GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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PACAP (1-38), human, ovine, rat TFA
<p>PACAP (1-38), neuropeptide from bovine brain, surpasses VIP in adenylate cyclase activation (EC50=7 nM), alters peptide release, affects gastrin and motility.</p>Fórmula:C203H331N63O53S·C2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:4648.28K41498
CAS:<p>Potent CRF2α/β antagonist; Ki: 0.66/0.62 nM, weak for CRF1 (425 nM). Blocks sauvagine in hCRF2 cells and urocortin hypotension in rats.</p>Fórmula:C162H276N48O46Pureza:98%Cor e Forma:SolidPeso molecular:3632.26Sarafotoxin S6b
CAS:<p>non-selective endothelin receptor agonist</p>Fórmula:C110H163N27O34S5Pureza:98%Cor e Forma:SolidPeso molecular:2567.96Adrenomedullin (AM) (22-52), human
CAS:<p>Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.</p>Fórmula:C159H252N46O48Pureza:98%Cor e Forma:SolidPeso molecular:3576.04BA 1
CAS:<p>Potent BB1, BB2, and BB3 agonist; IC50: 0.26, 1.55, 2.52 nM. Boosts glucose transport in myocytes, promotes cancer cell growth in vitro.</p>Fórmula:C57H76N14O11Pureza:98%Cor e Forma:SolidPeso molecular:1133.32mPGES-1/sEH-IN-1
<p>mPGES-1/sEH-IN-1 (compound 1f) is an sEH inhibitor with an IC50 value of 5 μM. It also exhibits antitumor activity by inhibiting mPGES-1, with an IC50 value of 25 µM.</p>Fórmula:C20H16F3N3O2Cor e Forma:SolidPeso molecular:387.355Sibenadet hydrochloride
CAS:<p>Sibenadet, a D2/beta2-agonist, is potential useful for the treatment of symptoms of chronic obstructive pulmonary disease.</p>Fórmula:C22H29ClN2O5S2Cor e Forma:SolidPeso molecular:501.06d[Leu4,Lys8]-VP acetate
<p>d[Leu4,Lys8]-VP acetate: Vasopressin V1b agonist. Ki: rat 0.16 nM, human 0.52 nM, mouse 1.38 nM. Low antidiuretic/vasopressor effects.</p>Fórmula:C49H71N11O13S2Pureza:98.86%Cor e Forma:SolidPeso molecular:1086.28P2Y14 antagonist 1
<p>P2Y14 antagonist 1 (compound 45) is a highly selective and orally active P2Y14 receptor antagonist with an IC50 value of 0.70 nM. It demonstrates significant anti-inflammatory effects by effectively reducing pulmonary infiltration of immune cells and inflammatory responses through the inhibition of the NLRP3 signaling pathway. P2Y14 antagonist 1 is suitable for studying acute lung injury.</p>Fórmula:C24H21N3O3Cor e Forma:SolidPeso molecular:399.442CCR6 antagonist 2
<p>CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.</p>Fórmula:C19H24N4O4Cor e Forma:SolidPeso molecular:372.42CHS-114
<p>CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.</p>Cor e Forma:Odour Liquid5-HT6R antagonist 6
<p>5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.</p>Fórmula:C24H26N4O2SCor e Forma:SolidPeso molecular:434.55Arotinolol hydrochloride
CAS:<p>Arotinolol HCl is a non-selective α/β-blocker, anti-hypertensive, anti-obesity, and improves aortic stiffness.</p>Fórmula:C15H22ClN3O2S3Pureza:99.84%Cor e Forma:SolidPeso molecular:408Petrelintide acetate
<p>Petrelintide (ZP8396) acetate is an amylin analog with potential for weight reduction, suitable for diabetes research.</p>Fórmula:C185H305N49O61·xC2H4O2Cor e Forma:SolidPeso molecular:4191.69 (free base)β-MSH, human
