential for CVD research.</p>Fórmula:C24H23F2N3O2Cor e Forma:SolidPeso molecular:423.46LE 300
CAS:<p>LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.</p>Fórmula:C20H22N2Pureza:97.91% - 98.79%Cor e Forma:SolidPeso molecular:290.4TRPV1/CB2 agonist 1
<p>TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.</p>Cor e Forma:Odour SolidSpantide I
CAS:<p>Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.</p>Fórmula:C75H108N20O13Pureza:98%Cor e Forma:SolidPeso molecular:1497.79L-796,778 acetate
<p>L-796,778 acetate is a slective somatostatin receptor agonist with IC50 of 24nM for sst3, for sst1, sst2, sst4 and sst5, IC50 is >1000nM.</p>Fórmula:C31H44N6O9Pureza:98%Cor e Forma:SoildPeso molecular:644.72(3R,5R,6S)-Atogepant
<p>(3R,5R,6S)-Atogepant (MK-8031) is a CGRP antagonist enantiomer used in migraine research.</p>Fórmula:C29H23F6N5O3Cor e Forma:SolidPeso molecular:603.52S 16474
CAS:S 16474 is an antagonist of Neurokinin-1 Receptor.Fórmula:C44H48N6NaO8Pureza:98%Cor e Forma:SolidPeso molecular:811.892Tiaprost
CAS:Tiaprost is a analog of prostaglandin F2α .Fórmula:C20H28O6SPureza:98%Cor e Forma:SolidPeso molecular:396.5CGRP antagonist 6
<p>CGRP Antagonist 6 (Compound 23) is a potent CGRP receptor antagonist (Ki: 0.84 nM). It is utilized in the study of migraines.</p>Cor e Forma:Odour SolidMrgprX2 antagonist-2
CAS:<p>MrgprX2 antagonist-2, from patent WO2021092262A1 E163, is potent for skin inflammation studies.</p>Fórmula:C17H16F5N3O3Cor e Forma:SolidPeso molecular:405.325DOAM
CAS:<p>DOAM is an antagonist of the 5-HT2 receptor.</p>Fórmula:C16H27NO2Cor e Forma:SolidPeso molecular:265.39[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
CAS:<p>Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage.</p>Fórmula:C50H75N15O10Pureza:98%Cor e Forma:SolidPeso molecular:1046.23Kassinin
CAS:<p>Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.</p>Fórmula:C59H95N15O18SPureza:98%Cor e Forma:SolidPeso molecular:1334.54Elabela(19-32)
CAS:<p>APJ receptor agonist with Ki of 0.93 nM, derived from ELA-32, activates Gαi1, β-arrestin-2, lowers rat heart arterial pressure, effective in vivo.</p>Fórmula:C75H119N25O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1707.0313,14-dihydro Prostaglandin F2α
CAS:<p>13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain.</p>Fórmula:C20H36O5Cor e Forma:SolidPeso molecular:356.503U-46619 serinol amide
<p>U-46619 serinol amide is a derivative of U-46619, acting as a stable analog of Thromboxane A2 (TXA2). It effectively functions as a TXA2 agonist, capable of inducing platelet shape change and aggregation.</p>Fórmula:C24H41NO5Cor e Forma:SolidPeso molecular:423.29847Triazolomethylindole-3-acetic acid
CAS:<p>Triazolomethylindole-3-acetic acid is a metabolite of Rizatriptan, which acts as an agonist for the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.</p>Fórmula:C13H12N4O2Cor e Forma:SolidPeso molecular:256.26Haloperidol D4
CAS:<p>Haloperidol D4 is deuterium-labeled haloperidol.</p>Fórmula:C21H23ClFNO2Pureza:98%Cor e Forma:SolidPeso molecular:379.89
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