GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.948 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(409 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5373 produtos de "GPCR/Proteína-G"
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Cloprostenol isopropyl ester
CAS:<p>(+)-Chloprostol is a PGF2α agonist, mimics prostaglandin F2α, induces luteal dissolution in mares without side effects or stress.</p>Fórmula:C25H35ClO6Cor e Forma:SolidPeso molecular:466.99Dulaglutide
CAS:<p>Dulaglutide (LY2189265) is a GLP-1 receptor agonist for studying type 2 diabetes mellitus (T2DM).</p>Cor e Forma:SolidP2Y6R antagonist 1
<p>P2Y6R antagonist 1 (compound 5ab) is a selective, orally active antagonist of P2Y6R, featuring an IC50 value of 19.6 nM. This compound also exhibits anti-inflammatory properties.</p>Cor e Forma:Odour SolidIRL-1620
CAS:<p>IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).</p>Fórmula:C86H117N17O27Pureza:98%Cor e Forma:SolidPeso molecular:1820.974HDAC6-IN-49
<p>HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.</p>Cor e Forma:Odour SolidGalanin (1-30), human
CAS:Galanin (1-30), human is a neuropeptide agonist for GalR1/R2 receptors with 1 nM affinity, influencing endocrine, metabolism, and neurotransmission.Fórmula:C139H210N42O43Pureza:98%Cor e Forma:SolidPeso molecular:3157.46Adrenocorticotropic Hormone (ACTH) (1-39), rat
CAS:ACTH (1-39), rat: potent MC2 agonist, forms fragments in vitro, isolated by HPLC, characterized by amino acids and NH2-terminus.Fórmula:C210H315N57O57SPureza:98%Cor e Forma:SolidPeso molecular:4582.23Anthramycin
CAS:<p>Anthramycin: a PBD family antibiotic with antitumor effects and CNS cholecystokinin antagonist properties in mice.</p>Fórmula:C16H17N3O4Cor e Forma:SolidPeso molecular:315.328-iso Prostaglandin E1
CAS:<p>8-iso Prostaglandin E1 causes spasm in the pulmonary veins of dogs and also acts as a vasodilator.</p>Fórmula:C20H34O5Cor e Forma:Light Yellow Crystalline SolidPeso molecular:354.48CB1R agonist 1
<p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>Fórmula:C20H18F3N3O3SCor e Forma:SolidPeso molecular:437.435Cortistatin 14, human, rat acetate
Cortistatin 14, human, rat acetate is a neuropeptide having structural similarity to somatostatin-14 and shows anticonvulsive, neuroprotective effects andFórmula:C80H112N18O19S2Pureza:97.86%Cor e Forma:SolidPeso molecular:1693.985-HT2C agonist-4
CAS:<p>Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.</p>Fórmula:C24H25N5OCor e Forma:SolidPeso molecular:399.49ALD1613
<p>ALD1613 is a potent neutralizing monoclonal antibody targeting adrenocorticotropic hormone (ACTH). It neutralizes ACTH-induced signaling and inhibits cyclic adenosine monophosphate accumulation in ACTH-stimulated Y1 (mouse adrenal cell line) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats and is applicable in studies involving elevated ACTH-related conditions.</p>Cor e Forma:Odour Liquidethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
CAS:<p>ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.</p>Fórmula:C22H18N4O3Pureza:99.86%Cor e Forma:SolidPeso molecular:386.4JKC363
CAS:<p>MC4 receptor antagonist; IC50: 0.5 nM (MC4), 44.9 nM (MC3). Blocks α-MSH, reduces TRH, food intake, and pain.</p>Fórmula:C69H91N19O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1506.72Metaterol
CAS:<p>Metaterol is a bioactive chemical.</p>Fórmula:C11H17NO2Cor e Forma:SolidPeso molecular:195.258213,14-dihydro Prostaglandin F2α
CAS:<p>13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain.</p>Fórmula:C20H36O5Cor e Forma:SolidPeso molecular:356.503Neuropeptide Y5 receptor ligand-1
CAS:<p>Neuropeptide Y5 receptor ligand-1 (Compound 54), a carbazole derivative, acts as a powerful antagonist to the neuropeptide Y5 (NPY-5) receptor [1].</p>Fórmula:C19H17N3O2Cor e Forma:SolidPeso molecular:319.36GRL018-21
<p>GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].</p>Cor e Forma:Odour Solid[D-Trp34]-Neuropeptide Y
CAS:<p>Potent NPY Y5 receptor agonist (pEC50 = 7.82); highly selective; induces hyperphagia, body weight gain; orally active.</p>Fórmula:C196H289N55O56Pureza:98%Cor e Forma:SolidPeso molecular:4311.77Alosetron-d3
CAS:<p>Alosetron D3 (GR 68755 D3) is a deuterium-labeled Alosetron. Alosetron is an antagonist of 5HT3-receptor.</p>Fórmula:C17H18N4OPureza:98%Cor e Forma:SolidPeso molecular:297.37Imelciment
CAS:<p>Imelciment (REGN-9035) is a humanised monoclonal antibody targeting NPR1, which can be used for research into heart failure.</p>Pureza:95%Cor e Forma:SoildFlunarizine
CAS:<p>Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.</p>Fórmula:C26H26F2N2Pureza:99.9%Cor e Forma:SolidPeso molecular:404.50Cannabidiolic acid methyl ester
