GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(993 produtos)
- Receptor de adenosina(246 produtos)
- Receptor adrenérgico(3.004 produtos)
- Receptor de Bombesina(33 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(153 produtos)
- CaSR(33 produtos)
- Receptor de Canabinóides(212 produtos)
- Receptor de Dopamina(433 produtos)
- Receptor Endotelina(79 produtos)
- Receptor GNRH(77 produtos)
- GPCR19(32 produtos)
- GRK(32 produtos)
- GTPase(22 produtos)
- Receptor Glucagon(182 produtos)
- Hedgehog/Smoothened(47 produtos)
- Receptor de Histamina(381 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(310 produtos)
- PAFR(12 produtos)
- PKA(51 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5745 produtos de "GPCR/Proteína-G"
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Amitriptyline
CAS:<p>Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.</p>Fórmula:C20H23NPureza:98.24% - 99.64%Cor e Forma:Crystals SolidPeso molecular:277.4Physalaemin acetate
<p>Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.</p>Fórmula:C60H88N14O18SPureza:99.13%Cor e Forma:SolidPeso molecular:1325.49KB-5492 anhydrous
CAS:KB 5492 is an agent of anti-ulcer. It preventing cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion.Fórmula:C27H34N2O10Cor e Forma:SolidPeso molecular:546.57Syk Inhibitor II dihydrochloride
CAS:Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.Fórmula:C14H17Cl2F3N6OPureza:98.53%Cor e Forma:SolidPeso molecular:413.22Ibrolipim
CAS:<p>Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.</p>Fórmula:C19H20BrN2O4PPureza:98.04%Cor e Forma:SolidPeso molecular:451.25Carmoxirole (free base)
CAS:Carmoxirole: a dopamine D2 agonist, reduces pre-load/afterload, aids heart failure, lowers blood pressure by inhibiting noradrenaline release.Fórmula:C24H26N2O2Cor e Forma:SolidPeso molecular:374.48(S)-Amisulpride
CAS:(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist.Fórmula:C17H27N3O4SPureza:98.38%Cor e Forma:SolidPeso molecular:369.48Facinicline (free base)
CAS:Facinicline (free base) is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's.Fórmula:C15H18N4OCor e Forma:SolidPeso molecular:270.33SB-203186 hydrochloride
CAS:<p>SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist</p>Fórmula:C16H20N2O2·HClPureza:99.64%Cor e Forma:SolidPeso molecular:308.81HCGRP-(8-37) acetate
<p>HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.</p>Fórmula:C141H234N44O40Pureza:99.29%Cor e Forma:SolidPeso molecular:3185.64Ponesimod
CAS:<p>Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.</p>Fórmula:C23H25ClN2O4SPureza:99.42% - 99.96%Cor e Forma:SolidPeso molecular:460.97Cinaciguat
CAS:<p>Cinaciguat (BAY 58-2667) is a pioneering sGC activator for acute heart failure treatment.</p>Fórmula:C36H39NO5Pureza:98% - 99.18%Cor e Forma:SolidPeso molecular:565.7Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Fórmula:C22H21ClN2NaO4SCor e Forma:SolidPeso molecular:467.92Tetracosactide acetate
CAS:Cosyntropin (acetate) stimulates the release of corticosteroids such as cortisol from the adrenal gland.Fórmula:C138H214N40O33SPureza:99.76%Cor e Forma:SolidPeso molecular:2993.54Sonepiprazole hydrochloride
CAS:Sonepiprazole HCl is a a selective dopamine D4 antagonist.Fórmula:C21H28ClN3O3SCor e Forma:SolidPeso molecular:437.98[Sar9] Substance P acetate(77128-75-7 free base)
[Sar9]-Substance P acetate, an NK-1 receptor agonist, mimics SP's effect on progesterone metabolism.Fórmula:C66H104N18O15SPureza:96.67%Cor e Forma:SolidPeso molecular:1421.71AM1241
CAS:<p>AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.</p>Fórmula:C22H22IN3O3Pureza:98.937% - 99.1%Cor e Forma:SolidPeso molecular:503.33BD 1008 Free Base
CAS:BD 1008 Free Base: Sigma-1 receptor antagonist, Kᵢ = 2 ± 1 nM, 4x more selective for sigma-1 than sigma-2.Fórmula:C15H22Cl2N2Cor e Forma:SolidPeso molecular:301.25[Lys8, Lys9]-Neurotensin (8-13) acetate
<p>[Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2</p>Fórmula:C40H68N8O10Pureza:99.31%Cor e Forma:SolidPeso molecular:821.02Benzotript
CAS:<p>Benzotript is an gastrin-receptor antagonist, with anti-gastrinic.</p>Fórmula:C18H15ClN2O3Pureza:97.82%Cor e Forma:SolidPeso molecular:342.776EST64454 free base
CAS:EST64454: σ1R antagonist for pain, high solubility, permeable, BCS class I, metabolically stable.Fórmula:C18H22F2N4O2Cor e Forma:SolidPeso molecular:364.392'-O-Methylisoliquiritigenin
CAS:2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-Fórmula:C16H14O4Pureza:98.75%Cor e Forma:SolidPeso molecular:270.28Urantide acetate(669089-53-6 free base)
<p>Urantide acetate: selective UT receptor blocker, doesn't affect other contractions or relaxations, partial agonist in Ca²⁺ assay.</p>Fórmula:C53H70N10O14S2Pureza:99.22%Cor e Forma:SolidPeso molecular:1135.31Preladenant
