GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Vapiprost hydrochloride
CAS:<p>Vapiprost hydrochloride is a biochemicla.</p>Fórmula:C30H40ClNO4Cor e Forma:SolidPeso molecular:514.1Spantide II
CAS:<p>Spantide II is an antagonist of tachykinin.</p>Fórmula:C86H104Cl2N18O13Pureza:98%Cor e Forma:SolidPeso molecular:1668.77Bertilimumab
CAS:<p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>Cor e Forma:LiquidLY 293284
CAS:<p>LY 293284 is a potent, selective full agonist of 5-HT1A receptor with anxiogenic effects in animal studies.</p>Fórmula:C19H26N2OCor e Forma:SolidPeso molecular:298.42AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Fórmula:C22H28N2Pureza:98%Cor e Forma:SolidPeso molecular:320.47[D-Trp8]-γ-MSH
CAS:<p>[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively).</p>Fórmula:C74H99N21O16SPureza:98%Cor e Forma:SolidPeso molecular:1570.79Ala5-Galanin (2-11)
CAS:<p>Ala5-Galanin (2-11) is a specific agonist for the galanin receptor 2 (GAL2R) with an affinity constant (Ki) of 258 nM [1].</p>Fórmula:C54H81N13O13Pureza:98%Cor e Forma:SolidPeso molecular:1120.3Val9-Oxytocin
CAS:<p>Val9-Oxytocin, an Oxytocin analog where Gly9 is substituted with Val9 [1], functions as a complete antagonist of the vasopressin (V1a) receptor.</p>Fórmula:C46H72N12O12S2Pureza:98%Cor e Forma:SolidPeso molecular:1049.27HTL22562
CAS:<p>HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.</p>Fórmula:C40H49N11O5Cor e Forma:SolidPeso molecular:763.904Tetrapeptide-1
CAS:<p>Tetrapeptide-1 is a bioactive peptide renowned for its antioxidant properties and has been cited as an ingredient in cosmetics [1].</p>Fórmula:C20H36N4O6Pureza:98%Cor e Forma:SolidPeso molecular:428.52NPC 567
CAS:<p>NPC 567 is an antagonist of the bradykinin receptor.</p>Fórmula:C60H87N19O13Pureza:98%Cor e Forma:SolidPeso molecular:1282.48[D-Pro2] Spantide I TFA
<p>[D-Pro2] Spantide I TFA is an analog of Spantide I, a selective antagonist of the NK1 receptor [1].</p>Fórmula:C75H108N20O13·xC2HF3O2Pureza:98%Cor e Forma:SolidSB656104
CAS:<p>SB656104 is a bioactive chemical.</p>Fórmula:C25H30ClN3O3SCor e Forma:SolidPeso molecular:488.04Misoprostol acid
CAS:<p>Misoprostol acid is an active metabolite of Misoprostol,can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.</p>Fórmula:C21H36O5Pureza:98%Cor e Forma:SolidPeso molecular:368.51Substance P (1-9)
CAS:<p>Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.</p>Fórmula:C52H77N15O12Pureza:98%Cor e Forma:SolidPeso molecular:1104.26NF 340
CAS:<p>P2Y11 antagonist</p>Fórmula:C37H30N4Na4O15S4Pureza:98%Cor e Forma:SolidPeso molecular:990.87Neuropeptide Y 13-36 (porcine)
CAS:<p>Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist.</p>Fórmula:C135H209N41O36Cor e Forma:SolidPeso molecular:2982.408MRS7925
<p>MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosis</p>Fórmula:C20H26IN5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.36FGH31
<p>FGH31 (Compound 24), a dopamine D4 agonist, exhibits potent and selective GRK2-dependency with a K i of 1.6 nM and partially activates β-arrestin [1].</p>Fórmula:C33H36N4O2Pureza:98%Cor e Forma:SolidPeso molecular:520.66DETQ
CAS:<p>DETQ enhances human D1 dopamine receptor signaling, EC50=5.8 nM, less effective in rats/mice, inactive on D5.</p>Fórmula:C22H25Cl2NO3Cor e Forma:SolidPeso molecular:422.34(R)-V-0219 hydrochloride
<p>(R)-V-0219 hydrochloride: Oral GLP-1R PAM, enantiomer of V-0219, triggers Ca2+ flux in hGLP-1R HEK cells.</p>Fórmula:C20H26ClF3N4O2Cor e Forma:SolidPeso molecular:446.89CB2R agonist 3
<p>CB2R agonist 3, a potent activator of cannabinoid receptor 2 (CB2R), exhibits an EC50 value of 0.37μM, indicative of its significant role in the immune system [</p>Pureza:98%Cor e Forma:Odour SolidBAY-6672 hydrochloride
CAS:BAY-6672 hydrochloride is a potent, selective antagonist of the human Prostaglandin F (FP) receptor, exhibiting an IC50 value of 11 nM.Fórmula:C26H28BrCl2N3O3Cor e Forma:SolidPeso molecular:581.33IRL-3630
CAS:<p>IRL 3460 is an enantiomer.</p>Fórmula:C31H40N4O6SPureza:98%Cor e Forma:SolidPeso molecular:596.74Lisuride maleate
CAS:<p>Lisuride maleate is a non-selective dopamine agonist and G-protein-biased 5-HT2A receptor agonist capable of blocking prolactin release.</p>Fórmula:C24H30N4O5Pureza:99.85%Cor e Forma:SolidPeso molecular:454.52LHRH
CAS:<p>Luteinizing hormone-releasing hormone (LHRH) is a neuropeptide produced in the hypothalamus that plays a pivotal role in regulating reproduction and has</p>Fórmula:C55H74N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1183.27Sigma-1 receptor antagonist 5
<p>Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors</p>Fórmula:C26H27N3OPureza:98%Cor e Forma:SolidPeso molecular:397.51GLP-1R agonist 4
