GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47RS 18286
CAS:<p>RS 18286 is a LHRH antagonist.</p>Fórmula:C74H101Cl2N17O14Cor e Forma:SolidPeso molecular:1523.6Abediterol napadisylate
CAS:<p>Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.</p>Fórmula:C60H68F4N4O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1209.32Vapiprost
CAS:<p>Vapiprost is an antagonist of the thromboxane receptor and a prostaglandin receptor.</p>Fórmula:C30H39NO4Pureza:98%Cor e Forma:SolidPeso molecular:477.64A-286501
CAS:<p>A-286501: Oral adenosine kinase inhibitor, IC50=0.47 nM, reduces pain via non-opioid, non-NSAID ADO receptors.</p>Fórmula:C11H14BrN5O2Pureza:98%Cor e Forma:SolidPeso molecular:328.17WAY-639418
CAS:<p>WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.</p>Fórmula:C17H16ClN5Pureza:99.62%Cor e Forma:SolidPeso molecular:325.8L 366811
CAS:<p>L 366811 is a potent oxytocin antagonist.</p>Fórmula:C43H56N8O6Cor e Forma:SolidPeso molecular:780.95Denrakibart
<p>Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.</p>Cor e Forma:Odour LiquidMet-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Cor e Forma:Odour SolidCCR8 antagonist 1
CAS:<p>CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.</p>Fórmula:C26H29N3O5SPureza:99.51%Cor e Forma:SolidPeso molecular:495.59[Ala11,D-Leu15]-Orexin B acetate
<p>[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).</p>Fórmula:C122H210N44O37SPureza:98.18%Cor e Forma:SolidPeso molecular:2917.31PG 106 acetate
<p>PG 106 acetate: Selective hMC3 receptor antagonist, IC50=210 nM; inactive on hMC5 and hMC4, EC50=9900 nM.</p>Fórmula:C53H73N13O11Pureza:98.24%Cor e Forma:SolidPeso molecular:1068.23Tizanidine
CAS:<p>Tizanidine, an α2-adrenergic receptor agonist, suppresses the release of neurotransmitters from central nervous system (CNS) noradrenergic neurons.</p>Fórmula:C9H8ClN5SPureza:99.11%Cor e Forma:White SolidPeso molecular:253.71α-CGRP (mouse, rat) TFA
<p>α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions and</p>Fórmula:C162H262N50O52S2·C2HF3O2Pureza:98%Cor e Forma:Solid(+)-Dropropizine
CAS:<p>(+)-Dropropizine can inhibit histamine receptor, anti-allergic, and reduce a cough by modulation of neuropeptides involved in the cough reflex.</p>Fórmula:C13H20N2O2Pureza:>99.99%Cor e Forma:White Or Off White Crystalline PowderPeso molecular:236.31APJ receptor agonist 1
CAS:<p>Potent APJ-R agonist 1, biphenyl acid, EC50: 0.093 nM (human), 0.12 nM (rat), targets apelin-13, promising for heart failure study.</p>Fórmula:C31H26ClN3O3Cor e Forma:SolidPeso molecular:524.02A 76154
CAS:<p>A 76154 is an antagonist of leutenizing hormone releasing hormone (LHRH).</p>Fórmula:C70H93FN12O12Cor e Forma:SolidPeso molecular:1313.584Femoxetine
CAS:<p>Femoxetine: antidepressant, enhances morphine, inhibits MAO-A/B, boosts mice's exercise capacity.</p>Fórmula:C20H25NO2Pureza:99.1% - 99.35%Cor e Forma:SolidPeso molecular:311.42GM-60186
GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.Fórmula:C30H33FN2O4Cor e Forma:SolidPeso molecular:504.59B7-33
CAS:B7-33 is a single-chain relaxin analog and a selective agonist for relaxin receptor 1 (RXFP1). It binds to RXFP1 and preferentially activates the pERK pathway in cells expressing RXFP1, rather than cAMP. B7-33 serves as an antifibrotic agent and provides cardioprotective effects.Fórmula:C131H229N41O36SCor e Forma:SolidPeso molecular:2986.54LEK 8804
CAS:<p>LEK 8804 is a 5-HT(2) receptor antagonist and 5-HT(1A) receptor agonist.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Fórmula:C22H28N2O2Cor e Forma:SolidPeso molecular:352.47L-779976
CAS:<p>L-779,976 is an agonist of somatostatin receptor.</p>Fórmula:C33H43N7O3Cor e Forma:SolidPeso molecular:585.74Sphinganine 1-phosphate
CAS:<p>Sphinganine 1-phosphate has protects kidney and liver through activation of the S1P1 receptor in mice and acts as an agonist for S1P4 in Homo sapien.</p>Fórmula:C18H40NO5PCor e Forma:SolidPeso molecular:381.49Substance P(1-7)
CAS:Substance P(1-7) is a bioactive metabolite of tachykinin SP with anti-inflammatory and analgesic properties.Fórmula:C41H65N13O10Pureza:98%Cor e Forma:SolidPeso molecular:900.04LHRH, Ala(6)-
CAS:<p>LHRH, Ala(6)- is a synthetic luteinizing hormone-releasing hormone agonist agent.</p>Fórmula:C56H77N17O13Cor e Forma:SolidPeso molecular:1196.32Bucindolol Formate
Bucindolol is a β1-adrenergic blocker with sympathomimetic activity, used in heart failure research.Fórmula:C23H27N3O4Pureza:99.76% - 99.88%Cor e Forma:SolidPeso molecular:409.48Rubraxanthone
CAS:<p>Rubraxanthone is a PAF inhibitor isolated from Garcinia parvifolia Miq.</p>Fórmula:C24H26O6Cor e Forma:SolidPeso molecular:410.466Tecastemizole