CAS:<p>beta-MSH, human is an endogenous peptide hormone and neurotransmitter by POMC, an agonist of MC4-R (melanocortin 4 receptor).</p>Fórmula:C118H174N34O35SPureza:98%Cor e Forma:SolidPeso molecular:2660.92BMS-196085
CAS:<p>BMS-196085 is an effective and selective human β( 3) All agonists of adrenergic receptors, in β( 1) Partial agonist activity was 45%.</p>Fórmula:C24H26F2N2O5SCor e Forma:SolidPeso molecular:492.54Nemifitide diTFA
CAS:<p>Nemifitide diTFA is a synthetic pentapeptide with antidepressant properties, resembling MIF, that crosses the blood-brain barrier.</p>Fórmula:C37H45F7N10O10Pureza:99.78% - 99.84%Cor e Forma:SolidPeso molecular:922.8KISS1-305
CAS:KISS1-305: Metastin analog, prototype peptide, resists protease degradation, suboptimal KISS1R agonist.Fórmula:C56H76N16O12Pureza:98%Cor e Forma:SolidPeso molecular:1165.3SRA880 malonate
CAS:<p>SRA880: non-peptide sst(1) antagonist, low affinity for other sst receptors, binds dopamine D4, boosts SRIF, antidepressant-like effects.</p>Fórmula:C29H36N4O8Pureza:98%Cor e Forma:SolidPeso molecular:568.62SR-140603
CAS:<p>SR-140603, the less potent enantiomer of SR 140333, is used as the negative control.</p>Fórmula:C37H45Cl3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:656.12(R,R)-Palonosetron Hydrochloride
CAS:<p>(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron</p>Fórmula:C19H25ClN2OPureza:98%Cor e Forma:SolidPeso molecular:332.87Amitraz
CAS:<p>Amitraz (NSC 324552): white monoclinic crystals, mp 86-87°C, water-insoluble, used as acaricide and in canine demodectic mange.</p>Fórmula:C19H23N3Pureza:99.88%Cor e Forma:White/Pale Yellow Crystalline SolidPeso molecular:293.41Acetyl neurotensin (8-13)
CAS:Acetyl neurotensin (8-13), the most concise analog of neurotensin, retains complete binding and pharmacological properties [1].Fórmula:C40H66N12O9Peso molecular:859.03Spantide acetate
<p>Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.</p>Fórmula:C77H112N20O15Pureza:98.9200%Cor e Forma:SolidPeso molecular:1557.84[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide
[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a LHRH peptide analogue.Fórmula:C58H82N16O12Peso molecular:1195.37Neuropeptide Y (1-24) (human)
CAS:Neuropeptide Y (1-24) inhibits rat vas deferens twitch and activates NMDA-induced neurons in rat hippocampus.Fórmula:C116H170N30O40SPeso molecular:2656.83Prolactin-Releasing Peptide (12-31), rat
CAS:Prolactin-Releasing Peptide (12-31), rat, a fragment of PrRP, exhibits high affinity for GPR10 receptors and stimulates calcium mobilization in CHOK1 cellsFórmula:C104H158N32O26Peso molecular:2272.57Sorbinicate
CAS:<p>Sorbinicate is an antihypercholesterolaemic and vasodilating nicotinic acid ester.</p>Fórmula:C42H32N6O12Pureza:98%Cor e Forma:SolidPeso molecular:812.74Levitide
CAS:<p>Levitide is a neurohormone-like peptide which is from the skin of Xenopus laevis.</p>Fórmula:C66H119N21O19SPureza:98%Cor e Forma:SolidPeso molecular:1542.85Kisspeptin-10, rat
CAS:<p>Kisspeptin-10, rat is an Endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).</p>Fórmula:C63H83N17O15Pureza:98%Cor e Forma:SolidPeso molecular:1318.44Brain Natriuretic Peptide-45, rat
CAS:<p>BNP-45 (rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.</p>Fórmula:C213H349N71O65S3Pureza:98%Cor e Forma:SolidPeso molecular:5040.67ORG 2766