CAS:<p>GLP-1R agonist 4, potentially for diabetes research, is a potent GLP-1R stimulator linked to hypoglycemia.</p>Fórmula:C32H30ClF2N3O5Cor e Forma:SolidPeso molecular:610.05TCMCB07
CAS:<p>TCMCB07, a cyclic nonapeptide, serves as an orally active, brain-penetrant antagonist of the melanocortin receptor 4 (MC4R), with significant implications in</p>Fórmula:C63H87N15O11Pureza:98%Cor e Forma:SolidPeso molecular:1230.46Galanin-Like Peptide (rat)
CAS:<p>Galanin-Like Peptide (rat), a neuropeptide comprising 60 amino acids, plays a crucial role in regulating feeding, body weight, and energy metabolism [1].</p>Fórmula:C288H461N87O83SPureza:98%Cor e Forma:SolidPeso molecular:6502.34PACAP (6-38), human, ovine, rat acetate
<p>PACAP (6-38), human, ovine, rat acetate is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor</p>Fórmula:C184H303N55O48SPureza:99.84%Cor e Forma:SoildPeso molecular:4085.84Mibenratide TFA
<p>Mibenratide TFA, a small cyclic peptide, functions as an adrenergic β1 receptor antagonist and has potential applications in heart failure research [1].</p>Pureza:98%Cor e Forma:Odour SolidTamuzimod
CAS:<p>Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2].</p>Fórmula:C21H13Cl3F3N5O3Cor e Forma:SolidPeso molecular:546.71Ro60-0175
CAS:<p>Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.</p>Fórmula:C11H12ClFN2Pureza:97.09%Cor e Forma:SolidPeso molecular:226.68LY 344864 racemate
CAS:<p>LY 344864 racemate is a 5-HT1F receptor agonist.</p>Fórmula:C21H22FN3OPureza:99.75%Cor e Forma:SoildPeso molecular:351.42LUF6096
CAS:<p>LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while</p>Fórmula:C22H21Cl2N3OPureza:99.5%Cor e Forma:SolidPeso molecular:414.33(Leu31,Pro34)-Peptide YY (human) (TFA)
<p>"(Leu31,Pro34)-Peptide YY (human) (TFA) is the trifluoroacetic acid (TFA) form of (Leu31,Pro34)-Peptide YY (human), a derivative of Peptide YY that acts as a</p>Fórmula:C195H296N54O56·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:4292.75 (free base)SB 201146
CAS:<p>SB 201146 is a leukotriene B4 antagonist with high affinity.</p>Fórmula:C30H35LiN2O5SCor e Forma:SolidPeso molecular:542.61GLP-1R agonist 29
<p>GLP-1R agonist 29 (Compound 20) is a GLP-1R agonist that induces hGLP-1R-mediated cAMP stimulation with an EC50 of 0.018 nM. It exhibits favorable pharmacokinetic properties and shows good in vivo exposure, with an AUC0-∞,sc of 77688 ng·h/mL.</p>Cor e Forma:Odour SolidSpns2-IN-1
<p>Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune</p>Pureza:98%Cor e Forma:Odour SolidACT-1016-0707
CAS:<p>ACT-1016-0707 is a selective, insurmountable LPA1 antagonist with antifibrotic and anti-inflammatory activity in lung fibrosis models</p>Fórmula:C19H23ClN4O4SPureza:99.905%Cor e Forma:SolidPeso molecular:438.93Hemokinin 1, human TFA
<p>Hemokinin-1 is a human TFA and selective NK1 agonist; also activates NK2 & NK3 and induces opioid-independent analgesia.</p>Fórmula:C56H85F3N14O16SCor e Forma:SolidPeso molecular:1299.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Fórmula:C24H32N2O8Pureza:98.12%Cor e Forma:SolidPeso molecular:476.52Secretin (33-59), rat TFA
<p>Secretin (33-59), rat (TFA), a 27-aa peptide, stimulates the secretin receptor, increasing pancreas secretion of bicarbonate, enzymes, and K+.</p>Fórmula:C131H217F3N42O44Cor e Forma:SolidPeso molecular:3141.37BAM(8-22) TFA
<p>BAM(8-22) TFA activates Mrgprs, induces mouse scratching, and is a proenkephalin A derivative.</p>Fórmula:C93H128F3N25O25SCor e Forma:SolidPeso molecular:2085.22Neuropeptide W-30 (human)
CAS:<p>Neuropeptide W-30 (human) serves as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It acts as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8, binding and activating them at comparable effective doses [1] [2] [3].</p>Fórmula:C165H249N49O37SCor e Forma:SolidPeso molecular:3543.11PACAP (1-38) free acid
CAS:<p>PACAP (1-38) free acid, an endogenous neuropeptide, potently modulates gastrointestinal and neuroendocrine functions.</p>Cor e Forma:SolidSelepressin acetate
<p>Selepressin acetate is a useful organic compound for research related to life sciences and the catalog number is T73654.</p>Fórmula:C48H77N13O13S2Cor e Forma:SolidPeso molecular:1108.33[Ala2] Endothelin-3, human
CAS:<p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>Fórmula:C120H166N26O32S4Cor e Forma:SolidPeso molecular:2613.02Dotanoc
CAS:<p>Dotanoc is a ligand to make gallium Ga 68-DOTANOC, which is a gallium Ga 68-radiolabeled analog of somatostatin.</p>Fórmula:C69H94N14O17S2Cor e Forma:SolidPeso molecular:1455.71
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