GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(985 produtos)
- Receptor de adenosina(244 produtos)
- Receptor adrenérgico(2.991 produtos)
- Receptor de Bombesina(32 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(153 produtos)
- CaSR(33 produtos)
- Receptor de Canabinóides(209 produtos)
- Receptor de Dopamina(433 produtos)
- Receptor Endotelina(79 produtos)
- Receptor GNRH(77 produtos)
- GPCR19(32 produtos)
- GRK(33 produtos)
- GTPase(22 produtos)
- Receptor Glucagon(181 produtos)
- Hedgehog/Smoothened(46 produtos)
- Receptor de Histamina(380 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(309 produtos)
- PAFR(12 produtos)
- PKA(51 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5696 produtos de "GPCR/Proteína-G"
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N6-Benzyl-5'-ethylcarboxamido adenosine
CAS:N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist.Fórmula:C19H22N6O4Cor e Forma:SolidPeso molecular:398.424-Butyl-α-agarofuran
CAS:4-Butyl-alpha-agarofuran, a Gharu-wood derivative, is an anxiolytic, antidepressant, and aids neurological research.Fórmula:C18H30OCor e Forma:SolidPeso molecular:262.43Drinabant
CAS:<p>Drinabant (AVE-1625) is an orally active CB1 receptor antagonist.</p>Fórmula:C23H20Cl2F2N2O2SPureza:99.8%Cor e Forma:SolidPeso molecular:497.38Bamosiran
CAS:Bamosiran, a small interfering RNA (siRNA), specifically targets the β-adrenergic receptor 2 to reduce intraocular pressure.Cor e Forma:SolidPEN (rat)
CAS:PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C102H169N27O33Pureza:98%Cor e Forma:SolidPeso molecular:2301.62Alosetron-d3
CAS:<p>Alosetron D3 (GR 68755 D3) is a deuterium-labeled Alosetron. Alosetron is an antagonist of 5HT3-receptor.</p>Fórmula:C17H18N4OPureza:98%Cor e Forma:SolidPeso molecular:297.3715(S)-HpEPE
CAS:15(S)-HpEPE, a monohydroperoxy fatty acid, forms when 15-lipoxygenase acts on EPA, with expected biological activities akin to 15(S)-HpETE.Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.456AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Fórmula:C25H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:438.52Muscarinic toxin 3
CAS:<p>Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57</p>Fórmula:C319H489N89O97S8Pureza:98%Cor e Forma:SolidPeso molecular:7379.35Fasitibant chloride
CAS:<p>Fasitibant chloride, a potent B2R blocker, alleviates pain and swelling in arthritis.</p>Fórmula:C36H49Cl3N6O6SCor e Forma:SolidPeso molecular:800.23Spns2-IN-1
<p>Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune</p>Pureza:98%Cor e Forma:Odour SolidNorisoboldine hydrochloride
CAS:<p>Norisoboldine hydrochloride: an oral AhR agonist from Radix Linderae, for Rheumatoid arthritis and Ulcerative colitis research.</p>Fórmula:C18H20ClNO4Cor e Forma:SolidPeso molecular:349.81Maridebart
CAS:<p>Maridebart is a humanized IgG1-kappa monoclonal antibody that targets the GIPR (gastric inhibitory polypeptide receptor) [1].</p>Cor e Forma:LiquidSamelisant
CAS:<p>Samelisant (SUVN-G3031), a selective H3 inverse agonist, Ki=8.7/9.8 nM in humans/rats, has anti-narcoleptic properties.</p>Fórmula:C21H31N3O3Pureza:99.59%Cor e Forma:SolidPeso molecular:373.49Cetirizine Impurity C
CAS:Cetirizine Impurity C - a metabolite of hydroxyzine, is a long-acting, oral H1-antihistamine.Fórmula:C21H25ClN2O3Cor e Forma:SolidPeso molecular:388.89[Deamino-Pen1,Val4,D-Arg8]-vasopressin
CAS:<p>[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP).</p>Fórmula:C48H69N13O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1068.27GLP-1(7-37)
CAS:GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.Fórmula:C151H228N40O47Pureza:98%Cor e Forma:SolidPeso molecular:3355.67(S)-Osanetant
CAS:(S)-Osanetant, an S-enantiomer, is a selective NK3 antagonist with potential for treating schizophrenia and has anxiolytic and antidepressant effects.Fórmula:C35H41Cl2N3O2Cor e Forma:SolidPeso molecular:606.62ARC 239 dihydrochloride
CAS:<p>ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).</p>Fórmula:C24H31Cl2N3O3Pureza:99.72%Cor e Forma:SolidPeso molecular:480.43(Hyp³)-Bradykinin acetate
(Hyp³)-Bradykinin acetate is an agonist of bradykinin B2 receptor and stimulates inositol phosphate production in cultured human fibroblasts.Fórmula:C52H77N15O14Pureza:99.46%Cor e Forma:SolidPeso molecular:1136.26AC-264613
CAS:<p>AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.</p>Fórmula:C19H18BrN3O2Pureza:98%Cor e Forma:SolidPeso molecular:400.28(D-Arg8)-Inotocin
CAS:<p>'(D-Arg8)-Inotocin is a potent, selective, and competitive antagonist of the vasopressin receptor (V 1a R), exhibiting a binding affinity (K i) of 1.3 nM.</p>Fórmula:C39H68N14O11S2Pureza:98%Cor e Forma:SolidPeso molecular:973.17(±)5(6)-EET
CAS:<p>5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.473Pafenolol