CAS:<p>ORG 2766 is an ACTH 4-9 (H-Met(O)-Glu-His-Phe-D-Lys-Phe-OH) analog and neurotrophic peptide.</p>Fórmula:C40H55N9O11SCor e Forma:SolidPeso molecular:869.99Secretoneurin, rat
CAS:<p>Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).</p>Fórmula:C159H252N40O58Pureza:98%Cor e Forma:SolidPeso molecular:3651.95Physalaemin
CAS:<p>Physalaemin is a non-mammalian tachykinin.</p>Fórmula:C58H84N14O16SPureza:98%Cor e Forma:SolidPeso molecular:1265.45GR 82334
CAS:<p>Tachykinin NK1 receptor antagonist.</p>Fórmula:C69H91N15O16Pureza:98%Cor e Forma:SolidPeso molecular:1386.57Ularitide
CAS:<p>Ularitide is a 32-amino acid peptide from ANP prohormone, resistant to dog kidney cortex peptidase.</p>Fórmula:C145H234N52O44S3Pureza:98%Cor e Forma:SolidPeso molecular:3505.97(+)-ORM-10921
CAS:<p>(+)-ORM-10921 is a conformation of ORM-10921 and can be used in chemical synthesis studies.</p>Fórmula:C18H23NO2Pureza:99.85%Cor e Forma:SoildPeso molecular:285.38tcY-NH2
CAS:<p>Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Fórmula:C40H49N7O7Pureza:98%Cor e Forma:SolidPeso molecular:739.87PD 142893
CAS:<p>PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.</p>Fórmula:C50H65N7O10Pureza:98%Cor e Forma:SolidPeso molecular:924.09Quinelorane
CAS:<p>Quinelorane is dextrorotary isomer.</p>Fórmula:C14H22N4Cor e Forma:SolidPeso molecular:246.3516-phenoxy tetranor Prostaglandin F2α isopropyl ester
CAS:<p>Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.</p>Fórmula:C25H36O6Cor e Forma:SolidPeso molecular:432.55717-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
CAS:<p>A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones</p>Fórmula:C24H33F3O5Cor e Forma:SolidPeso molecular:458.518Lanepitant
CAS:<p>Lanepitant (LY303870) is a non-peptide neurokinin-1 (NK-1) antagonist with analgesic activity for the prevention of migraine.</p>Fórmula:C33H45N5O3Pureza:97.71%Cor e Forma:SolidPeso molecular:559.74Spantide I
CAS:<p>Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.</p>Fórmula:C75H108N20O13Pureza:98%Cor e Forma:SolidPeso molecular:1497.79MrgprX2 antagonist-4
CAS:<p>MrgprX2 antagonist-4, from patent US20210128561A1, inhibits MrgprX2 receptor; useful for skin inflammation studies.</p>Fórmula:C16H19N3OCor e Forma:SolidPeso molecular:269.348Olcegepant hydrochloride
CAS:<p>Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist.</p>Fórmula:C38H48Br2ClN9O5Pureza:99.69%Cor e Forma:SolidPeso molecular:906.11Prosaptide TX14(A)
CAS:<p>GPR37L1/GPR37 agonist with EC50 of 5/7 nM, activates G proteins, enhances ERK, myelin synthesis, neuro/glioprotection.</p>Fórmula:C69H110N16O26Pureza:98%Cor e Forma:SolidPeso molecular:1579.72Surfagon
CAS:<p>Surfagon is an effective LHRH agonist.</p>Fórmula:C56H78N16O12Pureza:98%Cor e Forma:SolidPeso molecular:1167.345(S),6(R)-11-trans DiHETE
CAS:<p>5(S),6(R)-11-trans DiHETE, a C-11 isomer of 5(S),6(R)-DiHETE, occurs in rat kidneys, formed enzymatically; not a soybean lipoxygenase substrate.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47Terazosin dimer impurity dihydrochloride
CAS:<p>Terazosin dimer impurity dihydrochloride is a chemical byproduct of the α1-antagonist Terazosin, derived from quinazoline.</p>Fórmula:C24H30Cl2N8O4Cor e Forma:SolidPeso molecular:565.46
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