GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(985 produtos)
- Receptor de adenosina(244 produtos)
- Receptor adrenérgico(2.991 produtos)
- Receptor de Bombesina(32 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(153 produtos)
- CaSR(33 produtos)
- Receptor de Canabinóides(209 produtos)
- Receptor de Dopamina(433 produtos)
- Receptor Endotelina(79 produtos)
- Receptor GNRH(77 produtos)
- GPCR19(32 produtos)
- GRK(33 produtos)
- GTPase(22 produtos)
- Receptor Glucagon(181 produtos)
- Hedgehog/Smoothened(46 produtos)
- Receptor de Histamina(380 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(309 produtos)
- PAFR(12 produtos)
- PKA(51 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5696 produtos de "GPCR/Proteína-G"
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Felypressin
CAS:<p>Felypressin, a Lypressin analog with a phenylalanine substitution, acts as a vasoconstrictor with less antidiuretic effect.</p>Fórmula:C46H65N13O11S2Pureza:99.65%Cor e Forma:SolidPeso molecular:1040.22NIBR189
CAS:<p>NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)</p>Fórmula:C21H21BrN2O3Pureza:97%Cor e Forma:ColourlessPeso molecular:429.31NGB 2904
CAS:NGB 2904 is a potent and selective antagonist of dopamine D3 receptor. NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).Fórmula:C28H29Cl2N3OPureza:98.79%Cor e Forma:SolidPeso molecular:494.46Niaprazine
CAS:<p>Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.</p>Fórmula:C20H25FN4OPureza:99.56%Cor e Forma:SolidPeso molecular:356.44JNJ-10229570
CAS:<p>JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland</p>Fórmula:C22H19N3O2SPureza:98.41%Cor e Forma:SolidPeso molecular:389.47AHN 1-055 hydrochloride
CAS:AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).Fórmula:C21H24ClF2NOPureza:99.89%Cor e Forma:SolidPeso molecular:379.87ML-SI3
CAS:<p>CCG-143140 is a GLP-1 receptor inverse agonists.</p>Fórmula:C23H31N3O3SPureza:99.75%Cor e Forma:SolidPeso molecular:429.58Etrasimod
CAS:Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).Fórmula:C26H26F3NO3Pureza:98.52% - 99.73%Cor e Forma:SolidPeso molecular:457.48Riociguat
CAS:Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterialFórmula:C20H19FN8O2Pureza:99.28% - 99.95%Cor e Forma:SolidPeso molecular:422.42Tropisetron
CAS:Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.Fórmula:C17H20N2O2Pureza:99.68%Cor e Forma:White SolidPeso molecular:284.35Geissoschizine methyl ether
CAS:Geissoschizine methyl ether: an alkaloid from Uncaria hook, key in Yokukansan, impacts mood and social behavior enhancing serotonin activity.Fórmula:C22H26N2O3Pureza:99.24% - 99.68%Cor e Forma:SolidPeso molecular:366.45LGnRH-III, lamprey acetate(147859-97-0 free base)
LGnRH-III, lamprey acetate is an evolutionarily conserved member of the GnRH family, can stimulate the secretion of gonadotropins, it stimulates the secretionFórmula:C61H78N18O16Pureza:99.66%Cor e Forma:SolidPeso molecular:1319.38MK 571
CAS:<p>MK 571 (L660711) is an orally active antagonist of CysLT1 receptor.</p>Fórmula:C26H27ClN2O3S2Pureza:98.69% - 99.65%Cor e Forma:SolidPeso molecular:515.09HTMT dimaleate