CAS:<p>Cannabidiolic acid methyl ester (HU-580) is an orally active analogue of cannabidiolic acid. It enhances the activation of 5-HT1A receptors and increases the expression of c-Fos and NeuN in specific hypothalamic nuclei in rats. Cannabidiolic acid methyl ester exhibits anti-nausea, anxiolytic, and anti-nociceptive effects.</p>Fórmula:C23H32O4Cor e Forma:SolidPeso molecular:372.5Veldoreotide
CAS:Veldoreotide (Somatoprim): a somatostatin analogue targeting receptors 2, 4, 5, reduces GH in pituitary adenomas.Fórmula:C60H74N12O10Pureza:98%Cor e Forma:SolidPeso molecular:1123.312(S)-HpEPE
CAS:<p>12(S)-HpEPE, a fatty acid created by 12-lipoxygenase on EPA, has unclear biological activities but may resemble 12(S)-HpETE.</p>Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.456Poly-D-lysine hydrobromide (MW 1000-5000)
<p>Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.</p>Cor e Forma:Odour SolidSGLT1/2-IN-2
CAS:<p>SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).</p>Fórmula:C23H26F2O7Cor e Forma:SolidPeso molecular:452.45115(S)-HpEPE
CAS:<p>15(S)-HpEPE, a monohydroperoxy fatty acid, forms when 15-lipoxygenase acts on EPA, with expected biological activities akin to 15(S)-HpETE.</p>Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.456Efranarelaxin alfa
CAS:<p>Efranarelaxin alfa is an agonist of the relaxin receptor. It shows potential for research in cardiovascular diseases and tissue repair.</p>Cor e Forma:Liquid11-deoxy Prostaglandin E2
CAS:<p>11-deoxy PGE2 is a synthetic PGE2 analog, a potent bronchoconstrictor, 5-30x stronger than PGF2α on human respiratory muscles.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47PEN (rat)
CAS:<p>PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>Fórmula:C102H169N27O33Pureza:98%Cor e Forma:SolidPeso molecular:2301.62FR 113680
CAS:FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.Fórmula:C35H39N5O6Pureza:98%Cor e Forma:SolidPeso molecular:625.726PF-07062119
<p>PF-07062119 is a humanized immunoglobulin G1 (IgG1) monoclonal antibody designed to target and inhibit GUCY2C.</p>Cor e Forma:Odour LiquidLGnRH-III, lamprey
CAS:<p>GnRH III triggers luteinizing and follicle-stimulating hormone release, part of the conserved GnRH family.</p>Fórmula:C59H74N18O14Pureza:98%Cor e Forma:SolidPeso molecular:1259.33Israpafant
CAS:<p>Israpafant: PAF receptor blocker, IC50 0.84nM, hinders platelet aggregation, eosinophil activation, boosts calcium transit, anti-nephrotoxic.</p>Fórmula:C28H29ClN4SCor e Forma:SolidPeso molecular:489.07GS-2278
CAS:<p>GS-2278 is an antagonist of LPAR1 (lysophosphatidic acid receptor 1) with potential applications in the study of idiopathic pulmonary fibrosis (IPF).</p>Fórmula:C22H16F5N9O3Cor e Forma:SolidPeso molecular:549.41N6-Benzyl-5'-ethylcarboxamido adenosine
CAS:<p>N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist.</p>Fórmula:C19H22N6O4Cor e Forma:SolidPeso molecular:398.42MI 1544
CAS:<p>MI 1544 is a LHRH antagonist.</p>Fórmula:C71H94ClN17O13Cor e Forma:SolidPeso molecular:1429.094-Butyl-α-agarofuran
CAS:<p>4-Butyl-alpha-agarofuran, a Gharu-wood derivative, is an anxiolytic, antidepressant, and aids neurological research.</p>Fórmula:C18H30OCor e Forma:SolidPeso molecular:262.43CRF, bovine
CAS:CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.Fórmula:C206H340N60O63SPureza:98%Cor e Forma:SolidPeso molecular:4697.344-fluoro MBZP
CAS:<p>4-fluoro MBZP is a novel psychoactive substance in the phenylpiperazine class, utilized for studies on the 5-HT2 receptors in the central nervous system.</p>Fórmula:C12H17FN2Cor e Forma:SolidPeso molecular:208.28Amylin (IAPP), feline
<p>Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.</p>Fórmula:C165H270N52O54S2Pureza:98%Cor e Forma:SolidPeso molecular:3910.45SB-206606
CAS:<p>SB-206606 is a novel, highly specific radioactive ligand for the β3-adrenergic receptor.</p>Fórmula:C19H22ClNO4Cor e Forma:SolidPeso molecular:363.83MK-0493 HCl
CAS:<p>MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R).</p>Fórmula:C30H39Cl2F2N3O2Cor e Forma:SolidPeso molecular:582.55S1P2 antagonist 1
CAS:<p>S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.</p>Fórmula:C23H21ClN4O4Cor e Forma:SolidPeso molecular:452.9Motilin, canine
CAS:<p>Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist.</p>Fórmula:C120H194N36O34Pureza:98%Cor e Forma:SolidPeso molecular:2685.05[Leu31,Pro34]-Neuropeptide Y(human,rat)
CAS:<p>High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.</p>Fórmula:C189H284N54O56SPureza:98%Cor e Forma:SolidPeso molecular:4241LY83583
CAS:<p>LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.</p>Fórmula:C15H10N2O2Pureza:99.54% - 99.80%Cor e Forma:SolidPeso molecular:250.25Anti-TSHR Antibody (M22)
<p>Anti-TSHR Antibody (M22) is a humanized IgG1 monoclonal antibody targeting the thyroid-stimulating hormone receptor (TSHR). This antibody is capable of inhibiting the interaction between TSH and TSHR.</p>Cor e Forma:Odour Liquid
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