GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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PU02
CAS:<p>PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.</p>Fórmula:C16H12N4SPureza:99.35%Cor e Forma:SolidPeso molecular:292.36Chlorcyclizine
CAS:<p>CHLORCYCLIZINE is a histamine H1 antagonist and a potent hepatitis C virus (HCV) entry inhibitor.</p>Fórmula:C18H21ClN2Pureza:98.75%Cor e Forma:SolidPeso molecular:300.83RU 24969 succinate
CAS:<p>RU 24969 succinate, a 5-HT receptor agonist, exhibits K i values of 0.38 nM for 5-HT 1B and 2.5 nM for 5-HT 1A, indicating its affinity towards these receptors. It reduces fluid consumption and enhances forward locomotion. This compound is utilized in neurological disease research.</p>Fórmula:C18H22N2O5Cor e Forma:SolidPeso molecular:346.38Naratriptan hydrochloride
CAS:<p>Naratriptan Hydrochloride, a selective 5-HT1 receptor agonist with anti-migraine effect, induces vasoconstriction and reduces inflammation in migraines.</p>Fórmula:C17H25N3O2S·HClPureza:99.17% - 99.93%Cor e Forma:Beige SolidPeso molecular:371.93Tribenoside
CAS:<p>Tribenoside (BG-356) is a vasoprotectant with mild anti-inflammatory, analgesic, and wound healing properties.</p>Fórmula:C29H34O6Pureza:≥98%Cor e Forma:LiquidPeso molecular:478.58Lodoxamide
CAS:<p>Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.</p>Fórmula:C11H6ClN3O6Pureza:99.13% - 99.81%Cor e Forma:SolidPeso molecular:311.63Sonidegib
CAS:<p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Cor e Forma:SolidPeso molecular:485.5SCH-37370
CAS:<p>SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine.</p>Fórmula:C21H21ClN2OPureza:99.07%Cor e Forma:SolidPeso molecular:352.86S26131
CAS:<p>S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of</p>Fórmula:C31H34N2O4Pureza:99.77%Cor e Forma:SolidPeso molecular:498.61Salmeterol Xinafoate
CAS:<p>Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma.</p>Fórmula:C36H45NO7Pureza:98% - 98.24%Cor e Forma:White SolidPeso molecular:603.75MRT-81
CAS:<p>MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.</p>Fórmula:C31H29N3O5SPureza:99.72%Cor e Forma:SolidPeso molecular:555.64Brompheniramine
CAS:<p>Brompheniramine, an alkylamine antihistamine, targets H1 receptors (Kd=6.06nM) and has anticholinergic/depressant qualities. Blocks Ca/Na/hERG channels.</p>Fórmula:C16H19BrN2Cor e Forma:SolidPeso molecular:319.24SB-649868
CAS:<p>SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).</p>Fórmula:C26H24FN3O3SPureza:99.53%Cor e Forma:SolidPeso molecular:477.55Lofexidine
CAS:<p>Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms.</p>Fórmula:C11H12Cl2N2OPureza:98.78%Cor e Forma:SolidPeso molecular:259.13Neuropeptide S (Mouse) acetate
<p>Neuropeptide S (Mouse) acetate is a bioactive peptide.</p>Fórmula:C95H160N34O29Pureza:98.25%Cor e Forma:SolidPeso molecular:2242.5Ranitidine
CAS:<p>Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors).</p>Fórmula:C13H22N4O3SPureza:99.52%Cor e Forma:Solid SolidPeso molecular:314.40Benorilate
CAS:<p>Benorilate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.</p>Fórmula:C17H15NO5Pureza:98.39% - 99.85%Cor e Forma:SolidPeso molecular:313.3AdipoRon
CAS:<p>AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).</p>Fórmula:C27H28N2O3Pureza:97.90% - 99.86%Cor e Forma:SolidPeso molecular:428.52FAUC 346
CAS:<p>FAUC 346 is a highly selective D3 partial agonist with EC50 of 1.5 nM.</p>Fórmula:C24H29N3O2SPureza:99.46%Cor e Forma:SolidPeso molecular:423.57S 38093
CAS:<p>S 38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).</p>Fórmula:C17H24N2O2Pureza:99.95%Cor e Forma:SolidPeso molecular:288.38[Lys5,MeLeu9,Nle10]-NKA(4-10)
CAS:<p>Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).</p>Fórmula:C39H65N9O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:803.99Almotriptan
CAS:<p>Almotriptan (LAS 31416), a triptan and 5-HT1B/1D agonist, treats migraines by constricting cranial vessels and altering blood flow.</p>Fórmula:C17H25N3O2SPureza:99.85%Cor e Forma:Light Yellow Or White PowerPeso molecular:335.46TCS 1102
CAS:<p>TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).</p>Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Cor e Forma:SolidPeso molecular:470.59BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08[Sar9,Met(O2)11]-Substance P acetate
<p>[Sar9,Met(O2)11]-Substance P acetate is an NK1 agonist, raising MAP and HR equally to septide but with unique timing and behaviors.</p>Fórmula:C66H106N18O18SPureza:>99.99%Cor e Forma:SolidPeso molecular:1471.75Ralmitaront