CAS:<p>HTMT dimaleate (Histamine Trifluoromethyl Toluidide Dimaleate) is an H1 and H2 receptor agonist.</p>Fórmula:C27H33F3N4O9Pureza:99.51%Cor e Forma:SolidPeso molecular:614.57Flibanserin
CAS:<p>Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder.</p>Fórmula:C20H21F3N4OPureza:99.37% - 99.93%Cor e Forma:White PowderPeso molecular:390.4Nomifensine maleate
CAS:<p>Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.</p>Fórmula:C20H22N2O4Pureza:98.46%Cor e Forma:SolidPeso molecular:354.4CAY10444
CAS:<p>CAY10444 is an S1P3 specific antagonist.</p>Fórmula:C15H29NO2SPureza:99.15% - 99.61%Cor e Forma:SolidPeso molecular:287.46ABT-724
CAS:ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)Fórmula:C17H19N5Pureza:99.73%Cor e Forma:SolidPeso molecular:293.37CYM50358
CAS:<p>N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4).</p>Fórmula:C20H18Cl2N2O2Pureza:98.05% - 99.76%Cor e Forma:SolidPeso molecular:389.28ONO-AE3-208
CAS:<p>ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.</p>Fórmula:C24H21FN2O3Pureza:98.04% - 99.55%Cor e Forma:SolidPeso molecular:404.43GW 405833
CAS:GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selectiveFórmula:C23H24Cl2N2O3Pureza:99.82% - 99.93%Cor e Forma:SolidPeso molecular:447.35Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Fórmula:C19H23NOPureza:99.87%Cor e Forma:SolidPeso molecular:281.39Trimethobenzamide hydrochloride
CAS:<p>Trimethobenzamide hydrochloride (Ro 2-9578) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.</p>Fórmula:C21H29ClN2O5Pureza:99.52%Cor e Forma:SolidPeso molecular:424.92TC-G 1005
CAS:TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).Fórmula:C25H25N3O2Pureza:98.60% - 99.78%Cor e Forma:SolidPeso molecular:399.48CRF (6-33) acetate(120066-38-8 free base)
<p>CRFBP inhibitor peptide; reduces weight gain, boosts activity in obese rats.</p>Fórmula:C143H235N41O45SPureza:97.12%Cor e Forma:SolidPeso molecular:3280.76VUF10460
CAS:VUF10460 is a non-imidazole histamine H4 receptor agonist.Fórmula:C15H19N5Pureza:99.44% - 99.57%Cor e Forma:SolidPeso molecular:269.34SCH442416
CAS:<p>SCH442416: selective A2A adenosine receptor antagonist; Ki: 0.048 nM (human), 0.5 nM (rat).</p>Fórmula:C20H19N7O2Pureza:99.58%Cor e Forma:SolidPeso molecular:389.41NAV-2729
CAS:<p>NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.</p>Fórmula:C25H17ClN4O3Pureza:98.83% - 98.91%Cor e Forma:SolidPeso molecular:456.88Serotonin hydrochloride
CAS:<p>Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (</p>Fórmula:C10H13ClN2OPureza:98.05% - 99.93%Cor e Forma:White To Cream PowderPeso molecular:212.676Cerlapirdine
CAS:<p>Cerlapirdine (PF-05212365), a 5-HT6 receptor antagonist, is in trials for Alzheimer's and schizophrenia cognition issues.</p>Fórmula:C22H23N3O3SPureza:98.77%Cor e Forma:SolidPeso molecular:409.5Xaliproden hydrochloride
CAS:<p>Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist.</p>Fórmula:C24H23ClF3NPureza:99.99%Cor e Forma:SolidPeso molecular:417.89Cetrorelix diacetate
CAS:Cetrorelix diacetate (NS-75A) is is a gonadotropin-releasing hormone antagonist.Fórmula:C74H100ClN17O18Pureza:98.38%Cor e Forma:SolidPeso molecular:1551.17ELA-14(human) acetate
<p>ELA-14(human) acetate, a fragment of ELA, targets APJ, activates Gαi1 and β-arrestin-2, and prompts receptor internalization like its parent peptide.</p>Fórmula:C77H123N25O19S2Pureza:97.2%Cor e Forma:SolidPeso molecular:1767.09Antalarmin