CAS:<p>Preladenant (SCH-420814) is an orally bioavailable antagonist of the adenosine A2A receptor (Ki: 1.1 nM) and has >1000-fold selectivity over all other adenosine</p>Fórmula:C25H29N9O3Pureza:98.02% - 99.68%Cor e Forma:SolidPeso molecular:503.56ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFórmula:C14H11BrO3Pureza:99.12%Cor e Forma:SolidPeso molecular:307.139Fexofenadine hydrochloride
CAS:<p>Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis,</p>Fórmula:C32H39NO4·HClPureza:99.39% - ≥95%Cor e Forma:SolidPeso molecular:538.13Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant toFórmula:C49H70N12O13Pureza:99.93%Cor e Forma:SolidPeso molecular:1035.15Bromodiphenhydramine hydrochloride
CAS:<p>Bromodiphenhydramine hydrochloride is a new antihistaminic in the control of cutaneous.</p>Fórmula:C17H21BrClNOPureza:97.29%Cor e Forma:SolidPeso molecular:370.71Bupranolol HCl
CAS:Bupranolol: non-selective beta blocker, no ISA, strong membrane stabilizer, fast gut absorption, high first-pass metabolism, 2-4hr half-life.Fórmula:C14H23Cl2NO2Cor e Forma:SolidPeso molecular:308.243Bavisant dihydrochloride hydrate
CAS:Bavisant dihydrochloride (JNJ31001074AAC) is an oral H3 receptor antagonist for ADHD treatment. Phase 2 trials show no significant benefits at 10 mg/day.Fórmula:C19H31Cl2N3O3Cor e Forma:SolidPeso molecular:420.38Protease-Activated Receptor-2, amide
CAS:<p>Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)</p>Fórmula:C28H54N8O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:614.782-Methoxyidazoxan monohydrochloride
CAS:L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor.Fórmula:C12H14N2O3·HClPureza:98.99%Cor e Forma:SolidPeso molecular:270.72RS-127445 hydrochloride
CAS:<p>RS-127445 hydrochloride (MT 500) is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).</p>Fórmula:C17H17ClFN3Pureza:99.48%Cor e Forma:SolidPeso molecular:317.79BGC-20-1531 hydrochloride(1186532-61-5 free base)
CAS:<p>BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine.</p>Fórmula:C26H25ClN2O6SPureza:98.94% - 99.85%Cor e Forma:SolidPeso molecular:529Lanreotide acetate
CAS:Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity, used for carcinoid syndromeFórmula:C56H73N11O12S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:1156.39BRL-15572 hydrochloride
CAS:<p>BRL-15572 hydrochloride: selective h5-HT1D antagonist with high affinity; useful for studying h5-HT1D responses.</p>Fórmula:C25H28Cl2N2OCor e Forma:SolidPeso molecular:443.41Bromopride hydrochloride
CAS:Bromopride HCl: Salt of a D2 blocker used for upper GI disorders, like dyspepsia and emesis.Fórmula:C14H23BrClN3O2Cor e Forma:SolidPeso molecular:380.71ML-191
CAS:ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.Fórmula:C24H25N3O3Pureza:99.58%Cor e Forma:SolidPeso molecular:403.47BETP
CAS:BETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor).Fórmula:C20H17F3N2O2SPureza:98.51%Cor e Forma:SolidPeso molecular:406.42BisfluoroModafinil
CAS:CRL-40940 is a selective dopaminergic reuptake inhibitorFórmula:C15H13F2NO2SPureza:99.19%Cor e Forma:SolidPeso molecular:309.33Vilanterol trifenatate
CAS:Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively)Fórmula:C44H49Cl2NO7Pureza:99.51% - >99.99%Cor e Forma:SolidPeso molecular:774.77Fluparoxan HCl
CAS:<p>Fluparoxan is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold).</p>Fórmula:C10H11ClFNO2Cor e Forma:SolidPeso molecular:231.65Opaganib
CAS:Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).Fórmula:C23H25ClN2OPureza:98.86% - 99.85%Cor e Forma:SolidPeso molecular:380.91Temanogrel
CAS:<p>Temanogrel (APD791) is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM).</p>Fórmula:C24H28N4O4Pureza:99.24%Cor e Forma:SolidPeso molecular:436.5Loxiglumide
CAS:<p>Loxiglumide (CR-1505) is an antagonist of cholecystokinin (CCK-1) receptor.</p>Fórmula:C21H30Cl2N2O5Pureza:97.55% - 99.81%Cor e Forma:SolidPeso molecular:461.38Tesmilifene fumarate
CAS:Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist。Fórmula:C23H29NO5Pureza:99.86%Cor e Forma:SolidPeso molecular:399.48PRX-08066
CAS:PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.Fórmula:C19H17ClFN5SPureza:97.79% - 98.07%Cor e Forma:SolidPeso molecular:401.89Tianeptine
CAS:Tianeptine (Tianeptine sodium) 是一种选择性5-HT 摄取促进剂，具有抗抑郁、抗焦虑和神经保护作用，可用于缓解疼痛的研究。Fórmula:C21H25ClN2O4SPureza:99.04%Cor e Forma:SolidPeso molecular:436.95TG4-155
CAS:<p>TG4-155: brain-penetrant EP2 inhibitor, KB 2.4 nM; >1000x weaker at EP4, KB 11.4 μM; selective over other receptors/channels.</p>Fórmula:C23H26N2O4Pureza:97.2%Cor e Forma:SolidPeso molecular:394.46Phentolamine
CAS:Phentolamine mesylate is an alpha-1 and alpha-2 selective adrenergic receptor antagonistFórmula:C17H19N3OPureza:99.86% - 99.94%Cor e Forma:Crystals SolidPeso molecular:281.35
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