CAS:<p>Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.</p>Fórmula:C19H21FN4Pureza:99.70%Cor e Forma:SolidPeso molecular:324.4Emoghrelin
CAS:<p>Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].</p>Fórmula:C24H22O13Pureza:98%Cor e Forma:SolidPeso molecular:518.42α-CGRP(human)
CAS:<p>Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.</p>Fórmula:C163H267N51O49S2Pureza:98%Cor e Forma:SolidPeso molecular:3789.33Alverine hydrochloride
CAS:<p>Alverine hydrochloride is a parasympatholytic.</p>Fórmula:C20H28ClNCor e Forma:SolidPeso molecular:317.9Endolide F
Endolide F (Compound 2) is a proline-containing lactone that serves as a moderate antagonist of the arginine vasopressin V1A receptor.Fórmula:C25H32N4O6Peso molecular:484.23218Myristoylated ARF6 (2-13)
<p>Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.</p>Fórmula:C74H128N16O18Peso molecular:1528.95925CI-988 hemihydrate
<p>CI-988 hemihydrate (PD134308) is a potent and selective orally active CCK2R (cholecystokinin 2 receptor) antagonist, with an IC50 of 1.7 nM for mouse cortical CCK2. It is over 1600 times more selective for CCK2 than for CCK1 receptors. CI-988 hemihydrate exhibits anxiolytic and antitumor properties.</p>Fórmula:C35H42N4O6H2OPeso molecular:632.321MR33317
<p>MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41 nM. Additionally, it acts as an agonist for brain 5-HT4 receptors.</p>Fórmula:C22H28ClN3O2Peso molecular:401.187Cyclic AC253
<p>Cyclic AC253 is an amylin receptor antagonist with an IC50 of 0.3 μM. It offers neuroprotective effects against Aβ toxicity and mitigates Aβ-induced impairments in hippocampal long-term potentiation. Additionally, Cyclic AC253 is capable of penetrating the blood-brain barrier.</p>Fórmula:C126H202N42O40S2Peso molecular:3007.45049TCMCB07
CAS:<p>TCMCB07, a cyclic nonapeptide, serves as an orally active, brain-penetrant antagonist of the melanocortin receptor 4 (MC4R), with significant implications in</p>Fórmula:C63H87N15O11Pureza:98%Cor e Forma:SolidPeso molecular:1230.46Galanin-Like Peptide (rat)
CAS:<p>Galanin-Like Peptide (rat), a neuropeptide comprising 60 amino acids, plays a crucial role in regulating feeding, body weight, and energy metabolism [1].</p>Fórmula:C288H461N87O83SPureza:98%Cor e Forma:SolidPeso molecular:6502.34A 77636 hydrochloride
CAS:<p>A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM).</p>Fórmula:C20H28ClNO3Pureza:99.57%Cor e Forma:SolidPeso molecular:365.89A3AR agonist 1
<p>A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective</p>Fórmula:C28H34N6O6Pureza:98%Cor e Forma:SolidPeso molecular:550.61palm-PrRP31
palm-PrRP31 is a potent dual agonist for GPR10 (EC50=72 pM) and NPFF-R2. It activates downstream signaling pathways by binding to GPR10 and NPFF-R2 receptors, leading to reduced appetite and increased energy expenditure. palm-PrRP31 can be utilized to investigate its mechanism of action in the nervous system, thereby elucidating the complex biological processes involved in the regulation of appetite and energy expenditure.Fórmula:C176H282N56O43SPeso molecular:3900.132215(R)-17-phenyl trinor Prostaglandin F2α
CAS:<p>17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular</p>Fórmula:C23H32O5Cor e Forma:SolidPeso molecular:388.5Lys-(Des-Arg9,Leu8)-Bradykinin
CAS:<p>Lys-(Des-Arg9,Leu8)-Bradykinin is a selective antagonist of the bradykinin B1 receptor [1].</p>Fórmula:C47H75N13O11Pureza:98%Cor e Forma:SolidPeso molecular:998.18RFRP-3(human)
CAS:<p>NPFF1 receptor agonist, IC50 0.7 nM, blocks cAMP by forskolin. A GnIH homolog, it inhibits GnRH neuron activity.</p>Fórmula:C45H72N14O10Pureza:98%Cor e Forma:SolidPeso molecular:969.15PSB-1114 triethylamine
<p>PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50</p>Fórmula:C10H15F2N3O13P3S·xC6H15NPureza:98%Cor e Forma:SolidSemaglutide TFA
<p>Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels and reduces cardiovascular risk in diabetic patients</p>Fórmula:C189H290F3N45O61Pureza:99.69%Cor e Forma:SolidPeso molecular:4225.6482(±)14(15)-EpETE
CAS:<p>(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45Tiapride-d3
Tiapride-d3 is a deuterated form of Tiapride, a selective dopamine D2 receptor antagonist and an antipsychotic compound.Fórmula:C15H21D3N2O4SCor e Forma:SolidPeso molecular:331.45Lysosphingomyelin (d18:1)
CAS:<p>Sphingomyelins are phosphorylcholine, sphingosine, and fatty acid. Lysosphingomyelin, missing the fatty acid, activates diverse cellular pathways.</p>Fórmula:C23H49N2O5PCor e Forma:SolidPeso molecular:464.628
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