CAS:<p>Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.</p>Fórmula:C18H31N3O3Pureza:98.33%Cor e Forma:SolidPeso molecular:337.46Vatinoxan
CAS:Vatinoxan is a peripheral α2 adrenoreceptor antagonist.Fórmula:C20H26N4O4SPureza:98%Cor e Forma:SolidPeso molecular:418.51CCR4 antagonist 3
CAS:<p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.43SC-53116
CAS:SC-53116 HCl can increase the production of serotonin in central nervous system tissues and is a psychoactive agent.Fórmula:C16H22ClN3O2Cor e Forma:SolidPeso molecular:323.82Neuropeptide Y5 receptor ligand-1
CAS:Neuropeptide Y5 receptor ligand-1 (Compound 54), a carbazole derivative, acts as a powerful antagonist to the neuropeptide Y5 (NPY-5) receptor [1].Fórmula:C19H17N3O2Cor e Forma:SolidPeso molecular:319.36GB-110 hydrochloride
GB-110 HCl: potent, nonpeptidic oral PAR2 agonist; triggers Ca2+ release in HT29 cells; EC50 0.28 μM.Fórmula:C33H49ClN6O5Cor e Forma:SolidPeso molecular:645.23HTL22562
CAS:HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.Fórmula:C40H49N11O5Cor e Forma:SolidPeso molecular:763.904Metipranolol
CAS:<p>Metipranolol (Betamann) is a type of β- Adrenergic receptors（ β- A potent antagonist of adrenergic receptor on guinea pig atria β 1- Adrenergic receptors and rat uterus β The 2-adrenergic receptor exhibited the beta blocking potentials (pA2) of 8.3 and 8.4, respectively. It is also a potent substituent in the 3H DHA binding assay, with a ligand concentration of 0.7 nM and a Ki of 39 ± 24 nM.</p>Fórmula:C17H27NO4Pureza:98.37%Cor e Forma:SolidPeso molecular:309.4Neurokinin B
CAS:<p>NKB, a tachykinin peptide, impacts human functions like gonadotropin-releasing hormone secretion.</p>Fórmula:C55H79N13O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1210.42Ramelteon metabolite M-II
CAS:Ramelteon M-II binds MT1/MT2 with IC50s: 208/1470 pM; it's the main metabolite and a melatonin receptor agonist.Fórmula:C16H21NO3Pureza:98%Cor e Forma:SolidPeso molecular:275.34Adenosine 2',5'-diphosphate sodium
CAS:<p>Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.</p>Fórmula:C10H15N5NaO10P2Cor e Forma:SolidPeso molecular:450.192CAY10509
CAS:<p>CAY10509 is a PGF2α analogue and acts as an FP receptor inhibitor with an IC50 of 30 nM. It shows potential for use in studying the physiological regulatory mechanisms related to prostaglandins.</p>Fórmula:C23H35FO5SCor e Forma:SolidPeso molecular:442.588-iso Prostaglandin E2
CAS:"8-iso PGE2: Isoprostane from arachidonic acid, potent rat renal vasoconstrictor, reduces GFR and renal flow by 80%, no BP effect."Fórmula:C20H32O5Cor e Forma:SolidPeso molecular:352.47{Val1}-Exendin-3/4
{Val1}- exendin-3/4 is the first n-terminal 1-28 residue of exendin-4 peptide.Fórmula:NAPureza:98%Cor e Forma:SolidPeso molecular:3241.7GLP-1R agonist 16
CAS:Compound 115a, a GLP-1R agonist, effectively activates the GLP-1 receptor with an EC50 of 0.15 nM [1].Fórmula:C50H58FN10O6PCor e Forma:SolidPeso molecular:945.03Galanin Receptor Ligand M35
CAS:<p>M35, a galanin(1-13)-bradykinin(2-9) amide, acts as a galanin antagonist in rats and inhibits mouse pancreatic islets.</p>Fórmula:C107H153N27O26Pureza:98%Cor e Forma:SolidPeso molecular:2233.6GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].Fórmula:C19H16FN5O2Cor e Forma:SolidPeso molecular:365.36PACAP-38 (31-38), human, mouse, rat acetate
PACAP-38 (31-38) acetate stimulates PAC1 receptor and boosts NPY and catecholamine in sympathetic neurons.Fórmula:C49H87N17O13Pureza:99.92%Cor e Forma:SolidPeso molecular:1122.32Tamuzimod
CAS:Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2].Fórmula:C21H13Cl3F3N5O3Cor e Forma:SolidPeso molecular:546.71Ro60-0175
CAS:<p>Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.</p>Fórmula:C11H12ClFN2Pureza:97.09%Cor e Forma:SolidPeso molecular:226.68SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Fórmula:C19H18F2N4OPureza:99.81%Cor e Forma:SolidPeso molecular:356.37LUF6096
CAS:<p>LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while</p>Fórmula:C22H21Cl2N3OPureza:99.5%Cor e Forma:SolidPeso molecular:414.33Firazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.51PROTAC(H-PGDS)-8
CAS:PROTAC(H-PGDS)-8 is a PROTAC degrader targeting Hematopoietic prostaglandin D synthase (H-PGDS), exhibiting an IC50 of 0.14 μM [1].Fórmula:C41H40N8O7Cor e Forma:SolidPeso molecular:756.819-deoxy-9-methylene Prostaglandin E2
CAS:9-deoxy-9-methylene PGE2: stable PGE2 analog with similar effects, less side effects, equal potency in rats, gerbils, primates.Fórmula:C21H34O4Cor e Forma:SolidPeso molecular:350.499DOTA-LM3 TFA
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2.Fórmula:C71H94ClF3N16O21S2Cor e Forma:SolidPeso molecular:1664.18PG106 TFA
<p>PG106 TFA is a potent hMC3 antagonist (IC50=210 nM), inactive at hMC4 (EC50=9900 nM) and hMC5 receptors.</p>Fórmula:C53H70F3N13O11Cor e Forma:SolidPeso molecular:1122.2
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