CAS:<p>Ralmitaront (RO6889450) is a potent, orally active partial agonist of the trace amine-associated receptor 1 (TAAR1).</p>Fórmula:C17H22N4O2Pureza:99.71% - 99.79%Cor e Forma:SolidPeso molecular:314.38CYM 50358 hydrochloride (1314212-39-9 free base)
CAS:<p>CYM50358 HCl is an S1P4 antagonist.</p>Fórmula:C20H19Cl3N2O2Pureza:99.57%Cor e Forma:SolidPeso molecular:425.73Geissoschizine methyl ether
CAS:<p>Geissoschizine methyl ether: an alkaloid from Uncaria hook, key in Yokukansan, impacts mood and social behavior enhancing serotonin activity.</p>Fórmula:C22H26N2O3Pureza:99.24% - 99.68%Cor e Forma:SolidPeso molecular:366.45Bepotastine Besilate
CAS:<p>Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).</p>Fórmula:C21H25ClN2O3·C6H6O3SPureza:99.83% - 99.9%Cor e Forma:Brown Viscous LiquidPeso molecular:547.06CYM5442
CAS:<p>CYM5442 is an S1P agonist, targeting to Sphingosine.</p>Fórmula:C23H27N3O4Pureza:98.02% - 99.48%Cor e Forma:SolidPeso molecular:409.48Chlorpheniramine
CAS:<p>Chlorpheniramine is an H1 anti-histamine agent for IgE-mediated inflammation that is commonly used for allergic diseases.</p>Fórmula:C16H19ClN2Cor e Forma:SolidPeso molecular:274.79Siramesine
CAS:<p>Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent</p>Fórmula:C30H31FN2OPureza:98%Cor e Forma:SolidPeso molecular:454.58SBI-553
CAS:<p>SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).</p>Fórmula:C26H31FN4O2Pureza:99.33%Cor e Forma:SolidPeso molecular:450.55MK-571 sodium
CAS:<p>MK-571 sodium, a CysLT1 antagonist and MRP2 inhibitor, obstructs drug efflux and hampers enterocyte phase-2 conjugation of flavonoids.</p>Fórmula:C26H27ClN2O3S2·NaPureza:97.86% - 99.58%Cor e Forma:SolidPeso molecular:537.07Raclopride tartrate
CAS:<p>Raclopride is a selective antagonist on D2 dopamine receptor ( D2 Ki: 1.8 nm, D3 Ki: 3.5 nm, D4 Ki: 2400, D1 Ki: 18000 nM).</p>Fórmula:C19H26Cl2N2O9Cor e Forma:SolidPeso molecular:497.32Amitriptyline
CAS:<p>Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.</p>Fórmula:C20H23NPureza:98.24% - 99.64%Cor e Forma:Crystals SolidPeso molecular:277.4NPS ALX Compound 4a
CAS:<p>NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)</p>Fórmula:C25H25N3O2SPureza:98%Cor e Forma:SolidPeso molecular:431.55Brefonalol
CAS:<p>Brefonalol is a vasodilating beta-adrenergic receptor blocker.</p>Fórmula:C22H28N2O2Cor e Forma:SolidPeso molecular:352.47Zafirlukast
CAS:<p>Zafirlukast (ICI 204219) is an orally leukotriene D4 receptor (LTD4) antagonist. Zafirlukast has anti-asthmatic and anti-inflammatory effects. Cost-effective and quality-assured.</p>Fórmula:C31H33N3O6SPureza:99% - 99.83%Cor e Forma:SolidPeso molecular:575.68Zuclopenthixol dihydrochloride
CAS:<p>Zuclopenthixol dihydrochloride is an D1 and D2 dopamine receptors antagonist.</p>Fórmula:C22H27Cl3N2OSPureza:98%Cor e Forma:SolidPeso molecular:473.89Parethoxycaine hydrochloride
CAS:<p>Parethoxycaine hydrochloride (2-(diethylamino)ethyl 4-ethoxybenzoate hydrochloride) is an anesthetic[1].</p>Fórmula:C15H24ClNO3Pureza:99.46%Cor e Forma:SolidPeso molecular:301.81Ansofaxine hydrochloride
CAS:<p>Ansofaxine hydrochloride (LY03005) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).</p>Fórmula:C24H32ClNO3Pureza:99.57% - 99.77%Cor e Forma:SolidPeso molecular:417.97Quipazine
CAS:<p>Quipazine: 5-HT agonist, Ki 1.4 nM at 5-HT3R, anti-SARS-CoV-2 (EC50 31.64 μM), for neurological research.</p>Fórmula:C13H15N3Cor e Forma:SolidPeso molecular:213.28Icatibant Acetate
CAS:<p>Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.</p>Fórmula:C61H93N19O15SPureza:99.68%Cor e Forma:SolidPeso molecular:1364.57MK-2894 sodium salt
CAS:<p>MK-2894 sodium salt is a highly potent and selective antagonist of second generation EP4.</p>Fórmula:C25H22F3NNaO3SPureza:98%Cor e Forma:SolidPeso molecular:496.5Terazosin
CAS:<p>Terazosin: oral α1-blocker, relaxes blood vessels, treats BPH and hypertension.</p>Fórmula:C19H25N5O4Cor e Forma:SolidPeso molecular:387.43Melanotan I
CAS:<p>Melanotan I is a non-specific melanocortin receptor (MCR) agonist, an α-melanocyte-stimulating hormone (α-MSH) analog, which is injected subcutaneously to</p>Fórmula:C78H111N21O19Pureza:>99.99%Cor e Forma:SolidPeso molecular:1646.85Ibrolipim
CAS:<p>Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.</p>Fórmula:C19H20BrN2O4PPureza:98.04%Cor e Forma:SolidPeso molecular:451.25HCGRP-(8-37) acetate
<p>HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.</p>Fórmula:C141H234N44O40Pureza:99.29%Cor e Forma:SolidPeso molecular:3185.64Ponesimod
CAS:<p>Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.</p>Fórmula:C23H25ClN2O4SPureza:99.42% - 99.96%Cor e Forma:SolidPeso molecular:460.97
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