CAS:<p>Antalarmin is a CRHR1 antagonist that blocks adrenocorticotropin-releasing hormone-induced hypertension, blocks CRF activation.</p>Fórmula:C24H34N4Cor e Forma:SolidPeso molecular:378.559-FLUORENOL
CAS:<p>9-FLUORENOL is a dopamine reuptake inhibitor with IC50 of 9 μM, and a major metabolite of a compound developed as a wakefulness-promoting agent.</p>Fórmula:C13H10OPureza:99.98%Cor e Forma:Off-White Crystalline PowderPeso molecular:182.22Paltusotine
CAS:Paltusotine: nonpeptide SST2 agonist, orally bioavailable, regulates GH/IGF-1 in acromegaly.Fórmula:C27H22F2N4OPureza:99.91%Cor e Forma:SolidPeso molecular:456.49Ebastine
CAS:Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine.Fórmula:C32H39NO2Pureza:99.65% - 99.99%Cor e Forma:White To Off-White PowderPeso molecular:469.66Propionylpromazine hydrochloride
CAS:<p>Propionylpromazine hydrochloride (Propiopromazine hydrochloride) is a dopamine receptor D2 (DRD2) antagonist.</p>Fórmula:C20H25ClN2OSPureza:99.17%Cor e Forma:SolidPeso molecular:376.94Ocaperidone
CAS:<p>Ocaperidona (Ocaperidone (Ocaperidona)), a very high affinity dopamine D2 antagonist.</p>Fórmula:C24H25FN4O2Pureza:99.33%Cor e Forma:SolidPeso molecular:420.48CYM-5520
CAS:<p>CYM-5520 is a noncompetitive allosteric agonist of S1P2</p>Fórmula:C21H19N3O2Pureza:99.47%Cor e Forma:SolidPeso molecular:345.39Dimaprit dihydrochloride
CAS:<p>Dimaprit dihydrochloride: selective H2 agonist, inhibits nNOS (IC50: 49 μM), boosts gastric acid.</p>Fórmula:C6H15N3S·2HClPureza:99.79%Cor e Forma:SolidPeso molecular:234.19Gadolinium chloride
CAS:<p>Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist</p>Fórmula:Cl3GdPureza:98%Cor e Forma:White Crystalline SolidPeso molecular:263.61TNCA
CAS:<p>TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.</p>Fórmula:C12H12N2O2Pureza:97.33% - 97.73%Cor e Forma:SolidPeso molecular:216.24Clobenpropit 2HBr
CAS:Clobenpropit 2HBr is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in the brain.Fórmula:C14H17ClN4SCor e Forma:SolidPeso molecular:308.83PNU 22394 hydrochloride
CAS:PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonistFórmula:C13H17ClN2Pureza:97.83%Cor e Forma:SolidPeso molecular:236.74CS 2100
CAS:<p>CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.</p>Fórmula:C25H23N3O4SPureza:99.19%Cor e Forma:SolidPeso molecular:461.53AnaMorelin hydrochloride
CAS:AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).Fórmula:C31H43ClN6O3Pureza:99.18% - ≥98%Cor e Forma:SolidPeso molecular:583.16R715 TFA(185052-09-9 free base)
R715 TFA(185052-09-9 free base) is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49).Fórmula:C59H82F3N13O14Pureza:>99.99%Cor e Forma:SolidPeso molecular:1254.36L-DOPA methyl ester (hydrochloride)
CAS:<p>L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.</p>Fórmula:C10H14ClNO4Pureza:98.69% - 99.81%Cor e Forma:White SolidPeso molecular:247.675Diphenhydramine
CAS:<p>Diphenhydramine (Syntedril): first-gen antihistamine for allergies, antiemetic, antitussive, anticholinergic, sedative, treats drug-induced parkinsonism.</p>Fórmula:C17H21NOPureza:98.07%Cor e Forma:SolidPeso molecular:255.35
